{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T16:22:37Z","timestamp":1768580557223,"version":"3.49.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T00:00:00Z","timestamp":1504656000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-04083-10"],"award-info":[{"award-number":["APQ-04083-10"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biol Trace Elem Res"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1007\/s12011-017-1147-3","type":"journal-article","created":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T19:01:03Z","timestamp":1504724463000},"page":"305-313","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Effects of Arsenic Compounds on Microminerals Content and Antioxidant Enzyme Activities in Rat Liver"],"prefix":"10.1007","volume":"183","author":[{"given":"Ana Cl\u00e1udia Ferreira","family":"Souza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah Cozzer","family":"Marchesi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graziela Domingues","family":"de Almeida Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Machado-Neves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,9,6]]},"reference":[{"key":"1147_CR1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-4274(02)00084-X","volume":"133","author":"MF Hughes","year":"2002","unstructured":"Hughes MF (2002) Arsenic toxicity and potential mechanisms of action. Toxicol Lett 133:1\u201316","journal-title":"Toxicol Lett"},{"key":"1147_CR2","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1136\/pmj.79.933.391","volume":"79","author":"RN Ratnaike","year":"2003","unstructured":"Ratnaike RN (2003) Acute and chronic arsenic toxicity. Postgrad Med J 79:391\u2013396","journal-title":"Postgrad Med J"},{"key":"1147_CR3","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1289\/ehp.021101147","volume":"110","author":"SH Frisbie","year":"2002","unstructured":"Frisbie SH, Ortega R, Maynard DM, Sarkar B (2002) The concentrations of arsenic and others elements in Bangladesh\u2019s drinking water. Environ Health Perspect 110:1147\u20131153","journal-title":"Environ Health Perspect"},{"key":"1147_CR4","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s10653-006-9074-9","volume":"29","author":"BR Figueiredo","year":"2007","unstructured":"Figueiredo BR, Borba RT, Angelica RS (2007) Arsenic occurrence in Brazil and human exposure. Environ Geochem Health 29:109\u2013118","journal-title":"Environ Geochem Health"},{"key":"1147_CR5","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.etap.2015.09.016","volume":"40","author":"KSM Abdul","year":"2015","unstructured":"Abdul KSM, Jayasinghe SS, Chandana EPS, Jayasumana C, De Silva PMCS (2015) Arsenic and human health effects: a review. Environ Toxicol Pharmacol 40:828\u2013846","journal-title":"Environ Toxicol Pharmacol"},{"key":"1147_CR6","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.etap.2016.10.020","volume":"48","author":"A Sattar","year":"2016","unstructured":"Sattar A, Xie S, Hafeez MA, Wang X, Hussain HI, Iqbal Z, Pan Y, Iqbal M, Shabbir MA, Yuan Z (2016) Metabolism and toxicity of arsenicals in mammals. Environ Toxicol Pharmacol 48:214\u2013224","journal-title":"Environ Toxicol Pharmacol"},{"key":"1147_CR7","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s10653-008-9235-0","volume":"S1","author":"MM Rahman","year":"2009","unstructured":"Rahman MM, Ng JC, Naidu R (2009) Chronic exposure of arsenic via drinking water and its adverse health impacts on humans. Environ Geochem Health S1:189\u2013200","journal-title":"Environ Geochem Health"},{"key":"1147_CR8","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1080\/01926230490502566","volume":"32","author":"RNP Neves","year":"2004","unstructured":"Neves RNP, Carvalho F, Carvalho M, Fernandes E, Soares E, Bastos ML, Pereira ML (2004) Protective activity of hesperidin and lipoic acid against sodium arsenite acute toxicity in mice. Toxicol Pathol 32:527\u2013535","journal-title":"Toxicol Pathol"},{"key":"1147_CR9","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/jbt.20416","volume":"26","author":"T Rana","year":"2012","unstructured":"Rana T, Bera AK, Das S, Bhattacharya D, Pan D, Das SK (2012) Metabolic adaptations to arsenic-induced oxidative stress in male Wistar rats. J Biochem Mol Toxicol 26:109\u2013116","journal-title":"J Biochem Mol Toxicol"},{"key":"1147_CR10","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.etap.2013.09.003","volume":"36","author":"D Kotyzov\u00e1","year":"2013","unstructured":"Kotyzov\u00e1 D, Bludovsk\u00e1 M, Eybl V (2013) Differential influences of various arsenic compounds on antioxidant defense system in liver and kidney of rats. Environ Toxicol Pharmacol 36:1015\u20131021","journal-title":"Environ Toxicol Pharmacol"},{"key":"1147_CR11","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s12011-015-0436-y","volume":"171","author":"MR Sepand","year":"2016","unstructured":"Sepand MR, Razavi-Azarkhiavi K, Omidi A, Zirak MR, Sabzevari S, Kazemi AR, Sabzevari O (2016) Effect of acetyl-L-carnitine on antioxidant status, lipid peroxidation, and oxidative damage of arsenic in rat. Biol Trace Elem Res 171:107\u2013115","journal-title":"Biol Trace Elem Res"},{"key":"1147_CR12","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1002\/tox.21808","volume":"29","author":"E Lu","year":"2014","unstructured":"Lu E, Zhao F, Sun D, Zhong Y, Yu X, Li G, Lv X, Sun G, Jin Y (2014) Comparison of speciated arsenic levels in the liver and brain of mice between arsenate and arsenite exposure at the early life. Environ Toxicol 29:797\u2013803","journal-title":"Environ Toxicol"},{"key":"1147_CR13","doi-asserted-by":"crossref","first-page":"3646","DOI":"10.1016\/j.fct.2008.09.040","volume":"46","author":"X Cui","year":"2008","unstructured":"Cui X, Okayasu R (2008) Arsenic accumulation, elimination, and interaction with copper, zinc and manganese in liver and kidney of rats. Food Chem Toxicol 46:3646\u20133650","journal-title":"Food Chem Toxicol"},{"key":"1147_CR14","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1007\/s11356-013-2057-3","volume":"21","author":"W Kharroubi","year":"2014","unstructured":"Kharroubi W, Dhibi M, Haouas Z, Chreif I, Neffati F, Hammami M, Sakly R (2014) Effects of sodium arsenate exposure on liver fatty acid profiles and oxidative stress in rats. Environ Sci Pollut Res 21:1648\u20131657","journal-title":"Environ Sci Pollut Res"},{"key":"1147_CR15","volume-title":"315\u2013318","author":"World Health Organization \u2013 WHO","year":"2011","unstructured":"World Health Organization \u2013 WHO (2011) Guidelines for drinking water quality. 4th ed. Geneva pp. In: 315\u2013318"},{"key":"1147_CR16","first-page":"200","volume":"4","author":"KO Soetan","year":"2010","unstructured":"Soetan KO, Olaiya CO, Oyewole OE (2010) The importance of mineral elements for humans, domestic animals and plants: a review. Afr J Food Sci 4:200\u2013222","journal-title":"Afr J Food Sci"},{"key":"1147_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2016\/5464373","volume":"2016","author":"Preeti Tomar Bhattacharya","year":"2016","unstructured":"Bhattacharya PT, Misra SR, Hussain M (2016) Nutritional aspects of essential trace elements in oral health and disease: an extensive review. Scientifica:1\u201312 \nhttps:\/\/doi.org\/10.1155\/2016\/5464373","journal-title":"Scientifica"},{"key":"1147_CR18","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1097\/CAD.0b013e32830c456b","volume":"19","author":"Y Molin","year":"2008","unstructured":"Molin Y, Frisk P, Ilback NG (2008) Sequential effects of daily arsenic trioxide treatment on essential and nonessential trace elements in tissues in mice. Anti-Cancer Drugs 19:812\u2013818","journal-title":"Anti-Cancer Drugs"},{"key":"1147_CR19","first-page":"83","volume":"29","author":"Y Molin","year":"2009","unstructured":"Molin Y, Frisk P, Ilback N-G (2009) Arsenic trioxide affects the trace element balance in tissues in infected and healthy mice differently. Anticancer Res 29:83\u201390","journal-title":"Anticancer Res"},{"key":"1147_CR20","doi-asserted-by":"crossref","first-page":"21741","DOI":"10.1007\/s11356-016-7318-5","volume":"23","author":"Y He","year":"2016","unstructured":"He Y, Sun B, Li S, Sun X, Guo Y, Zhao H, Wang Y, Jiang G, Xing M (2016) Simultaneous analysis 26 mineral element contents from highly consumed cultured chicken overexposed to arsenic trioxide by inductively coupled plasma mass spectrometry. Environ Sci Pollut Res 23:21741\u201321750","journal-title":"Environ Sci Pollut Res"},{"key":"1147_CR21","first-page":"463","volume":"98","author":"KR Mahaffey","year":"1981","unstructured":"Mahaffey KR, Capar SG, Gladen BC, Fowler BA (1981) Concurrent exposure to lead, cadmium, and arsenic. Effects on toxicity and tissue metal concentrations in the rat. J Lab Clin Med 98:463\u2013481","journal-title":"J Lab Clin Med"},{"key":"1147_CR22","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.freeradbiomed.2011.04.008","volume":"51","author":"SJS Flora","year":"2011","unstructured":"Flora SJS (2011) Arsenic-induced oxidative stress and its reversibility. Free Radic Biol Med 51:257\u2013281","journal-title":"Free Radic Biol Med"},{"key":"1147_CR23","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1177\/0192623311425059","volume":"40","author":"RD Novaes","year":"2012","unstructured":"Novaes RD, Gon\u00e7alves RV, Marques DCS, Cupertino MC, Peluzio MCG, Leite JPV, Maldonado IRSC (2012) Effect of bark extract of Bathysa cuspidata on hepatic oxidative damage and blood glucose kinetics in rats exposed to paraquat. Toxicol Pathol 40:62\u201370","journal-title":"Toxicol Pathol"},{"key":"1147_CR24","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.carpath.2012.12.001","volume":"22","author":"RD Novaes","year":"2013","unstructured":"Novaes RD, Penitente AR, Gon\u00e7alves RV, Talvani A, Peluzio MCG, Neves CA, Natali AJ, Madonado IRSC (2013) Trypanosoma cruzi infection induces morphological reorganization of the myocardium parenchyma and stroma, and modifies the mechanical properties of atrial and ventricular cardiomyocytes in rats. Cardiovasc Pathol 22:270\u2013279","journal-title":"Cardiovasc Pathol"},{"key":"1147_CR25","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1161\/01.CIR.101.1.33","volume":"101","author":"S Dieterich","year":"2000","unstructured":"Dieterich S, Bieligk U, Beulich K, Hasenfuss G, Prestle J (2000) Gene expression of antioxidative enzymes in the human heart: increase expression of catalase in the end-stage failing heart. Circulation 101:33\u201339","journal-title":"Circulation"},{"key":"1147_CR26","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/0003-2697(70)90083-7","volume":"34","author":"G Cohen","year":"1970","unstructured":"Cohen G, Dembiec D, Marcus J (1970) Measurement of catalase activity in tissue extracts. Anal Biochem 34:30\u201338","journal-title":"Anal Biochem"},{"key":"1147_CR27","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/s12011-015-0523-0","volume":"171","author":"ACF Souza","year":"2016","unstructured":"Souza ACF, Marchesi SC, Lima GDA, Ferraz RP, Santos FC, Matta SLP, Machado-Neves M (2016) Effects of sodium arsenite and arsenate in testicular histomorphometry and antioxidants enzymes activities in rats. Biol Trace Elem Res 171:354\u2013362","journal-title":"Biol Trace Elem Res"},{"key":"1147_CR28","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1152\/physrev.1993.73.1.79","volume":"73","author":"BL Vallee","year":"1993","unstructured":"Vallee BL, Falchuk KF (1993) The biochemical basis of zinc physiology. Physiol Rev 73:79\u2013118","journal-title":"Physiol Rev"},{"key":"1147_CR29","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.mam.2005.07.013","volume":"26","author":"CG Fraga","year":"2005","unstructured":"Fraga CG (2005) Relevance, essentiality and toxicity of trace elements in human health. Mol Asp Med 26:235\u2013244","journal-title":"Mol Asp Med"},{"key":"1147_CR30","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1385\/BTER:78:1-3:149","volume":"78","author":"VN Izg\u00fct-Uysal","year":"2000","unstructured":"Izg\u00fct-Uysal VN, Derin N, A\u011fa\u00e7 A (2000) Effect of cold-restraint stress on the distribution of trace elements in rat tissues. Biol Trace Elem Res 78:149\u2013155","journal-title":"Biol Trace Elem Res"},{"key":"1147_CR31","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev.bi.56.070187.002143","volume":"56","author":"E Carafoli","year":"1987","unstructured":"Carafoli E (1987) Intracellular calcium homeostasis. Annu Rev Biochem 56:395\u2013433","journal-title":"Annu Rev Biochem"},{"key":"1147_CR32","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s10534-012-9599-6","volume":"26","author":"X Wang","year":"2013","unstructured":"Wang X, Zhang J, Zhao L, Hu S, Piao F (2013) Effect of subchronic exposure to arsenic on levels of essential trace elements in mice brain and its gender difference. Biometals 26:123\u2013131","journal-title":"Biometals"},{"key":"1147_CR33","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/s12011-015-0400-x","volume":"169","author":"R Ganger","year":"2016","unstructured":"Ganger R, Garla R, Mohanty BP, Bansal MP, Garg ML (2016) Protective effects of zinc against acute arsenic toxicity by regulating antioxidant defense system and cumulative metallothionein expression. Biol Trace Elem Res 169:218\u2013229","journal-title":"Biol Trace Elem Res"},{"key":"1147_CR34","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0009-2797(92)90057-R","volume":"85","author":"A Albores","year":"1992","unstructured":"Albores A, Koropatnick J, Cherian MG, Zelazowski AJ (1992) Arsenic induces and enhances rat hepatic metallothionein production in vivo. Chem Biol Interact 85:127\u2013140","journal-title":"Chem Biol Interact"},{"key":"1147_CR35","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0009-8981(00)00422-8","volume":"305","author":"ME Inal","year":"2001","unstructured":"Inal ME, Kanbak G, Sunal E (2001) Antioxidant enzymes activities and malonaldehyde levels related to aging. Clin Chim Acta 305:75\u201380","journal-title":"Clin Chim Acta"},{"key":"1147_CR36","first-page":"15","volume":"9","author":"EC Jardim","year":"1979","unstructured":"Jardim EC, Neto JMF, Fichtner SS (1979) Prote\u00ednas totais, transaminase glut\u00e2mica oxalac\u00e9tica e transaminase glut\u00e2mica piruvica em bovinos intoxicados experimentalmente pelo tetracloreto de carbono. Pesq Agropec Trop 9:15\u201331","journal-title":"Pesq Agropec Trop"},{"key":"1147_CR37","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.tox.2005.02.013","volume":"211","author":"D Nandi","year":"2005","unstructured":"Nandi D, Patra RC, Swarup D (2005) Effect of cysteine, methionine, ascorbic acid and thiamine on arsenic-induced oxidative stress and biochemical alterations in rats. Toxicology 211:26\u201335","journal-title":"Toxicology"},{"key":"1147_CR38","doi-asserted-by":"crossref","first-page":"3506","DOI":"10.1016\/j.fct.2008.08.031","volume":"46","author":"MI Yousef","year":"2008","unstructured":"Yousef MI, El-Demerdash FM, Radwan FME (2008) Sodium arsenite induced biochemical perturbations in rats: ameliorating effect of curcumin. Food Chem Toxicol 46:3506\u20133511","journal-title":"Food Chem Toxicol"},{"key":"1147_CR39","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/iep.12046","volume":"94","author":"MC Cupertino","year":"2013","unstructured":"Cupertino MC, Costa KLC, Santos DCM, Novaes RD, Condessa SS, Neves AC, Oliveira JA, Matta SLP (2013) Long-lasting morphofunctional remodelling of liver parenchyma and stroma after a single exposure to low and moderate doses of cadmium in rats. Int J Exp Pathol 94:343\u2013351","journal-title":"Int J Exp Pathol"},{"key":"1147_CR40","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1080\/01926230490261348","volume":"32","author":"X Cui","year":"2004","unstructured":"Cui X, Li S, Shraim A, Kobayashi Y, Hayakawa T, Kanno S, Yamamoto M, Hirano S (2004) Subchronic exposure to arsenic through drinking water alters expression of cancer-related genes in rat liver. Toxicol Pathol 32:64\u201372","journal-title":"Toxicol Pathol"},{"key":"1147_CR41","doi-asserted-by":"crossref","first-page":"229","DOI":"10.5115\/acb.2012.45.4.229","volume":"45","author":"A Bhattacharya","year":"2012","unstructured":"Bhattacharya A, Dhar P, Mehra RD (2012) Preliminary morphological and biochemical changes in rat liver following postnatal exposure to sodium arsenite. Anat Cell Biol 45:229\u2013240","journal-title":"Anat Cell Biol"},{"key":"1147_CR42","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/S0140-6736(02)11214-1","volume":"360","author":"F Braet","year":"2002","unstructured":"Braet F, Vanbesien J, De Zanger R, Wisse E (2002) Ageing of the liver sieve and pseudocapillarisation. Lancet 360:1171\u20131172","journal-title":"Lancet"},{"key":"1147_CR43","first-page":"225","volume":"32","author":"AM Gressner","year":"1994","unstructured":"Gressner AM (1994) Activation of proteoglycan synthesis in injured liver- a brief review of molecular and cellular aspects. Eur J Clin Chem Clin Biochem 32:225\u2013237","journal-title":"Eur J Clin Chem Clin Biochem"},{"key":"1147_CR44","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s00795-003-0228-x","volume":"37","author":"M Naito","year":"2004","unstructured":"Naito M, Hasegawa G, Ebe Y, Yamamoto T (2004) Differentiation and function of Kupffer cells. Med Electron Microsc 37:16\u201328","journal-title":"Med Electron Microsc"}],"container-title":["Biological Trace Element Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12011-017-1147-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-017-1147-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-017-1147-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T08:09:32Z","timestamp":1583309372000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12011-017-1147-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,6]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["1147"],"URL":"https:\/\/doi.org\/10.1007\/s12011-017-1147-3","relation":{},"ISSN":["0163-4984","1559-0720"],"issn-type":[{"value":"0163-4984","type":"print"},{"value":"1559-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,6]]},"assertion":[{"value":"3 July 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 September 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The experimental procedures were conducted in accordance with the ethical principles in animal research adopted by the Ethics Committee of Animal Use of the Federal University of Vi\u00e7osa, Brazil (CEUA protocol 19\/2011).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}