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Five heavy metals (Cu, Cr, Mn, Ni, and Ag) and lithium (Li) were analyzed in the sediment, water, and crayfish tissues. Elements (heavy metals and lithium) concentrations in sediment, water, and crayfish tissues showed significant differences between the two sampling stations (El-Qanatir and El-Rahawi drain). However, the levels of elements in crayfish tissues were arranged in declining order as hepatopancreas\u2009&gt;\u2009gills\u2009&gt;\u2009exoskeleton\u2009&gt;\u2009muscles for Cu and Cr; hepatopancreas\u2009&gt;\u2009exoskeleton\u2009&gt;\u2009gills\u2009&gt;\u2009muscles for Ni and Ag; and exoskeleton\u2009&gt;\u2009gills\u2009&gt;\u2009hepatopancreas\u2009&gt;\u2009muscles for Li and Mn. The human health hazard evaluation of heavy metals and lithium exposure via edible tissue consumption was assessed for both children and adult consumers. The target hazard quotient THQ values of crayfish edible tissues (less than 1) will not impose any health implications for consumers who ingest edible tissues in sufficient quantities. Furthermore, the hazard index (HI) values reported for children and adult consumers were lower than one, indicating non-carcinogenic and carcinogenic hazards, suggesting that crayfish edible tissues are safe for human ingestion. This evidence also found that <jats:italic>Procambarus clarkii<\/jats:italic> could be a good bio-indicator organism for monitoring potentially metals in aquatic systems.<\/jats:p>","DOI":"10.1007\/s12011-022-03380-7","type":"journal-article","created":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T03:24:21Z","timestamp":1660879461000},"page":"3050-3059","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Bioaccumulation, Biosedimentation, and Health Hazards of Elements in Crayfish, Procambarus clarkii from El-Rahawi Drain and El-Qanatir in the River Nile, Egypt"],"prefix":"10.1007","volume":"201","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2061-4101","authenticated-orcid":false,"given":"Mahmoud Mahrous M.","family":"Abbas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.E.","family":"Abd El-Aziz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed M.Y.","family":"Kaddah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdel-Kader","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussein A.","family":"El-Naggar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Radwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.M.","family":"El-Tabakh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moharam A.","family":"Afifi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansour A.E.","family":"Bashar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,19]]},"reference":[{"key":"3380_CR1","first-page":"493","volume":"10","author":"MH Abdo","year":"2013","unstructured":"Abdo MH (2013) Physico-chemical studies on the pollutants effect in the aquatic environment of Rosetta Branch River Nile. 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