{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T09:20:35Z","timestamp":1792833635931,"version":"4.5.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T00:00:00Z","timestamp":1624665600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T00:00:00Z","timestamp":1624665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100006668","name":"Fondo para la Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT 2016-2131"],"award-info":[{"award-number":["PICT 2016-2131"]}],"id":[{"id":"10.13039\/501100006668","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006668","name":"Fondo para la Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT 2016-3727"],"award-info":[{"award-number":["PICT 2016-3727"]}],"id":[{"id":"10.13039\/501100006668","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biol Trace Elem Res"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1007\/s12011-021-02795-y","type":"journal-article","created":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T14:02:15Z","timestamp":1624716135000},"page":"1617-1625","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Parenteral Copper Administration at the Beginning of a Fixed-Time Artificial Insemination Protocol in Beef Cattle: Effect on Ovarian Function and Pregnancy Rates"],"prefix":"10.1007","volume":"200","author":[{"given":"Juan Patricio","family":"Anchordoquy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago Nicol\u00e1s","family":"Lorenti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Sebasti\u00e1n","family":"Polero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00e1s Agust\u00edn","family":"Farnetano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana Esther","family":"Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Carolina","family":"Fabra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Cristina","family":"Carranza-Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noelia","family":"Nikoloff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia Cristina","family":"Furnus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Mateo","family":"Anchordoquy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,26]]},"reference":[{"key":"2795_CR1","first-page":"127","volume":"1","author":"V Mudgal","year":"2012","unstructured":"Mudgal V, Gupta VK, Srivastava S, Ganie AA (2012) Effect of species variation on level of different trace elements in the serum of anoestrous cattle. Rumin Sci 1:127\u2013129","journal-title":"Rumin Sci"},{"key":"2795_CR2","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.3168\/jds.S0022-0302(79)83400-1","volume":"62","author":"M Hidiroglou","year":"1979","unstructured":"Hidiroglou M (1979) Trace Element Deficiencies and Fertility in Ruminants: A Review. J Dairy Sci 62:1195\u20131206. https:\/\/doi.org\/10.3168\/jds.S0022-0302(79)83400-1","journal-title":"J Dairy Sci"},{"key":"2795_CR3","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1017\/S0263967X00034042","volume":"26","author":"NR Kendall","year":"2001","unstructured":"Kendall NR, Illingworth DV, Telfer SB (2001) Copper responsive infertility in British cattle: the use of a blood caeruloplasmin to copper ratio in determining a requirement for copper supplementation. BSAP Occas Publ 26:429\u2013432. https:\/\/doi.org\/10.1017\/S0263967X00034042","journal-title":"BSAP Occas Publ"},{"key":"2795_CR4","doi-asserted-by":"publisher","unstructured":"Garc\u00eda DH, Cuesta MM, Pedroso RS, et al (2007) Suplementaci\u00f3n parenteral de cobre en vacas gestantes: efecto sobre postparto y terneros. Revista MVZ C\u00f3rdoba https:\/\/doi.org\/10.21897\/rmvz.419","DOI":"10.21897\/rmvz.419"},{"issue":"E-Suppl","key":"2795_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2527\/jas2000.77E-Suppl1x77","volume":"77","author":"RL Kincaid","year":"2000","unstructured":"Kincaid RL (2000) Assessment of trace mineral status of ruminants: a review. J Anim Sci 77(E-Suppl):1. https:\/\/doi.org\/10.2527\/jas2000.77E-Suppl1x77","journal-title":"J Anim Sci"},{"key":"2795_CR6","volume-title":"Minerals in animals and human nutrition","author":"LR McDowell","year":"1992","unstructured":"McDowell LR (1992) Minerals in animals and human nutrition. Academic Press, New York"},{"key":"2795_CR7","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/S0301-6226(98)00120-1","volume":"55","author":"Ram\u0131\u0301rez CE, Mattioli GA, Tittarell","year":"1998","unstructured":"Ram\u0131\u0301rez CE, Mattioli GA, Tittarelli CM, et al (1998) Cattle hypocuprosis in Argentina associated with periodically flooded soils. Livest Prod Sci 55:47\u201352. https:\/\/doi.org\/10.1016\/S0301-6226(98)00120-1","journal-title":"Livest Prod Sci"},{"key":"2795_CR8","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1936.117.1.68","author":"HL Fevold","year":"1936","unstructured":"Fevold HL, Hisaw FL, Greep R (1936) Augmentation of the gonad stimulating action of pituitary extracts by inorganic substances, particularly copper salts. AJP Content. https:\/\/doi.org\/10.1152\/ajplegacy.1936.117.1.68","journal-title":"AJP Content"},{"key":"2795_CR9","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1210\/endo-76-6-1205","volume":"76","author":"M Suzuki","year":"1965","unstructured":"Suzuki M, Watanabe S, Hoshii M (1965) Effect of estrogen on copper-induced ovulation in the rabbit. Endocrinology 76:1205\u20131207. https:\/\/doi.org\/10.1210\/endo-76-6-1205","journal-title":"Endocrinology"},{"key":"2795_CR10","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/0006-291x(83)91831-4","volume":"112","author":"E Hazum","year":"1983","unstructured":"Hazum E (1983) Copper and thiol regulation of gonadotropin releasing hormone binding and luteinizing hormone release. Biochem Biophys Res Commun 112:306\u2013312. https:\/\/doi.org\/10.1016\/0006-291x(83)91831-4","journal-title":"Biochem Biophys Res Commun"},{"key":"2795_CR11","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/0162-0134(92)80051-v","volume":"48","author":"K Kochman","year":"1992","unstructured":"Kochman K, Gajewska A, Kozlowski H et al (1992) Increased LH and FSH release from the anterior pituitary of ovariectomized rat, in vivo, by copper-, nickel-, and zinc-LHRH complexes. J Inorg Biochem 48:41\u201346. https:\/\/doi.org\/10.1016\/0162-0134(92)80051-v","journal-title":"J Inorg Biochem"},{"key":"2795_CR12","first-page":"377","volume":"26","author":"K Kochman","year":"2005","unstructured":"Kochman K, Blitek A, Kaczmarek M et al (2005) Different signaling in pig anterior pituitary cells by GnRH and its complexes with copper and nickel. Neuro Endocrinol Lett 26:377\u2013382","journal-title":"Neuro Endocrinol Lett"},{"key":"2795_CR13","doi-asserted-by":"crossref","DOI":"10.1079\/9780851991283.0000","volume-title":"Themineral nutrition of livestock","author":"EJ Underwood","year":"1999","unstructured":"Underwood EJ, Suttle NF (1999) Themineral nutrition of livestock. CABI Publishing, London"},{"key":"2795_CR14","unstructured":"Herd DB, Sprott LR (1986) Body condition, nutrition and reproduction of beef cows. Texas Agricultural Experiment Station. Available electronically from https:\/\/hdl.handle.net\/1969.1\/129135"},{"key":"2795_CR15","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1177\/036985646700400701","volume":"4","author":"KG Piper","year":"1967","unstructured":"Piper KG, Higgins G (1967) Estimation of Trace Metals in Biological Material by Atomic Absorption Spectrophotometry. Proc Assoc Clin Biochem 4:190\u2013197. https:\/\/doi.org\/10.1177\/036985646700400701","journal-title":"Proc Assoc Clin Biochem"},{"key":"2795_CR16","doi-asserted-by":"publisher","first-page":"5612","DOI":"10.3168\/jds.2018-15853","volume":"102","author":"LG Siqueira","year":"2019","unstructured":"Siqueira LG, Arashiro EK, Ghetti AM et al (2019) Vascular and morphological features of the corpus luteum 12 to 20 days after timed artificial insemination in dairy cattle. J Dairy Sci 102:5612\u20135622. https:\/\/doi.org\/10.3168\/jds.2018-15853","journal-title":"J Dairy Sci"},{"key":"2795_CR17","doi-asserted-by":"publisher","first-page":"113","DOI":"10.5194\/aab-55-113-2012","volume":"55","author":"JR Garc\u00eda-D\u00edaz","year":"2012","unstructured":"Garc\u00eda-D\u00edaz JR, Joseph-Ajakaiye J, Cuesta-Mazorra M et al (2012) Effects of parenteral supplementation of Cu in female cattle with different levels of cupremia. Arch Anim Breed 55:113\u2013122. https:\/\/doi.org\/10.5194\/aab-55-113-2012","journal-title":"Arch Anim Breed"},{"key":"2795_CR18","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1017\/S0021859600030148","volume":"99","author":"M Phillippo","year":"1982","unstructured":"Phillippo M, Humphries WR, Lawrence CB, Price J (1982) Investigation of the effect of copper status and therapy on fertility in beef suckler herds. J Agric Sci 99:359\u2013364. https:\/\/doi.org\/10.1017\/S0021859600030148","journal-title":"J Agric Sci"},{"key":"2795_CR19","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1677\/joe.0.1150273","volume":"115","author":"AS McNeilly","year":"1987","unstructured":"McNeilly AS, Fraser HM (1987) Effect of gonadotrophin-releasing hormone agonist-induced suppression of LH and FSH on follicle growth and corpus luteum function in the ewe. J Endocrinol 115:273\u2013282. https:\/\/doi.org\/10.1677\/joe.0.1150273","journal-title":"J Endocrinol"},{"key":"2795_CR20","doi-asserted-by":"publisher","first-page":"2","DOI":"10.4103\/0974-1208.82351","volume":"4","author":"P Kumar","year":"2011","unstructured":"Kumar P, Sait SF (2011) Luteinizing hormone and its dilemma in ovulation induction. J Hum Reprod Sci 4:2\u20137. https:\/\/doi.org\/10.4103\/0974-1208.82351","journal-title":"J Hum Reprod Sci"},{"key":"2795_CR21","first-page":"193","volume":"7","author":"A Michaluk","year":"2007","unstructured":"Michaluk A, Kochman K (2007) Involvement of copper in female reproduction. Reprod Biol 7:193\u2013205","journal-title":"Reprod Biol"},{"key":"2795_CR22","first-page":"10","volume":"24","author":"B Yu","year":"2008","unstructured":"Yu B, Fu W-L, Liu P-X (2008) Effects of Cu2+ on growth hormone secretion of pig pituitary cells in culture. Zhongguo Ying Yong Sheng Li Xue Za Zhi 24:10\u201313","journal-title":"Zhongguo Ying Yong Sheng Li Xue Za Zhi"},{"key":"2795_CR23","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1620\/tjem.108.9","volume":"108","author":"M Suzuki","year":"1972","unstructured":"Suzuki M, Tnemoto Y, Takahashi K (1972) The effect of copper salts on ovulation, especially on hypothalamic ovulatory hormone releasing factor. Tohoku J Exp Med 108:9\u201318. https:\/\/doi.org\/10.1620\/tjem.108.9","journal-title":"Tohoku J Exp Med"},{"key":"2795_CR24","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1210\/endo-101-2-534","volume":"101","author":"RC Tsou","year":"1977","unstructured":"Tsou RC, Dailey RA, McLanahan CS et al (1977) Luteinizing hormone releasing hormone (LHRH) levels in pituitary stalk plasma during the preovulatory gonadotropin surge of rabbits. Endocrinology 101:534\u2013539. https:\/\/doi.org\/10.1210\/endo-101-2-534","journal-title":"Endocrinology"},{"key":"2795_CR25","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.theriogenology.2011.08.009","volume":"77","author":"SJ Picco","year":"2012","unstructured":"Picco SJ, Rosa DE, Anchordoquy JP et al (2012) Effects of copper sulphate concentrations during in vitro maturation of bovine oocytes. Theriogenology 77:373\u2013381. https:\/\/doi.org\/10.1016\/j.theriogenology.2011.08.009","journal-title":"Theriogenology"},{"key":"2795_CR26","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1017\/S0967199416000204","volume":"24","author":"DE Rosa","year":"2016","unstructured":"Rosa DE, Anchordoquy JM, Anchordoquy JP et al (2016) Analyses of apoptosis and DNA damage in bovine cumulus cells after in vitro maturation with different copper concentrations: consequences on early embryo development. Zygote 24:869\u2013879. https:\/\/doi.org\/10.1017\/S0967199416000204","journal-title":"Zygote"},{"key":"2795_CR27","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1080\/10934529.2014.865404","volume":"49","author":"S Roychoudhury","year":"2014","unstructured":"Roychoudhury S, Bulla J, Sirotkin AV, Kolesarova A (2014) In vitro changes in porcine ovarian granulosa cells induced by copper. J Environ Sci Health A Tox Hazard Subst Environ Eng 49:625\u2013633. https:\/\/doi.org\/10.1080\/10934529.2014.865404","journal-title":"J Environ Sci Health A Tox Hazard Subst Environ Eng"},{"key":"2795_CR28","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1095\/biolreprod66.3.651","volume":"66","author":"TJ Acosta","year":"2002","unstructured":"Acosta TJ, Yoshizawa N, Ohtani M, Miyamoto A (2002) Local changes in blood flow within the early and midcycle corpus luteum after prostaglandin F(2 alpha) injection in the cow. Biol Reprod 66:651\u2013658. https:\/\/doi.org\/10.1095\/biolreprod66.3.651","journal-title":"Biol Reprod"},{"key":"2795_CR29","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1111\/j.1447-0578.2008.00205.x","volume":"7","author":"N Sugino","year":"2008","unstructured":"Sugino N, Matsuoka A, Taniguchi K, Tamura H (2008) Angiogenesis in the human corpus luteum. Reprod Med Biol 7:91\u2013103. https:\/\/doi.org\/10.1111\/j.1447-0578.2008.00205.x","journal-title":"Reprod Med Biol"},{"key":"2795_CR30","doi-asserted-by":"publisher","first-page":"2274","DOI":"10.1093\/jn\/127.12.2274","volume":"127","author":"DA Schuschke","year":"1997","unstructured":"Schuschke DA (1997) Dietary Copper in the Physiology of the Microcirculation. J Nutr 127:2274\u20132281. https:\/\/doi.org\/10.1093\/jn\/127.12.2274","journal-title":"J Nutr"}],"container-title":["Biological Trace Element Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-021-02795-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12011-021-02795-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-021-02795-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T11:55:35Z","timestamp":1672574135000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12011-021-02795-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,26]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["2795"],"URL":"https:\/\/doi.org\/10.1007\/s12011-021-02795-y","relation":{},"ISSN":["0163-4984","1559-0720"],"issn-type":[{"value":"0163-4984","type":"print"},{"value":"1559-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,26]]},"assertion":[{"value":"20 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The experimental procedures were approved by the School of Veterinary Sciences Institutional Animal Care and Use Committee (National University of La Plata, Buenos Aires, Argentina; Protocol No. 105\u20133-20P).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare that there are no conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}