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Candesartan is an angiotensin II (Ang II) receptor antagonist with promising diverse health benefits. The current study is planned to investigate the hepatorenal protective effects of candesartan against Cd-induced hepatic and renal intoxication. Our results demonstrated that candesartan effectively attenuated Cd-induced hepatorenal intoxication, as evidenced by improving hepatic and renal function biomarkers. Besides, candesartan reversed hepatic and renal histopathological abrasions induced by Cd toxicity. Candesartan antioxidant effect was mediated by Nrf2 activation. Also, candesartan suppressed hepatorenal inflammation by modulating NF-\u03baB\/I\u03baB. Moreover, candesartan attenuated Cd hepatorenal apoptosis by upregulating Bcl-2 and downregulating Bax and Cyt-C proteins. Interestingly, these effects are suggested to be an outcome of modulating of Ang II\/Ang 1\u20137 signal. Overall, our findings revealed that candesartan could attenuate Cd-induced hepatorenal intoxication through modulation of Nrf2, NF-\u03baB\/I\u03baB, Bax\/Bcl-2\/Cyt-c, and Ang II\/Ang 1\u20137 signaling pathways.<\/jats:p>","DOI":"10.1007\/s12011-022-03286-4","type":"journal-article","created":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T18:06:13Z","timestamp":1652983573000},"page":"1846-1863","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["RETRACTED ARTICLE: Candesartan Protects Against Cadmium-Induced Hepatorenal Syndrome by Affecting Nrf2, NF-\u03baB, Bax\/Bcl-2\/Cyt-C, and Ang II\/Ang 1\u20137 Signals"],"prefix":"10.1007","volume":"201","author":[{"given":"Esam O.","family":"Kamel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wail M.","family":"Gad-Elrab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed A.","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuhair M.","family":"Mohammedsaleh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emad H. 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