{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T15:47:16Z","timestamp":1762876036028,"version":"3.37.3"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,11,7]],"date-time":"2018-11-07T00:00:00Z","timestamp":1541548800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Scientific Foundation of China","doi-asserted-by":"crossref","award":["81472924","81620108026"],"award-info":[{"award-number":["81472924","81620108026"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["xjj2018154"],"award-info":[{"award-number":["xjj2018154"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biol Trace Elem Res"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1007\/s12011-018-1560-2","type":"journal-article","created":{"date-parts":[[2018,11,7]],"date-time":"2018-11-07T05:28:51Z","timestamp":1541568531000},"page":"295-302","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Expression Profiles of Selenium-Related Genes in Human Chondrocytes Exposed to T-2 Toxin and Deoxynivalenol"],"prefix":"10.1007","volume":"190","author":[{"given":"Lei","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,11,7]]},"reference":[{"issue":"7182","key":"1560_CR1","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1136\/bmj.318.7182.485","volume":"318","author":"R Tomlinson","year":"1999","unstructured":"Tomlinson R (1999) Beijing conference reviews Kashin-Beck disease. BMJ 318(7182):485","journal-title":"BMJ"},{"key":"1560_CR2","volume-title":"China statistical yearbook of health and family planning","author":"National Health and Family Planning Commission","year":"2015","unstructured":"National Health and Family Planning Commission (2015) China statistical yearbook of health and family planning. Pecking Union Medical College Press, Beijing"},{"issue":"11","key":"1560_CR3","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1016\/j.joca.2014.07.023","volume":"22","author":"X Guo","year":"2014","unstructured":"Guo X, Ma WJ, Zhang F, Ren FL, Qu CJ, Lammi MJ (2014) Recent advances in the research of an endemic osteochondropathy in China: Kashin-Beck disease. Osteoarthr Cartil 22(11):1774\u20131783. \n                    https:\/\/doi.org\/10.1016\/j.joca.2014.07.023","journal-title":"Osteoarthr Cartil"},{"issue":"3","key":"1560_CR4","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/s002640100248","volume":"25","author":"X Guo","year":"2001","unstructured":"Guo X (2001) Diagnostic, clinical and radiological characteristics of Kashin-Beck disease in Shaanxi Province, PR China. Int Orthop 25(3):147\u2013150","journal-title":"Int Orthop"},{"issue":"3","key":"1560_CR5","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s002640000179","volume":"25","author":"P Sudre","year":"2001","unstructured":"Sudre P, Mathieu F (2001) Kashin-Beck disease: from etiology to prevention or from prevention to etiology? Int Orthop 25(3):175\u2013179","journal-title":"Int Orthop"},{"key":"1560_CR6","first-page":"201","volume":"14","author":"JB Yang","year":"1995","unstructured":"Yang JB (1995) Research report on the etiology of Kashin-Beck disease. Chin J Endemiol 14:201\u2013204","journal-title":"Chin J Endemiol"},{"issue":"1","key":"1560_CR7","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1007\/s12011-015-0495-0","volume":"171","author":"R Lei","year":"2015","unstructured":"Lei R, Jiang N, Zhang Q, Hu S, Dennis BS, He S, Guo X (2015) Prevalence of selenium, T-2 toxin, and deoxynivalenol in Kashin-Beck disease areas in Qinghai province, northwest China. Biol Trace Elem Res 171(1):34\u201340. \n                    https:\/\/doi.org\/10.1007\/s12011-015-0495-0","journal-title":"Biol Trace Elem Res"},{"issue":"1","key":"1560_CR8","doi-asserted-by":"publisher","first-page":"2231","DOI":"10.1038\/s41598-017-02568-5","volume":"7","author":"L Yang","year":"2017","unstructured":"Yang L, Zhao GH, Wang X, Wang YT, Lin XL, Yu FF, Goldring MB, Guo X, Lammi MJ (2017) Cellular responses to T-2 toxin and\/or deoxynivalenol that induce cartilage damage are not specific to chondrocytes. Sci Rep 7(1):2231. \n                    https:\/\/doi.org\/10.1038\/s41598-017-02568-5","journal-title":"Sci Rep"},{"issue":"1","key":"1560_CR9","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s12011-015-0463-8","volume":"170","author":"L Yang","year":"2016","unstructured":"Yang L, Zhao GH, Yu FF, Zhang RQ, Guo X (2016) Selenium and iodine levels in subjects with Kashin-Beck disease: a meta-analysis. Biol Trace Elem Res 170(1):43\u201354. \n                    https:\/\/doi.org\/10.1007\/s12011-015-0463-8","journal-title":"Biol Trace Elem Res"},{"issue":"3","key":"1560_CR10","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1159\/000335046","volume":"196","author":"M Lu","year":"2012","unstructured":"Lu M, Cao J, Liu F, Li S, Chen J, Fu Q, Zhang Z, Liu J, Luo M, Wang J, Li J, Caterson B (2012) The effects of mycotoxins and selenium deficiency on tissue-engineered cartilage. Cells Tissues Organs 196(3):241\u2013250. \n                    https:\/\/doi.org\/10.1159\/000335046","journal-title":"Cells Tissues Organs"},{"issue":"2","key":"1560_CR11","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.tiv.2010.12.001","volume":"25","author":"J Chen","year":"2011","unstructured":"Chen J, Chu Y, Cao J, Wang W, Liu J, Wang J (2011) Effects of T-2 toxin and selenium on chondrocyte expression of matrix metalloproteinases (MMP-1, MMP-13), alpha2-macroglobulin (alpha2M) and TIMPs. Toxicol in Vitro 25(2):492\u2013499. \n                    https:\/\/doi.org\/10.1016\/j.tiv.2010.12.001","journal-title":"Toxicol in Vitro"},{"key":"1560_CR12","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.toxicon.2017.06.014","volume":"140","author":"L Yang","year":"2017","unstructured":"Yang L, Zhang J, Zhao G, Wu C, Ning Y, Wang X, Lammi MJ, Guo X (2017) Gene expression profiles and molecular mechanism of cultured human chondrocytes\u2019 exposure to T-2 toxin and deoxynivalenol. Toxicon 140:38\u201344. \n                    https:\/\/doi.org\/10.1016\/j.toxicon.2017.06.014","journal-title":"Toxicon"},{"key":"1560_CR13","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) method. Methods 25:402\u2013408. \n                    https:\/\/doi.org\/10.1006\/meth.2001.1262","journal-title":"Methods"},{"issue":"5","key":"1560_CR14","doi-asserted-by":"publisher","first-page":"351","DOI":"10.3967\/bes2017.046","volume":"30","author":"HJ Yang","year":"2017","unstructured":"Yang HJ, Zhang Y, Wang ZL, Xue SH, Li SY, Zhou XR, Zhang M, Fang Q, Wang WJ, Chen C, Deng XH, Chen JH (2017) Increased chondrocyte apoptosis in Kashin-Beck disease and rats induced by T-2 toxin and selenium deficiency. Biomed Environ Sci 30(5):351\u2013362. \n                    https:\/\/doi.org\/10.3967\/bes2017.046","journal-title":"Biomed Environ Sci"},{"issue":"3","key":"1560_CR15","first-page":"152","volume":"12","author":"JL Cao","year":"1993","unstructured":"Cao JL, Xiong YM, Li SC (1993) The effect of seleniun and zinc on the growth of cultured chondrocytes. Chin J Endemiol 12(3):152\u2013154","journal-title":"Chin J Endemiol"},{"issue":"3","key":"1560_CR16","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1002\/art.27282","volume":"62","author":"C Duan","year":"2010","unstructured":"Duan C, Guo X, Zhang XD, Yu HJ, Yan H, Gao Y, Ma WJ, Gao ZQ, Xu P, Lammi M (2010) Comparative analysis of gene expression profiles between primary knee osteoarthritis and an osteoarthritis endemic to Northwestern China, Kashin-Beck disease. Arthritis Rheum 62(3):771\u2013780. \n                    https:\/\/doi.org\/10.1002\/art.27282","journal-title":"Arthritis Rheum"},{"issue":"2","key":"1560_CR17","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1007\/s10534-013-9610-x","volume":"26","author":"J Yan","year":"2013","unstructured":"Yan J, Zheng Y, Min Z, Ning Q, Lu S (2013) Selenium effect on selenoprotein transcriptome in chondrocytes. Biometals 26(2):285\u2013296. \n                    https:\/\/doi.org\/10.1007\/s10534-013-9610-x","journal-title":"Biometals"},{"issue":"1","key":"1560_CR18","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s12011-017-1160-6","volume":"184","author":"X Wang","year":"2018","unstructured":"Wang X, Zuo Z, Deng J, Zhang Z, Chen C, Fan Y, Peng G, Cao S, Hu Y, Yu S, Chen C, Ren Z (2018) Protective role of selenium in immune-relevant cytokine and immunoglobulin production by piglet splenic lymphocytes exposed to deoxynivalenol. Biol Trace Elem Res 184(1):83\u201391. \n                    https:\/\/doi.org\/10.1007\/s12011-017-1160-6","journal-title":"Biol Trace Elem Res"},{"issue":"1","key":"1560_CR19","first-page":"64","volume":"12","author":"A Ahmadi","year":"2015","unstructured":"Ahmadi A, Poursasan N, Amani J, Salimian J (2015) Adverse effect of T-2 toxin and the protective role of selenium and vitamin E on peripheral blood B lymphocytes. Iran J Immunol 12(1):64\u201369","journal-title":"Iran J Immunol"},{"issue":"1\u20132","key":"1560_CR20","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1007\/s12011-014-0189-z","volume":"163","author":"D Shi","year":"2015","unstructured":"Shi D, Liao S, Guo S, Li H, Yang M, Tang Z (2015) Protective effects of selenium on aflatoxin B1-induced mitochondrial permeability transition, DNA damage, and histological alterations in duckling liver. Biol Trace Elem Res 163(1\u20132):162\u2013168. \n                    https:\/\/doi.org\/10.1007\/s12011-014-0189-z","journal-title":"Biol Trace Elem Res"},{"issue":"1","key":"1560_CR21","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1007\/s12011-017-1030-2","volume":"181","author":"J Fang","year":"2018","unstructured":"Fang J, Yin H, Zheng Z, Zhu P, Peng X, Zuo Z, Cui H, Zhou Y, Ouyang P, Geng Y, Deng J (2018) The molecular mechanisms of protective role of Se on the G2\/M phase arrest of jejunum caused by AFB1. Biol Trace Elem Res 181(1):142\u2013153. \n                    https:\/\/doi.org\/10.1007\/s12011-017-1030-2","journal-title":"Biol Trace Elem Res"},{"issue":"9","key":"1560_CR22","doi-asserted-by":"publisher","first-page":"e108394","DOI":"10.1371\/journal.pone.0108394","volume":"9","author":"J Liu","year":"2014","unstructured":"Liu J, Wang L, Guo X, Pang Q, Wu S, Wu C, Xu P, Bai Y (2014) The role of mitochondria in T-2 toxin-induced human chondrocytes apoptosis. PLoS One 9(9):e108394. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0108394","journal-title":"PLoS One"},{"issue":"7","key":"1560_CR23","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1007\/s00204-014-1280-0","volume":"88","author":"QH Wu","year":"2014","unstructured":"Wu QH, Wang X, Yang W, Nussler AK, Xiong LY, Kuca K, Dohnal V, Zhang XJ, Yuan ZH (2014) Oxidative stress-mediated cytotoxicity and metabolism of T-2 toxin and deoxynivalenol in animals and humans: an update. Arch Toxicol 88(7):1309\u20131326. \n                    https:\/\/doi.org\/10.1007\/s00204-014-1280-0","journal-title":"Arch Toxicol"},{"issue":"2","key":"1560_CR24","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.toxlet.2012.12.003","volume":"217","author":"C Arunachalam","year":"2013","unstructured":"Arunachalam C, Doohan FM (2013) Trichothecene toxicity in eukaryotes: cellular and molecular mechanisms in plants and animals. Toxicol Lett 217(2):149\u2013158. \n                    https:\/\/doi.org\/10.1016\/j.toxlet.2012.12.003","journal-title":"Toxicol Lett"},{"issue":"8","key":"1560_CR25","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1111\/boc.201500015","volume":"107","author":"D Lorendeau","year":"2015","unstructured":"Lorendeau D, Christen S, Rinaldi G, Fendt SM (2015) Metabolic control of signalling pathways and metabolic auto-regulation. Biol Cell 107(8):251\u2013272. \n                    https:\/\/doi.org\/10.1111\/boc.201500015","journal-title":"Biol Cell"},{"key":"1560_CR26","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.jsbmb.2015.07.015","volume":"164","author":"G Eelen","year":"2016","unstructured":"Eelen G, Verlinden L, Maes C, Beullens I, Gysemans C, Paik JH, DePinho RA, Bouillon R, Carmeliet G, Verstuyf A (2016) Forkhead box O transcription factors in chondrocytes regulate endochondral bone formation. J Steroid Biochem Mol Biol 164:337\u2013343. \n                    https:\/\/doi.org\/10.1016\/j.jsbmb.2015.07.015","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"12","key":"1560_CR27","doi-asserted-by":"publisher","first-page":"2279","DOI":"10.1016\/j.joca.2015.06.020","volume":"23","author":"C Shen","year":"2015","unstructured":"Shen C, Cai GQ, Peng JP, Chen XD (2015) Autophagy protects chondrocytes from glucocorticoids-induced apoptosis via ROS\/Akt\/FOXO3 signaling. Osteoarthr Cartil 23(12):2279\u20132287. \n                    https:\/\/doi.org\/10.1016\/j.joca.2015.06.020","journal-title":"Osteoarthr Cartil"},{"issue":"11","key":"1560_CR28","doi-asserted-by":"publisher","first-page":"1936","DOI":"10.1016\/j.joca.2014.08.010","volume":"22","author":"C Wu","year":"2014","unstructured":"Wu C, Zheng J, Yao X, Shan H, Li Y, Xu P, Guo X (2014) Defective autophagy in chondrocytes with Kashin-Beck disease but higher than osteoarthritis. Osteoarthr Cartil 22(11):1936\u20131946. \n                    https:\/\/doi.org\/10.1016\/j.joca.2014.08.010","journal-title":"Osteoarthr Cartil"},{"issue":"7","key":"1560_CR29","doi-asserted-by":"publisher","first-page":"2424","DOI":"10.1016\/j.fct.2012.04.023","volume":"50","author":"G Yang","year":"2012","unstructured":"Yang G, Zhou X, Wang J, Zhang W, Zheng H, Lu W, Yuan J (2012) MEHP-induced oxidative DNA damage and apoptosis in HepG2 cells correlates with p53-mediated mitochondria-dependent signaling pathway. Food Chem Toxicol 50(7):2424\u20132431. \n                    https:\/\/doi.org\/10.1016\/j.fct.2012.04.023","journal-title":"Food Chem Toxicol"},{"issue":"52","key":"1560_CR30","doi-asserted-by":"publisher","first-page":"e5669","DOI":"10.1097\/MD.0000000000005669","volume":"95","author":"FF Yu","year":"2016","unstructured":"Yu FF, Zhang YX, Zhang LH, Li WR, Guo X, Lammi MJ (2016) Identified molecular mechanism of interaction between environmental risk factors and differential expression genes in cartilage of Kashin-Beck disease. Medicine 95(52):e5669. \n                    https:\/\/doi.org\/10.1097\/md.0000000000005669","journal-title":"Medicine"},{"key":"1560_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-1-4614-8289-5_1","volume":"793","author":"JM Salvador","year":"2013","unstructured":"Salvador JM, Brown-Clay JD, Fornace AJ Jr (2013) Gadd45 in stress signaling, cell cycle control, and apoptosis. Adv Exp Med Biol 793:1\u201319. \n                    https:\/\/doi.org\/10.1007\/978-1-4614-8289-5_1","journal-title":"Adv Exp Med Biol"}],"container-title":["Biological Trace Element Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-018-1560-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12011-018-1560-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-018-1560-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T19:27:21Z","timestamp":1573068441000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12011-018-1560-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,7]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["1560"],"URL":"https:\/\/doi.org\/10.1007\/s12011-018-1560-2","relation":{},"ISSN":["0163-4984","1559-0720"],"issn-type":[{"type":"print","value":"0163-4984"},{"type":"electronic","value":"1559-0720"}],"subject":[],"published":{"date-parts":[[2018,11,7]]},"assertion":[{"value":"27 May 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 October 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}}]}}