{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T16:24:57Z","timestamp":1793895897769,"version":"4.8.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T00:00:00Z","timestamp":1572912000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T00:00:00Z","timestamp":1572912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biol Trace Elem Res"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1007\/s12011-019-01943-9","type":"journal-article","created":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T14:05:13Z","timestamp":1572962713000},"page":"393-399","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Association Between Thyroid Hormone Status and Trace Elements in Serum of Patients with Nodular Goiter"],"prefix":"10.1007","volume":"196","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0867-2023","authenticated-orcid":false,"given":"Victor I.","family":"Kravchenko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5827-3384","authenticated-orcid":false,"given":"Iryna M.","family":"Andrusyshyna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2022-8235","authenticated-orcid":false,"given":"Ihor A.","family":"Luzanchuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3403-5821","authenticated-orcid":false,"given":"Maksym O.","family":"Polumbryk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4787-359X","authenticated-orcid":false,"given":"Yuriy M.","family":"Tarashchenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,11,5]]},"reference":[{"issue":"4","key":"1943_CR1","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1210\/er.2009-0011","volume":"30","author":"MB Zimmermann","year":"2009","unstructured":"Zimmermann MB (2009) Iodine deficiency. Endocr Rev 30(4):376\u2013408. \nhttps:\/\/doi.org\/10.1210\/er.2009-0011","journal-title":"Endocr Rev"},{"key":"1943_CR2","doi-asserted-by":"publisher","unstructured":"Rocha HS, Lopesa RT, Valiante PM, Tirao G, Mazzarod I, Honnicked MG, Cusatis C, Gilese C (2005) Diagnosis of thyroid nodular goiter using diffraction-enhanced imaging. Nucl Instrum Meth A 548:175\u2013180. \nhttps:\/\/doi.org\/10.1016\/j.nima.2005.03.086","DOI":"10.1016\/j.nima.2005.03.086"},{"issue":"4","key":"1943_CR3","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.beem.2014.01.001","volume":"28","author":"A Carle","year":"2014","unstructured":"Carle A, Krejbjerg A, Laurberg P (2014) Epidemiology of nodular goitre. Influence of iodine intake. Best Pract Res Clin Endocrinol Metab 28(4):465\u2013479. \nhttps:\/\/doi.org\/10.1016\/j.beem.2014.01.001","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"11","key":"1943_CR4","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1089\/thy.2000.10.951","volume":"10","author":"P Laurberg","year":"2000","unstructured":"Laurberg P, N\u00f8hr SB, Pedersen KM, Hreidarsson AB, Andersen S, B\u00fclow Pedersen I, Knudsen N, Perrild H, J\u00f8rgensen T, Ovesen L (2000) Thyroid disorders in mild iodine deficiency. Thyroid 10(11):951\u2013963. \nhttps:\/\/doi.org\/10.1089\/thy.2000.10.951","journal-title":"Thyroid"},{"key":"1943_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2458-13-1153","volume":"13","author":"Y Liu","year":"2013","unstructured":"Liu Y, Huang H, Zeng J, Sun C (2013) Thyroid volume, goiter prevalence, and selenium levels in an iodine-sufficient area: a cross-sectional study. BMC Public Health 13:1\u20137. \nhttps:\/\/doi.org\/10.1186\/1471-2458-13-1153","journal-title":"BMC Public Health"},{"key":"1943_CR6","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1210\/endo-128-2-779","volume":"128","author":"B Corvillian","year":"1991","unstructured":"Corvillian B, van Sande J, Laurent E, Dumont JE (1991) The H2O2-generating system modulates protein iodination and the activity of the pentose phosphate pathway in dog thyroid. Endocrinology 128:779\u2013785. \nhttps:\/\/doi.org\/10.1210\/endo-128-2-779","journal-title":"Endocrinology"},{"issue":"4","key":"1943_CR7","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1203\/01.PDR.0000111282.98401.93","volume":"55","author":"H Gydee","year":"2004","unstructured":"Gydee H, O\u2019Neill JT, Patel A, Bauer AJ, Tuttle RM, Francis GL (2004) Differentiated thyroid carcinomas from children and adolescents express IGF-I and the IGF-I-receptor (IGF-I-R). Pediatr Res 55(4):709\u2013715. \nhttps:\/\/doi.org\/10.1203\/01.PDR.0000111282.98401.93","journal-title":"Pediatr Res"},{"issue":"4","key":"1943_CR8","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1677\/erc.1.01226","volume":"13","author":"MW Yeh","year":"2006","unstructured":"Yeh MW, Rougier JP, Park JW, Duh QY, Wong M, Werb Z, Clark OH (2006) Differentiated thyroid cancer cells invasion is regulated through epidermal growth factor receptor-dependent activation of matrix metalloproteinase (MMP)-2 gelatinase. Endocr Relat Cancer 13(4):1173\u20131183. \nhttps:\/\/doi.org\/10.1677\/erc.1.01226","journal-title":"Endocr Relat Cancer"},{"issue":"1-3","key":"1943_CR9","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s12011-010-8719-9","volume":"141","author":"E Przybylik-Mazurek","year":"2011","unstructured":"Przybylik-Mazurek E, Zagrodzki P, Ku\u017aniarz-Rymarz S, Hubalewska-Dydejczyk A (2011) Thyroid disorders-assessments of trace elements, clinical, and laboratory parameters. Biol Trace Elem Res 141(1-3):65\u201375. \nhttps:\/\/doi.org\/10.1007\/s12011-010-8719-9","journal-title":"Biol Trace Elem Res"},{"key":"1943_CR10","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1210\/er.2001-0034","volume":"26","author":"J K\u00f6hrle","year":"2005","unstructured":"K\u00f6hrle J, Jakob F, Contempre B, Dumont JE (2005) Selenium, the thyroid, and the endocrine system. Endocr Rev 26:944\u2013984. \nhttps:\/\/doi.org\/10.1210\/er.2001-0034","journal-title":"Endocr Rev"},{"key":"1943_CR11","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1089\/thy.2005.15.841","volume":"184","author":"GJ Beckett","year":"2005","unstructured":"Beckett GJ, Arthur JR (2005) Selenium and endocrine systems. J Endocrinol 184:455\u2013465. \nhttps:\/\/doi.org\/10.1089\/thy.2005.15.841","journal-title":"J Endocrinol"},{"key":"1943_CR12","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1146\/annurev.nu.09.070189.001221","volume":"9","author":"E Danforth Jr","year":"1989","unstructured":"Danforth E Jr, Burger AG (1989) The impact of nutrition on thyroid hormone physiology and action. Annu Rev Nutr 9:201\u2013227. \nhttps:\/\/doi.org\/10.1146\/annurev.nu.09.070189.001221","journal-title":"Annu Rev Nutr"},{"issue":"3","key":"1943_CR13","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1677\/joe.0.1430527","volume":"143","author":"S MacNeil","year":"1994","unstructured":"MacNeil S, Munro DS, Metcalfe R, Cotterell S, Ruban L, Davies R, Weetman AP (1994) An investigation of the ability of TSH and Graves\u2019 immunoglobulin G to increase intracellular calcium in human thyroid cells, rat FRTL-5 thyroid cells and eukaryotic cells transfected with the human TSH receptor. J Endocrinol 143(3):527\u2013540. \nhttps:\/\/doi.org\/10.1677\/joe.0.1430527","journal-title":"J Endocrinol"},{"key":"1943_CR14","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s004110050081","volume":"36","author":"GM Goulko","year":"1998","unstructured":"Goulko GM, Chepurny NI, Jacob P, Kairo IA et al (1998) Thyroid dose and thyroid cancer incidence after the Chernobyl accident: assessments for the Zhytomyr region (Ukraine). Radiat Environ Biophys 36:261\u2013273","journal-title":"Radiat Environ Biophys"},{"key":"1943_CR15","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/S0025-6196(12)61611-5","volume":"69","author":"H Gharib","year":"1994","unstructured":"Gharib H (1994) Fine-needle aspiration biopsy of thyroid nodules: advantages, limitations, and effect. Mayo Clin Proc 69:44\u201349","journal-title":"Mayo Clin Proc"},{"key":"1943_CR16","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1089\/thy.1993.3.119","volume":"3","author":"JT Dunn","year":"1993","unstructured":"Dunn JT, Grutchfield HE, Gutekunst R, Dunn AD (1993) Two simple methods for measuring iodine in urine. Thyroid. 3:119\u2013123. \nhttps:\/\/doi.org\/10.1089\/thy.1993.3.119","journal-title":"Thyroid."},{"key":"1943_CR17","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1055\/s-2008-1070506","volume":"106","author":"J Brunn","year":"1981","unstructured":"Brunn J, Block U, Ruf et al (1981) Volumetrie der Schilddr\u00fcsenlappen mittels Real-time-Sonographie. Dtsch Med Wochenschr 106:1338\u20131340","journal-title":"Dtsch Med Wochenschr"},{"key":"1943_CR18","volume-title":"Radiation, microelements, antioxidants, and immunity (trace elements and antioxidants in health improving)","author":"AV Skalnyi","year":"2000","unstructured":"Skalnyi AV, Kudrin AV (2000) Radiation, microelements, antioxidants, and immunity (trace elements and antioxidants in health improving). Mir, Moscow (in Russian)"},{"issue":"1","key":"1943_CR19","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s12011-016-0688-1","volume":"174","author":"D Sakiz","year":"2016","unstructured":"Sakiz D, Kaya A, Kulaksizoglu M (2016) Serum selenium levels in euthyroid nodular thyroid diseases. Biol Trace Elem Res 174(1):21\u201326. \nhttps:\/\/doi.org\/10.1007\/s12011-016-0688-1","journal-title":"Biol Trace Elem Res"},{"issue":"8","key":"1943_CR20","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.biopha.2006.07.007","volume":"60","author":"A Iervasi","year":"2006","unstructured":"Iervasi A, Iervasi G, Carpi A, Zucchelli GC (2006) Serum thyroglobulin measurement: clinical background and main methodological aspects with clinical impact. Biomed Pharmacother 60(8):414\u2013424. \nhttps:\/\/doi.org\/10.1016\/j.biopha.2006.07.007","journal-title":"Biomed Pharmacother"},{"issue":"9","key":"1943_CR21","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1111\/j.1753-4887.2001.tb07017.x","volume":"59","author":"ED Harris","year":"2001","unstructured":"Harris ED (2001) Copper homeostasis: the role of cellular transporters. Nutr Rev 59(9):281\u2013285. \nhttps:\/\/doi.org\/10.1111\/j.1753-4887.2001.tb07017.x","journal-title":"Nutr Rev"},{"issue":"2","key":"1943_CR22","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.jtemb.2009.11.003","volume":"24","author":"B Giray","year":"2010","unstructured":"Giray B, Arnaud J, Sayek I, Favier A, Hincal F (2010) Trace elements status in multinodular goiter. J Trace Elem Med Biol 24(2):106\u2013110. \nhttps:\/\/doi.org\/10.1016\/j.jtemb.2009.11.003","journal-title":"J Trace Elem Med Biol"},{"issue":"1","key":"1943_CR23","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1093\/ajcn\/40.1.26","volume":"40","author":"K Aihara","year":"1984","unstructured":"Aihara K, Nishi Y, Hatano S, Kihara M, Yoshimitsu K, Takeichi N, Ito T, Ezaki H, Usui T (1984) Zinc, copper, manganese, and selenium metabolism in thyroid disease. Am J Clin Nutr 40(1):26\u201335. \nhttps:\/\/doi.org\/10.1093\/ajcn\/40.1.26","journal-title":"Am J Clin Nutr"},{"key":"1943_CR24","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1007\/s12011-009-8478-7","volume":"134","author":"GL Kazi","year":"2009","unstructured":"Kazi GL, Kandhro GA, Afridi HA et al (2009) Interaction of copper with iron, iodine, and thyroid hormone status in goitrous patients. Biol Trace Elem Res 134:265\u2013279. \nhttps:\/\/doi.org\/10.1007\/s12011-009-8478-7","journal-title":"Biol Trace Elem Res"},{"key":"1943_CR25","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.jchromb.2009.11.014","volume":"878","author":"A B\u0142azewicz","year":"2010","unstructured":"B\u0142azewicz A, Dolliver W, Sivsammye S, Deol A (2010) Determination of cadmium, cobalt, copper, iron, manganese, and zinc in thyroid glands of patients with diagnosed nodular goitre using ion chromatography. J Chromatogr B 878:34\u201338. \nhttps:\/\/doi.org\/10.1016\/j.jchromb.2009.11.014","journal-title":"J Chromatogr B"},{"key":"1943_CR26","doi-asserted-by":"publisher","first-page":"40","DOI":"10.4103\/0974-7753.114714","volume":"5","author":"A Betsy","year":"2013","unstructured":"Betsy A, Binitha M, Sarita S (2013) Zinc deficiency associated with hypothyroidism: an overlooked cause of severe alopecia. Int J Trichol 5:40\u201342. \nhttps:\/\/doi.org\/10.4103\/0974-7753.114714","journal-title":"Int J Trichol"},{"key":"1943_CR27","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s12011-014-9992-9","volume":"159","author":"RB Jain","year":"2014","unstructured":"Jain RB (2014) Thyroid function and serum copper, selenium, and zinc in general U.S. population. Biol Trace Elem Res 159:87\u201398. \nhttps:\/\/doi.org\/10.1007\/s12011-014-9992-9","journal-title":"Biol Trace Elem Res"},{"key":"1943_CR28","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s12011-016-0711-6","volume":"174","author":"K Kudabayeva","year":"2016","unstructured":"Kudabayeva K, Koshmaganbetova G, Mickuviene N, Skalnaya M et al (2016) Hair trace elements are associated with increased thyroid volume in schoolchildren with goiter. Biol Trace Elem Res 174:261\u2013266. \nhttps:\/\/doi.org\/10.1007\/s12011-016-0711-6","journal-title":"Biol Trace Elem Res"},{"key":"1943_CR29","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/S0271-5317(05)80208-8","volume":"14","author":"SM Smith","year":"1994","unstructured":"Smith SM, Finley J, Johnson LK, Lukaski HC (1994) Indices of in vivo and in vitro thyroid hormone metabolism in iron-deficient rats. Nutr Res 14:729\u2013739. \nhttps:\/\/doi.org\/10.1016\/S0271-5317(05)80208-8","journal-title":"Nutr Res"},{"key":"1943_CR30","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.bbacli.2014.12.005","volume":"3","author":"R Moncayo","year":"2015","unstructured":"Moncayo R, Moncayo H (2015) Proof of concept of the WOMED model of benign thyroid disease: restitution of thyroid morphology after correction of physical and psychological stressors and magnesium supplementation. BBA Clin 3:113\u2013122 \nhttps:\/\/doi.org\/10.1016\/j.bbacli.2014.12.005","journal-title":"BBA Clin"},{"issue":"2","key":"1943_CR31","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/0006-3223(93)90314-4","volume":"33","author":"GM Hasey","year":"1993","unstructured":"Hasey GM, D\u2019alssendro E, Cooke RG (1993) The interface between thyroid activity, and depression: a pilot study. Biol Psychiatry 33(2):133\u2013135","journal-title":"Biol Psychiatry"},{"key":"1943_CR32","doi-asserted-by":"publisher","unstructured":"(1984) The hypocalcemia associated with magnesium infusion is mediated through parathyroid hormone. Nutr Rev.42(9):315\u2013317. \nhttps:\/\/doi.org\/10.1111\/j.1753-4887.1984.tb02374.x","DOI":"10.1111\/j.1753-4887.1984.tb02374.x"},{"issue":"6","key":"1943_CR33","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1007\/BF01478206","volume":"59","author":"ZS Szabo","year":"1981","unstructured":"Szabo ZS, Ritzl F (1981) Hypercalcemia in hyperthyroidism. Role of age and goiter type. Klin Wochenschr 59(6):275\u2013279","journal-title":"Klin Wochenschr"},{"key":"1943_CR34","doi-asserted-by":"publisher","unstructured":"Kravchenko VI, Luzanchuk IA, Andrusyshyna IM, Polumbryk M (2018) Study of macro- and microelement status in patients with nodular goiter residing in Kyiv region. Galician Med J 25(4). \nhttps:\/\/doi.org\/10.21802\/gmj.2018.2.2","DOI":"10.21802\/gmj.2018.2.2"}],"container-title":["Biological Trace Element Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-019-01943-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12011-019-01943-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-019-01943-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T00:19:56Z","timestamp":1604449196000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12011-019-01943-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,5]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["1943"],"URL":"https:\/\/doi.org\/10.1007\/s12011-019-01943-9","relation":{},"ISSN":["0163-4984","1559-0720"],"issn-type":[{"value":"0163-4984","type":"print"},{"value":"1559-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,5]]},"assertion":[{"value":"27 March 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 October 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 November 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study protocol was approved by the Ethics Committee of V.P. Komissarenko Institute of Endocrinology and Metabolism and all participants gave informed consent before blood and urine sampling.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}