{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T11:26:45Z","timestamp":1778153205588,"version":"3.51.4"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T00:00:00Z","timestamp":1546387200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Laboratory of Atomic Emission Spectrometry"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biol Trace Elem Res"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1007\/s12011-018-1592-7","type":"journal-article","created":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T01:02:09Z","timestamp":1546390929000},"page":"34-44","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Trace Elements Associated with Systemic Lupus Erythematosus and Insulin Resistance"],"prefix":"10.1007","volume":"191","author":[{"given":"Eliel Marcio","family":"Pedro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena Flor","family":"da Rosa Franchi Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruna Miglioranza","family":"Scavuzzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana Mayumi Veiga","family":"Iriyoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiago Severo","family":"Peixe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcell Alysson Batiste","family":"Lozovoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edna Maria Vissoci","family":"Reiche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isaias","family":"Dichi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9a Name Colado","family":"Sim\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Josefa","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,1,2]]},"reference":[{"key":"1592_CR1","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.rdc.2014.05.003","volume":"40","author":"DL Kamen","year":"2014","unstructured":"Kamen DL (2014) Environmental influences on systemic lupus erythematosus expression. Rheum Dis Clin N Am 40:401\u2013412. https:\/\/doi.org\/10.1016\/j.rdc.2014.05.003","journal-title":"Rheum Dis Clin N Am"},{"key":"1592_CR2","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1586\/eci.10.98","volume":"7","author":"M McMahon","year":"2011","unstructured":"McMahon M, Hahn BH, Skaggs BJ (2011) Systemic lupus erythematosus and cardiovascular disease: prediction and potential for therapeutic intervention. Expert Rev Clin Immunol 7:227\u2013241. https:\/\/doi.org\/10.1586\/eci.10.98","journal-title":"Expert Rev Clin Immunol"},{"key":"1592_CR3","doi-asserted-by":"publisher","first-page":"2110","DOI":"10.1056\/NEJMra1100359","volume":"365","author":"GC Tsokos","year":"2011","unstructured":"Tsokos GC (2011) Systemic lupus erythematosus. N Engl J Med 365:2110\u20132121. https:\/\/doi.org\/10.1056\/NEJMra1100359","journal-title":"N Engl J Med"},{"key":"1592_CR4","first-page":"55","volume":"11","author":"B Chowdhury","year":"1987","unstructured":"Chowdhury B, Chandra R (1987) Biological and health implications of toxic heavy metal and essential trace element interactions. Prog Food Nutr Sci 11:55\u2013113","journal-title":"Prog Food Nutr Sci"},{"key":"1592_CR5","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/978-3-7643-8340-4_6","volume":"101","author":"PB Tchounwou","year":"2012","unstructured":"Tchounwou PB, Yedjou CG, Patlolla AK, Sutton DJ (2012) Heavy metals toxicity and the environment. EXS 101:133\u2013164. https:\/\/doi.org\/10.1007\/978-3-7643-8340-4_6","journal-title":"EXS"},{"key":"1592_CR6","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1093\/toxsci\/kfq345","volume":"119","author":"KM Gilbert","year":"2011","unstructured":"Gilbert KM, Rowley B, Gomez-Acevedo H, Blossom SJ (2011) Coexposure to mercury increases immunotoxicity of trichloroethylene. Toxicol Sci 119:281\u2013292. https:\/\/doi.org\/10.1093\/toxsci\/kfq345","journal-title":"Toxicol Sci"},{"key":"1592_CR7","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1080\/15287390306456","volume":"66","author":"C Hudson","year":"2003","unstructured":"Hudson C, Cao L, Kasten-Jolly J, Kirkwood J, Lawrence D (2003) Susceptibility of lupus-prone Nzm mouse strains to lead exacerbation of systemic lupus erythematosus symptoms. J Toxicol Environ Health A 66:895\u2013918. https:\/\/doi.org\/10.1080\/15287390306456","journal-title":"J Toxicol Environ Health A"},{"key":"1592_CR8","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/S0300-483X(03)00092-1","volume":"188","author":"EK Leffel","year":"2003","unstructured":"Leffel EK, Wolf C, Poklis A, White KL (2003) Drinking water exposure to cadmium, an environmental contaminant, results in the exacerbation of autoimmune disease in the murine model. Toxicology 188:233\u2013250","journal-title":"Toxicology"},{"key":"1592_CR9","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/BF00205193","volume":"7","author":"I Durak","year":"1994","unstructured":"Durak I, Kavutcu M, Canbola\u0163 O et al (1994) Concentrations of some major and minor elements in larynx tissues with and without cancer. Biometals 7:45\u201348","journal-title":"Biometals"},{"key":"1592_CR10","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1163\/156856903770196827","volume":"15","author":"S Taysi","year":"2003","unstructured":"Taysi S, Gulcin I, Sari RA, Kuskay S, Bakan N (2003) Trace elements and disease activity score in patients with rheumatoid arthritis. Pain Clin 15:435\u2013439. https:\/\/doi.org\/10.1163\/156856903770196827","journal-title":"Pain Clin"},{"key":"1592_CR11","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1093\/jn\/137.5.1345","volume":"137","author":"AS Prasad","year":"2007","unstructured":"Prasad AS (2007) Zinc: mechanisms of host defense. J Nutr 137:1345\u20131349","journal-title":"J Nutr"},{"key":"1592_CR12","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1097\/MCO.0b013e3283312956","volume":"12","author":"AS Prasad","year":"2009","unstructured":"Prasad AS (2009) Zinc: role in immunity, oxidative stress and chronic inflammation. Curr Opin Clin Nutr Metab Care 12:646\u2013652. https:\/\/doi.org\/10.1097\/MCO.0b013e3283312956","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"1592_CR13","doi-asserted-by":"publisher","first-page":"2543","DOI":"10.1093\/jn\/133.8.2543","volume":"133","author":"E Ho","year":"2003","unstructured":"Ho E, Courtemanche C, Ames BN (2003) Zinc deficiency induces oxidative DNA damage and increases p53 expression in human lung fibroblasts. J Nutr 133:2543\u20132548","journal-title":"J Nutr"},{"key":"1592_CR14","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/S0021-9150(97)00130-5","volume":"133","author":"GAA Ferns","year":"1997","unstructured":"Ferns GAA, Lamb DJ, Taylor A (1997) The possible role of copper ions in atherogenesis: the blue Janus. Atherosclerosis 133:139\u2013152. https:\/\/doi.org\/10.1016\/S0021-9150(97)00130-5","journal-title":"Atherosclerosis"},{"key":"1592_CR15","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1177\/0961203314530792","volume":"23","author":"M Sahebari","year":"2014","unstructured":"Sahebari M, Abrishami-Moghaddam M, Moezzi A, Ghayour-Mobarhan M, Mirfeizi Z, Esmaily H, Ferns G (2014) Association between serum trace element concentrations and the disease activity of systemic lupus erythematosus. Lupus 23:793\u2013801. https:\/\/doi.org\/10.1177\/0961203314530792","journal-title":"Lupus"},{"key":"1592_CR16","doi-asserted-by":"publisher","first-page":"2993","DOI":"10.4049\/jimmunol.170.6.2993","volume":"170","author":"M Marikovsky","year":"2003","unstructured":"Marikovsky M, Ziv V, Nevo N, Harris-Cerruti C, Mahler O (2003) Cu\/Zn superoxide dismutase plays important role in immune response. J Immunol 170:2993\u20133001","journal-title":"J Immunol"},{"key":"1592_CR17","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1007\/s11906-017-0701-x","volume":"19","author":"SK Panchal","year":"2017","unstructured":"Panchal SK, Wanyonyi S, Brown L (2017) Selenium, vanadium, and chromium as micronutrients to improve metabolic syndrome. Curr Hypertens Rep 19:10. https:\/\/doi.org\/10.1007\/s11906-017-0701-x","journal-title":"Curr Hypertens Rep"},{"key":"1592_CR18","doi-asserted-by":"publisher","first-page":"515","DOI":"10.3109\/08923979309019728","volume":"15","author":"EJ Kucharz","year":"1993","unstructured":"Kucharz EJ, Sierakowski SJ, Goodwin JS (1993) Lithium in vitro enhances interleukin-2 production by T cells from patients with systemic lupus erythematosus. Immunopharmacol Immunotoxicol 15:515\u2013523. https:\/\/doi.org\/10.3109\/08923979309019728","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"1592_CR19","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1136\/ard.53.6.403","volume":"53","author":"M Federmann","year":"1994","unstructured":"Federmann M, Morell B, Graetz G, Wyss M, Elsner P, von Thiessen R, Wuthrich B, Grob D (1994) Hypersensitivity to molybdenum as a possible trigger of ANA-negative systemic lupus erythematosus. Ann Rheum Dis 53:403\u2013405","journal-title":"Ann Rheum Dis"},{"key":"1592_CR20","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/1758-5996-2-70","volume":"2","author":"N Wiernsperger","year":"2010","unstructured":"Wiernsperger N, Rapin J (2010) Trace elements in glucometabolic disorders: an update. Diabetol Metab Syndr 2:70. https:\/\/doi.org\/10.1186\/1758-5996-2-70","journal-title":"Diabetol Metab Syndr"},{"key":"1592_CR21","doi-asserted-by":"publisher","first-page":"65","DOI":"10.5487\/TR.2016.32.1.065","volume":"32","author":"R Chunhabundit","year":"2016","unstructured":"Chunhabundit R (2016) Cadmium exposure and potential health risk from foods in contaminated area, Thailand. Toxicol Res 32:65\u201372. https:\/\/doi.org\/10.5487\/TR.2016.32.1.065","journal-title":"Toxicol Res"},{"key":"1592_CR22","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1002\/acr.23237","volume":"70","author":"CNH Miyake","year":"2018","unstructured":"Miyake CNH, Gualano B, Dantas WS, Pereira RT, Neves W, Zambelli VO, Shinjo SK, Pereira RM, Silva ER, S\u00e1-Pinto AL, Borba E, Roschel H, Bonf\u00e1 E, Benatti FB (2018) Increased insulin resistance and glucagon levels in mild\/inactive systemic lupus erythematosus patients despite normal glucose tolerance. Arthritis Care Res 70:114\u2013124. https:\/\/doi.org\/10.1002\/acr.23237","journal-title":"Arthritis Care Res"},{"key":"1592_CR23","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1136\/ard.2006.054973","volume":"66","author":"CP Chung","year":"2007","unstructured":"Chung CP, Avalos I, Oeser A, Gebretsadik T, Shintani A, Raggi P, Michael Stein C (2007) High prevalence of the metabolic syndrome in patients with systemic lupus erythematosus: association with disease characteristics and cardiovascular risk factors. AnnRheumDis 66:208\u2013214. https:\/\/doi.org\/10.1136\/ard.2006.054973","journal-title":"AnnRheumDis"},{"key":"1592_CR24","doi-asserted-by":"publisher","first-page":"303","DOI":"10.3109\/03009742.2012.754942","volume":"42","author":"M Lozovoy","year":"2013","unstructured":"Lozovoy M, Sim\u00e3o A, Oliveira S, Iryioda TMV, Panis C, Cecchini R, Dichi I (2013) Relationship between iron metabolism, oxidative stress, and insulin resistance in patients with systemic lupus erythematosus. Scand J Rheumatol 42:303\u2013310. https:\/\/doi.org\/10.3109\/03009742.2012.754942","journal-title":"Scand J Rheumatol"},{"key":"1592_CR25","doi-asserted-by":"publisher","first-page":"59","DOI":"10.3109\/03009742.2013.834963","volume":"43","author":"M Lozovoy","year":"2014","unstructured":"Lozovoy M, Sim\u00e3o A, Morimoto H, Iryioda TMV, Panis C, Reiche EMV, Borelli SD, Oliveira SR, Cecchini R, Dichi I (2014) Hypertension is associated with serologically active disease in patients with systemic lupus erythematosus: role of increased Th1\/Th2 ratio and oxidative stress. Scand J Rheumatol 43:59\u201362. https:\/\/doi.org\/10.3109\/03009742.2013.834963","journal-title":"Scand J Rheumatol"},{"key":"1592_CR26","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.jaut.2014.01.004","volume":"48\u201349","author":"C Yu","year":"2014","unstructured":"Yu C, Gershwin ME, Chang C (2014) Diagnostic criteria for systemic lupus erythematosus: a critical review. J Autoimmun 48\u201349:10\u201313. https:\/\/doi.org\/10.1016\/j.jaut.2014.01.004","journal-title":"J Autoimmun"},{"key":"1592_CR27","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1002\/art.1780350606","volume":"35","author":"C Bombardier","year":"1992","unstructured":"Bombardier C, Gladman D, Urowitz M et al (1992) Derivation of the SLEDAI. A disease activity index for lupus patients. The committee on prognosis studies in SLE. Arthritis Rheum 35:630\u2013640","journal-title":"Arthritis Rheum"},{"key":"1592_CR28","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1002\/art.1780340802","volume":"34","author":"M Petri","year":"1991","unstructured":"Petri M, Genovese M, Engle E, Hochberg M (1991) Definition, incidence, and clinical description of flare in systemic lupus erythematosus: a prospective cohort study. Arthritis Rheum 34:937\u2013944","journal-title":"Arthritis Rheum"},{"key":"1592_CR29","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1161\/01.CIR.0000138740.84883.9C","volume":"110","author":"M Reilly","year":"2004","unstructured":"Reilly M, Wolfe M, Rhodes T et al (2004) Measures of insulin resistance add incremental value to the clinical diagnosis of metabolic syndrome in association with coronary atherosclerosis. Circulation 110:803\u2013809","journal-title":"Circulation"},{"key":"1592_CR30","unstructured":"International Conference On Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use; ICH Harmonized Tripartite Guideline, Validation of Analytical Procedures: Text and Methodology Q2(R 1), Complementary Guideline on Methodology dated 06 November 1996, incorporated in November 2005, London"},{"key":"1592_CR31","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1007\/s10067-004-1028-y","volume":"24","author":"A Yilmaz","year":"2005","unstructured":"Yilmaz A, Sari RA, Gundogdu M, Kose N, Dag E (2005) Trace elements and some extracellular antioxidant proteins levels in serum of patients with systemic lupus erythematosus. Clin Rheumatol 24:331\u2013335. https:\/\/doi.org\/10.1007\/s10067-004-1028-y","journal-title":"Clin Rheumatol"},{"key":"1592_CR32","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1007\/s12011-017-0945-y","volume":"179","author":"CN T\u00f3th","year":"2017","unstructured":"T\u00f3th CN, Baranyai E, Cs\u00edp\u0151 I, Tarr T, Zeher M, Posta J, F\u00e1bi\u00e1n I (2017) Elemental analysis of whole and protein separated blood serum of patients with systemic lupus erythematosus and Sj\u00f6gren\u2019s syndrome. Biol Trace Elem Res 179:14\u201322. https:\/\/doi.org\/10.1007\/s12011-017-0945-y","journal-title":"Biol Trace Elem Res"},{"key":"1592_CR33","doi-asserted-by":"publisher","first-page":"59","DOI":"10.2174\/1573397111666151026223501","volume":"13","author":"J Nossent","year":"2017","unstructured":"Nossent J, Lester S, Rischmueller M, Zalewski P (2017) No zinc deficiency but a putative immunosuppressive role for labile Zn in patients with systemic autoimmune disease. Curr Rheumatol Rev 13:59\u201364. https:\/\/doi.org\/10.2174\/1573397111666151026223501","journal-title":"Curr Rheumatol Rev"},{"key":"1592_CR34","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1590\/S0021-75572009000600007","volume":"85","author":"MC Caetano","year":"2009","unstructured":"Caetano MC, Ortiz TT, Terreri MTSLR et al (2009) Inadequate dietary intake of children and adolescents with juvenile idiopathic arthritis and systemic lupus erythematosus. J Pediatr 85:509\u2013515. https:\/\/doi.org\/10.2223\/JPED.1941","journal-title":"J Pediatr"},{"key":"1592_CR35","doi-asserted-by":"publisher","first-page":"1872","DOI":"10.1002\/art.37967","volume":"65","author":"FM Strickland","year":"2013","unstructured":"Strickland FM, Hewagama A, Wu A, Sawalha AH, Delaney C, Hoeltzel MF, Yung R, Johnson K, Mickelson B, Richardson BC (2013) Diet influences expression of autoimmune associated genes and disease severity by epigenetic mechanisms in a transgenic lupus model. Arthritis Rheum 65:1872\u20131881. https:\/\/doi.org\/10.1002\/art.37967","journal-title":"Arthritis Rheum"},{"key":"1592_CR36","doi-asserted-by":"publisher","first-page":"353","DOI":"10.2119\/2008-00033.Prasad","volume":"14","author":"A Prasad","year":"2008","unstructured":"Prasad A (2008) Zinc in human health: effect of zinc on immune cells. Mol Med 14:353\u2013357. https:\/\/doi.org\/10.2119\/2008-00033.Prasad","journal-title":"Mol Med"},{"key":"1592_CR37","doi-asserted-by":"publisher","first-page":"S20","DOI":"10.1038\/sj.ejcn.1601479","volume":"56","author":"M Dardenne","year":"2002","unstructured":"Dardenne M (2002) Zinc and immune function. Eur J Clin Nutr 56:S20\u2013S23. https:\/\/doi.org\/10.1038\/sj.ejcn.1601479","journal-title":"Eur J Clin Nutr"},{"key":"1592_CR38","doi-asserted-by":"publisher","first-page":"E1002","DOI":"10.1152\/ajpendo.1997.272.6.E1002","volume":"272","author":"FW Beck","year":"1997","unstructured":"Beck FW, Prasad AS, Kaplan J, Fitzgerald JT, Brewer GJ (1997) Changes in cytokine production and T cell subpopulations in experimentally induced zinc-deficient humans. Am J Phys 272:E1002\u2013E1007. https:\/\/doi.org\/10.1152\/ajpendo.1997.272.6.E1002","journal-title":"Am J Phys"},{"key":"1592_CR39","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1681\/ASN.V103666","volume":"10","author":"RT Timmer","year":"1999","unstructured":"Timmer RT, Sands JM (1999) Lithium intoxication. JASN 10:666\u2013674","journal-title":"JASN"},{"key":"1592_CR40","first-page":"167","volume-title":"The challenges of lupus: insights and hope","author":"HS Shapiro","year":"1998","unstructured":"Shapiro HS (1998) Psychiatric side effects of medicines used in SLE. In: Aladjem H (ed) The challenges of lupus: insights and hope, 1st edn. Avery Publishing Group, New York, p 167","edition":"1"},{"key":"1592_CR41","doi-asserted-by":"publisher","first-page":"2549","DOI":"10.1172\/JCI119073","volume":"98","author":"SNC Liossis","year":"1996","unstructured":"Liossis SNC, Kovacs B, Dennis G et al (1996) B cells from patients with systemic lupus erythematosus display abnormal antigen receptor-mediated early signal transduction events. J Clin Invest 98:2549\u20132557. https:\/\/doi.org\/10.1172\/JCI119073","journal-title":"J Clin Invest"},{"key":"1592_CR42","doi-asserted-by":"publisher","first-page":"338","DOI":"10.4049\/jimmunol.181.1.338","volume":"181","author":"P Sarno De","year":"2008","unstructured":"De Sarno P, Axtell RC, Raman C et al (2008) Lithium prevents and ameliorates experimental autoimmune encephalomyelitis. J Immunol 181:338\u2013345","journal-title":"J Immunol"},{"key":"1592_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2016\/4013639","volume":"2016","author":"O Tsave","year":"2016","unstructured":"Tsave O, Petanidis S, Kioseoglou E, Yavropoulou MP, Yovos JG, Anestakis D, Tsepa A, Salifoglou A (2016) Role of vanadium in cellular and molecular immunology: association with immune-related inflammation and pharmacotoxicology mechanisms. Oxidative Med Cell Longev 2016:1\u201310. https:\/\/doi.org\/10.1155\/2016\/4013639","journal-title":"Oxidative Med Cell Longev"},{"key":"1592_CR44","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1080\/1547691X.2016.1250848","volume":"14","author":"M Ustarroz-Cano","year":"2017","unstructured":"Ustarroz-Cano M, Garcia-Pelaez I, Cervantes-Yepez S, Lopez-Valdez N, Fortoul TI (2017) Thymic cytoarchitecture changes in mice exposed to vanadium. J Immunotoxicol 14:9\u201314. https:\/\/doi.org\/10.1080\/1547691X.2016.1250848","journal-title":"J Immunotoxicol"},{"key":"1592_CR45","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/0006-3223(88)90253-3","volume":"24","author":"CA Campbell","year":"1988","unstructured":"Campbell CA, Peet M, Ward NI (1988) Vanadium and other trace elements in patients taking lithium. Biol Psychiatry 24:775\u2013781. https:\/\/doi.org\/10.1016\/0006-3223(88)90253-3","journal-title":"Biol Psychiatry"},{"key":"1592_CR46","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1289\/ehp.941021052","volume":"102","author":"SJ Waterman","year":"1994","unstructured":"Waterman SJ, El-Fawal HAN, Snyder CA (1994) Lead alters the immunogenicity of two neural proteins: a potential mechanism for the progression of lead-induced neurotoxicity. Environ Health Perspect 102:1052\u20131056","journal-title":"Environ Health Perspect"},{"key":"1592_CR47","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1289\/ehp.99107s5767","volume":"107","author":"HAN El-Fawal","year":"1999","unstructured":"El-Fawal HAN, Waterman SJ, De Feo A, Shamy MY (1999) Neuroimmunotoxicology: humoral assessment of neurotoxicity and autoimmune mechanisms. Environ Health Perspect 107:767\u2013775. https:\/\/doi.org\/10.1289\/ehp.99107s5767","journal-title":"Environ Health Perspect"},{"key":"1592_CR48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/269610","volume":"2015","author":"R Ram\u00edrez-Sandoval","year":"2015","unstructured":"Ram\u00edrez-Sandoval R, Lu\u00e9vano-Rodr\u00edguez N, Rodr\u00edguez-Rodr\u00edguez M, P\u00e9rez-P\u00e9rez ME, Sald\u00edvar-Elias S, Gurrola-Carlos R, Avalos-D\u00edaz E, Bollain-y-Goytia JJ, Herrera-Esparza R (2015) An animal model using metallic ions to produce autoimmune nephritis. J Immunol Res 2015:1\u201311. https:\/\/doi.org\/10.1155\/2015\/269610","journal-title":"J Immunol Res"},{"key":"1592_CR49","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s13098-017-0211-7","volume":"9","author":"M Drehmer","year":"2017","unstructured":"Drehmer M, Odegaard AO, Schmidt MI, Duncan BB, Cardoso LO, Matos SMA, Molina MCB, Barreto SM, Pereira MA (2017) Brazilian dietary patterns and the dietary approaches to stop hypertension (DASH) diet-relationship with metabolic syndrome and newly diagnosed diabetes in the ELSA-Brasil study. Diabetol Metab Syndr 9:13. https:\/\/doi.org\/10.1186\/s13098-017-0211-7","journal-title":"Diabetol Metab Syndr"},{"key":"1592_CR50","doi-asserted-by":"publisher","first-page":"27","DOI":"10.2174\/157339910790442628","volume":"6","author":"Y Mugabo","year":"2010","unstructured":"Mugabo Y, Li L, Renier G (2010) The connection between C-reactive protein (CRP) and diabetic vasculopathy. Focus on preclinical findings. Curr Diabetes Rev 6:27\u201334. https:\/\/doi.org\/10.2174\/157339910790442628","journal-title":"Curr Diabetes Rev"},{"key":"1592_CR51","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/j.annepidem.2009.02.005","volume":"19","author":"Y Lin","year":"2009","unstructured":"Lin Y, Rathod D, Ho W, Caffrey J (2009) Cadmium exposure is associated with elevated blood C-reactive protein and fibrinogen in the U. S. Population: the third national health and nutrition examination survey (NHANES III, 1988-1994). Ann Epidemiol 19:592\u2013596. https:\/\/doi.org\/10.1016\/j.annepidem.2009.02.005","journal-title":"Ann Epidemiol"},{"key":"1592_CR52","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.envres.2014.02.003","volume":"131","author":"JA Colacino","year":"2014","unstructured":"Colacino JA, Arthur AE, Ferguson KK, Rozek LS (2014) Dietary antioxidant and anti-inflammatory intake modifies the effect of cadmium exposure on markers of systemic inflammation and oxidative stress. Environ Res 131:6\u201312. https:\/\/doi.org\/10.1016\/j.envres.2014.02.003","journal-title":"Environ Res"},{"key":"1592_CR53","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1007\/s12011-012-9358-0","volume":"148","author":"VQ Bui","year":"2012","unstructured":"Bui VQ, Stein AD, DiGirolamo AM et al (2012) Associations between serum C-reactive protein and serum zinc, ferritin, and copper in Guatemalan school children. Biol Trace Elem Res 148:154\u2013160. https:\/\/doi.org\/10.1007\/s12011-012-9358-0","journal-title":"Biol Trace Elem Res"},{"key":"1592_CR54","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1258\/0004563054889990","volume":"42","author":"M Ghayour-Mobarhan","year":"2005","unstructured":"Ghayour-Mobarhan M, Taylor A, New S, Lamb DJ, Ferns GAA (2005) Determinants of serum copper, zinc and selenium in healthy subjects. Ann Clin Biochem 42:364\u2013375. https:\/\/doi.org\/10.1258\/0004563054889990","journal-title":"Ann Clin Biochem"},{"key":"1592_CR55","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1093\/jn\/138.2.305","volume":"138","author":"S Bo","year":"2008","unstructured":"Bo S, Gambino R, Berutti C, Milanesio N, Caropreso A, Gentile L, Cassader M, Cavallo-Perin P, Pagano GDM (2008) Associations of dietary and serum copper with inflammation, oxidative stress, and metabolic variables in adults. J Nutr 138:305\u2013310","journal-title":"J Nutr"},{"key":"1592_CR56","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1177\/096120339400300604","volume":"3","author":"PE Bigazzi","year":"1994","unstructured":"Bigazzi PE (1994) Autoimmunity and heavy metals. Lupus 3:449\u2013453","journal-title":"Lupus"},{"key":"1592_CR57","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1177\/0961203313502570","volume":"22","author":"B Parker","year":"2013","unstructured":"Parker B, Bruce I (2013) SLE and metabolic syndrome. Lupus 22:1259\u20131266. https:\/\/doi.org\/10.1177\/0961203313502570","journal-title":"Lupus"},{"key":"1592_CR58","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1038\/nrrheum.2017.43","volume":"13","author":"L Morel","year":"2017","unstructured":"Morel L (2017) Immunometabolism in systemic lupus erythematosus. Nat Rev Rheumatol 13:280\u2013290. https:\/\/doi.org\/10.1038\/nrrheum.2017.43","journal-title":"Nat Rev Rheumatol"},{"key":"1592_CR59","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1007\/s11306-015-0772-0","volume":"11","author":"A Perl","year":"2015","unstructured":"Perl A, Hanczko R, Lai ZW, Oaks Z, Kelly R, Borsuk R, Asara JM, Phillips PE (2015) Comprehensive metabolome analyses reveal N-acetylcysteine-responsive accumulation of kynurenine in systemic lupus erythematosus: implications for activation of the mechanistic target of rapamycin. Metabolomics 11:1157\u20131174. https:\/\/doi.org\/10.1007\/s11306-015-0772-0","journal-title":"Metabolomics"},{"key":"1592_CR60","doi-asserted-by":"publisher","first-page":"274ra18","DOI":"10.1126\/scitranslmed.aaa0835","volume":"7","author":"Y Yin","year":"2015","unstructured":"Yin Y, Choi S-C, Xu Z, Perry DJ, Seay H, Croker BP, Sobel ES, Brusko TM, Morel L (2015) Normalization of CD4 + T cell metabolism reverses lupus. Sci Transl Med 7:274ra18. https:\/\/doi.org\/10.1126\/scitranslmed.aaa0835","journal-title":"Sci Transl Med"},{"key":"1592_CR61","doi-asserted-by":"publisher","first-page":"R106","DOI":"10.1186\/ar3387","volume":"13","author":"ES Sobel","year":"2011","unstructured":"Sobel ES, Brusko TM, Butfiloski EJ, Hou W, Li S, Cuda CM, Abid AN, Reeves WH, Morel L (2011) Defective response of CD4(+) T cells to retinoic acid and TGF\u03b2 in systemic lupus erythematosus. Arthritis Res Ther 13:R106. https:\/\/doi.org\/10.1186\/ar3387","journal-title":"Arthritis Res Ther"},{"key":"1592_CR62","doi-asserted-by":"publisher","first-page":"4476","DOI":"10.4049\/jimmunol.180.7.4476","volume":"180","author":"SR Jacobs","year":"2008","unstructured":"Jacobs SR, Herman CE, Maciver NJ et al (2008) Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways. J Immunol 180:4476\u20134486","journal-title":"J Immunol"},{"key":"1592_CR63","first-page":"103","volume":"3","author":"A Peretz","year":"1989","unstructured":"Peretz A, Neve J, Famaey J (1989) Effects of chronic and acute corticosteroid therapy on zinc and copper status in rheumatoid arthritis patients. J Trace Elem Electrolytes Health Dis 3:103\u2013108","journal-title":"J Trace Elem Electrolytes Health Dis"},{"key":"1592_CR64","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1191\/096120399678847858","volume":"8","author":"HJ Haga","year":"1999","unstructured":"Haga HJ, Brun JG, Rekvig OP, Wetterberg L (1999) Seasonal variations in activity of systemic lupus erythematosus in a subarctic region. Lupus 8:269\u2013273. https:\/\/doi.org\/10.1191\/096120399678847858","journal-title":"Lupus"}],"container-title":["Biological Trace Element Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-018-1592-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12011-018-1592-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-018-1592-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T13:05:25Z","timestamp":1662728725000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12011-018-1592-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,2]]},"references-count":64,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["1592"],"URL":"https:\/\/doi.org\/10.1007\/s12011-018-1592-7","relation":{},"ISSN":["0163-4984","1559-0720"],"issn-type":[{"value":"0163-4984","type":"print"},{"value":"1559-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,2]]},"assertion":[{"value":"27 November 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 November 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}}]}}