{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T15:22:20Z","timestamp":1792164140627,"version":"4.4.0"},"reference-count":96,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T00:00:00Z","timestamp":1676419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T00:00:00Z","timestamp":1676419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100017160","name":"Beni Suef University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100017160","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biol Trace Elem Res"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Atrazine, as an herbicide, is used widely worldwide. Because of its prolonged persistence in the environment and accumulation in the body, atrazine exposure is a potential threat to human health. The present study evaluated the possible protective effects of zinc oxide nanoparticles and vitamin C against atrazine-induced hepatotoxicity in rats. Atrazine administered to rats orally at a dose of 300\u00a0mg\/kg for 21\u00a0days caused liver oxidative stress as it increased malondialdehyde (MDA) formation and decreased reduced glutathione (GSH) contents. Atrazine induced inflammation accompanied by apoptosis via upregulation of hepatic gene expression levels of NF-\u03baB, TNF-\u03b1, BAX, and caspase-3 and downregulation of Bcl-2 gene expression levels. Additionally, it disturbed the metabolic activities of cytochrome P450 as it downregulated hepatic gene expression levels of CYP1A1, CYP1B1, CYP2E1. The liver function biomarkers were greatly affected upon atrazine administration, and the serum levels of AST and ALT were significantly increased, while BWG%, albumin, globulins, and total proteins levels were markedly decreased. As a result of the above-mentioned influences of atrazine, histopathological changes in liver tissue were recorded in our findings. The administration of zinc oxide nanoparticles or vitamin C orally at a dose of 10\u00a0mg\/kg and 200\u00a0mg\/kg, respectively, for 30\u00a0days prior and along with atrazine, could significantly ameliorate the oxidative stress, inflammation, and apoptosis induced by atrazine and regulated the hepatic cytochrome P450 activities. Furthermore, they improved liver function biomarkers and histopathology. In conclusion, our results revealed that zinc oxide nanoparticles and vitamin C supplementations could effectively protect against atrazine-induced hepatotoxicity.<\/jats:p>","DOI":"10.1007\/s12011-023-03587-2","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T02:20:23Z","timestamp":1676600423000},"page":"5257-5271","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Zinc Oxide Nanoparticles and Vitamin C Ameliorate Atrazine-Induced Hepatic Apoptosis in Rat via CYP450s\/ROS Pathway and Immunomodulation"],"prefix":"10.1007","volume":"201","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6890-8731","authenticated-orcid":false,"given":"Eman T.","family":"Mohammed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3218-4786","authenticated-orcid":false,"given":"Ghada M.","family":"Safwat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1503-2219","authenticated-orcid":false,"given":"Esraa A.","family":"Bahnasawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7982-5827","authenticated-orcid":false,"given":"Abdel-Razik H.","family":"Abdel-Razik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9601-8499","authenticated-orcid":false,"given":"Doaa Sh.","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,2,15]]},"reference":[{"issue":"2","key":"3587_CR1","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.etap.2010.12.001","volume":"31","author":"CD Nwani","year":"2011","unstructured":"Nwani CD, Nagpure NS, Kumar R, Kushwaha B, Kumar P, Lakra WS (2011) Mutagenic and genotoxic assessment of atrazine-based herbicide to freshwater fish Channa punctatus (Bloch) using micronucleus test and single cell gel electrophoresis. Environ Toxicol Pharmacol 31(2):314\u2013322. https:\/\/doi.org\/10.1016\/j.etap.2010.12.001","journal-title":"Environ Toxicol Pharmacol"},{"issue":"2","key":"3587_CR2","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.etap.2012.06.004","volume":"34","author":"K Pogrmic-Majkic","year":"2012","unstructured":"Pogrmic-Majkic K, Kaisarevic S, Fa S, Dakic V, Glisic B, Hrubik J, Kovacevic R (2012) Atrazine effects on antioxidant status and xenobiotic metabolizing enzymes after oral administration in peripubertal male rat. Environ Toxicol Pharmacol 34(2):495\u2013501. https:\/\/doi.org\/10.1016\/j.etap.2012.06.004","journal-title":"Environ Toxicol Pharmacol"},{"key":"3587_CR3","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.ecoenv.2016.11.016","volume":"137","author":"C Zhang","year":"2017","unstructured":"Zhang C, Li XN, Xiang LR, Qin L, Lin J, Li JL (2017) Atrazine triggers hepatic oxidative stress and apoptosis in quails (Coturnix C. coturnix) via blocking Nrf2-mediated defense response. Ecotoxicol Environ Saf 137:49\u201356. https:\/\/doi.org\/10.1016\/j.ecoenv.2016.11.016","journal-title":"Ecotoxicol Environ Saf"},{"issue":"3","key":"3587_CR4","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/S0045-6535(02)00080-2","volume":"48","author":"AC Gerecke","year":"2002","unstructured":"Gerecke AC, Sch\u00e4rer M, Singer HP, M\u00fcller SR, Schwarzenbach RP, S\u00e4gesser M, Popow G (2002) Sources of pesticides in surface waters in Switzerland: pesticide load through waste water treatment plants\u2013\u2013current situation and reduction potential. Chemosphere 48(3):307\u2013315","journal-title":"Chemosphere"},{"key":"3587_CR5","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.ecoenv.2011.11.020","volume":"78","author":"FD Campos-Pereira","year":"2012","unstructured":"Campos-Pereira FD, Oliveira CA, Pigoso EC, Silva-Zacarin R, Barbieri EF, Spatti EF, Marin-Morales MA, Severi-Aguiar Gd (2012) Early cytotoxic and genotoxic effects of atrazine on Wistar rat liver: a morphological, immunohistochemical, biochemical and molecular study. Ecotoxic Environ Safe 78:170\u2013177","journal-title":"Ecotoxic Environ Safe"},{"issue":"2","key":"3587_CR6","doi-asserted-by":"publisher","first-page":"148","DOI":"10.4103\/0971-6580.139794","volume":"21","author":"SO Abarikwu","year":"2014","unstructured":"Abarikwu SO (2014) Protective effect of quercetin on atrazine-induced oxidative stress in the liver, kidney, brain, and heart of adult Wistar rats. Toxicol Int 21(2):148. https:\/\/doi.org\/10.4103\/0971-6580.139794","journal-title":"Toxicol Int"},{"issue":"2","key":"3587_CR7","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.taap.2008.09.004","volume":"233","author":"C Leoni","year":"2008","unstructured":"Leoni C, Buratti FM, Testai E (2008) The participation of human hepatic P450 isoforms, flavin-containing monooxygenases and aldehyde oxidase in the biotransformation of the insecticide fenthion. Toxicol Appl Pharmacol 233(2):343\u2013352. https:\/\/doi.org\/10.1016\/j.taap.2008.09.004","journal-title":"Toxicol Appl Pharmacol"},{"key":"3587_CR8","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.ecoenv.2013.04.018","volume":"94","author":"Y Fu","year":"2013","unstructured":"Fu Y, Li M, Liu C, Qu JP, Zhu WJ, Xing HJ, Li S (2013) Effect of atrazine and chlorpyrifos exposure on cytochrome P450 contents and enzyme activities in common carp gills. Ecotoxicol Environ Saf 94:28\u201336. https:\/\/doi.org\/10.1016\/j.ecoenv.2013.04.018","journal-title":"Ecotoxicol Environ Saf"},{"issue":"4","key":"3587_CR9","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.jobaz.2014.03.003","volume":"67","author":"EM Abdella","year":"2014","unstructured":"Abdella EM, Galaly SR, Mohammed HM, Khadrawy SM (2014) Protective role of vitamin E against valproic acid-induced cytogenotoxicity and hepatotoxicity in mice. J Basic Appl Zool 67(4):127\u2013139. https:\/\/doi.org\/10.1016\/j.jobaz.2014.03.003","journal-title":"J Basic Appl Zool"},{"issue":"12","key":"3587_CR10","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1002\/mawe.200290008","volume":"33","author":"D Beyersmann","year":"2002","unstructured":"Beyersmann D (2002) Homeostasis and cellular functions of zinc. Materialwiss Werkstofftech 33(12):764\u2013769","journal-title":"Materialwiss Werkstofftech"},{"issue":"2","key":"3587_CR11","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s12011-016-0891-0","volume":"177","author":"E Mohammadi","year":"2017","unstructured":"Mohammadi E, Qujeq D, Taheri H, Hajian-Tilaki K (2017) Evaluation of serum trace element levels and superoxide dismutase activity in patients with inflammatory bowel disease: translating basic research into clinical application. Biol Trace Elem Res 177(2):235\u2013240. https:\/\/doi.org\/10.1007\/s12011-016-0891-0","journal-title":"Biol Trace Elem Res"},{"issue":"2","key":"3587_CR12","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1177\/156482651303400210","volume":"34","author":"M Ruz","year":"2013","unstructured":"Ruz M, Carrasco F, Rojas P, Codoceo J, Inostroza J, Basfi-fer K, Valencia A, V\u00e1squez K, Galgani J, P\u00e9rez A, L\u00f3pez G, Arredondo M, Perez-Bravo F (2013) Zinc as a potential coadjuvant in therapy for type 2 diabetes. Food Nutr Bull 34(2):215\u201321. https:\/\/doi.org\/10.1177\/156482651303400210","journal-title":"Food Nutr Bull"},{"issue":"2","key":"3587_CR13","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.celrep.2013.01.009","volume":"3","author":"MJ Liu","year":"2013","unstructured":"Liu MJ, Bao S, G\u00e1lvez-Peralta M, Pyle CJ, Rudawsky AC, Pavlovicz RE, Killilea DW, Li C, Nebert DW, Wewers MD, Knoell DL (2013) ZIP8 regulates host defense through zinc-mediated inhibition of NF-\u03baB. Cell Rep. 3(2):386\u2013400. https:\/\/doi.org\/10.1016\/j.celrep.2013.01.009","journal-title":"Cell Rep."},{"issue":"6","key":"3587_CR14","doi-asserted-by":"publisher","first-page":"224","DOI":"10.22159\/ijap.2018v10i6.29376","volume":"10","author":"D Manyasree","year":"2018","unstructured":"Manyasree D, Kiranmayi P, Venkata RK (2018) Characterization and antibacterial activity of ZnO nanoparticles synthesized by co-precipitation method. Int J App Pharm 10(6):224\u2013228","journal-title":"Int J App Pharm"},{"issue":"7","key":"3587_CR15","doi-asserted-by":"publisher","first-page":"403","DOI":"10.29252\/IJRM.15.7.403","volume":"15","author":"F Torabi","year":"2017","unstructured":"Torabi F, Shafaroudi MM, Rezaei N (2017) Combined protective effect of zinc oxide nanoparticles and melatonin on cyclophosphamide-induced toxicity in testicular histology and sperm parameters in adult Wistar rats. Int J Reprod BioMed 15(7):403. https:\/\/doi.org\/10.29252\/IJRM.15.7.403","journal-title":"Int J Reprod BioMed"},{"key":"3587_CR16","doi-asserted-by":"publisher","first-page":"132420","DOI":"10.1016\/j.molstruc.2022.132420","volume":"1255","author":"K Velsankar","year":"2022","unstructured":"Velsankar K, Venkatesan A, Muthumari P, Suganya S, Mohandoss S, Sudhahar S (2022) Green inspired synthesis of ZnO nanoparticles and its characterizations with biofilm, antioxidant, anti-inflammatory, and anti-diabetic activities. Journal of Molecular Structure 1255:132420. https:\/\/doi.org\/10.1016\/j.molstruc.2022.132420","journal-title":"Journal of Molecular Structure"},{"key":"3587_CR17","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.jhazmat.2016.12.048","volume":"327","author":"X Hou","year":"2017","unstructured":"Hou X, Huang X, Ai Z, Zhao J, Zhang L (2017) Ascorbic acid induced atrazine degradation. J Hazard Mater 327:71\u201378. https:\/\/doi.org\/10.1016\/j.jhazmat.2016.12.048","journal-title":"J Hazard Mater"},{"issue":"5","key":"3587_CR18","doi-asserted-by":"publisher","first-page":"359","DOI":"10.3390\/antiox9050359","volume":"9","author":"M Attia","year":"2020","unstructured":"Attia M, Essa EA, Zaki RM, Elkordy AA (2020) An overview of the antioxidant effects of ascorbic acid and alpha lipoic acid (in liposomal forms) as adjuvant in cancer treatment. Antioxidants 9(5):359. https:\/\/doi.org\/10.3390\/antiox9050359","journal-title":"Antioxidants"},{"key":"3587_CR19","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1007\/s00441-004-1030-3","volume":"320","author":"N Serbecic","year":"2005","unstructured":"Serbecic N, Beutelspacher SC (2005) Anti-oxidative vitamins prevent lipidperoxidation and apoptosis in corneal endothelial cells. Cell Tissue Res 320:465\u2013475","journal-title":"Cell Tissue Res"},{"key":"3587_CR20","doi-asserted-by":"publisher","first-page":"134882","DOI":"10.1016\/j.scitotenv.2019.134882","volume":"701","author":"AM Radi","year":"2020","unstructured":"Radi AM, Mohammed ET, Abushouk AI, Aleya L, Abdel-Daim MM (2020) The effects of abamectin on oxidative stress and gene expression in rat liver and brain tissues: modulation by sesame oil and ascorbic acid. Sci Total Environ 701:134882. https:\/\/doi.org\/10.1016\/j.scitotenv.2019.134882","journal-title":"Sci Total Environ"},{"issue":"26","key":"3587_CR21","doi-asserted-by":"publisher","first-page":"265302","DOI":"10.1088\/0957-4484\/19\/26\/265302","volume":"19","author":"AI Gusev","year":"2008","unstructured":"Gusev AI, Kurlov AS (2008) Production of nanocrystalline powders by high-energy ball milling: model and experiment. Nanotechnology 19(26):265302. https:\/\/doi.org\/10.1088\/0957-4484\/19\/26\/265302","journal-title":"Nanotechnology"},{"issue":"1","key":"3587_CR22","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1080\/0886022X.2017.1351373","volume":"39","author":"SO Abarikwu","year":"2017","unstructured":"Abarikwu SO, Duru QC, Njoku R-C, Amadi BA, Tamunoibuomie A, Keboh E (2017) Effects of co-exposure to atrazine and ethanol on the oxidative damage of kidney and liver in Wistar rats. Ren Fail 39(1):588\u2013596","journal-title":"Ren Fail"},{"key":"3587_CR23","volume-title":"Herbicide Handbook of the Weed Science Society of America","author":"Weed Science Society of America (WSSA)","year":"1994","unstructured":"Weed Science Society of America (WSSA) (1994) Herbicide Handbook of the Weed Science Society of America, 7th edn. W.F. Humphrey Press, Genevea, NY","edition":"7"},{"key":"3587_CR24","doi-asserted-by":"publisher","unstructured":"Fonger GC (1995) Hazardous substances data bank (HSDB) as a source of environmental fate information on chemicals. Toxicology 103(2):137\u2013145. https:\/\/doi.org\/10.1016\/0300-483x(95)03145-6","DOI":"10.1016\/0300-483x(95)03145-6"},{"issue":"2","key":"3587_CR25","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1007\/s00441-018-2909-8","volume":"375","author":"DA Mohamed","year":"2019","unstructured":"Mohamed DA, Abdelrahman SA (2019) The possible protective role of zinc oxide nanoparticles (ZnONPs) on testicular and epididymal structure and sperm parameters in nicotine-treated adult rats (a histological and biochemical study). Cell Tissue Res 375(2):543\u2013558. https:\/\/doi.org\/10.1007\/s00441-018-2909-8","journal-title":"Cell Tissue Res"},{"key":"3587_CR26","first-page":"1","volume":"13","author":"A Youssef","year":"2021","unstructured":"Youssef A, Salem M, Saber S, Nabeeh A (2021) Therapeutic effects of ascorbic acid on hormonal and histological alteration produced in the reproductive system of albino rats intoxicated by herbicide atrazine. Egypt Acad J Biol Sci 13:1\u201316","journal-title":"Egypt Acad J Biol Sci"},{"issue":"5","key":"3587_CR27","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1139\/o59-074","volume":"37","author":"DG Chapman","year":"1959","unstructured":"Chapman DG, Castillo R, Campbell JA (1959) Evaluation of protein in foods: 1. A method for the determination of protein efficiency ratios. Canadian J Biochem Physiol 37(5):679\u2013686","journal-title":"Canadian J Biochem Physiol"},{"issue":"3","key":"3587_CR28","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/0165-022X(86)90092-8","volume":"13","author":"PW Albro","year":"1986","unstructured":"Albro PW, Corbett JT, Schroeder JL (1986) Application of the thiobarbiturate assay to the measurement of lipid peroxidation products in microsomes. J Biochem Biophys Methods 13(3):185\u2013194","journal-title":"J Biochem Biophys Methods"},{"issue":"1","key":"3587_CR29","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","volume":"82","author":"GL Ellman","year":"1959","unstructured":"Ellman GL (1959) Tissue sulfhydryl groups. Arch Biochem Biophys 82(1):70\u201377","journal-title":"Arch Biochem Biophys"},{"issue":"4","key":"3587_CR30","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method. Methods 25(4):402\u2013408. https:\/\/doi.org\/10.1006\/meth.2001.1262","journal-title":"Methods"},{"issue":"1","key":"3587_CR31","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/0009-8981(71)90365-2","volume":"31","author":"BT Doumas","year":"1971","unstructured":"Doumas BT, Watson WA, Biggs HG (1971) Albumin standards and the measurement of serum albumin with bromcresol green. Clin Chim Acta 31(1):87\u201396","journal-title":"Clin Chim Acta"},{"key":"3587_CR32","unstructured":"Henry RJ (1964) Colorimetric determination of total protein. In: Clinical Chemistry. Harper & Row Publishers, New York, p 181"},{"issue":"45","key":"3587_CR33","first-page":"1092","volume":"83","author":"M Noverraz","year":"1953","unstructured":"Noverraz M (1953) Colorimetric determination of the albumin\/globulin ratio in blood serum. Schweizerische Medizinische Wochenschrift 83(45):1092\u20131093","journal-title":"Schweizerische Medizinische Wochenschrift"},{"key":"3587_CR34","unstructured":"Steven CK (1996) Alanine and Aspartate aminotransferase, principle and usage. In: James JT, Jenifer R (eds) Liver function, In Clinical chemistry theory, analysis and correlation. M, 3rd edn. Mosby, London, pp 504\u2013527"},{"key":"3587_CR35","unstructured":"Suvarna KS, Layton C, Bancroft JD (eds) (2018) Bancroft\u2019s theory and practice of histological techniques E-Book. Elsevier health sciences, Amsterdam, The Netherlands"},{"issue":"10","key":"3587_CR36","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1103\/PhysRev.56.978","volume":"56","author":"AL Patterson","year":"1939","unstructured":"Patterson AL (1939) The Scherrer formula for X-ray particle size determination. Phys Rev 56(10):978","journal-title":"Phys Rev"},{"key":"3587_CR37","first-page":"845","volume":"7","author":"MJ Akhtar","year":"2012","unstructured":"Akhtar MJ, Ahamed M, Kumar S, Khan MM, Ahmad J, Alrokayan SA (2012) Zinc oxide nanoparticles selectively induce apoptosis in human cancer cells through reactive oxygen species. Int J Nanomed 7:845","journal-title":"Int J Nanomed"},{"key":"3587_CR38","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.ecoenv.2016.11.016","volume":"137","author":"C Zhang","year":"2016","unstructured":"Zhang C, Li XN, Xiang LR, Qin L, Lin J, Li JL (2016) Atrazine triggers hepatic oxidative stress and apoptosis in quails (Coturnix C. coturnix) via blocking Nrf2-mediated defense response. Ecotoxicol Environ Saf 137:49\u201356","journal-title":"Ecotoxicol Environ Saf"},{"issue":"1","key":"3587_CR39","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.dci.2014.06.012","volume":"47","author":"J Sifkarovski","year":"2014","unstructured":"Sifkarovski J, Grayfer L, De Jesus Andino F, Lawrence BP, Robert J (2014) Negative effects of low dose atrazine exposure on the development of effective immunity to FV3 in Xenopus laevis. Dev Comp Immunol 47(1):52\u201358","journal-title":"Dev Comp Immunol"},{"issue":"9\u201310","key":"3587_CR40","first-page":"453","volume":"57","author":"S Gawe\u0142","year":"2004","unstructured":"Gawe\u0142 S, Wardas M, Niedworok E, Wardas P (2004) Dialdehyd malonowy (MDA) jako wska\u017anik proces\u00f3w peroksydacji lipid\u00f3w w organizmie [Malondialdehyde (MDA) as a lipid peroxidation marker]. Wiad Lek 57(9\u201310):453\u20135 (Polish)","journal-title":"Wiad Lek"},{"issue":"4","key":"3587_CR41","first-page":"302","volume":"21","author":"L Soleo","year":"1999","unstructured":"Soleo L, Strzelczyk R (1999) Xenobiotici e glutatione [Xenobiotics and glutathione]. G Ital Med Lav Ergon Oct-Dec 21(4):302\u2013308","journal-title":"G Ital Med Lav Ergon Oct-Dec"},{"issue":"3","key":"3587_CR42","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.etp.2009.11.008","volume":"63","author":"AC Adesiyan","year":"2011","unstructured":"Adesiyan AC, Oyejola TO, Abarikwu SO, Oyeyemi MO, Farombi EO (2011) Selenium provides protection to the liver but not the reproductive organs in an atrazine-model of experimental toxicity. Exp Toxicol Pathol 63(3):201\u2013207","journal-title":"Exp Toxicol Pathol"},{"key":"3587_CR43","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/536759","author":"DB Jestadi","year":"2014","unstructured":"Jestadi DB, Phaniendra A, Babji U, Srinu T, Shanmuganathan B, Periyasamy L (2014) Effects of short-term exposure of atrazine on the liver and kidney of normal and diabetic rats. J Toxicol. https:\/\/doi.org\/10.1155\/2014\/536759","journal-title":"J Toxicol"},{"issue":"1","key":"3587_CR44","doi-asserted-by":"publisher","first-page":"001","DOI":"10.29328\/journal.ibm.1001016","volume":"4","author":"AE Azab","year":"2020","unstructured":"Azab AE, Shkal KEM, Attia AM, El-Banna SG, Yahya RA (2020) Zinc oxide nanoparticles attenuate the oxidative damage and disturbance in antioxidant defense system induced by cyclophosphamide in male albino rats. Insights Biol Med 4(1):001\u2013008. https:\/\/doi.org\/10.29328\/journal.ibm.1001016","journal-title":"Insights Biol Med"},{"key":"3587_CR45","doi-asserted-by":"publisher","first-page":"111686","DOI":"10.1016\/j.biopha.2021.111686","volume":"140","author":"A Awadalla","year":"2021","unstructured":"Awadalla A, Hussein AM, Yousra M, Barakat N, Hamam ET, El-Sherbiny M, Shokeir AA (2021) Effect of zinc oxide nanoparticles and ferulic acid on renal ischemia\/reperfusion injury: possible underlying mechanisms. Biomed Pharmacother 140:111686","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"3587_CR46","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1080\/07315724.2003.10719272","volume":"22","author":"SJ Padayatty","year":"2003","unstructured":"Padayatty SJ, Katz A, Wang Y, Eck P, Kwon O, Lee JH, Chen S, Corpe C, Dutta A, Dutta SK, Levine M (2003) Vitamin C as an antioxidant: evaluation of its role in disease prevention. J Am Coll Nutr 22(1):18\u201335. https:\/\/doi.org\/10.1080\/07315724.2003.10719272. (PMID: 12569111)","journal-title":"J Am Coll Nutr"},{"key":"3587_CR47","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-016-6637-x","author":"MA Abass","year":"2016","unstructured":"Abass MA, Elkhateeb SA, Abd El-Baset SA, Kattaia AA, Mohamed EM, Atteia HH (2016) Lycopene ameliorates atrazine-induced oxidative damage in adrenal cortex of male rats by activation of the Nrf2\/HO-1 pathway. Environ Sci Pollut Res. https:\/\/doi.org\/10.1007\/s11356-016-6637-x","journal-title":"Environ Sci Pollut Res"},{"key":"3587_CR48","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.jff.2016.12.029","volume":"29","author":"X-N Li","year":"2017","unstructured":"Li X-N, Lin J, Xia J, Qin L, Zhu S-Y, Li J-L (2017) Lycopene mitigates atrazine-induced cardiac inflammation via blocking the NF-\u03baB pathway and NO production. J Funct Foods 29:208\u2013216. https:\/\/doi.org\/10.1016\/j.jff.2016.12.029","journal-title":"J Funct Foods"},{"issue":"4","key":"3587_CR49","doi-asserted-by":"publisher","first-page":"e93837","DOI":"10.1371\/journal.pone.0093837","volume":"9","author":"X Wang","year":"2014","unstructured":"Wang X, Luo F, Zhao H (2014) Paraquat-induced reactive oxygen species inhibit neutrophil apoptosis via a p38 MAPK\/NF-\u03baB\u2013IL-6\/TNF-\u03b1 positive-feedback circuit. Plos One 9(4):e93837","journal-title":"Plos One"},{"key":"3587_CR50","doi-asserted-by":"publisher","first-page":"413","DOI":"10.33594\/000000393","volume":"55","author":"R D\u2019Amicoa","year":"2021","unstructured":"D\u2019Amicoa R, Monacob F, Fuscoa R, Peritorea AF, Genovesea T, Impellizzeria D, Di Paolaa R (2021) Exposure to atrazine induces lung inflammation through Nrf2-HO1 and Beclin 1\/LC3 pathways. Cell Physiol Biochem 55:413\u2013427. https:\/\/doi.org\/10.33594\/000000393","journal-title":"Cell Physiol Biochem"},{"issue":"2","key":"3587_CR51","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.4049\/jimmunol.165.2.1013","volume":"165","author":"NS Chandel","year":"2000","unstructured":"Chandel NS, Trzyna WC, McClintock DS, Schumacker PT (2000) Role of oxidants in NF-kappa B activation and TNF-alpha gene transcription induced by hypoxia and endotoxin. J Immunol 165(2):1013","journal-title":"J Immunol"},{"issue":"1","key":"3587_CR52","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1111\/imr.12381","volume":"269","author":"JA Hamerman","year":"2016","unstructured":"Hamerman JA, Pottle J, Ni M, He Y, Zhang ZY, Buckner JH (2016) Negative regulation of TLR signaling in myeloid cells\u2014implications for autoimmune diseases. Immunol Rev 269(1):212\u2013227","journal-title":"Immunol Rev"},{"key":"3587_CR53","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/272474","author":"X Huang","year":"2015","unstructured":"Huang X, Tang J, Cai H, Pan Y, He Y, Dai C et al (2015) Anti-Inflammatory effects of monoammonium glycyrrhizinate on lipopolysaccharide-induced acute lung injury in mice through regulating nuclear factor-kappa B signaling pathway. Evid Based Complement Alternat Med. https:\/\/doi.org\/10.1155\/2015\/272474","journal-title":"Evid Based Complement Alternat Med"},{"key":"3587_CR54","doi-asserted-by":"publisher","first-page":"16","DOI":"10.22159\/ijpps.2020v12i1.35956","volume":"15","author":"SM Mahmoud","year":"2020","unstructured":"Mahmoud SM, Kassab RB, Moneim AEA (2020) Zinc oxide nanoparticles ameliorate aluminum chloride-induced hepato-renal oxidative stress and inflammation in rats. Lab Anim 15:16. https:\/\/doi.org\/10.22159\/ijpps.2020v12i1.35956","journal-title":"Lab Anim"},{"issue":"9","key":"3587_CR55","doi-asserted-by":"publisher","first-page":"6509","DOI":"10.1166\/jnn.2015.10319","volume":"15","author":"MH Kim","year":"2015","unstructured":"Kim MH, Jeong HJ (2015) Zinc oxide nanoparticles suppress LPS-induced NF-\u03baB activation by inducing A20, a negative regulator of NF-\u03baB, in RAW 264.7 macrophages. J Nanosci Nanotechnol 15(9):6509\u20136515","journal-title":"J Nanosci Nanotechnol"},{"issue":"12","key":"3587_CR56","doi-asserted-by":"publisher","first-page":"7180","DOI":"10.4049\/jimmunol.165.12.7180","volume":"165","author":"AG Bowie","year":"2000","unstructured":"Bowie AG, O\u2019Neill LA (2000) Vitamin C inhibits NF-\u03baB activation by TNF via the activation of p38 mitogen-activated protein kinase. J Immunol 165(12):7180\u20137188","journal-title":"J Immunol"},{"key":"3587_CR57","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.ecoenv.2016.06.035","volume":"132","author":"KO Erinle","year":"2016","unstructured":"Erinle KO, Jiang Z, Ma B, Li J, Chen Y, Ur-Rehman K, Shahla A, Zhang Y (2016) Exogenous calcium induces tolerance to atrazine stress in Pennisetum seedlings and promotes photosynthetic activity, antioxidant enzymes and psbA gene transcripts. Ecotoxicol Environ Saf 132:403\u2013412","journal-title":"Ecotoxicol Environ Saf"},{"key":"3587_CR58","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.aquatox.2011.04.021","volume":"104","author":"RM Zaya","year":"2011","unstructured":"Zaya RM, Amini Z, Whitaker AS, Kohler SL, Ide CF (2011) Atrazine exposure affects growth, body condition and liver health in Xenopus laevis tadpoles. Aquat Toxicol 104:243\u2013253","journal-title":"Aquat Toxicol"},{"key":"3587_CR59","doi-asserted-by":"publisher","first-page":"34924","DOI":"10.1007\/s11356-019-06604-x","volume":"26","author":"AM Morgan","year":"2019","unstructured":"Morgan AM, Ibrahim MA, Hussien AM (2019) Glycyrrhizic acid modulates the atrazine-induced apoptosis in rabbit spleen. Environ Sci Pollut Res Int 26:34924\u201334930. https:\/\/doi.org\/10.1007\/s11356-019-06604-x","journal-title":"Environ Sci Pollut Res Int"},{"issue":"1","key":"3587_CR60","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s11899-017-0359-0","volume":"12","author":"BL Lampson","year":"2017","unstructured":"Lampson BL, Davids MS (2017) The development and current use of BCL-2 inhibitors for the treatment of chronic lymphocytic leukemia. Curr Hematol Malig Rep 12(1):11\u201319","journal-title":"Curr Hematol Malig Rep"},{"key":"3587_CR61","doi-asserted-by":"publisher","first-page":"118503","DOI":"10.1016\/j.lfs.2020.118503","volume":"262","author":"LA Barakat","year":"2020","unstructured":"Barakat LA, Barakat N, Zakaria MM, Khirallah SM (2020) Protective role of zinc oxide nanoparticles in kidney injury induced by cisplatin in rats. Life Sci 262:118503","journal-title":"Life Sci"},{"issue":"2","key":"3587_CR62","doi-asserted-by":"publisher","first-page":"137","DOI":"10.18203\/2319-2003.ijbcp20220413","volume":"11","author":"N Shanmugam","year":"2022","unstructured":"Shanmugam N, Siddharaman R, Ekambaram M, Rajendran R, Ramasamy Y, Balasubramanian A (2022) Ascorbic acid attenuates ethanol induced apoptotic and oxidative response by blocking the Bax, Bcl2 and caspase signaling pathway. Int J Basic Clin Pharma 11(2):137\u2013143. https:\/\/doi.org\/10.18203\/2319-2003.ijbcp20220413","journal-title":"Int J Basic Clin Pharma"},{"key":"3587_CR63","doi-asserted-by":"publisher","first-page":"100179","DOI":"10.1016\/j.metop.2022.100179","volume":"14","author":"OT Somade","year":"2022","unstructured":"Somade OT, Adeyi OE, Ajayi BO, Asunde OO, Iloh PD, Adesanya AA, Lawal OF (2022) Syringic and ascorbic acids prevent NDMA-induced pulmonary fibrogenesis, inflammation, apoptosis, and oxidative stress through the regulation of PI3K-Akt\/PKB-mTOR-PTEN signaling pathway. Metab Open 14:100179. https:\/\/doi.org\/10.1016\/j.metop.2022.100179","journal-title":"Metab Open"},{"issue":"1","key":"3587_CR64","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13578-016-0074-x","volume":"6","author":"Y Dong","year":"2016","unstructured":"Dong Y, Liu Y, Kou X, Jing Y, Sun K, Sheng D, Wei L (2016) The protective or damaging effect of tumor necrosis factor-\u03b1 in acute liver injury is concentration-dependent. Cell Biosci 6(1):1\u201310. https:\/\/doi.org\/10.1186\/s13578-016-0074-x","journal-title":"Cell Biosci"},{"key":"3587_CR65","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.ecoenv.2013.04.018","volume":"94","author":"Y Fu","year":"2013","unstructured":"Fu Y, Li M, Liu C, Qu JP, Zhu WJ, Xing HJ, Xu SW, Li S (2013) Effect of atrazine and chlorpyrifos exposure on cytochrome P450 contents and enzyme activities in common carp gills. Ecotoxicol Environ Saf 94:28\u201336","journal-title":"Ecotoxicol Environ Saf"},{"key":"3587_CR66","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.taap.2008.09.023","volume":"234","author":"I Salaberria","year":"2009","unstructured":"Salaberria I, Hansen BH, Asensio V, Olsvik PA, Andersen RA, Jenssen BM (2009) Effects of atrazine on hepatic v metabolism and endocrine homeostasis in rainbow trout (Oncorhynchus mykiss). Toxicol Appl Pharmacol 234:98\u2013106","journal-title":"Toxicol Appl Pharmacol"},{"key":"3587_CR67","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1016\/0006-2952(90)90106-U","volume":"39","author":"RD Medh","year":"1990","unstructured":"Medh RD, Gupta V, Zhang Y, Awasthi YC, Belli JA (1990) Glutathione S-transferase and P-glycoprotein in multidrug resistant Chinese hamster cells. Biochem Pharmacol 39:1641\u20131645","journal-title":"Biochem Pharmacol"},{"issue":"25","key":"3587_CR68","doi-asserted-by":"publisher","first-page":"6402","DOI":"10.1021\/acs.jafc.8b01413","volume":"66","author":"J Lin","year":"2018","unstructured":"Lin J, Zhao HS, Qin L, Li XN, Zhang C, Xia J, Li JL (2018) Atrazine triggers mitochondrial dysfunction and oxidative stress in quail (Coturnix C. coturnix) cerebrum via activating xenobiotic-sensing nuclear receptors and modulating cytochrome P450 systems. J Agric Food Chem 66(25):6402\u20136413. https:\/\/doi.org\/10.1021\/acs.jafc.8b01413","journal-title":"J Agric Food Chem"},{"issue":"1","key":"3587_CR69","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.toxlet.2006.07.342","volume":"169","author":"A Goel","year":"2007","unstructured":"Goel A, Dani V, Dhawan DK (2007) Zinc mediates normalization of hepatic drug metabolizing enzymes in chlorpyrifos-induced toxicity. Toxicol Lett 169(1):26\u201333","journal-title":"Toxicol Lett"},{"issue":"1\u20133","key":"3587_CR70","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.ejphar.2006.01.015","volume":"534","author":"JY Kim","year":"2006","unstructured":"Kim JY, Lee SM (2006) Vitamins C and E protect hepatic cytochrome P450 dysfunction induced by polymicrobial sepsis. Eur J Pharmacol 534(1\u20133):202\u2013209","journal-title":"Eur J Pharmacol"},{"key":"3587_CR71","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1517\/17425255.2012.695347","volume":"8","author":"RM Irving","year":"2012","unstructured":"Irving RM, Elfarra AA (2012) Role of reactive metabolites in the circulation in extrahepatic toxicity. Expert Opin Drug Metab Toxicol 8:1157\u20131172","journal-title":"Expert Opin Drug Metab Toxicol"},{"issue":"6","key":"3587_CR72","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1002\/jat.2550140603","volume":"14","author":"B Simi\u0107","year":"1994","unstructured":"Simi\u0107 B, Kniewald J, Kniewald Z (1994) Effects of atrazine on reproductive performance in the rat. J Appl Toxicol Nov-Dec 14(6):401\u2013404. https:\/\/doi.org\/10.1002\/jat.2550140603. (PMID: 7884143)","journal-title":"J Appl Toxicol Nov-Dec"},{"key":"3587_CR73","doi-asserted-by":"publisher","first-page":"121055","DOI":"10.1016\/j.lfs.2022.121055","volume":"310","author":"Q Lang","year":"2022","unstructured":"Lang Q, Wei J, Tian M, Wei S, Yu X, Zhao C, Zhang J, Huang B (2022) Attenuated effect of zinc gluconate on oxidative stress, inflammation, and angiogenic imbalance in pre-eclampsia rats. Life Sci 310:121055. https:\/\/doi.org\/10.1016\/j.lfs.2022.121055","journal-title":"Life Sci"},{"key":"3587_CR74","first-page":"430","volume":"9","author":"MA Mamoun","year":"2015","unstructured":"Mamoun MA, Rizvi HSMT, Qazi SM (2015) Protective effect of vitamin C on body weight of albino rats with lead toxicity. Pakistan J Med Health Sci 9:430\u2013433","journal-title":"Pakistan J Med Health Sci"},{"issue":"3","key":"3587_CR75","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1016\/j.sjbs.2021.01.001","volume":"28","author":"N Akhtar","year":"2021","unstructured":"Akhtar N, Khan MF, Tabassum S, Zahran E (2021) Adverse effects of atrazine on blood parameters, biochemical profile and genotoxicity of snow trout (Schizothorax plagiostomus). Saudi J Biol Sci 28(3):1999\u20132003","journal-title":"Saudi J Biol Sci"},{"issue":"2","key":"3587_CR76","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.mce.2011.10.021","volume":"355","author":"PA Fowler","year":"2012","unstructured":"Fowler PA, Bellingham M, Sinclair KD (2012) Impact of endocrine-disrupting compounds (EDCs) on female reproductive health. Mol Cell Endocrinol 355(2):231\u2013239","journal-title":"Mol Cell Endocrinol"},{"issue":"4","key":"3587_CR77","first-page":"107","volume":"24","author":"SG Konstantinova","year":"1999","unstructured":"Konstantinova SG, Russanov EM (1999) Studies on paraquatinduced oxidative stress in rat liver. Acta Physiol Pharmacol Bulg 24(4):107\u2013111","journal-title":"Acta Physiol Pharmacol Bulg"},{"key":"3587_CR78","unstructured":"Zilva JF, Pannall PR, Mayne PD (1988) Plasma enzymes in diagnosis. In: Arnold E (ed) Clinical Chemistry in Diagnosis and Treatment. A division of Holdder and Stoughton, London UK, pp 310\u2013315"},{"key":"3587_CR79","unstructured":"Walker HK, Hall WD, Hurst JW (eds) (1990) Clinical methods: The history, physical, and laboratory examinations. 3rd ed. Butterworths, Boston"},{"issue":"1","key":"3587_CR80","first-page":"114","volume":"7","author":"R Sing","year":"2020","unstructured":"Sing R (2020) Studies on atrazine induced changes in some cat fish: aspects of female African catfish (Clarias gariepinus). Int J Fauna Biol Stud 7(1):114\u2013117 (ISSN 2347-2677)","journal-title":"Int J Fauna Biol Stud"},{"key":"3587_CR81","doi-asserted-by":"publisher","first-page":"920057","DOI":"10.3389\/fmars.2022.920057","volume":"9","author":"MM Ahmed","year":"2022","unstructured":"Ahmed MM, Mohammed AT, Farag MR, Hassan MA, Mawed SA, Alagawany M, Zizzadoro C, Di Cerbo A, Abdel-Latif HMR (2022) Dietary supplementation of Nile tilapia (Oreochromis niloticus) with Panax ginseng essential oil: positive impact on animal health and productive performance, and mitigating effects on atrazine-induced toxicity. Front Mar Sci 9:920057. https:\/\/doi.org\/10.3389\/fmars.2022.920057","journal-title":"Front Mar Sci"},{"issue":"1","key":"3587_CR82","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.pestbp.2012.03.001","volume":"103","author":"R Hussain","year":"2012","unstructured":"Hussain R, Mahmood F, Khan A, Javed MT, Rehan S, Mehdi T (2012) Cellular and biochemical effects induced by atrazine on blood of male Japanese quail (Coturnix japonica). Pestic Biochem Physiol 103(1):38\u201342","journal-title":"Pestic Biochem Physiol"},{"issue":"6","key":"3587_CR83","doi-asserted-by":"publisher","first-page":"2529","DOI":"10.3390\/cimb44060172","volume":"44","author":"RZ Hamza","year":"2022","unstructured":"Hamza RZ, Alaryani FS, Omara F, Said MA, El-Aziz SAA, El-Sheikh SM (2022) Ascorbic acid ameliorates cardiac and hepatic toxicity induced by azithromycin-etoricoxib drug interaction. Curr Issues Mol Biol 44(6):2529\u20132541","journal-title":"Curr Issues Mol Biol"},{"issue":"8","key":"3587_CR84","doi-asserted-by":"publisher","first-page":"2281","DOI":"10.1007\/s13204-021-02006-z","volume":"11","author":"SA Hassan","year":"2021","unstructured":"Hassan SA, Mujahid H, Ali MM, Irshad S, Naseer R, Saeed S, Arooj F (2021) Synthesis, characterization and protective effect of green tea-mediated zinc oxide nanoparticles against ochratoxin A induced hepatotoxicity and nephrotoxicity in albino rats. Appl Nanosci 11(8):2281\u20132289. https:\/\/doi.org\/10.1007\/s13204-021-02006-z","journal-title":"Appl Nanosci"},{"issue":"3","key":"3587_CR85","doi-asserted-by":"publisher","first-page":"372","DOI":"10.3390\/ani10030372","volume":"10","author":"DE Abou-Kassem","year":"2020","unstructured":"Abou-Kassem DE, Abd El-Hack ME, Taha AE, Ajarem JS, Maodaa NS, Allam AA (2020) Detoxification impacts of ascorbic acid and clay on laying Japanese quail fed diets polluted by various levels of cadmium. Animals 10(3):372. https:\/\/doi.org\/10.3390\/ani10030372","journal-title":"Animals"},{"key":"3587_CR86","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.fct.2009.11.044","volume":"48","author":"S Kalender","year":"2010","unstructured":"Kalender S, Uzun FG, Durak D, Demir F, Kalender Y (2010) Malathion-induced hepatotoxicity in rats: the effects of vitamins C and E. Food Chem Toxicol 48:633\u2013638","journal-title":"Food Chem Toxicol"},{"key":"3587_CR87","doi-asserted-by":"publisher","first-page":"111","DOI":"10.2131\/jts.32.111","volume":"32","author":"S Ambali","year":"2007","unstructured":"Ambali S, Akanbi D, Igbokwe N, Shittu M, Kawu M, Ayo J (2007) Evaluation of subchronic chlorpyrifos poisoning on hematological and serum biochemical changes in mice and protective effect of vitamin C. J Toxicol Sci 32:111\u2013120","journal-title":"J Toxicol Sci"},{"key":"3587_CR88","doi-asserted-by":"publisher","first-page":"125","DOI":"10.17582\/journal.pujz\/2021.36.2.165.170","volume":"36","author":"S Batool","year":"2021","unstructured":"Batool S, Batool S, Shameem S, Khalid F, Batool T, Yasmeen S, Batool S (2021) Atrazine induced histopathological alterations in the liver of adult male mice. Punjab Univ J Zool 36:125\u2013252","journal-title":"Punjab Univ J Zool"},{"key":"3587_CR89","doi-asserted-by":"publisher","unstructured":"Lin J, Li HX, Qin L, Du ZH, Xia J, Li JL (2016) A novel mechanism underlies atrazine toxicity in quails (Coturnix Coturnix coturnix): triggering ionic disorder via disruption of ATPases. Oncotarget 7:83880\u201383892. https:\/\/doi.org\/10.18632\/oncotarget. 13794.","DOI":"10.18632\/oncotarget"},{"key":"3587_CR90","doi-asserted-by":"publisher","first-page":"11776","DOI":"10.3390\/app112411776","volume":"11","author":"L Sena","year":"2021","unstructured":"Sena L, Asouzo J, Nkomozepi P, Mbajiorgu EF (2021) Atrazineinduced hepato-renal toxicity in adult male Xenopus laevis frogs. Appl Sci 11:11776","journal-title":"Appl Sci"},{"key":"3587_CR91","doi-asserted-by":"publisher","unstructured":"Duval F, Moreno-Cuevas JE, Gonzalez-Garza MT, Rodriguez-Montalvo C, Cruz-Vega DE (2014) Liver fibrosis and protection mechanisms action of medicinal plants targeting apoptosis of hepatocytes and hepatic stellate cells. Adv Pharmacol Sci 2014:373295. https:\/\/doi.org\/10.1155\/2014\/373295","DOI":"10.1155\/2014\/373295"},{"issue":"4","key":"3587_CR92","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1007\/s00204-011-0782-2","volume":"86","author":"R Pal","year":"2012","unstructured":"Pal R, Mamidi MK, Das AK, Bhonde R (2012) Diverse effects of dimethyl sulfoxide (DMSO) on the differentiation potential of human embryonic stem cells. Arch Toxicol 86(4):651\u2013661","journal-title":"Arch Toxicol"},{"key":"3587_CR93","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1111\/jpi.12198","volume":"58","author":"YA Cho","year":"2015","unstructured":"Cho YA, Noh K, Jue SS, Lee SY, Kim EC (2015) Melatonin promotes hepatic differentiation of human dental pulp stem cells: clinical implications for the prevention of liver fibrosis. J Pineal Res 58:127\u2013135","journal-title":"J Pineal Res"},{"issue":"4","key":"3587_CR94","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1139\/cjpp-2017-0247","volume":"96","author":"SA Bashandy","year":"2018","unstructured":"Bashandy SA, Alaamer A, Moussa SAA, Omara EA (2018) Role of zinc oxide nanoparticles in alleviating hepatic fibrosis and nephrotoxicity induced by thioacetamide in rats. Can J Physiol Pharmacol 96(4):337\u2013344. https:\/\/doi.org\/10.1139\/cjpp-2017-0247","journal-title":"Can J Physiol Pharmacol"},{"issue":"11","key":"3587_CR95","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1136\/gut.31.11.1311","volume":"31","author":"RD Situnayake","year":"1990","unstructured":"Situnayake RD, Crump BJ, Thurnham DI, Davies JA, Gearty J, Davis M (1990) Lipid peroxidation and hepatic antioxidants in alcoholic liver disease. Gut 31(11):1311\u20131317. https:\/\/doi.org\/10.1136\/gut.31.11.1311","journal-title":"Gut"},{"issue":"5","key":"3587_CR96","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1002\/cbf.1575","volume":"27","author":"IC Ozturk","year":"2009","unstructured":"Ozturk IC, Ozturk F, Gul M, Ates B, Cetin A (2009) Protective effects of ascorbic acid on hepatotoxicity and oxidative stress caused by carbon tetrachloride in the liver of Wistar rats. Cell Biochem Funct 27(5):309\u2013315. https:\/\/doi.org\/10.1002\/cbf.1575","journal-title":"Cell Biochem Funct"}],"container-title":["Biological Trace Element Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-023-03587-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12011-023-03587-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-023-03587-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T02:20:58Z","timestamp":1695090058000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12011-023-03587-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,15]]},"references-count":96,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["3587"],"URL":"https:\/\/doi.org\/10.1007\/s12011-023-03587-2","relation":{},"ISSN":["0163-4984","1559-0720"],"issn-type":[{"value":"0163-4984","type":"print"},{"value":"1559-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,15]]},"assertion":[{"value":"29 November 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 February 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}