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However, it is not yet known if this phenomenon occurs in broilers. To investigate the change in zinc homeostasis of broilers against<jats:italic>Salmonella<\/jats:italic>challenge, 1-day-old male broilers were fed with the basal diet for 7\u00a0days. Afterwards, broilers were orally inoculated with either 0 or 0.5\u2009\u00d7\u200910<jats:sup>8<\/jats:sup>\u00a0CFU<jats:italic>Salmonella<\/jats:italic>Typhimurium (ST). The serum and selected tissues of<jats:italic>Salmonella<\/jats:italic>-challenged and non-challenged broilers were collected at 1, 3 and 7\u00a0days post-challenge for zinc homeostasis analysis. Our results showed that<jats:italic>Salmonella<\/jats:italic>challenge results in hypozincaemia (serum zinc decrease and liver zinc increase) via modulating the systemic zinc homeostasis of broilers. A profound, zinc transporter\u2013mediated zinc absorption and redistribution affecting zinc homeostasis provided a mechanistic explanation for this phenomenon. In addition, we found that the zinc importers<jats:italic>Zip5<\/jats:italic>,<jats:italic>Zip10<\/jats:italic>,<jats:italic>Zip11<\/jats:italic>,<jats:italic>Zip12<\/jats:italic>,<jats:italic>Zip13<\/jats:italic>and<jats:italic>Zip14<\/jats:italic>were mainly downregulated in<jats:italic>Salmonella<\/jats:italic>-challenged broilers to reduce zinc absorption in the duodenum, while the<jats:italic>Zip14<\/jats:italic>mRNA expression was upregulated to redistribute zinc into the liver. Collectively, these findings reveal that broilers counteract<jats:italic>Salmonella<\/jats:italic>infection via modulating their systemic zinc homeostasis.<\/jats:p>","DOI":"10.1007\/s12011-019-01921-1","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T07:07:16Z","timestamp":1571814436000},"page":"243-251","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Systemic Zinc Homeostasis Was Modulated in Broilers Challenged by Salmonella"],"prefix":"10.1007","volume":"196","author":[{"given":"Aimin","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiping","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiufeng","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanwei","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,10,22]]},"reference":[{"key":"1921_CR1","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1080\/03079457.2012.692155","volume":"41","author":"B Zhang","year":"2012","unstructured":"Zhang B et al (2012) Zinc prevents Salmonella enterica serovar Typhimurium-induced loss of intestinal mucosal barrier function in broiler chickens. 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