{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T18:29:31Z","timestamp":1788719371911,"version":"build-2803163510"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T00:00:00Z","timestamp":1674518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T00:00:00Z","timestamp":1674518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Shanxi Graduate Education Innovation Program","award":["2020BY051"],"award-info":[{"award-number":["2020BY051"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82173644"],"award-info":[{"award-number":["82173644"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biol Trace Elem Res"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1007\/s12011-023-03568-5","type":"journal-article","created":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T15:25:48Z","timestamp":1674573948000},"page":"4870-4881","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Identifying Serum Metabolites and Gut Bacterial Species Associated with Nephrotoxicity Caused by Arsenic and Fluoride Exposure"],"prefix":"10.1007","volume":"201","author":[{"given":"Xiaolin","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xushen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penghui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiyan","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,1,24]]},"reference":[{"key":"3568_CR1","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1016\/j.jhazmat.2015.07.080","volume":"300","author":"K Pi","year":"2015","unstructured":"Pi K, Wang Y, Xie X, Su C, Ma T, Li J, Liu Y (2015) Hydrogeochemistry of co-occurring geogenic arsenic, fluoride and iodine in groundwater at Datong Basin, northern China. J Hazard Mater 300:652\u2013661. https:\/\/doi.org\/10.1016\/j.jhazmat.2015.07.080","journal-title":"J Hazard Mater"},{"key":"3568_CR2","doi-asserted-by":"publisher","first-page":"117940","DOI":"10.1016\/j.envpol.2021.117940","volume":"289","author":"MS Rahaman","year":"2021","unstructured":"Rahaman MS, Rahman MM, Mise N, Sikder MT, Ichihara G, Uddin MK, Kurasaki M, Ichihara S (2021) Environmental arsenic exposure and its contribution to human diseases, toxicity mechanism and management. Environ Pollut 289:117940. https:\/\/doi.org\/10.1016\/j.envpol.2021.117940","journal-title":"Environ Pollut"},{"issue":"7","key":"3568_CR3","doi-asserted-by":"publisher","first-page":"5661","DOI":"10.1007\/s11033-021-06523-6","volume":"48","author":"AH Nagendra","year":"2021","unstructured":"Nagendra AH, Bose B, Shenoy PS (2021) Recent advances in cellular effects of fluoride: an update on its signalling pathway and targeted therapeutic approaches. Mol Biol Rep 48(7):5661\u20135673. https:\/\/doi.org\/10.1007\/s11033-021-06523-6","journal-title":"Mol Biol Rep"},{"key":"3568_CR4","doi-asserted-by":"publisher","unstructured":"Levin-Schwartz Y, Politis M, Gennings C, Tamayo-Ortiz M, Flores D, Amarasiriwardena C, Pantic I, Tolentino M, Estrada-Gutierrez G, Lamadrid-Figueroa H, Tellez-Rojo M, Baccarelli A, Wright R, Sanders A (2021) Nephrotoxic metal mixtures and preadolescent kidney function. Children (Basel) 8(8):673. https:\/\/doi.org\/10.3390\/children8080673","DOI":"10.3390\/children8080673"},{"key":"3568_CR5","doi-asserted-by":"publisher","first-page":"136071","DOI":"10.1016\/j.scitotenv.2019.136071","volume":"710","author":"KM Khan","year":"2020","unstructured":"Khan KM, Chakraborty R, Bundschuh J, Bhattacharya P, Parvez F (2020) Health effects of arsenic exposure in Latin America: an overview of the past eight years of research. Sci Total Environ 710:136071. https:\/\/doi.org\/10.1016\/j.scitotenv.2019.136071","journal-title":"Sci Total Environ"},{"issue":"3","key":"3568_CR6","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1177\/0960327118814161","volume":"38","author":"RW Dharmaratne","year":"2019","unstructured":"Dharmaratne RW (2019) Exploring the role of excess fluoride in chronic kidney disease: a review. Hum Exp Toxicol 38(3):269\u2013279. https:\/\/doi.org\/10.1177\/0960327118814161","journal-title":"Hum Exp Toxicol"},{"issue":"3","key":"3568_CR7","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1289\/ehp.1307429","volume":"122","author":"K Lu","year":"2014","unstructured":"Lu K, Abo RP, Schlieper KA, Graffam ME, Levine S, Wishnok JS, Swenberg JA, Tannenbaum SR, Fox JG (2014) Arsenic exposure perturbs the gut microbiome and its metabolic profile in mice: an integrated metagenomics and metabolomics analysis. Environ Health Perspect 122(3):284\u2013291. https:\/\/doi.org\/10.1289\/ehp.1307429","journal-title":"Environ Health Perspect"},{"issue":"3","key":"3568_CR8","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1021\/acs.jproteome.8b00697","volume":"18","author":"J Xue","year":"2019","unstructured":"Xue J, Lai Y, Chi L, Tu P, Leng J, Liu CW, Ru H, Lu K (2019) Serum metabolomics reveals that gut microbiome perturbation mediates metabolic disruption induced by arsenic exposure in mice. J Proteome Res 18(3):1006\u20131018. https:\/\/doi.org\/10.1021\/acs.jproteome.8b00697","journal-title":"J Proteome Res"},{"issue":"1","key":"3568_CR9","doi-asserted-by":"publisher","first-page":"5424","DOI":"10.1038\/s41467-018-07803-9","volume":"9","author":"M Coryell","year":"2018","unstructured":"Coryell M, McAlpine M, Pinkham NV, McDermott TR, Walk ST (2018) The gut microbiome is required for full protection against acute arsenic toxicity in mouse models. Nat Commun 9(1):5424. https:\/\/doi.org\/10.1038\/s41467-018-07803-9","journal-title":"Nat Commun"},{"issue":"7","key":"3568_CR10","doi-asserted-by":"publisher","first-page":"7596","DOI":"10.1007\/s11356-019-07201-8","volume":"27","author":"HW Wang","year":"2020","unstructured":"Wang HW, Miao CY, Liu J, Zhang Y, Zhu SQ, Zhou BH (2020) Fluoride-induced rectal barrier damage and microflora disorder in mice. Environ Sci Pollut Res Int 27(7):7596\u20137607. https:\/\/doi.org\/10.1007\/s11356-019-07201-8","journal-title":"Environ Sci Pollut Res Int"},{"key":"3568_CR11","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.chemosphere.2019.06.080","volume":"234","author":"J Liu","year":"2019","unstructured":"Liu J, Wang HW, Lin L, Miao CY, Zhang Y, Zhou BH (2019) Intestinal barrier damage involved in intestinal microflora changes in fluoride-induced mice. Chemosphere 234:409\u2013418. https:\/\/doi.org\/10.1016\/j.chemosphere.2019.06.080","journal-title":"Chemosphere"},{"key":"3568_CR12","doi-asserted-by":"publisher","first-page":"144924","DOI":"10.1016\/j.scitotenv.2020.144924","volume":"767","author":"X Yan","year":"2021","unstructured":"Yan X, Chen X, Tian X, Qiu Y, Wang J, Yu G, Dong N, Feng J, Xie J, Nalesnik M, Niu R, Xiao B, Song G, Quinones S, Ren X (2021) Co-exposure to inorganic arsenic and fluoride prominently disrupts gut microbiota equilibrium and induces adverse cardiovascular effects in offspring rats. Sci Total Environ 767:144924. https:\/\/doi.org\/10.1016\/j.scitotenv.2020.144924","journal-title":"Sci Total Environ"},{"key":"3568_CR13","doi-asserted-by":"publisher","first-page":"105763","DOI":"10.1016\/j.envint.2020.105763","volume":"140","author":"Y Qiu","year":"2020","unstructured":"Qiu Y, Chen X, Yan X, Wang J, Yu G, Ma W, Xiao B, Quinones S, Tian X, Ren X (2020) Gut microbiota perturbations and neurodevelopmental impacts in offspring rats concurrently exposure to inorganic arsenic and fluoride. Environ Int 140:105763. https:\/\/doi.org\/10.1016\/j.envint.2020.105763","journal-title":"Environ Int"},{"issue":"5","key":"3568_CR14","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/s41581-019-0118-7","volume":"15","author":"F Knauf","year":"2019","unstructured":"Knauf F, Brewer JR, Flavell RA (2019) Immunity, microbiota and kidney disease. Nat Rev Nephrol 15(5):263\u2013274. https:\/\/doi.org\/10.1038\/s41581-019-0118-7","journal-title":"Nat Rev Nephrol"},{"issue":"9","key":"3568_CR15","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1038\/s41581-019-0172-1","volume":"15","author":"B Meijers","year":"2019","unstructured":"Meijers B, Evenepoel P, Anders HJ (2019) Intestinal microbiome and fitness in kidney disease. Nat Rev Nephrol 15(9):531\u2013545. https:\/\/doi.org\/10.1038\/s41581-019-0172-1","journal-title":"Nat Rev Nephrol"},{"issue":"12","key":"3568_CR16","doi-asserted-by":"publisher","first-page":"2097","DOI":"10.1136\/gutjnl-2017-315734","volume":"67","author":"A Ticinesi","year":"2018","unstructured":"Ticinesi A, Milani C, Guerra A, Allegri F, Lauretani F, Nouvenne A, Mancabelli L, Lugli GA, Turroni F, Duranti S, Mangifesta M, Viappiani A, Ferrario C, Dodi R, Dall\u2019Asta M, Del Rio D, Ventura M, Meschi T (2018) Understanding the gut-kidney axis in nephrolithiasis: an analysis of the gut microbiota composition and functionality of stone formers. Gut 67(12):2097\u20132106. https:\/\/doi.org\/10.1136\/gutjnl-2017-315734","journal-title":"Gut"},{"key":"3568_CR17","doi-asserted-by":"publisher","unstructured":"Margiotta E, Caldiroli L, Callegari ML, Miragoli F, Zanoni F, Armelloni S, Rizzo V, Messa P, Vettoretti S (2021) Association of sarcopenia and gut microbiota composition in older patients with advanced chronic kidney disease, investigation of the interactions with uremic toxins, inflammation and oxidative stress. Toxins (Basel) 13(7):472. https:\/\/doi.org\/10.3390\/toxins13070472","DOI":"10.3390\/toxins13070472"},{"issue":"12","key":"3568_CR18","doi-asserted-by":"publisher","first-page":"2131","DOI":"10.1136\/gutjnl-2019-319766","volume":"69","author":"X Wang","year":"2020","unstructured":"Wang X, Yang S, Li S, Zhao L, Hao Y, Qin J, Zhang L, Zhang C, Bian W, Zuo L, Gao X, Zhu B, Lei XG, Gu Z, Cui W, Xu X, Li Z, Zhu B, Li Y, Chen S, Guo H, Zhang H, Sun J, Zhang M, Hui Y, Zhang X, Liu X, Sun B, Wang L, Qiu Q, Zhang Y, Li X, Liu W, Xue R, Wu H, Shao D, Li J, Zhou Y, Li S, Yang R, Pedersen OB, Yu Z, Ehrlich SD, Ren F (2020) Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents. Gut 69(12):2131\u20132142. https:\/\/doi.org\/10.1136\/gutjnl-2019-319766","journal-title":"Gut"},{"issue":"16","key":"3568_CR19","doi-asserted-by":"publisher","first-page":"7384","DOI":"10.7150\/thno.45455","volume":"10","author":"Y Huang","year":"2020","unstructured":"Huang Y, Zhou J, Wang S, Xiong J, Chen Y, Liu Y, Xiao T, Li Y, He T, Li Y, Bi X, Yang K, Han W, Qiao Y, Yu Y, Zhao J (2020) Indoxyl sulfate induces intestinal barrier injury through IRF1-DRP1 axis-mediated mitophagy impairment. Theranostics 10(16):7384\u20137400. https:\/\/doi.org\/10.7150\/thno.45455","journal-title":"Theranostics"},{"key":"3568_CR20","doi-asserted-by":"publisher","unstructured":"Bundschuh J, Farias B, Martin R, Storniolo A, Bhattacharya P, Cortes J, Bonorino G, Albouy R (2004) Groundwater arsenic in the Chaco-Pampean Plain, Argentina: case study from Robles county, Santiago del Estero Province. Appl Geochem19(2):231\u2013243. https:\/\/doi.org\/10.1016\/j.apgeochem.2003.09.009","DOI":"10.1016\/j.apgeochem.2003.09.009"},{"key":"3568_CR21","doi-asserted-by":"publisher","unstructured":"Sivasankar V, Darchen A, Omine K, Sakthivel R (2016) Fluoride: a world ubiquitous compound, its chemistry, and ways of contamination. In: Surface Modified Carbons as Scavengers for Fluoride from Water pp 5\u201332. Springer, Cham. https:\/\/doi.org\/10.1007\/978-3-319-40686-2_2","DOI":"10.1007\/978-3-319-40686-2_2"},{"key":"3568_CR22","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1016\/j.scitotenv.2019.04.409","volume":"686","author":"X Tian","year":"2019","unstructured":"Tian X, Feng J, Dong N, Lyu Y, Wei C, Li B, Ma Y, Xie J, Qiu Y, Song G, Ren X, Yan X (2019) Subchronic exposure to arsenite and fluoride from gestation to puberty induces oxidative stress and disrupts ultrastructure in the kidneys of rat offspring. Sci Total Environ 686:1229\u20131237. https:\/\/doi.org\/10.1016\/j.scitotenv.2019.04.409","journal-title":"Sci Total Environ"},{"key":"3568_CR23","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/bs.ircmb.2015.10.001","volume":"321","author":"E Calzada","year":"2016","unstructured":"Calzada E, Onguka O, Claypool SM (2016) Phosphatidylethanolamine metabolism in health and disease. Int Rev Cell Mol Biol 321:29\u201388. https:\/\/doi.org\/10.1016\/bs.ircmb.2015.10.001","journal-title":"Int Rev Cell Mol Biol"},{"issue":"3","key":"3568_CR24","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1080\/10773525.2016.1203097","volume":"22","author":"S Rajapakse","year":"2016","unstructured":"Rajapakse S, Shivanthan MC, Selvarajah M (2016) Chronic kidney disease of unknown etiology in Sri Lanka. Int J Occup Environ Health 22(3):259\u2013264. https:\/\/doi.org\/10.1080\/10773525.2016.1203097","journal-title":"Int J Occup Environ Health"},{"issue":"7","key":"3568_CR25","first-page":"666","volume":"48","author":"S Chouhan","year":"2010","unstructured":"Chouhan S, Flora SJ (2010) Arsenic and fluoride: two major ground water pollutants. Indian J Exp Biol 48(7):666\u2013678","journal-title":"Indian J Exp Biol"},{"issue":"3","key":"3568_CR26","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1007\/s00204-019-02651-y","volume":"94","author":"X Tian","year":"2020","unstructured":"Tian X, Xie J, Chen X, Dong N, Feng J, Gao Y, Tian F, Zhang W, Qiu Y, Niu R, Ren X, Yan X (2020) Deregulation of autophagy is involved in nephrotoxicity of arsenite and fluoride exposure during gestation to puberty in rat offspring. Arch Toxicol 94(3):749\u2013760. https:\/\/doi.org\/10.1007\/s00204-019-02651-y","journal-title":"Arch Toxicol"},{"issue":"7","key":"3568_CR27","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1038\/s41401-018-0167-7","volume":"40","author":"M Wu","year":"2019","unstructured":"Wu M, Lao YZ, Tan HS, Lu G, Ren Y, Zheng ZQ, Yi J, Fu WW, Shen HM, Xu HX (2019) Oblongifolin C suppresses lysosomal function independently of TFEB nuclear translocation. Acta Pharmacol Sin 40(7):929\u2013937. https:\/\/doi.org\/10.1038\/s41401-018-0167-7","journal-title":"Acta Pharmacol Sin"},{"issue":"7","key":"3568_CR28","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/ncb2788","volume":"15","author":"P Boya","year":"2013","unstructured":"Boya P, Reggiori F, Codogno P (2013) Emerging regulation and functions of autophagy. Nat Cell Biol 15(7):713\u2013720. https:\/\/doi.org\/10.1038\/ncb2788","journal-title":"Nat Cell Biol"},{"issue":"6","key":"3568_CR29","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1080\/15548627.2020.1840796","volume":"17","author":"X Zhang","year":"2021","unstructured":"Zhang X, Wei M, Fan J, Yan W, Zha X, Song H, Wan R, Yin Y, Wang W (2021) Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal storage and associated synaptic impairments in neurons. Autophagy 17(6):1519\u20131542. https:\/\/doi.org\/10.1080\/15548627.2020.1840796","journal-title":"Autophagy"},{"key":"3568_CR30","doi-asserted-by":"publisher","first-page":"106959","DOI":"10.1016\/j.intimp.2020.106959","volume":"88","author":"P Liu","year":"2020","unstructured":"Liu P, Xue Y, Zheng B, Liang Y, Zhang J, Shi J, Chu X, Han X, Chu L (2020) Crocetin attenuates the oxidative stress, inflammation and apoptosisin arsenic trioxide-induced nephrotoxic rats: Implication of PI3K\/AKT pathway. Int Immunopharmacol 88:106959. https:\/\/doi.org\/10.1016\/j.intimp.2020.106959","journal-title":"Int Immunopharmacol"},{"key":"3568_CR31","doi-asserted-by":"publisher","first-page":"112851","DOI":"10.1016\/j.ecoenv.2021.112851","volume":"226","author":"H Li","year":"2021","unstructured":"Li H, Fan J, Zhao Y, Yang J, Xu H, Manthari RK, Cheng X, Wang J, Wang J (2021) Calcium alleviates fluoride-induced kidney damage via FAS\/FASL, TNFR\/TNF, DR5\/TRAIL pathways in rats. Ecotoxicol Environ Saf 226:112851. https:\/\/doi.org\/10.1016\/j.ecoenv.2021.112851","journal-title":"Ecotoxicol Environ Saf"},{"issue":"1","key":"3568_CR32","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1002\/bab.2111","volume":"69","author":"F Zhan","year":"2022","unstructured":"Zhan F, Wang X, Zhang J, Yi S, He P (2022) Glutamine alleviates the renal dysfunction associated with gentamicin-induced acute kidney injury in Sprague-Dawley rats. Biotechnol Appl Biochem 69(1):323\u2013329. https:\/\/doi.org\/10.1002\/bab.2111","journal-title":"Biotechnol Appl Biochem"},{"key":"3568_CR33","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.2147\/dmso.s369090","volume":"15","author":"L Guo","year":"2022","unstructured":"Guo L, Chen S, Ou L, Li S, Ye ZN, Liu HF (2022) Disrupted alpha-ketoglutarate homeostasis: understanding kidney diseases from the view of metabolism and beyond. Diabetes Metab Syndr Obes 15:1961\u20131974. https:\/\/doi.org\/10.2147\/dmso.s369090","journal-title":"Diabetes Metab Syndr Obes"},{"issue":"3","key":"3568_CR34","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1161\/circresaha.114.303788","volume":"116","author":"D Gatica","year":"2015","unstructured":"Gatica D, Chiong M, Lavandero S, Klionsky DJ (2015) Molecular mechanisms of autophagy in the cardiovascular system. Circ Res 116(3):456\u2013467. https:\/\/doi.org\/10.1161\/circresaha.114.303788","journal-title":"Circ Res"},{"issue":"11","key":"3568_CR35","doi-asserted-by":"publisher","first-page":"3277","DOI":"10.1007\/s00204-018-2305-x","volume":"92","author":"Y Zhao","year":"2018","unstructured":"Zhao Y, Li Y, Wang J, Manthari RK, Wang J (2018) Fluoride induces apoptosis and autophagy through the IL-17 signaling pathway in mice hepatocytes. Arch Toxicol 92(11):3277\u20133289. https:\/\/doi.org\/10.1007\/s00204-018-2305-x","journal-title":"Arch Toxicol"},{"key":"3568_CR36","doi-asserted-by":"publisher","first-page":"4829180","DOI":"10.1155\/2017\/4829180","volume":"2017","author":"D Patel","year":"2017","unstructured":"Patel D, Witt SN (2017) Ethanolamine and phosphatidylethanolamine: partners in health and disease. Oxid Med Cell Longev 2017:4829180. https:\/\/doi.org\/10.1155\/2017\/4829180","journal-title":"Oxid Med Cell Longev"},{"issue":"1","key":"3568_CR37","doi-asserted-by":"publisher","first-page":"10147","DOI":"10.1038\/s41598-019-46657-z","volume":"9","author":"G Runwal","year":"2019","unstructured":"Runwal G, Stamatakou E, Siddiqi FH, Puri C, Zhu Y, Rubinsztein DC (2019) LC3-positive structures are prominent in autophagy-deficient cells. Sci Rep 9(1):10147. https:\/\/doi.org\/10.1038\/s41598-019-46657-z","journal-title":"Sci Rep"},{"issue":"10","key":"3568_CR38","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1007\/s002040000177","volume":"74","author":"ZZ Guan","year":"2000","unstructured":"Guan ZZ, Xiao KQ, Zeng XY, Long YG, Cheng YH, Jiang SF, Wang YN (2000) Changed cellular membrane lipid composition and lipid peroxidation of kidney in rats with chronic fluorosis. Arch Toxicol 74(10):602\u2013608. https:\/\/doi.org\/10.1007\/s002040000177","journal-title":"Arch Toxicol"},{"issue":"2\u20133","key":"3568_CR39","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/s0300-483x(00)00167-0","volume":"146","author":"YN Wang","year":"2000","unstructured":"Wang YN, Xiao KQ, Liu JL, Dallner G, Guan ZZ (2000) Effect of long term fluoride exposure on lipid composition in rat liver. Toxicology 146(2\u20133):161\u2013169. https:\/\/doi.org\/10.1016\/s0300-483x(00)00167-0","journal-title":"Toxicology"},{"key":"3568_CR40","doi-asserted-by":"publisher","first-page":"152906","DOI":"10.1016\/j.tox.2021.152906","volume":"461","author":"Y Li","year":"2021","unstructured":"Li Y, Liu Y, Yi J, Li Y, Yang B, Shang P, Mehmood K, Bilal RM, Zhang H, Chang YF, Tang Z, Wang Y, Li Y (2021) The potential risks of chronic fluoride exposure on nephrotoxic via altering glucolipid metabolism and activating autophagy and apoptosis in ducks. Toxicology 461:152906. https:\/\/doi.org\/10.1016\/j.tox.2021.152906","journal-title":"Toxicology"},{"key":"3568_CR41","doi-asserted-by":"publisher","first-page":"754706","DOI":"10.3389\/fpubh.2021.754706","volume":"9","author":"C Kim","year":"2021","unstructured":"Kim C, Ashrap P, Watkins DJ, Mukherjee B, Rosario-Pab\u00f3n ZY, V\u00e9lez-Vega CM, Alshawabkeh AN, Cordero JF, Meeker JD (2021) Maternal metals\/metalloid blood levels are associated with lipidomic profiles among pregnant women in Puerto Rico. Front Public Health 9:754706. https:\/\/doi.org\/10.3389\/fpubh.2021.754706","journal-title":"Front Public Health"},{"key":"3568_CR42","doi-asserted-by":"publisher","first-page":"145972","DOI":"10.1016\/j.scitotenv.2021.145972","volume":"776","author":"X Du","year":"2021","unstructured":"Du X, Zhang J, Zhang X, Schramm KW, Nan B, Huang Q, Tian M, Shen H (2021) Persistence and reversibility of arsenic-induced gut microbiome and metabolome shifts in male rats after 30-days recovery duration. Sci Total Environ 776:145972. https:\/\/doi.org\/10.1016\/j.scitotenv.2021.145972","journal-title":"Sci Total Environ"},{"issue":"7610","key":"3568_CR43","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/535047a","volume":"535","author":"CT Kahrstrom","year":"2016","unstructured":"Kahrstrom CT, Pariente N, Weiss U (2016) Intestinal microbiota in health and disease. Nature 535(7610):47","journal-title":"Nature"},{"issue":"3","key":"3568_CR44","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1007\/s11845-020-02437-7","volume":"190","author":"I Colombo","year":"2021","unstructured":"Colombo I, Aiello-Battan F, Elena R, Ruiz A, Petraglia L, Musso CG (2021) Kidney-gut crosstalk in renal disease. Ir J Med Sci 190(3):1205\u20131212. https:\/\/doi.org\/10.1007\/s11845-020-02437-7","journal-title":"Ir J Med Sci"},{"key":"3568_CR45","doi-asserted-by":"publisher","first-page":"847468","DOI":"10.3389\/fmicb.2022.847468","volume":"13","author":"N Sun","year":"2022","unstructured":"Sun N, Zhu B, Xin J, Li L, Gan B, Cao X, Fang J, Pan K, Jing B, Zeng Y, Lv C, Zhao L, Zeng D, Xu P, Wang H, Ni X (2022) Psychoactive effects of Lactobacillus johnsonii BS15 on preventing memory dysfunction induced by acute ethanol exposure through modulating intestinal microenvironment and improving alcohol metabolic level. Front Microbiol 13:847468. https:\/\/doi.org\/10.3389\/fmicb.2022.847468","journal-title":"Front Microbiol"},{"issue":"Pt 3","key":"3568_CR46","doi-asserted-by":"publisher","first-page":"132658","DOI":"10.1016\/j.chemosphere.2021.132658","volume":"288","author":"R Fu","year":"2022","unstructured":"Fu R, Niu R, Zhao F, Wang J, Cao Q, Yu Y, Liu C, Zhang D, Sun Z (2022) Exercise alleviated intestinal damage and microbial disturbances in mice exposed to fluoride. Chemosphere 288(Pt 3):132658. https:\/\/doi.org\/10.1016\/j.chemosphere.2021.132658","journal-title":"Chemosphere"},{"key":"3568_CR47","doi-asserted-by":"publisher","first-page":"109159","DOI":"10.1016\/j.intimp.2022.109159","volume":"111","author":"S Niu","year":"2022","unstructured":"Niu S, Zhu X, Zhang J, Ma Y, Lang X, Luo L, Li W, Zhao Y, Zhang Z (2022) Arsenic trioxide modulates the composition and metabolic function of the gut microbiota in a mouse model of rheumatoid arthritis. Int Immunopharmacol 111:109159. https:\/\/doi.org\/10.1016\/j.intimp.2022.109159","journal-title":"Int Immunopharmacol"},{"key":"3568_CR48","doi-asserted-by":"publisher","first-page":"112934","DOI":"10.1016\/j.ecoenv.2021.112934","volume":"227","author":"F Chen","year":"2021","unstructured":"Chen F, Luo Y, Li C, Wang J, Chen L, Zhong X, Zhang B, Zhu Q, Zou R, Guo X, Zhou Y, Guo L (2021) Sub-chronic low-dose arsenic in rice exposure induces gut microbiome perturbations in mice. Ecotoxicol Environ Saf 227:112934. https:\/\/doi.org\/10.1016\/j.ecoenv.2021.112934","journal-title":"Ecotoxicol Environ Saf"},{"issue":"5","key":"3568_CR49","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.3892\/etm.2021.10747","volume":"22","author":"M Zhao","year":"2021","unstructured":"Zhao M, Chen C, Yuan Z, Li W, Zhang M, Cui N, Duan Y, Zhang X, Zhang P (2021) Dietary Bacillus subtilis supplementation alleviates alcohol-induced liver injury by maintaining intestinal integrity and gut microbiota homeostasis in mice. Exp Ther Med 22(5):1312. https:\/\/doi.org\/10.3892\/etm.2021.10747","journal-title":"Exp Ther Med"},{"issue":"5","key":"3568_CR50","doi-asserted-by":"publisher","first-page":"2201","DOI":"10.1039\/d0fo02786c","volume":"12","author":"Y Liu","year":"2021","unstructured":"Liu Y, Yin F, Huang L, Teng H, Shen T, Qin H (2021) Long-term and continuous administration of Bacillus subtilis during remission effectively maintains the remission of inflammatory bowel disease by protecting intestinal integrity, regulating epithelial proliferation, and reshaping microbial structure and function. Food Funct 12(5):2201\u20132210. https:\/\/doi.org\/10.1039\/d0fo02786c","journal-title":"Food Funct"},{"issue":"5","key":"3568_CR51","doi-asserted-by":"publisher","first-page":"2715","DOI":"10.1007\/s12035-021-02655-9","volume":"59","author":"J Choi","year":"2022","unstructured":"Choi J, Kwon H, Kim YK, Han PL (2022) Extracellular vesicles from gram-positive and gram-negative probiotics remediate stress-induced depressive behavior in mice. Mol Neurobiol 59(5):2715\u20132728. https:\/\/doi.org\/10.1007\/s12035-021-02655-9","journal-title":"Mol Neurobiol"},{"key":"3568_CR52","doi-asserted-by":"publisher","first-page":"133993","DOI":"10.1016\/j.foodchem.2022.133993","volume":"399","author":"R Wang","year":"2023","unstructured":"Wang R, Lin F, Ye C, Aihemaitijiang S, Halimulati M, Huang X, Jiang Z, Li L, Zhang Z (2023) Multi-omics analysis reveals therapeutic effects of Bacillus subtilis-fermented Astragalus membranaceus in hyperuricemia via modulation of gut microbiota. Food Chem 399:133993. https:\/\/doi.org\/10.1016\/j.foodchem.2022.133993","journal-title":"Food Chem"},{"key":"3568_CR53","doi-asserted-by":"publisher","unstructured":"Chan KC, Kok KE, Huang KF, Weng YL, Chung YC (2020) Effects of fermented red bean extract on nephropathy in streptozocin-induced diabetic rats. Food Nutr Res 64:4272. https:\/\/doi.org\/10.29219\/fnr.v64.4272","DOI":"10.29219\/fnr.v64.4272"},{"issue":"11","key":"3568_CR54","doi-asserted-by":"publisher","first-page":"153174","DOI":"10.1016\/j.prp.2020.153174","volume":"216","author":"A Zhu","year":"2020","unstructured":"Zhu A, Yang X, Bai L, Hou Y, Guo C, Zhao D, Wen M, Jiang P, Liu Y, Huang Y, Li C, Meng H (2020) Analysis of microbial changes in the tonsillar formalin-fixed paraffin-embedded tissue of Chinese patients with IgA nephropathy. Pathol Res Pract 216(11):153174. https:\/\/doi.org\/10.1016\/j.prp.2020.153174","journal-title":"Pathol Res Pract"},{"issue":"1","key":"3568_CR55","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1080\/21505594.2017.1419116","volume":"9","author":"MP Ryan","year":"2018","unstructured":"Ryan MP, Pembroke JT (2018) Brevundimonas spp: Emerging global opportunistic pathogens. Virulence 9(1):480\u2013493. https:\/\/doi.org\/10.1080\/21505594.2017.1419116","journal-title":"Virulence"},{"issue":"3","key":"3568_CR56","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1159\/000517140","volume":"11","author":"V Paramasivam","year":"2021","unstructured":"Paramasivam V, Paez A, Verma A, Landry D, Braden GL (2021) Brevundimonas vesicularis peritonitis in a chronic peritoneal dialysis patient. Case Rep Nephrol Dial 11(3):314\u2013320. https:\/\/doi.org\/10.1159\/000517140","journal-title":"Case Rep Nephrol Dial"},{"issue":"5","key":"3568_CR57","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1002\/jat.3931","volume":"40","author":"P Mondal","year":"2020","unstructured":"Mondal P, Chattopadhyay A (2020) Environmental exposure of arsenic and fluoride and their combined toxicity: A recent update. J Appl Toxicol 40(5):552\u2013566. https:\/\/doi.org\/10.1002\/jat.3931","journal-title":"J Appl Toxicol"},{"issue":"1\u20132","key":"3568_CR58","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.jns.2009.07.001","volume":"285","author":"SJ Flora","year":"2009","unstructured":"Flora SJ, Mittal M, Mishra D (2009) Co-exposure to arsenic and fluoride on oxidative stress, glutathione linked enzymes, biogenic amines and DNA damage in mouse brain. J Neurol Sci 285(1\u20132):198\u2013205. https:\/\/doi.org\/10.1016\/j.jns.2009.07.001","journal-title":"J Neurol Sci"},{"key":"3568_CR59","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.chemosphere.2016.10.025","volume":"167","author":"Y Ma","year":"2017","unstructured":"Ma Y, Ma Z, Yin S, Yan X, Wang J (2017) Arsenic and fluoride induce apoptosis, inflammation and oxidative stress in cultured human umbilical vein endothelial cells. Chemosphere 167:454\u2013461. https:\/\/doi.org\/10.1016\/j.chemosphere.2016.10.025","journal-title":"Chemosphere"},{"issue":"6","key":"3568_CR60","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1007\/s00204-012-0803-9","volume":"86","author":"Y Ma","year":"2012","unstructured":"Ma Y, Niu R, Sun Z, Wang J, Luo G, Zhang J, Wang J (2012) Inflammatory responses induced by fluoride and arsenic at toxic concentration in rabbit aorta. Arch Toxicol 86(6):849\u2013856. https:\/\/doi.org\/10.1007\/s00204-012-0803-9","journal-title":"Arch Toxicol"},{"issue":"4","key":"3568_CR61","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1007\/s10534-011-9412-y","volume":"24","author":"SJ Flora","year":"2011","unstructured":"Flora SJ, Pachauri V, Mittal M, Kumar D (2011) Interactive effect of arsenic and fluoride on cardio-respiratory disorders in male rats: possible role of reactive oxygen species. Biometals 24(4):615\u2013628. https:\/\/doi.org\/10.1007\/s10534-011-9412-y","journal-title":"Biometals"},{"key":"3568_CR62","doi-asserted-by":"publisher","first-page":"112506","DOI":"10.1016\/j.ecoenv.2021.112506","volume":"222","author":"P Liu","year":"2021","unstructured":"Liu P, Li R, Tian X, Zhao Y, Li M, Wang M, Ying X, Yuan J, Xie J, Yan X, Lyu Y, Wei C, Qiu Y, Tian F, Zhao Q, Yan X (2021) Co-exposure to fluoride and arsenic disrupts intestinal flora balance and induces testicular autophagy in offspring rats. Ecotoxicol Environ Saf 222:112506. https:\/\/doi.org\/10.1016\/j.ecoenv.2021.112506","journal-title":"Ecotoxicol Environ Saf"}],"container-title":["Biological Trace Element Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-023-03568-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12011-023-03568-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-023-03568-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T07:24:13Z","timestamp":1691652253000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12011-023-03568-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,24]]},"references-count":62,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["3568"],"URL":"https:\/\/doi.org\/10.1007\/s12011-023-03568-5","relation":{},"ISSN":["0163-4984","1559-0720"],"issn-type":[{"value":"0163-4984","type":"print"},{"value":"1559-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,24]]},"assertion":[{"value":"22 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 January 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interests"}}]}}