{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:01:40Z","timestamp":1790503300359,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T00:00:00Z","timestamp":1549929600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biol Trace Elem Res"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1007\/s12011-019-1647-4","type":"journal-article","created":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T21:02:25Z","timestamp":1550005345000},"page":"196-205","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Se Regulates the Contractile Ability of Uterine Smooth Musclevia Selenoprotein N, Selenoprotein T, and Selenoprotein Win Mice"],"prefix":"10.1007","volume":"192","author":[{"given":"Fu-han","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0426-2203","authenticated-orcid":false,"given":"Meng-yao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,2,12]]},"reference":[{"key":"1647_CR1","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.ejphar.2018.05.042","volume":"833","author":"J Yu","year":"2018","unstructured":"Yu J, Dong XD, Wang LL, Ji HY, Liu AJ (2018) Antitumor effects of seleno-beta-lactoglobulin (Se-beta-Lg) against human gastric cancer MGC-803 cells. Eur J Pharmacol 833:109\u2013115","journal-title":"Eur J Pharmacol"},{"key":"1647_CR2","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.anifeedsci.2018.02.004","volume":"238","author":"L Shi","year":"2018","unstructured":"Shi L, Ren YS, Zhang CX, Yue WB, Lei FL (2018) Effects of organic selenium (Se-enriched yeast) supplementation in gestation diet on antioxidant status, hormone profile and haemato-biochemical parameters in Taihang black goats. Anim Feed Sci Technol 238:57\u201365","journal-title":"Anim Feed Sci Technol"},{"issue":"1\u20133","key":"1647_CR3","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1007\/s12011-011-9148-0","volume":"144","author":"MM Moeini","year":"2011","unstructured":"Moeini MM, Kiani A, Mikaeili E, Shabankareh HK (2011) Effect of prepartum supplementation of selenium and vitamin E on serum Se, IgG concentrations and colostrum of heifers and on hematology, passive immunity and se status of their offspring. Biol Trace Elem Res 144(1\u20133):529\u2013537","journal-title":"Biol Trace Elem Res"},{"issue":"4","key":"1647_CR4","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1016\/j.juro.2008.12.066","volume":"181","author":"SM Lippman","year":"2009","unstructured":"Lippman SM, Klein EA, Goodman PJ, Lucia MS, Thompson IM, Ford LG et al (2009) Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). J Urol 181(4):1686\u20131687","journal-title":"J Urol"},{"issue":"12","key":"1647_CR5","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/0968-0004(91)90180-4","volume":"16","author":"A Bock","year":"1991","unstructured":"Bock A, Forchhammer K, Heider J, Baron C (1991) Selenoprotein synthesis - an expansion of the genetic-code. Trends Biochem Sci 16(12):463\u2013467","journal-title":"Trends Biochem Sci"},{"issue":"10","key":"1647_CR6","first-page":"28","volume":"36","author":"M Mirone","year":"2013","unstructured":"Mirone M, Giannetta E, Isidori AM (2013) Selenium and reproductive function. A systematic review. J Endocrinol Investig 36(10):28\u201336","journal-title":"J Endocrinol Investig"},{"issue":"1","key":"1647_CR7","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1007\/s12011-016-0651-1","volume":"173","author":"XJ Gao","year":"2016","unstructured":"Gao XJ, Zhang ZW, Xing HJ, Yu J, Zhang NS, Xu SW (2016) Selenium deficiency-induced inflammation and increased expression of regulating inflammatory cytokines in the chicken gastrointestinal tract. Biol Trace Elem Res 173(1):210\u2013218","journal-title":"Biol Trace Elem Res"},{"issue":"12","key":"1647_CR8","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1016\/j.freeradbiomed.2004.04.010","volume":"36","author":"FF Chu","year":"2004","unstructured":"Chu FF, Esworthy RS, Doroshow JH (2004) Role of Se-dependent glutathoine peroxidases in gastrointestinal inflammation and cancer. Free Radic Biol Med 36(12):1481\u20131495","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"1647_CR9","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1007\/s12012-011-9134-y","volume":"12","author":"XL Jin","year":"2012","unstructured":"Jin XL, Hidiroglou N, Lok E, Taylor M, Kapal K, Ross N et al (2012) Dietary selenium (Se) and vitamin E (V-E) supplementation modulated methylmercury-mediated changes in markers of cardiovascular diseases in rats. Cardiovasc Toxicol 12(1):10\u201324","journal-title":"Cardiovasc Toxicol"},{"issue":"20","key":"1647_CR10","doi-asserted-by":"publisher","first-page":"4141","DOI":"10.1128\/MCB.00293-12","volume":"32","author":"LA Seale","year":"2012","unstructured":"Seale LA, Hashimoto AC, Kurokawa S, Gilman CL, Seyedali A, Bellinger FP, Raman AV, Berry MJ (2012) Disruption of the selenocysteine lyase-mediated selenium recycling pathway leads to metabolic syndrome in mice. Mol Cell Biol 32(20):4141\u20134154","journal-title":"Mol Cell Biol"},{"issue":"2","key":"1647_CR11","first-page":"406","volume":"32","author":"KR Hightower","year":"1991","unstructured":"Hightower KR, Mccready JP (1991) Effect of selenite on epithelium of cultured rabbit lens. Invest Ophthalmol Vis Sci 32(2):406\u2013409","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"1647_CR12","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1093\/jn\/117.3.460","volume":"117","author":"M. E. Whitacre","year":"1987","unstructured":"Whitacre ME, Combs GF, Combs SB, Parker RS (1987) Influence of dietary vitamin E on nutritional pancreatic atrophy in selenium-deficient chicks. J Nutr 117(3):460\u20137","journal-title":"The Journal of Nutrition"},{"issue":"1","key":"1647_CR13","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1385\/BTER:100:1:019","volume":"100","author":"WC Hawkes","year":"2004","unstructured":"Hawkes WC, Alkan Z, Lang K, King JC (2004) Plasma selenium decrease during pregnancy is associated with glucose intolerance. Biol Trace Elem Res 100(1):19\u201329","journal-title":"Biol Trace Elem Res"},{"key":"1647_CR14","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1186\/s12917-018-1508-y","volume":"14","author":"H Wang","year":"2018","unstructured":"Wang H, Bi CL, Wang YJ, Sun J, Meng X, Li JJ (2018) Selenium ameliorates Staphylococcus aureus-induced inflammation in bovine mammary epithelial cells by inhibiting activation of TLR2, NF-kappa B and MAPK signaling pathways. BMC Vet Res 14:197","journal-title":"BMC Vet Res"},{"issue":"2","key":"1647_CR15","doi-asserted-by":"publisher","first-page":"80","DOI":"10.3390\/nu8020080","volume":"8","author":"Ashley N. Ogawa-Wong","year":"2016","unstructured":"Ogawa-Wong, AN, Berry, MJ, Seale, LA (2016). Selenium and Metabolic Disorders: An Emphasis on Type 2 Diabetes Risk Nutrients 8(2):80","journal-title":"Nutrients"},{"issue":"34","key":"1647_CR16","doi-asserted-by":"publisher","first-page":"12485","DOI":"10.1073\/pnas.0806015105","volume":"105","author":"MJ Jurynec","year":"2008","unstructured":"Jurynec MJ, Xia RH, Mackrill JJ, Gunther D, Crawford T, Flanigan KM et al (2008) Selenoprotein N is required for ryanodine receptor calcium release channel activity in human and zebrafish muscle. Proc Natl Acad Sci U S A 105(34):12485\u201312490","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"1647_CR17","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1007\/s12011-016-0620-8","volume":"173","author":"JP Li","year":"2016","unstructured":"Li JP, Zhou JX, Wang Q, Gu GQ, Yang SJ, Li CY, Qiu CW, Deng GZ, Guo MY (2016) Se enhances MLCK activation by regulating Selenoprotein T (SelT) in the gastric smooth muscle of rats. Biol Trace Elem Res 173(1):116\u2013125","journal-title":"Biol Trace Elem Res"},{"issue":"36","key":"1647_CR18","doi-asserted-by":"publisher","first-page":"57618","DOI":"10.18632\/oncotarget.11459","volume":"7","author":"HD Yao","year":"2016","unstructured":"Yao HD, Fan RF, Zhao X, Zhao WC, Liu W, Yang J et al (2016) Selenoprotein W redox-regulated Ca2+ channels correlate with selenium deficiency-induced muscles Ca2+ leak. Oncotarget 7(36):57618\u201357632","journal-title":"Oncotarget"},{"issue":"1","key":"1647_CR19","doi-asserted-by":"publisher","first-page":"C1","DOI":"10.1152\/ajpcell.1981.240.1.C1","volume":"240","author":"EW Stephenson","year":"1981","unstructured":"Stephenson EW (1981) Activation of fast skeletal-muscle - contributions of studies on skinned fibers. Am J Physiol 240(1):C1\u2013C19","journal-title":"Am J Physiol"},{"issue":"6","key":"1647_CR20","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1111\/j.1742-4658.2005.04591.x","volume":"272","author":"AG Cook","year":"2005","unstructured":"Cook AG, Johnson LN, McDonnell JM (2005) Structural characterization of Ca2+\/CaM in complex with the phosphorylase kinase PhK5 peptide. FEBS J 272(6):1511\u20131522","journal-title":"FEBS J"},{"issue":"35","key":"1647_CR21","doi-asserted-by":"crossref","first-page":"19166","DOI":"10.1016\/S0021-9258(18)37405-2","volume":"263","author":"JC Colburn","year":"1988","unstructured":"Colburn JC, Michnoff CH, Hsu LC, Slaughter CA, Kamm KE, Stull JT (1988) Sites phosphorylated in myosin light chain in contracting smooth-muscle. J Biol Chem 263(35):19166\u201319173","journal-title":"J Biol Chem"},{"issue":"34","key":"1647_CR22","doi-asserted-by":"publisher","first-page":"20246","DOI":"10.1074\/jbc.271.34.20246","volume":"271","author":"M Amano","year":"1996","unstructured":"Amano M, Ito M, Kimura K, Fukata Y, Chihara K, Nakano T, Matsuura Y, Kaibuchi K (1996) Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase). J Biol Chem 271(34):20246\u201320249","journal-title":"J Biol Chem"},{"issue":"5","key":"1647_CR23","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1165\/ajrcmb.19.5.3126","volume":"19","author":"AD Verin","year":"1998","unstructured":"Verin AD, Gilbert-McClain LI, Patterson CE, Garcia JGN (1998) Biochemical regulation of the nonmuscle myosin light chain kinase isoform in bovine endothelium. Am J Respir Cell Mol Biol 19(5):767\u2013776","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"1","key":"1647_CR24","doi-asserted-by":"publisher","first-page":"C46","DOI":"10.1152\/ajpcell.1999.276.1.C46","volume":"276","author":"JZ Zhang","year":"1999","unstructured":"Zhang JZ, Wu YL, Williams BY, Rodney G, Mandel F, Strasburg GM et al (1999) Oxidation of the skeletal muscle Ca2+ release channel alters calmodulin binding. Am J Phys Cell Phys 276(1):C46\u2013C53","journal-title":"Am J Phys Cell Phys"},{"issue":"10","key":"1647_CR25","doi-asserted-by":"publisher","first-page":"2283","DOI":"10.1111\/j.1538-7836.2010.04000.x","volume":"8","author":"TM Getz","year":"2010","unstructured":"Getz TM, Dangelmaier CA, Jin J, Daniel JL, Kunapuli SP (2010) Differential phosphorylation of myosin light chain (Thr)18 and (Ser)19 and functional implications in platelets. J Thromb Haemost 8(10):2283\u20132293","journal-title":"J Thromb Haemost"},{"issue":"1","key":"1647_CR26","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1007\/s12011-017-1130-z","volume":"183","author":"JX Zhou","year":"2018","unstructured":"Zhou JX, Li CY, Gu GQ, Wang Q, Guo MY (2018) Selenoprotein N was required for the regulation of selenium on the uterine smooth muscle contraction in mice. Biol Trace Elem Res 183(1):138\u2013146","journal-title":"Biol Trace Elem Res"},{"key":"1647_CR27","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1042\/BJ4560475","volume":"456","author":"X Tian","year":"2013","unstructured":"Tian X, Tang Y, Liu Y, Wang R, Chen SRW (2013) Calmodulin modulates the termination threshold for cardiac ryanodine receptor-mediated Ca2+ release (vol 455, pg 367, 2013). Biochem J 456:475\u2013475","journal-title":"Biochem J"},{"key":"1647_CR28","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.ceca.2017.05.001","volume":"70","author":"MW Pitts","year":"2018","unstructured":"Pitts MW, Hoffmann PR (2018) Endoplasmic reticulum-resident selenoproteins as regulators of calcium signaling and homeostasis. Cell Calcium 70:76\u201386","journal-title":"Cell Calcium"},{"issue":"2","key":"1647_CR29","doi-asserted-by":"publisher","first-page":"C235","DOI":"10.1152\/ajpcell.2000.278.2.C235","volume":"278","author":"JH Jaggar","year":"2000","unstructured":"Jaggar JH, Porter VA, Lederer WJ, Nelson MT (2000) Calcium sparks in smooth muscle. Am J Phys Cell Phys 278(2):C235\u2013C256","journal-title":"Am J Phys Cell Phys"},{"issue":"3","key":"1647_CR30","doi-asserted-by":"publisher","first-page":"2203","DOI":"10.1074\/jbc.M109.067546","volume":"285","author":"R Zhuge","year":"2010","unstructured":"Zhuge R, Bao RF, Fogarty KE, Lifshitz LM (2010) Ca2+ Sparks act as potent regulators of excitation-contraction coupling in airway smooth muscle. J Biol Chem 285(3):2203\u20132210","journal-title":"J Biol Chem"}],"container-title":["Biological Trace Element Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12011-019-1647-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-019-1647-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-019-1647-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,11]],"date-time":"2022-09-11T20:05:11Z","timestamp":1662926711000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12011-019-1647-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,12]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["1647"],"URL":"https:\/\/doi.org\/10.1007\/s12011-019-1647-4","relation":{},"ISSN":["0163-4984","1559-0720"],"issn-type":[{"value":"0163-4984","type":"print"},{"value":"1559-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,12]]},"assertion":[{"value":"5 December 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 January 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 February 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}