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The aim was to observe the influence of hexavalent chromium Cr(VI) on the adrenal gland, and if this impact can be recovered by the administration of <jats:italic>A. melanocarpa.<\/jats:italic> Accordingly, 36 rats were divided into six groups: <jats:italic>control; Aronia<\/jats:italic>; <jats:italic>Cr<\/jats:italic> receiving Cr(VI) in distilled water for 3 months; <jats:italic>CrA<\/jats:italic> receiving a mix of Cr(VI) and <jats:italic>A. melanocarpa<\/jats:italic> at 2.5% aqueous extract for 3 months; <jats:italic>Cr2<\/jats:italic> receiving, for 3 months, Cr(VI) in distilled water, and next, for 1 month, only distilled water; and respectively, <jats:italic>CrA2<\/jats:italic> receiving, for 3 months, Cr(VI) in distilled water, followed by 1 month of <jats:italic>Aronia<\/jats:italic> at 2.5% extract administration. The adrenal gland samples were examined toward histological and molecular assessment, and results were statistically analyzed (ANOVA). Hexavalent chromium induced changes in the adrenal cortex expressed by focal or diffuse hypertrophies, cytoplasmic vacuolization (due to lipidic accumulation), and cells\u2019 shape and size alteration, including necrosis. These structural alterations were carried by <jats:italic>Bax<\/jats:italic> and <jats:italic>Bcl2<\/jats:italic> gene expression: the <jats:italic>Bax<\/jats:italic> gene expression levels, increased significantly (<jats:italic>p<\/jats:italic> &lt; 0.001) in all experimental groups, except the <jats:italic>Aronia<\/jats:italic> group, compared with control. In the <jats:italic>Cr2<\/jats:italic>, <jats:italic>CrA<\/jats:italic>, and <jats:italic>CrA2<\/jats:italic> groups, notable reduction of <jats:italic>Bax<\/jats:italic> gene expression (<jats:italic>p<\/jats:italic> &lt; 0.001) was reported compared with the <jats:italic>Cr<\/jats:italic> group. Regarding the <jats:italic>Bcl2<\/jats:italic> gene expression (<jats:italic>p<\/jats:italic> &lt; 0.001), a significant increase was observed in the experimental groups, compared with the control. The <jats:italic>Bcl2<\/jats:italic> expression level had a similar pattern to <jats:italic>Bax<\/jats:italic> gene, consequently trying to compensate its overexpression. <jats:italic>Aronia<\/jats:italic> administered concomitantly, or after Cr(VI), diminished structural changes and expression of the studied genes, thus reducing the <jats:italic>Bax\/Bcl2<\/jats:italic> ratio and suggesting that the active ingredients from <jats:italic>Aronia<\/jats:italic> are capable of blocking apoptotic cascade induced by the pathway of <jats:italic>Bax<\/jats:italic> and <jats:italic>Bcl2<\/jats:italic> proteins.<\/jats:p>","DOI":"10.1007\/s12011-020-02401-7","type":"journal-article","created":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T12:03:19Z","timestamp":1601553799000},"page":"2936-2944","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Aronia melanocarpa Ameliorates Adrenal Cytoarchitecture Against the Hexavalent Chromium-Induced Injury"],"prefix":"10.1007","volume":"199","author":[{"given":"Jelena","family":"Savici","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5420-1516","authenticated-orcid":false,"given":"Romeo Teodor","family":"Cristina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Brezovan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isidora","family":"Radulov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornel","family":"Balta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oana Maria","family":"Boldura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florin","family":"Muselin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,10,1]]},"reference":[{"key":"2401_CR1","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.reprotox.2007.07.009","volume":"24","author":"AK Chandra","year":"2007","unstructured":"Chandra AK, Chatterjee A, Ghosh R, Sarkar M, Chaube SK (2007) Chromium induced testicular impairment in relation to adrenocortical activities in adult albino rats. 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