{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:07:17Z","timestamp":1792109237837,"version":"4.4.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T00:00:00Z","timestamp":1653523200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T00:00:00Z","timestamp":1653523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biol Trace Elem Res"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1007\/s12011-022-03296-2","type":"journal-article","created":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T01:03:07Z","timestamp":1653526987000},"page":"1689-1694","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Iron Deficiency Increases Phosphorylation of SP1 to Upregulate SPNS2 Expression in Hepatocellular Carcinoma"],"prefix":"10.1007","volume":"201","author":[{"given":"Dongyao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zelong","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7576-8928","authenticated-orcid":false,"given":"Yuxiao","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,5,26]]},"reference":[{"key":"3296_CR1","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1038\/nature22352","volume":"546","author":"A Mendoza","year":"2017","unstructured":"Mendoza A et al (2017) Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells. Nature 546:158\u2013161","journal-title":"Nature"},{"key":"3296_CR2","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1194\/jlr.S091959","volume":"60","author":"S Spiegel","year":"2019","unstructured":"Spiegel S, Maczis MA, Maceyka M, Milstien S (2019) New insights into functions of the sphingosine-1-phosphate transporter SPNS2. J Lipid Res 60:484\u2013489","journal-title":"J Lipid Res"},{"key":"3296_CR3","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/nature20792","volume":"541","author":"L van der Weyden","year":"2017","unstructured":"van der Weyden L et al (2017) Genome-wide in vivo screen identifies novel host regulators of metastatic colonization. Nature 541:233\u2013236","journal-title":"Nature"},{"key":"3296_CR4","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.682773","volume":"11","author":"L Lv","year":"2021","unstructured":"Lv L, Yi Q, Yan Y, Chao F, Li M (2021) SPNS2 downregulation induces EMT and promotes colorectal cancer metastasis via activating AKT signaling pathway. Front Oncol 11:682773","journal-title":"Front Oncol"},{"key":"3296_CR5","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1111\/1440-1681.13124","volume":"46","author":"X Gu","year":"2019","unstructured":"Gu X et al (2019) SPNS2 promotes the malignancy of colorectal cancer cells via regulating Akt and ERK pathway. Clin Exp Pharmacol Physiol 46:861\u2013871","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"3296_CR6","doi-asserted-by":"crossref","unstructured":"Li M, et al. (2021) Sphingosine-1-phosphate transporter spinster homolog 2 is essential for iron-regulated metastasis of hepatocellular carcinoma. Mol Ther","DOI":"10.1016\/j.ymthe.2021.09.012"},{"key":"3296_CR7","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.atherosclerosis.2022.01.002","volume":"344","author":"N Villa-Roel","year":"2022","unstructured":"Villa-Roel N et al (2022) Hypoxia inducible factor 1alpha inhibitor PX-478 reduces atherosclerosis in mice. Atherosclerosis 344:20\u201330","journal-title":"Atherosclerosis"},{"key":"3296_CR8","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.canlet.2022.01.027","volume":"531","author":"F Luo","year":"2022","unstructured":"Luo F et al (2022) HIF-1alpha inhibition promotes the efficacy of immune checkpoint blockade in the treatment of non-small cell lung cancer. Cancer Lett 531:39\u201356","journal-title":"Cancer Lett"},{"key":"3296_CR9","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1158\/1535-7163.MCT-07-0463","volume":"7","author":"MY Koh","year":"2008","unstructured":"Koh MY et al (2008) Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1alpha. Mol Cancer Ther 7:90\u2013100","journal-title":"Mol Cancer Ther"},{"key":"3296_CR10","doi-asserted-by":"crossref","unstructured":"Han DS, Lee EO (2022) Sp1 plays a key role in vasculogenic mimicry of human prostate cancer cells. Int J Mol Sci 23","DOI":"10.3390\/ijms23031321"},{"key":"3296_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2021.114894","volume":"197","author":"J Gong","year":"2022","unstructured":"Gong J, Ji Y, Liu X, Zheng Y, Zhen Y (2022) Mithramycin suppresses tumor growth by regulating CD47 and PD-L1 expression. Biochem Pharmacol 197:114894","journal-title":"Biochem Pharmacol"},{"key":"3296_CR12","doi-asserted-by":"publisher","first-page":"7162","DOI":"10.1038\/srep07162","volume":"4","author":"ES Choi","year":"2014","unstructured":"Choi ES, Nam JS, Jung JY, Cho NP, Cho SD (2014) Modulation of specificity protein 1 by mithramycin A as a novel therapeutic strategy for cervical cancer. Sci Rep 4:7162","journal-title":"Sci Rep"},{"key":"3296_CR13","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/nrc3183","volume":"12","author":"B Keith","year":"2011","unstructured":"Keith B, Johnson RS, Simon MC (2011) HIF1alpha and HIF2alpha: sibling rivalry in hypoxic tumour growth and progression. Nat Rev Cancer 12:9\u201322","journal-title":"Nat Rev Cancer"},{"key":"3296_CR14","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.gde.2009.10.009","volume":"20","author":"GL Semenza","year":"2010","unstructured":"Semenza GL (2010) HIF-1: upstream and downstream of cancer metabolism. Curr Opin Genet Dev 20:51\u201356","journal-title":"Curr Opin Genet Dev"},{"key":"3296_CR15","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1038\/onc.2009.441","volume":"29","author":"GL Semenza","year":"2010","unstructured":"Semenza GL (2010) Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene 29:625\u2013634","journal-title":"Oncogene"},{"key":"3296_CR16","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/ncb1691","volume":"10","author":"MH Yang","year":"2008","unstructured":"Yang MH et al (2008) Direct regulation of TWIST by HIF-1alpha promotes metastasis. Nat Cell Biol 10:295\u2013305","journal-title":"Nat Cell Biol"},{"key":"3296_CR17","doi-asserted-by":"publisher","first-page":"4157","DOI":"10.1158\/0008-5472.CAN-06-2355","volume":"67","author":"T Hiraga","year":"2007","unstructured":"Hiraga T, Kizaka-Kondoh S, Hirota K, Hiraoka M, Yoneda T (2007) Hypoxia and hypoxia-inducible factor-1 expression enhance osteolytic bone metastases of breast cancer. Cancer Res 67:4157\u20134163","journal-title":"Cancer Res"},{"key":"3296_CR18","doi-asserted-by":"publisher","first-page":"16369","DOI":"10.1073\/pnas.1113483108","volume":"108","author":"CC Wong","year":"2011","unstructured":"Wong CC et al (2011) Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation. Proc Natl Acad Sci U S A 108:16369\u201316374","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3296_CR19","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.1038\/onc.2011.365","volume":"31","author":"H Zhang","year":"2012","unstructured":"Zhang H et al (2012) HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs. Oncogene 31:1757\u20131770","journal-title":"Oncogene"},{"key":"3296_CR20","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1158\/0008-5472.CAN-06-2701","volume":"67","author":"D Liao","year":"2007","unstructured":"Liao D, Corle C, Seagroves TN, Johnson RS (2007) Hypoxia-inducible factor-1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression. Cancer Res 67:563\u2013572","journal-title":"Cancer Res"},{"key":"3296_CR21","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1172\/JCI66715","volume":"123","author":"SC Hanna","year":"2013","unstructured":"Hanna SC et al (2013) HIF1alpha and HIF2alpha independently activate SRC to promote melanoma metastases. J Clin Invest 123:2078\u20132093","journal-title":"J Clin Invest"},{"key":"3296_CR22","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1126\/science.aaf4405","volume":"352","author":"EB Rankin","year":"2016","unstructured":"Rankin EB, Giaccia AJ (2016) Hypoxic control of metastasis. Science 352:175\u2013180","journal-title":"Science"},{"key":"3296_CR23","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.pharmthera.2015.05.008","volume":"152","author":"C Vizcaino","year":"2015","unstructured":"Vizcaino C, Mansilla S, Portugal J (2015) Sp1 transcription factor: a long-standing target in cancer chemotherapy. Pharmacol Ther 152:111\u2013124","journal-title":"Pharmacol Ther"},{"key":"3296_CR24","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1186\/1471-2164-8-420","volume":"8","author":"JF Collins","year":"2007","unstructured":"Collins JF, Hu Z (2007) Promoter analysis of intestinal genes induced during iron-deprivation reveals enrichment of conserved SP1-like binding sites. BMC Genomics 8:420","journal-title":"BMC Genomics"},{"key":"3296_CR25","doi-asserted-by":"publisher","first-page":"49310","DOI":"10.18632\/oncotarget.10336","volume":"7","author":"SJ Chen","year":"2016","unstructured":"Chen SJ et al (2016) Desferal regulates hCtr1 and transferrin receptor expression through Sp1 and exhibits synergistic cytotoxicity with platinum drugs in oxaliplatin-resistant human cervical cancer cells in vitro and in vivo. Oncotarget 7:49310\u201349321","journal-title":"Oncotarget"},{"key":"3296_CR26","doi-asserted-by":"publisher","first-page":"3559","DOI":"10.1038\/sj.onc.1210135","volume":"26","author":"MH Kweon","year":"2007","unstructured":"Kweon MH, Afaq F, Bhat KM, Setaluri V, Mukhtar H (2007) A novel antioxidant 3-O-Caffeoyl-1-methylquinic acid enhances ultraviolet A-mediated apoptosis in immortalized HaCaT keratinocytes via Sp1-dependent transcriptional activation of p21(WAF1\/Cip1). Oncogene 26:3559\u20133571","journal-title":"Oncogene"},{"key":"3296_CR27","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/j.bbagen.2017.10.009","volume":"1862","author":"RS Moussa","year":"2018","unstructured":"Moussa RS, Kovacevic Z, Bae DH, Lane DJR, Richardson DR (2018) Transcriptional regulation of the cyclin-dependent kinase inhibitor, p21(CIP1\/WAF1), by the chelator, Dp44mT. Biochim Biophys Acta 1862:761\u2013774","journal-title":"Biochim Biophys Acta"},{"key":"3296_CR28","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.jhep.2016.03.007","volume":"65","author":"WD Bao","year":"2016","unstructured":"Bao WD et al (2016) Iron overload in hereditary tyrosinemia type 1 induces liver injury through the Sp1\/Tfr2\/hepcidin axis. J Hepatol 65:137\u2013145","journal-title":"J Hepatol"},{"key":"3296_CR29","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.freeradbiomed.2020.10.013","volume":"161","author":"Y Tang","year":"2020","unstructured":"Tang Y et al (2020) Mild iron overload induces TRIP12-mediated degradation of YY1 to trigger hepatic inflammation. Free Radic Biol Med 161:187\u2013197","journal-title":"Free Radic Biol Med"},{"key":"3296_CR30","doi-asserted-by":"publisher","first-page":"7544","DOI":"10.1002\/jcp.30391","volume":"236","author":"Y Tang","year":"2021","unstructured":"Tang Y et al (2021) Rapid responses of adipocytes to iron overload increase serum TG level by decreasing adiponectin. J Cell Physiol 236:7544\u20137553","journal-title":"J Cell Physiol"}],"container-title":["Biological Trace Element Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-022-03296-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12011-022-03296-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-022-03296-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T15:57:27Z","timestamp":1676476647000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12011-022-03296-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,26]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["3296"],"URL":"https:\/\/doi.org\/10.1007\/s12011-022-03296-2","relation":{},"ISSN":["0163-4984","1559-0720"],"issn-type":[{"value":"0163-4984","type":"print"},{"value":"1559-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,26]]},"assertion":[{"value":"21 April 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}