{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T04:04:47Z","timestamp":1793333087789,"version":"4.5.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T00:00:00Z","timestamp":1549584000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"International (Regional) Cooperation and Exchange Projects of the National Natural Science Foundation of China","award":["31320103920"],"award-info":[{"award-number":["31320103920"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31772814"],"award-info":[{"award-number":["31772814"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biol Trace Elem Res"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1007\/s12011-019-1630-0","type":"journal-article","created":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T20:17:47Z","timestamp":1549657067000},"page":"474-484","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The Effects of Low Selenium on DNA Methylation in the Tissues of Chickens"],"prefix":"10.1007","volume":"191","author":[{"given":"Qiaojian","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shufang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengchen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiwen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,2,8]]},"reference":[{"issue":"4","key":"1630_CR1","doi-asserted-by":"publisher","first-page":"621","DOI":"10.3181\/00379727-95-23308","volume":"95","author":"K Schwarz","year":"1957","unstructured":"Schwarz K, Bieri J, Briggs G, Scott M (1957) Prevention of exudative diathesis in chicks by factor 3 and selenium. Proc Soc Exp Biol Med 95(4):621\u2013625","journal-title":"Proc Soc Exp Biol Med"},{"issue":"9225","key":"1630_CR2","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/S0140-6736(00)02490-9","volume":"356","author":"MP Rayman","year":"2000","unstructured":"Rayman MP (2000) The importance of selenium to human health. Lancet 356(9225):233\u2013241","journal-title":"Lancet"},{"key":"1630_CR3","doi-asserted-by":"publisher","unstructured":"Kaur R, Ghanghas P, Rastogi P, Kaushal N (2018) Protective role of selenium against hemolytic anemia is mediated through redox modulation. Biol Trace Elem Res 1\u201311. \n                    https:\/\/doi.org\/10.1007\/s12011-018-1483-y","DOI":"10.1007\/s12011-018-1483-y"},{"issue":"3","key":"1630_CR4","doi-asserted-by":"publisher","first-page":"64","DOI":"10.3390\/plants7030064","volume":"7","author":"M Malerba","year":"2018","unstructured":"Malerba M, Cerana R (2018) Effect of selenium on the responses induced by heat stress in plant cell cultures. Plants 7(3):64","journal-title":"Plants"},{"key":"1630_CR5","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.fsi.2018.08.038","volume":"82","author":"L Zheng","year":"2018","unstructured":"Zheng L, Jiang W, Feng L, Wu P, Tang L, Kuang S, Zeng Y, Zhou X, Liu Y (2018) Selenium deficiency impaired structural integrity of the head kidney, spleen and skin in young grass carp (Ctenopharyngodon idella). Fish Shellfish Immunol 82:408\u2013420","journal-title":"Fish Shellfish Immunol"},{"key":"1630_CR6","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.meatsci.2018.07.022","volume":"145","author":"G Papadomichelakis","year":"2018","unstructured":"Papadomichelakis G, Zoidis E, Pappas A, Danezis G, Georgiou C, Fegeros K (2018) Dietary organic selenium addition and accumulation of toxic and essential trace elements in liver and meat of growing rabbits. Meat Sci 145:383\u2013388","journal-title":"Meat Sci"},{"key":"1630_CR7","first-page":"159","volume":"13","author":"PD Whanger","year":"1976","unstructured":"Whanger PD, Weswig PH, Oldfield JE, Cheeke PR, Schmitz JA (1976) Selenium and white muscle disease in lambs: effects of vitamin E and ethoxyquin. Nutr Rep Int 13:159\u2013173","journal-title":"Nutr Rep Int"},{"issue":"7","key":"1630_CR8","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1039\/C8MT00083B","volume":"10","author":"R Fan","year":"2018","unstructured":"Fan R, Cao C, Chen M, Shi Q, Xu S (2018) Gga-let-7f-3p promotes apoptosis in selenium deficiency-induced skeletal muscle by targeting selenoprotein K. Metallomics 10(7):941\u2013952","journal-title":"Metallomics"},{"key":"1630_CR9","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.jtemb.2015.03.005","volume":"31","author":"H Shan","year":"2015","unstructured":"Shan H, Yan R, Diao J, Lin L, Wang S, Zhang M, Zhang R, Wei J (2015) Involvement of caspases and their upstream regulators in myocardial apoptosis in a rat model of selenium deficiency-induced dilated cardiomyopathy. J Trace Elem Med Biol 31:85\u201391","journal-title":"J Trace Elem Med Biol"},{"key":"1630_CR10","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/bs.acr.2017.07.002","volume":"136","author":"E Jab\u0142o\u0144ska","year":"2017","unstructured":"Jab\u0142o\u0144ska E, Reszka E (2017) Selenium and epigenetics in cancer: focus on DNA methylation. Adv Cancer Res 136:193\u2013234","journal-title":"Adv Cancer Res"},{"issue":"3","key":"1630_CR11","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1385\/BTER:109:3:201","volume":"109","author":"EO Uthus","year":"2006","unstructured":"Uthus EO, Ross SA, Davis CD (2006) Differential effects of dietary selenium (Se) and folate on methyl metabolism in liver and colon of rats. Biol Trace Elem Res 109(3):201\u2013214","journal-title":"Biol Trace Elem Res"},{"key":"1630_CR12","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.jnutbio.2017.07.002","volume":"48","author":"B Speckmann","year":"2017","unstructured":"Speckmann B, Schulz S, Hiller F, Hesse D, Schumacher F, Kleuser B, Geisel J, Obeid R, Grune T, Kipp A (2017) Selenium increases hepatic DNA methylation and modulates one-carbon metabolism in the liver of mice. J Nutr Biochem 48:112\u2013119","journal-title":"J Nutr Biochem"},{"issue":"8","key":"1630_CR13","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.3945\/jn.111.140715","volume":"141","author":"Z Huawei","year":"2011","unstructured":"Huawei Z, Lin Y, Wen-Hsing C, Uthus EO (2011) Dietary selenomethionine increases exon-specific DNA methylation of the p53 gene in rat liver and colon mucosa. J Nutr 141(8):1464\u20131468","journal-title":"J Nutr"},{"issue":"4","key":"1630_CR14","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1262\/jrd.11-034A","volume":"57","author":"Y Arai","year":"2011","unstructured":"Arai Y, Ohgane J, Yagi S, Ito R, Iwasaki Y, Saito K, Akutsu K, Takatori S, Ishii R, Hayashi R (2011) Epigenetic assessment of environmental chemicals detected in maternal peripheral and cord blood samples. J Reprod Dev 57(4):507\u2013517","journal-title":"J Reprod Dev"},{"issue":"11","key":"1630_CR15","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.1093\/carcin\/bgn179","volume":"29","author":"N Xiang","year":"2008","unstructured":"Xiang N, Zhao R, Song G, Zhong W (2008) Selenite reactivates silenced genes by modifying DNA methylation and histones in prostate cancer cells. Carcinogenesis 29(11):2175\u20132181","journal-title":"Carcinogenesis"},{"issue":"6","key":"1630_CR16","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1016\/S1534-5807(01)00101-0","volume":"1","author":"T Takizawa","year":"2001","unstructured":"Takizawa T, Nakashima K, Namihira M, Ochiai W, Uemura A, Yanagisawa M, Fujita N, Nakao M, Taga T (2001) DNA methylation is a critical cell-intrinsic determinant of astrocyte differentiation in the fetal brain. Dev Cell 1(6):749\u2013758","journal-title":"Dev Cell"},{"issue":"6","key":"1630_CR17","doi-asserted-by":"publisher","first-page":"655","DOI":"10.2217\/epi.13.69","volume":"5","author":"A Laird","year":"2013","unstructured":"Laird A, Thomson JP, Harrison DJ, Meehan RR (2013) 5-hydroxymethylcytosine profiling as an indicator of cellular state. Epigenomics 5(6):655\u2013669","journal-title":"Epigenomics"},{"issue":"22","key":"1630_CR18","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/B978-0-12-380866-0.60002-2","volume":"70","author":"M Kulis","year":"2010","unstructured":"Kulis M, Esteller M (2010) DNA methylation and cancer. Adv Genet 70(22):27","journal-title":"Adv Genet"},{"issue":"8","key":"1630_CR19","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1373\/49.8.1292","volume":"49","author":"R Castro","year":"2003","unstructured":"Castro R, Rivera I, Struys EA, Jansen EEW, Ravasco P, Camilo ME, Blom HJ, Jakobs C, Almeida ITD (2003) Increased homocysteine and S-adenosylhomocysteine concentrations and DNA hypomethylation in vascular disease. Clin Chem 49(8):1292\u20131296","journal-title":"Clin Chem"},{"issue":"12","key":"1630_CR20","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1093\/carcin\/7.12.2015","volume":"7","author":"R Cox","year":"1986","unstructured":"Cox R, Goorha S (1986) A study of the mechanism of selenite-induced hypomethylated DNA and differentiation of Friend erythroleukemic cells. Carcinogenesis 7(12):2015\u20132018","journal-title":"Carcinogenesis"},{"issue":"12","key":"1630_CR21","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.1002\/mnfr.201200386","volume":"56","author":"N Metes-Kosik","year":"2012","unstructured":"Metes-Kosik N, Luptak I, Dibello P, Handy D, Tang S, Zhi H, Qin F, Jacobsen D, Loscalzo J, Joseph J (2012) Both selenium deficiency and modest selenium supplementation lead to myocardial fibrosis in mice via effects on redox-methylation balance. Mol Nutr Food Res 56(12):1812\u20131824","journal-title":"Mol Nutr Food Res"},{"key":"1630_CR22","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.jhazmat.2018.06.003","volume":"357","author":"X Jin","year":"2018","unstructured":"Jin X, Jia T, Liu R, Xu S (2018) The antagonistic effect of selenium on cadmium-induced apoptosis via PPAR-\u03b3\/PI3K\/Akt pathway in chicken pancreas. J Hazard Mater 357:355\u2013362","journal-title":"J Hazard Mater"},{"issue":"3","key":"1630_CR23","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.etap.2008.11.012","volume":"27","author":"J Zhang","year":"2009","unstructured":"Zhang J, Fu Y, Li J, Wang J, He B, Xu S (2009) Effects of subchronic cadmium poisoning on DNA methylation in hens. Environ Toxicol Pharmacol 27(3):345\u2013349","journal-title":"Environ Toxicol Pharmacol"},{"key":"1630_CR24","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.jinorgbio.2018.06.013","volume":"186","author":"T Liu","year":"2018","unstructured":"Liu T, Yang T, Xu Z, Tan S, Pan T, Wan N, Li S (2018) MicroRNA-193b-3p regulates hepatocyte apoptosis in selenium-deficient broilers by targeting MAML1. J Inorg Biochem 186:235\u2013245","journal-title":"J Inorg Biochem"},{"key":"1630_CR25","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.jinorgbio.2017.02.006","volume":"170","author":"Y Jie","year":"2017","unstructured":"Jie Y, Yuan Z, Hamid S, Cai J, Qi L, Hao L, Zhao R, Hong W, Xu S, Zhang Z (2017) Interplay between autophagy and apoptosis in selenium deficient cardiomyocytes in chicken. J Inorg Biochem 170:17\u201325","journal-title":"J Inorg Biochem"},{"issue":"5","key":"1630_CR26","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1177\/030006051204000507","volume":"40","author":"J Cui","year":"2012","unstructured":"Cui J, Zhong R, Chu E, Zhang X, Zhang W, Fang C, Dong Q, Li FL, Li H (2012) Correlation between oxidative stress and L-type calcium channel expression in the ventricular myocardia of selenium-deficient mice. J Int Med Res 40(5):1677\u20131687","journal-title":"J Int Med Res"},{"issue":"11","key":"1630_CR27","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.1039\/C8MT00183A","volume":"10","author":"J Wang","year":"2018","unstructured":"Wang J, Lian S, He X, Yu D, Liang J, Sun D, Wu R (2018) Selenium deficiency induces splenic growth retardation by deactivating the IGF-1R\/PI3K\/Akt\/mTOR pathway. Metallomics 10(11):1570\u20131575","journal-title":"Metallomics"},{"issue":"11","key":"1630_CR28","doi-asserted-by":"publisher","first-page":"10495","DOI":"10.3168\/jds.2017-14196","volume":"101","author":"M Zahrazadeh","year":"2018","unstructured":"Zahrazadeh M, Riasi A, Farhangfar H, Mahyari SA (2018) Effects of close-up body condition score and selenium-vitamin E injection on lactation performance, blood metabolites, and oxidative status in high-producing dairy cows. J Dairy Sci 101(11):10495\u201310504","journal-title":"J Dairy Sci"},{"issue":"1","key":"1630_CR29","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1186\/s12917-018-1578-x","volume":"14","author":"AM Dalia","year":"2018","unstructured":"Dalia AM, Loh TC, Sazili AQ, Jahromi MF, Samsudin AA (2018) Effects of vitamin E, inorganic selenium, bacterial organic selenium, and their combinations on immunity response in broiler chickens. BMC Vet Res 14(1):249","journal-title":"BMC Vet Res"},{"issue":"1","key":"1630_CR30","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1186\/s13568-018-0641-0","volume":"8","author":"S Kumbhar","year":"2018","unstructured":"Kumbhar S, Khan AZ, Parveen F, Nizamani ZA, Siyal FA, El-Hack MEA, Gan F, Liu Y, Hamid M, Nido SA (2018) Impacts of selenium and vitamin E supplementation on mRNA of heat shock proteins, selenoproteins and antioxidants in broilers exposed to high temperature. AMB Express 8(1):112","journal-title":"AMB Express"},{"key":"1630_CR31","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.jnutbio.2018.05.010","volume":"59","author":"W Li","year":"2018","unstructured":"Li W, Tang R, Ma F, Ouyang S, Liu Z, Wu J (2018) Folic acid supplementation alters the DNA methylation profile and improves insulin resistance in high-fat-diet-fed mice. J Nutr Biochem 59:76\u201383","journal-title":"J Nutr Biochem"},{"issue":"14","key":"1630_CR32","doi-asserted-by":"publisher","first-page":"2838","DOI":"10.1002\/1522-2683(200108)22:14<2838::AID-ELPS2838>3.0.CO;2-M","volume":"22","author":"W Reik","year":"2001","unstructured":"Reik W, Dean W (2001) DNA methylation and mammalian epigenetics. Electrophoresis 22(14):2838\u20132843","journal-title":"Electrophoresis"},{"issue":"1","key":"1630_CR33","doi-asserted-by":"publisher","first-page":"21","DOI":"10.5732\/cjc.011.10245","volume":"32","author":"Y Jia","year":"2013","unstructured":"Jia Y, Guo M (2013) Epigenetic changes in colorectal cancer. Chin J Cancer 32(1):21\u201330","journal-title":"Chin J Cancer"},{"issue":"3","key":"1630_CR34","doi-asserted-by":"publisher","first-page":"232","DOI":"10.4236\/ajmb.2012.23024","volume":"2","author":"F Tian","year":"2012","unstructured":"Tian F, Luo J, Zhang H, Chang S, Song J (2012) Marek\u2019s disease virus challenge induced immune-related gene expression and chicken repeat 1 (CR1) methylation alterations in chickens. Am J Mol Biol 2(3):232\u2013241","journal-title":"Am J Mol Biol"},{"issue":"11","key":"1630_CR35","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1002\/art.1780331109","volume":"33","author":"B Richardson","year":"2014","unstructured":"Richardson B, Scheinbart L, Strahler J, Gross L, Hanash S, Johnson M (2014) Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis. Arthritis Rheum 33(11):1665\u20131673","journal-title":"Arthritis Rheum"},{"issue":"7","key":"1630_CR36","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1093\/jn\/122.7.1391","volume":"122","author":"M Balaghi","year":"1992","unstructured":"Balaghi M, Wagner C (1992) Methyl group metabolism in the pancreas of folate-deficient rats. J Nutr 122(7):1391\u20131396","journal-title":"J Nutr"},{"issue":"1","key":"1630_CR37","first-page":"1","volume":"6","author":"EN Bermingham","year":"2013","unstructured":"Bermingham EN, Bassett SA, Young W, Roy NC, Mcnabb WC, Cooney JM, Di TB, Laing WA, Barnett MP (2013) Post-weaning selenium and folate supplementation affects gene and protein expression and global DNA methylation in mice fed high-fat diets. BMC Med Genet 6(1):1\u201318","journal-title":"BMC Med Genet"},{"issue":"4","key":"1630_CR38","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1016\/j.jtemb.2014.06.017","volume":"28","author":"J Miranda de","year":"2014","unstructured":"de Miranda J, Andrade FO, Conti A, Dagli M, Moreno F, Ong T (2014) Effects of selenium compounds on proliferation and epigenetic marks of breast cancer cells. J Trace Elem Med Biol 28(4):486\u2013491","journal-title":"J Trace Elem Med Biol"},{"issue":"12","key":"1630_CR39","doi-asserted-by":"publisher","first-page":"2903","DOI":"10.1093\/jn\/130.12.2903","volume":"130","author":"C Davis","year":"2000","unstructured":"Davis C, Uthus E, Finley J (2000) Dietary selenium and arsenic affect DNA methylation in vitro in Caco-2 cells and in vivo in rat liver and colon. J Nutr 130(12):2903\u20132909","journal-title":"J Nutr"},{"issue":"1","key":"1630_CR40","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1002\/biot.201000267","volume":"6","author":"KM Armstrong","year":"2011","unstructured":"Armstrong KM, Bermingham EN, Bassett SA, Treloar BP, Roy NC, Barnett MP (2011) Global DNA methylation measurement by HPLC using low amounts of DNA. Biotechnol J 6(1):113\u2013117","journal-title":"Biotechnol J"},{"issue":"10","key":"1630_CR41","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1093\/jn\/104.10.1297","volume":"104","author":"CG Jr","year":"1974","unstructured":"Jr CG, Scott ML (1974) Antioxidant effects on selenium and vitamin E function in the chick. J Nutr 104(10):1297","journal-title":"J Nutr"},{"issue":"10","key":"1630_CR42","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1039\/C8MT00142A","volume":"10","author":"J Wang","year":"2018","unstructured":"Wang J, Liu Z, He X, Lian S, Liang J, Yu D, Sun D, Wu R (2018) Selenium deficiency induces duodenal villi cell apoptosis via an oxidative stress-induced mitochondrial apoptosis pathway and an inflammatory signaling-induced death receptor pathway. Metallomics 10(10):1390\u20131400","journal-title":"Metallomics"},{"key":"1630_CR43","doi-asserted-by":"publisher","unstructured":"Sun L, Huang J, Deng J, Lei X (2018) Avian selenogenome: response to dietary Se and vitamin E deficiency and supplementation. Poult Sci. \n                    https:\/\/doi.org\/10.3382\/ps\/pey408","DOI":"10.3382\/ps\/pey408"},{"issue":"11","key":"1630_CR44","doi-asserted-by":"publisher","first-page":"e0189001","DOI":"10.1371\/journal.pone.0189001","volume":"12","author":"RM Taylor","year":"2017","unstructured":"Taylor RM, Sunde RA (2017) Selenium requirements based on muscle and kidney selenoprotein enzyme activity and transcript expression in the turkey poult (Meleagris gallopavo). PLoS One 12(11):e0189001","journal-title":"PLoS One"},{"issue":"5","key":"1630_CR45","doi-asserted-by":"publisher","first-page":"613","DOI":"10.3945\/jn.112.172395","volume":"143","author":"H Yao","year":"2013","unstructured":"Yao H, Wu Q, Zhang Z, Zhang J, Li S, Huang J, Ren F, Xu S, Wang X, Lei X (2013) Gene expression of endoplasmic reticulum resident selenoproteins correlates with apoptosis in various muscles of Se-deficient chicks. J Nutr 143(5):613\u2013619","journal-title":"J Nutr"},{"issue":"2","key":"1630_CR46","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.plaphy.2011.10.016","volume":"51","author":"M Kumar","year":"2012","unstructured":"Kumar M, Bijo AJ, Baghel RS, Reddy CRK, Jha B (2012) Selenium and spermine alleviate cadmium induced toxicity in the red seaweed Gracilaria dura by regulating antioxidants and DNA methylation. Plant Physiol Biochem 51(2):129\u2013138","journal-title":"Plant Physiol Biochem"},{"issue":"16","key":"1630_CR47","doi-asserted-by":"publisher","first-page":"2395","DOI":"10.1093\/hmg\/9.16.2395","volume":"9","author":"TH Bestor","year":"2000","unstructured":"Bestor TH (2000) The DNA methyltransferases of mammals. Hum Mol Genet 9(16):2395\u20132402","journal-title":"Hum Mol Genet"},{"issue":"1","key":"1630_CR48","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1186\/s13148-018-0546-4","volume":"10","author":"V Dagar","year":"2018","unstructured":"Dagar V, Hutchison W, Muscat A, Krishnan A, Hoke D, Buckle A, Siswara P, Amor D, Mann J, Pinner J, Colley A, Wilson M, Sachdev R, McGillivray G, Edwards M, Kirk E, Collins F, Jones K, Taylor J, Hayes I, Thompson E, Barnett C, Haan E, Freckmann M, Turner A, White S, Kamien B, Ma A, Mackenzie F, Baynam G, Kiraly-Borri C, Field M, Dudding-Byth T, Algar E (2018) Genetic variation affecting DNA methylation and the human imprinting disorder, Beckwith-Wiedemann syndrome. Clin Epigenetics 10(1):114","journal-title":"Clin Epigenetics"},{"issue":"3","key":"1630_CR49","doi-asserted-by":"publisher","first-page":"2943","DOI":"10.1002\/jcp.27111","volume":"234","author":"B Li","year":"2018","unstructured":"Li B, Lu W, Qu J, Ye L, Du G, Wan X (2018) Loss of exosomal miR-148b from cancer-associated fibroblasts promotes endometrial cancer cell invasion and cancer metastasis. J Cell Physiol 234(3):2943\u20132953","journal-title":"J Cell Physiol"},{"key":"1630_CR50","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.tox.2018.08.004","volume":"410","author":"H Tao","year":"2018","unstructured":"Tao H, Dai C, Ding J, Yang J, Ding X, Xu S, Shi K (2018) Epigenetic aberrations of miR-369-5p and DNMT3A control Patched1 signal pathway in cardiac fibrosis. Toxicology 410:182\u2013192","journal-title":"Toxicology"},{"issue":"15","key":"1630_CR51","doi-asserted-by":"publisher","first-page":"10060","DOI":"10.1073\/pnas.152121799","volume":"99","author":"Y Saito","year":"2002","unstructured":"Saito Y, Kanai Y, Sakamoto M, Saito H, Ishii H, Hirohashi S (2002) Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis. Proc Natl Acad Sci U S A 99(15):10060\u201310065","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"1630_CR52","first-page":"4415","volume":"9","author":"I Girault","year":"2003","unstructured":"Girault I, Tozlu S, Lidereau R, Bi\u00e8che I (2003) Expression analysis of DNA methyltransferases 1, 3A, and 3B in sporadic breast carcinomas. Clin Cancer Res 9(12):4415\u20134422","journal-title":"Clin Cancer Res"},{"issue":"11","key":"1630_CR53","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1080\/09553000600960027","volume":"82","author":"J Loree","year":"2006","unstructured":"Loree J, Koturbash I, Kutanzi K, Baker M, Pogribny I, Kovalchuk O (2006) Radiation-induced molecular changes in rat mammary tissue: possible implications for radiation-induced carcinogenesis. Int J Radiat Biol 82(11):805\u2013815","journal-title":"Int J Radiat Biol"},{"key":"1630_CR54","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s12950-018-0191-x","volume":"15","author":"L Xu","year":"2018","unstructured":"Xu L, Sun W, Jia A, Qiu L, Xiao B, Mu L, Li J, Zhang X, Wei Y, Peng C, Zhang D, Xiang X (2018) MBD2 regulates differentiation and function of Th17 cells in neutrophils- dominant asthma via HIF-1\u03b1. J Inflamm (Lond) 15:15","journal-title":"J Inflamm (Lond)"},{"issue":"8","key":"1630_CR55","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1080\/15384047.2018.1450113","volume":"19","author":"L Cheng","year":"2018","unstructured":"Cheng L, Tang Y, Chen X, Zhao L, Liu S, Ma Y, Wang N, Zhou K, Zhou J, Zhou M (2018) Deletion of MBD2 inhibits proliferation of chronic myeloid leukaemia blast phase cells. Cancer Biol Ther 19(8):676\u2013686","journal-title":"Cancer Biol Ther"}],"container-title":["Biological Trace Element Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-019-1630-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12011-019-1630-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-019-1630-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T19:25:00Z","timestamp":1581103500000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12011-019-1630-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,8]]},"references-count":55,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["1630"],"URL":"https:\/\/doi.org\/10.1007\/s12011-019-1630-0","relation":{},"ISSN":["0163-4984","1559-0720"],"issn-type":[{"value":"0163-4984","type":"print"},{"value":"1559-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,8]]},"assertion":[{"value":"10 September 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 January 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 February 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}