{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:19:03Z","timestamp":1783477143500,"version":"3.55.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T00:00:00Z","timestamp":1632700800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T00:00:00Z","timestamp":1632700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Capital Featured Clinical Application Research Project","award":["Z171100001017126"],"award-info":[{"award-number":["Z171100001017126"]}]},{"name":"he key project of Peking University International Hospital","award":["YN2016ZD01"],"award-info":[{"award-number":["YN2016ZD01"]}]},{"name":"the key project of Peking University International Hospital Fund","award":["YN2019ZD04"],"award-info":[{"award-number":["YN2019ZD04"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biol Trace Elem Res"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Iodine is an essential trace element for humans and the main raw material for thyroid hormone synthesis. However, the association between iodine nutritional status and adverse pregnancy outcomes in different regions remains controversial. This single-center cohort study was focused on the association between iodine nutritional status and adverse pregnancy outcomes in Beijing, China. We enrolled 726 pregnant women who were registered at the Peking University International Hospital between February 2017 and December 2019. To analyze the association between\u00a0iodine nutritional status variations and adverse pregnancy outcomes, this study cohort included 390 (53.72%) participants with iodine deficiency, 206 (28.37%) with an adequate iodine level, 103 (14.19%) with a more than adequate iodine level, and 27 (3.72%) with iodine excess, according to the urinary iodine (UI) status of pregnant women. After adjusting for age, body mass index, parity, and history of spontaneous abortion, we identified iodine deficiency as a risk factor for anti-thyroid peroxidase antibody (TPOAb) positivity [odds ratio (OR), 3.646; 95% confidence interval (95% CI), 1.658\u20138.017], anti-thyroglobulin antibody (TGAb) positivity (OR, 3.109; 95% CI, 1.465\u20136.599), and thyroid autoimmunity (OR, 2.885; 95% CI, 1.539\u20135.407). There was a non-linear relationship between UI and the concentrations of TPOAb and TGAb (<jats:italic>P<\/jats:italic><jats:sub>non-linear<\/jats:sub>\u2009&lt;\u20090.05). Iodine deficiency during the first trimester is\u00a0a  risk factor for thyroid autoantibody positivity. The relationship between UI and the concentrations of TPOAb and TGAb follows a nearly U-shaped curve. Thus, physicians should critically consider the iodine nutritional status of pregnant women during the first trimester. Clinical Trials.gov Identifier: NCT02966405<\/jats:p>","DOI":"10.1007\/s12011-021-02887-9","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T08:39:16Z","timestamp":1632731956000},"page":"2620-2628","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Association Between Iodine Nutritional Status and Adverse Pregnancy Outcomes in Beijing, China: a Single-Center Cohort Study"],"prefix":"10.1007","volume":"200","author":[{"given":"Xiaomei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Nan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"QiaoLing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linong","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,27]]},"reference":[{"key":"2887_CR1","unstructured":"World Health Organization, United Nations Children\u2019s Fund, International Council for the Control of Iodine Deficiency Disorders. Assessment of iodine deficiency disorders and monitoring their elimination. A guide for programme managers, 3rd edn.Geneva: World Health Organization.[J]. 2007"},{"issue":"2","key":"2887_CR2","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/s12011-017-1101-4","volume":"182","author":"Y Xiao","year":"2018","unstructured":"Xiao Y, Sun H, Li C et al (2018) Effect of iodine nutrition on pregnancy outcomes in an iodine-sufficient area in China[J]. Biol Trace Elem Res 182(2):231\u2013237. https:\/\/doi.org\/10.1007\/s12011-017-1101-4","journal-title":"Biol Trace Elem Res"},{"issue":"1","key":"2887_CR3","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1186\/s12916-020-01676-w","volume":"18","author":"MH Abel","year":"2020","unstructured":"Abel MH, Caspersen IH, Sengpiel V et al (2020) Insufficient maternal iodine intake is associated with subfecundity, reduced foetal growth, and adverse pregnancy outcomes in the Norwegian mother, father and child cohort study[J]. 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Written informed consent was obtained from each participant before enrolment in this study before samples collection. This study was registered on ClinicalTrials.gov (number NCT02966405).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}