{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T03:46:53Z","timestamp":1775620013545,"version":"3.50.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T00:00:00Z","timestamp":1546473600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81602807"],"award-info":[{"award-number":["81602807"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biol Trace Elem Res"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1007\/s12011-018-1620-7","type":"journal-article","created":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T23:27:08Z","timestamp":1546471628000},"page":"294-299","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Selenium Content and\/or T-2 Toxin Contamination of Cereals, Soil, and Children\u2019s Hair in Some Areas of Heilongjiang and Gansu Provinces, China"],"prefix":"10.1007","volume":"191","author":[{"given":"Liyan","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silu","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhong","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaoping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,1,3]]},"reference":[{"key":"1620_CR1","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1016\/j.joca.2007.09.002","volume":"16","author":"J Cao","year":"2008","unstructured":"Cao J, Li S, Shi Z, Yue Y, Sun J, Chen J, Fu Q, Hughes CE, Caterson B (2008) Articular cartilage metabolism in patients with Kashin-Beck disease: an endemic osteoarthropathy in China. Osteoarthr Cartil 16:680\u2013688","journal-title":"Osteoarthr Cartil"},{"key":"1620_CR2","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1177\/0192623310396902","volume":"39","author":"LH Wang","year":"2011","unstructured":"Wang LH, Fu Y, Shi YX, Wang WG (2011) T-2 toxin induces degenerative articular changes in rodents: link to Kachin-Beck Disease. Toxicol Pathol 39:502\u2013507","journal-title":"Toxicol Pathol"},{"key":"1620_CR3","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.1016\/j.joca.2014.09.013","volume":"22","author":"LY Sun","year":"2014","unstructured":"Sun LY, Meng FG, Li Q, Zhao ZJ, He CZ, Wang SP, Sa RL, Man WW, Wang LH (2014) Effects of the consumption of rice from non-KBD areas and selenium supplementation on the prevention and treatment of paediatric Kashin-Beck disease: an epidemiological intervention trial in the Qinghai Province. Osteoarthr Cartil 22:2033\u20132040","journal-title":"Osteoarthr Cartil"},{"key":"1620_CR4","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1126\/science.324_1378","volume":"324","author":"R Stone","year":"2009","unstructured":"Stone R (2009) Diseases. A medical mystery in middle China. Science 324:1378\u20131381","journal-title":"Science"},{"key":"1620_CR5","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s002640000177","volume":"25","author":"M Hinsenkamp","year":"2001","unstructured":"Hinsenkamp M (2001) Kashin-Beck Disease. Int Orthop 25:133\u2013202","journal-title":"Int Orthop"},{"key":"1620_CR6","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1631\/jzus.B071322","volume":"9","author":"SY Li","year":"2008","unstructured":"Li SY, Cao JL, Shi ZL, Chen JH, Zhang ZT, Hughes CE, Caterson B (2008) Promotion of the articular cartilage proteoglycan degradation by T-2 toxin and selenium protective effect. J Zhejiang Univ Sci B 9:22\u201333","journal-title":"J Zhejiang Univ Sci B"},{"key":"1620_CR7","first-page":"201","volume":"14","author":"JB Yang","year":"1995","unstructured":"Yang JB (1995) A research report on the etiology of KBD (in Chinese). Chin J Endemiol 14:201\u2013205","journal-title":"Chin J Endemiol"},{"key":"1620_CR8","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1590\/S0102-09352001000300011","volume":"53","author":"J Nascimento","year":"2001","unstructured":"Nascimento J, Nunes VA, Guedes RM et al (2001) T-2 toxin and disturbed endochondral bone growth in broiler chicken. Arq Bras Med Vet Zootec 53:332\u2013340","journal-title":"Arq Bras Med Vet Zootec"},{"key":"1620_CR9","doi-asserted-by":"publisher","first-page":"259s","DOI":"10.1093\/ajcn\/57.2.259S","volume":"57","author":"K Ge","year":"1993","unstructured":"Ge K, Yang G (1993) The epidemiology of selenium deficiency in the etiological study of endemic diseases in China. Am J Clin Nutr 57:259s\u2013263s","journal-title":"Am J Clin Nutr"},{"key":"1620_CR10","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1007\/s10653-010-9366-y","volume":"33","author":"B Zhang","year":"2011","unstructured":"Zhang B, Yang L, Wang W, Li Y, Li H (2011) Environmental selenium in the Kashin-Beck disease area, Tibetan Plateau, China. Environ Geochem Health 33:495\u2013501","journal-title":"Environ Geochem Health"},{"key":"1620_CR11","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1056\/NEJM199810153391604","volume":"339","author":"R Moreno-Reyes","year":"1998","unstructured":"Moreno-Reyes R, Suetens C, Mathieu F, Begaux F, Zhu D, Rivera MT, Boelaert M, N\u00e8ve J, Perlmutter N, Vanderpas J (1998) Kashin-Beck osteoarthropathy in rural Tibet in relation to selenium and iodine status. N Engl J Med 339:1112\u20131120","journal-title":"N Engl J Med"},{"key":"1620_CR12","first-page":"60","volume":"3","author":"LW Cai","year":"2005","unstructured":"Cai LW, Zhang YL (2005) An observation by X-ray on effect of selenium in the treatment of 40 Kashin-Beck children (in Chinese). J Comm Med 3:60\u201361","journal-title":"J Comm Med"},{"key":"1620_CR13","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.joca.2008.06.011","volume":"17","author":"K Zou","year":"2009","unstructured":"Zou K, Liu G, Wu T, du L (2009) Selenium for preventing Kashin-Beck osteoarthropathy in children: a meta-analysis. Osteoarthr Cartil 17:144\u2013151","journal-title":"Osteoarthr Cartil"},{"key":"1620_CR14","unstructured":"Ministry of Health of the People\u2019s Republic of China Document: Guidelines for health. Diagnosis of Kashin-Beck Disease, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, 2010; Register June 2, 2010 (WS\/T 207\u20132010)"},{"key":"1620_CR15","first-page":"70","volume":"35","author":"FY Kang","year":"2013","unstructured":"Kang FY, Li YJ, Wei J (2013) Analysis of selenium content in hair samples of children in Kashin-Beck disease areas in Gansu Province (in Chinese). Chin J Endemiol 35:70\u201372","journal-title":"Chin J Endemiol"},{"key":"1620_CR16","first-page":"361","volume":"35","author":"XD Yang","year":"2016","unstructured":"Yang XD, Dai HX, Guo X (2016) Changes of selenium content in hair samples of people in Kashin-Beck disease areas two months after stopping selenium salt in Shanxi Province in 2012 (in Chinese). Chin J Endemiol 35:361\u2013364","journal-title":"Chin J Endemiol"},{"key":"1620_CR17","first-page":"5","volume":"3","author":"A Peng","year":"1991","unstructured":"Peng A, Wang Z, Wang W et al (1991) A new hypothesis for the etiology of Kashin-Beck disease (in Chinese). J Environ Sci (China) 3:5\u201314","journal-title":"J Environ Sci (China)"},{"key":"1620_CR18","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1016\/j.joca.2007.03.013","volume":"15","author":"FL Ren","year":"2007","unstructured":"Ren FL, Guo X, Zhang RJ, Wang SJ, Zuo H, Zhang ZT, Geng D, Yu Y, Su M (2007) Effects of selenium and iodine deficiency on bone, cartilage growth plate and chondrocyte differentiation in two generations of rats. Osteoarthr Cartil 15:1171\u20131177","journal-title":"Osteoarthr Cartil"},{"key":"1620_CR19","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.scitotenv.2008.06.024","volume":"400","author":"NA Miguel","year":"2008","unstructured":"Miguel NA, Carmen CV (2008) Selenium in food and the human body: a review. Sci Total Environ 400:115\u2013141","journal-title":"Sci Total Environ"},{"key":"1620_CR20","first-page":"2167","volume":"27","author":"SJ Li","year":"2008","unstructured":"Li SJ, Li W, Hu X et al (2008) Distribution of Kashin-Beck disease and its relation to selenium content in soil, plant, animal (human being) ecosystem in Tibet (in Chinese). Chin J Ecol 27:2167\u20132170","journal-title":"Chin J Ecol"},{"key":"1620_CR21","first-page":"51","volume":"1","author":"MY Wang","year":"1982","unstructured":"Wang MY (1982) Geographical distribution of selenium content of grains in China (in Chinese). Geogr Res 1:51\u201358","journal-title":"Geogr Res"},{"key":"1620_CR22","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.gexplo.2012.06.001","volume":"121","author":"CA Shand","year":"2012","unstructured":"Shand CA, Eriksson J, Dahlin AS, Lumsdon DG (2012) Selenium concentrations in national inventory soils from Scotland and Sweden and their relationship with geochemical factors. J Geochem Explor 121:4\u201314","journal-title":"J Geochem Explor"},{"key":"1620_CR23","unstructured":"Swaine DJ (1955) The trace element content of soils. Commonwealth Agricultural Bureaux 37\u201346"},{"key":"1620_CR24","first-page":"2239","volume":"7","author":"PT Mngadi","year":"2008","unstructured":"Mngadi PT, Govinden R, Odhav B (2008) Co-occurring mycotoxins in animal feeds. Afr J Biotechnol 7:2239\u20132243","journal-title":"Afr J Biotechnol"},{"key":"1620_CR25","doi-asserted-by":"publisher","first-page":"S124","DOI":"10.1016\/0272-0590(84)90144-1","volume":"4","author":"Y Ueno","year":"1984","unstructured":"Ueno Y (1984) Toxicological features of T-2 toxin and related trichothecenes. Fundam Appl Toxicol 4:S124\u2013S132","journal-title":"Fundam Appl Toxicol"},{"key":"1620_CR26","unstructured":"Scientific committee for food opinion of the scientific committee on food on Fusarium toxins. Part 5: T-2 toxin and HT-2 toxin (adapted on 30 May 2001). \n                    http:\/\/europa.eu.int\/comm\/food\/fs\/sc\/scf\/\/out88"},{"key":"1620_CR27","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/s12011-012-9469-7","volume":"150","author":"LY Sun","year":"2012","unstructured":"Sun LY, Li Q, Meng FG, Fu Y, Zhao ZJ, Wang LH (2012) T-2 toxin contamination in grains and selenium concentration in drinking water and grains in Kashin-Beck disease endemic areas of Qinghai Province. Biol Trace Elem Res 150:371\u2013375","journal-title":"Biol Trace Elem Res"}],"container-title":["Biological Trace Element Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-018-1620-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12011-018-1620-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-018-1620-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,2]],"date-time":"2020-01-02T19:28:29Z","timestamp":1577993309000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12011-018-1620-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,3]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["1620"],"URL":"https:\/\/doi.org\/10.1007\/s12011-018-1620-7","relation":{},"ISSN":["0163-4984","1559-0720"],"issn-type":[{"value":"0163-4984","type":"print"},{"value":"1559-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,3]]},"assertion":[{"value":"5 September 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 December 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}