{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T06:44:43Z","timestamp":1793256283706,"version":"4.5.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T00:00:00Z","timestamp":1546387200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biol Trace Elem Res"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1007\/s12011-018-1617-2","type":"journal-article","created":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T01:26:12Z","timestamp":1546392372000},"page":"412-418","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Role of Oxidative Stress in Lithium-Induced Nephropathy"],"prefix":"10.1007","volume":"191","author":[{"given":"Georgina P.","family":"Ossani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.","family":"Uceda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan M.","family":"Acosta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00e9stor R.","family":"Lago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa G.","family":"Repetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego J.","family":"Martino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge E.","family":"Toblli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,1,2]]},"reference":[{"issue":"1","key":"1617_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/bdi.12025","volume":"15","author":"LN Yatham","year":"2013","unstructured":"Yatham LN, Kennedy SH, Parikh SV, Schaffer A, Beaulieu S, Alda M, O\u2019Donovan C, MacQueen G, McIntyre RS, Sharma V, Ravindran A, Young LT, Milev R, Bond DJ, Frey BN, Goldstein BI, Lafer B, Birmaher B, Ha K, Nolen WA, Berk M (2013) Canadian network for mood and anxiety treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2013. Bipolar Disord 15(1):1\u201344","journal-title":"Bipolar Disord"},{"issue":"6","key":"1617_CR2","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1111\/j.1399-5618.2009.00737.x","volume":"11","author":"F Ng","year":"2009","unstructured":"Ng F, Mammen OK, Wilting I, Sachs GS, Ferrier IN, Cassidy F, Beaulieu S, Yatham LN, Berk M, International Society for Bipolar Disorders (2009) International Society for Bipolar Disorders. The International Society for Bipolar Disorders (ISBD) consensus guidelines for the safety monitoring of bipolar disorder treatments. Bipolar Disord 11(6):559\u2013595","journal-title":"Bipolar Disord"},{"issue":"4","key":"1617_CR3","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/S0924-9338(01)00565-X","volume":"16","author":"H Bendz","year":"2001","unstructured":"Bendz H, Aurell M, Lanke J (2001) A historical cohort study of kidney damage in long-term lithium patients: continued surveillance needed. Eur Psychiatry 16(4):199\u2013206","journal-title":"Eur Psychiatry"},{"issue":"2","key":"1617_CR4","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1093\/ndt\/gfm567","volume":"23","author":"N Bassilios","year":"2008","unstructured":"Bassilios N, Martel P, Godard V, Froissart M, Gr\u00fcnfeld JP, Stengel B, N\u00e9phropar R (2008) Monitoring of glomerular filtration rate in lithium-treated outpatients-an ambulatory laboratory database surveillance. Nephrol Dial Transplant 23(2):562\u2013565","journal-title":"Nephrol Dial Transplant"},{"issue":"11","key":"1617_CR5","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/1741-7015-11-33","volume":"11","author":"A Bocchetta","year":"2013","unstructured":"Bocchetta A, Ardau R, Carta P, Ligas F, Sardu C, Pani A, del Zompo M (2013) Duration of lithium treatment is a risk factor for reduced glomerular function: a cross-sectional study. BMC Med 11(11):33. https:\/\/doi.org\/10.1186\/1741-7015-11-33.","journal-title":"BMC Med"},{"issue":"2","key":"1617_CR6","first-page":"102","volume":"77","author":"SM McCann","year":"2008","unstructured":"McCann SM, Daly J, Kelly CB (2008) The impact of long-term lithium treatment on renal function in an outpatient population. Ulster Med J 77(2):102\u2013105","journal-title":"Ulster Med J"},{"issue":"3","key":"1617_CR7","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.jad.2010.04.018","volume":"126","author":"J Tredget","year":"2010","unstructured":"Tredget J, Kirov A, Kirov G (2010) Effects of chronic lithium treatment on renal function. J Affect Disord 126(3):436\u2013440","journal-title":"J Affect Disord"},{"issue":"3","key":"1617_CR8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090169","volume":"9","author":"H Close","year":"2014","unstructured":"Close H, Reilly J, Mason JM et al (2014) Renal failure in lithium-treated bipolar disorder: a retrospective cohort study. PLoS One 9(3):e90169","journal-title":"PLoS One"},{"key":"1617_CR9","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/S0140-6736(79)90609-3","volume":"1","author":"J Hestbech","year":"1979","unstructured":"Hestbech J, Aurell M (1979) Lithium-induced uraemia. Lancet 1:212\u2013213","journal-title":"Lancet"},{"issue":"8","key":"1617_CR10","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1681\/ASN.V1181439","volume":"11","author":"GS Markowitz","year":"2000","unstructured":"Markowitz GS, Radhakrishnan J, Kambham N, Am V, Hines WH, VD D\u2019A (2000) Lithium nephrotoxicity: a progressive combined glomerular and tubulointerstitial nephropathy. J Am Soc Nephrol 11(8):1439\u20131448","journal-title":"J Am Soc Nephrol"},{"issue":"3","key":"1617_CR11","doi-asserted-by":"publisher","first-page":"F300","DOI":"10.1152\/ajprenal.00182.2012","volume":"304","author":"RJ Walker","year":"2013","unstructured":"Walker RJ, Leader JP, Bedford JJ, Gobe G, Davis G, Vos FE, deJong S, Schollum JBW (2013) Chronic interstitial fibrosis in the rat kidney induced by long-term (6-mo) exposure to lithium. Am J Physiol Renal Physiol 304(3):F300\u2013F307","journal-title":"Am J Physiol Renal Physiol"},{"issue":"6","key":"1617_CR12","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1681\/ASN.2015080907","volume":"27","author":"M Alsady","year":"2016","unstructured":"Alsady M, Baumgarten R, Deen PM, de Groot T (2016) Lithium in the kidney: friend and foe? J Am Soc Nephrol 27(6):1587\u20131595","journal-title":"J Am Soc Nephrol"},{"issue":"11","key":"1617_CR13","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.1007\/s11255-016-1352-6","volume":"48","author":"S Rej","year":"2016","unstructured":"Rej S, Pira S, Marshe V, Do A, Elie D, Looper KJ, Herrmann N, M\u00fcller DJ (2016) Molecular mechanisms in lithium-associated renal disease: a systematic review. Int Urol Nephrol 48(11):1843\u20131853","journal-title":"Int Urol Nephrol"},{"issue":"1\u20132","key":"1617_CR14","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s11010-005-5426-5","volume":"277","author":"F Oktem","year":"2005","unstructured":"Oktem F, Ozguner F, Sulak O, Olgar \u015e, Akturk O, Yilmaz HR, Altuntas I (2005) Lithium-induced renal toxicity in rats: protection by a novel antioxidant caffeic acid phenethyl ester. Mol Cell Biochem 277(1\u20132):109\u2013115","journal-title":"Mol Cell Biochem"},{"issue":"1","key":"1617_CR15","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s13105-011-0113-3","volume":"68","author":"R Nciri","year":"2012","unstructured":"Nciri R, Allagui MS, Bourogaa E, Saoudi M, Murat JC, Croute F, Elfeki A (2012) Lipid peroxidation, antioxidant activities and stress protein (HSP72\/73, GRP94) expression in kidney and liver of rats under lithium treatment. J Physiol Biochem 68(1):11\u201318","journal-title":"J Physiol Biochem"},{"issue":"2","key":"1617_CR16","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/s12011-015-0425-1","volume":"169","author":"S Toplan","year":"2016","unstructured":"Toplan S, Ozdemir S, Tanriverdi G, Akyolcu MC, Ozcelik D, Dar\u0131yerli N (2016) The effects of lithium administration on oxidant\/antioxidant status in rats: biochemical and histomorphological evaluations. Biol Trace Elem Res 169(2):279\u2013284","journal-title":"Biol Trace Elem Res"},{"key":"1617_CR17","unstructured":"Ossani GP, Castiglia NI, Martino MF, Fari\u00f1a SL, Uceda AM, Monserrat AJ (2009) Morphometry of the glomerular tuft during normal postnatal growth in female rats. Effects of age, location of glomeruli and methods of obtaining and processing the renal tissue SJLAS 36(3):265\u2013269."},{"key":"1617_CR18","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/0891-5849(91)90002-K","volume":"10","author":"B Gonz\u00e1lez Flecha","year":"1991","unstructured":"Gonz\u00e1lez Flecha B, Llesuy S, Boveris A (1991) Hydroperoxide-initiated chemiluminescence: an assay for oxidative stress in biopsies of heart, liver, and muscle. Free Radic Biol Med 10:93\u2013100","journal-title":"Free Radic Biol Med"},{"key":"1617_CR19","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.yexmp.2009.11.002","volume":"88","author":"MG Repetto","year":"2010","unstructured":"Repetto MG, Ossani G, Monserrat AJ, Boveris A (2010) Oxidative damage: the biochemical mechanism of cellular injury and necrosis in choline deficiency. Exp Mol Pathol 88:143\u2013149","journal-title":"Exp Mol Pathol"},{"key":"1617_CR20","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/0891-5849(88)90023-8","volume":"4","author":"C Fraga","year":"1988","unstructured":"Fraga C, Leibovitz B, Tappel AL (1988) Lipid peroxidation measured as thiobarbituric acid-reactive substances in tissue slices: characterization and comparison with homogenates and microsomes. Free Radic Biol Med 4:155\u2013161","journal-title":"Free Radic Biol Med"},{"key":"1617_CR21","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/S0076-6879(94)33041-7","volume":"233","author":"A Reznick","year":"1994","unstructured":"Reznick A, Packer L (1994) Oxidative damage to proteins: spectrophotometric method for carbonyl assay. Meth Enzymol 233:357\u2013363","journal-title":"Meth Enzymol"},{"key":"1617_CR22","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/9780470110171.ch14","volume":"1","author":"AC Maehly","year":"1954","unstructured":"Maehly AC, Chance B (1954) The assay of catalases and peroxidases. Methods Biochem Anal 1:357\u2013424","journal-title":"Methods Biochem Anal"},{"key":"1617_CR23","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/S0076-6879(81)77050-2","volume":"77","author":"TP Akerboom","year":"1981","unstructured":"Akerboom TP, Sies H (1981) Assay of glutathione, glutathione disulfide, and glutathione mixed disulfides in biological samples. Methods Enzymol 77:373\u2013382","journal-title":"Methods Enzymol"},{"issue":"2","key":"1617_CR24","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1155\/MBD.1999.87","volume":"6","author":"F Loghin","year":"1999","unstructured":"Loghin F, Olinic A, Popa D, Socaciu C, Leucuta S (1999) Effects of long-term administration of lithium and hydrochlorothiazlde in rats. Met Based Drugs 6(2):87\u201393","journal-title":"Met Based Drugs"},{"issue":"2","key":"1617_CR25","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1248\/bpb.34.272","volume":"34","author":"M Ahmad","year":"2011","unstructured":"Ahmad M, Elnakady Y, Farooq M, Wadaan M (2011) Lithium induced toxicity in rats: blood serum chemistry, antioxidative enzymes in red blood cells and histopathological studies. Biol Pharm Bull 34(2):272\u2013277","journal-title":"Biol Pharm Bull"},{"key":"1617_CR26","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1002\/ar.1092320205","volume":"232","author":"JR Nyengaard","year":"1992","unstructured":"Nyengaard JR, Bendtsen TF (1992) Glomerular number and size in relation to age, kidney weight, and body surface in normal man. Anat Rec 232:194\u2013201","journal-title":"Anat Rec"},{"issue":"11","key":"1617_CR27","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/1741-7015-11-34","volume":"11","author":"E Severus","year":"2013","unstructured":"Severus E, Bauer M (2013) Managing the risk of lithium-induced nephropathy in the long-term treatment of patients with recurrent affective disorders. BMC Med 11(11):34. https:\/\/doi.org\/10.1186\/1741-7015-11-34.","journal-title":"BMC Med"},{"issue":"6","key":"1617_CR28","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1053\/j.ackd.2010.09.002","volume":"17","author":"P Devarajan","year":"2010","unstructured":"Devarajan P (2010) The use of targeted biomarkers for chronic kidney disease. Adv Chronic Kidney Dis 17(6):469\u2013479","journal-title":"Adv Chronic Kidney Dis"},{"issue":"3","key":"1617_CR29","doi-asserted-by":"publisher","first-page":"423","DOI":"10.26444\/aaem\/74473","volume":"24","author":"I Musik","year":"2017","unstructured":"Musik I, Kie\u0142czykowska M, Rajtar B, \u015awi\u0105tek L, Polz-Dacewicz M, Kocot J (2017) Lithium as a prooxidant? A possible protective role of selenium \u2013 in vitro study. Annals Agr Environ Med 24(3):423\u2013427","journal-title":"Annals Agr Environ Med"}],"container-title":["Biological Trace Element Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-018-1617-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12011-018-1617-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-018-1617-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T16:15:43Z","timestamp":1694535343000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12011-018-1617-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,2]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["1617"],"URL":"https:\/\/doi.org\/10.1007\/s12011-018-1617-2","relation":{},"ISSN":["0163-4984","1559-0720"],"issn-type":[{"value":"0163-4984","type":"print"},{"value":"1559-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,2]]},"assertion":[{"value":"22 May 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 December 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"All procedures performed in studies involving animals were in accordance with the ethical standards of the institution or practice at which the studies were conducted (Animal Welfare Committee number 2366).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}