{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:57:58Z","timestamp":1785891478602,"version":"3.56.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T00:00:00Z","timestamp":1690329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T00:00:00Z","timestamp":1690329600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Natural Science Foundation of Hebei Province Youth Science Foundation Project","award":["H2020109157"],"award-info":[{"award-number":["H2020109157"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biol Trace Elem Res"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1007\/s12011-023-03772-3","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T03:23:45Z","timestamp":1690341825000},"page":"1559-1567","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Improved Biocompatibility and Angiogenesis of the Bone Titanium Scaffold through ERK1\/2 Signaling Mediated by an Attached Strontium Element"],"prefix":"10.1007","volume":"202","author":[{"given":"Bingkun","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing Yong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahuan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,7,26]]},"reference":[{"issue":"2","key":"3772_CR1","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1002\/jbm.b.30009","volume":"70","author":"P Huang","year":"2004","unstructured":"Huang P et al (2004) Surface modification of titanium implant by microarc oxidation and hydrothermal treatment. J Biomed Mater Res B Appl Biomater 70(2):187\u2013190. https:\/\/doi.org\/10.1002\/jbm.b.30009","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"3772_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.actbio.2018.08.013","volume":"79","author":"S Spriano","year":"2018","unstructured":"Spriano S et al (2018) A critical review of multifunctional titanium surfaces: new frontiers for improving osseointegration and host response, avoiding bacteria contamination. Acta Biomater 79:1\u201322. https:\/\/doi.org\/10.1016\/j.actbio.2018.08.013","journal-title":"Acta Biomater"},{"issue":"24","key":"3772_CR3","doi-asserted-by":"publisher","first-page":"5883","DOI":"10.1016\/j.biomaterials.2013.04.031","volume":"34","author":"OZ Andersen","year":"2013","unstructured":"Andersen OZ et al (2013) Accelerated bone ingrowth by local delivery of strontium from surface functionalized titanium implants. Biomaterials 34(24):5883\u20135890. https:\/\/doi.org\/10.1016\/j.biomaterials.2013.04.031","journal-title":"Biomaterials"},{"key":"3772_CR4","doi-asserted-by":"publisher","first-page":"S124","DOI":"10.1016\/j.jallcom.2015.01.019","volume":"643","author":"Y-S Sun","year":"2015","unstructured":"Sun Y-S et al (2015) Nanoporous surface topography enhances bone cell differentiation on Ti\u20136Al\u20137Nb alloy in bone implant applications. J Alloy Compd 643:S124\u2013S132. https:\/\/doi.org\/10.1016\/j.jallcom.2015.01.019","journal-title":"J Alloy Compd"},{"key":"3772_CR5","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.bone.2016.02.020","volume":"86","author":"F Loi","year":"2016","unstructured":"Loi F et al (2016) Inflammation, fracture and bone repair. Bone 86:119\u2013130. https:\/\/doi.org\/10.1016\/j.bone.2016.02.020","journal-title":"Bone"},{"key":"3772_CR6","doi-asserted-by":"publisher","first-page":"102750","DOI":"10.1016\/j.copbio.2022.102750","volume":"76","author":"N Di Maggio","year":"2022","unstructured":"Di Maggio N, Banfi A (2022) The osteo-angiogenic signaling crosstalk for bone regeneration: harmony out of complexity. Curr Opin Biotechnol 76:102750. https:\/\/doi.org\/10.1016\/j.copbio.2022.102750","journal-title":"Curr Opin Biotechnol"},{"issue":"9","key":"3772_CR7","doi-asserted-by":"publisher","first-page":"3242","DOI":"10.3390\/ijms21093242","volume":"21","author":"F Diomede","year":"2020","unstructured":"Diomede F et al (2020) Functional relationship between osteogenesis and angiogenesis in tissue regeneration. Int J Mol Sci 21(9):3242. https:\/\/doi.org\/10.3390\/ijms21093242","journal-title":"Int J Mol Sci"},{"key":"3772_CR8","doi-asserted-by":"publisher","first-page":"112647","DOI":"10.1016\/j.msec.2022.112647","volume":"133","author":"Z Geng","year":"2022","unstructured":"Geng Z et al (2022) Optimizing the strontium content to achieve an ideal osseointegration through balancing apatite-forming ability and osteogenic activity. Biomater Adv 133:112647. https:\/\/doi.org\/10.1016\/j.msec.2022.112647","journal-title":"Biomater Adv"},{"issue":"7","key":"3772_CR9","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1177\/0885328217748124","volume":"32","author":"Z Geng","year":"2018","unstructured":"Geng Z et al (2018) Nanosized strontium substituted hydroxyapatite prepared from egg shell for enhanced biological properties. J Biomater Appl 32(7):896\u2013905. https:\/\/doi.org\/10.1177\/0885328217748124","journal-title":"J Biomater Appl"},{"key":"3772_CR10","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.jmst.2020.11.041","volume":"79","author":"Z Geng","year":"2021","unstructured":"Geng Z et al (2021) A novel snail-inspired bionic design of titanium with strontium-substituted hydroxyapatite coating for promoting osseointegration. J Mater Sci Technol 79:35\u201345. https:\/\/doi.org\/10.1016\/j.jmst.2020.11.041","journal-title":"J Mater Sci Technol"},{"issue":"3","key":"3772_CR11","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1093\/rb\/rbaa004","volume":"7","author":"D Huang","year":"2020","unstructured":"Huang D et al (2020) Strontium-substituted sub-micron bioactive glasses inhibit ostoclastogenesis through suppression of RANKL-induced signaling pathway. Regen Biomater 7(3):303\u2013311. https:\/\/doi.org\/10.1093\/rb\/rbaa004","journal-title":"Regen Biomater"},{"issue":"2","key":"3772_CR12","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.pharmthera.2012.07.009","volume":"136","author":"Z Saidak","year":"2012","unstructured":"Saidak Z, Marie PJ (2012) Strontium signaling: molecular mechanisms and therapeutic implications in osteoporosis. Pharmacol Ther 136(2):216\u2013226. https:\/\/doi.org\/10.1016\/j.pharmthera.2012.07.009","journal-title":"Pharmacol Ther"},{"issue":"1","key":"3772_CR13","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.msec.2012.08.040","volume":"33","author":"Z Gu","year":"2013","unstructured":"Gu Z et al (2013) Acceleration of segmental bone regeneration in a rabbit model by strontium-doped calcium polyphosphate scaffold through stimulating VEGF and bFGF secretion from osteoblasts. Mater Sci Eng C Mater Biol Appl 33(1):274\u2013281. https:\/\/doi.org\/10.1016\/j.msec.2012.08.040","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"issue":"29","key":"3772_CR14","doi-asserted-by":"publisher","first-page":"24484","DOI":"10.1021\/acsami.7b06521","volume":"9","author":"L Weng","year":"2017","unstructured":"Weng L et al (2017) Binary doping of strontium and copper enhancing osteogenesis and angiogenesis of bioactive glass nanofibers while suppressing osteoclast activity. ACS Appl Mater Interf 9(29):24484\u201324496. https:\/\/doi.org\/10.1021\/acsami.7b06521","journal-title":"ACS Appl Mater Interf"},{"key":"3772_CR15","doi-asserted-by":"publisher","first-page":"818137","DOI":"10.3389\/fbioe.2022.818137","volume":"10","author":"YJ Kuo","year":"2022","unstructured":"Kuo YJ et al (2022) Angiogenesis, osseointegration, and antibacterial applications of polyelectrolyte multilayer coatings incorporated with silver\/strontium containing mesoporous bioactive glass on 316L stainless steel. Front Bioeng Biotechnol 10:818137. https:\/\/doi.org\/10.3389\/fbioe.2022.818137","journal-title":"Front Bioeng Biotechnol"},{"issue":"2","key":"3772_CR16","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1007\/s12011-018-1564-y","volume":"190","author":"X Zhu","year":"2019","unstructured":"Zhu X et al (2019) Influence of strontium on vascular endothelial growth factor and fibroblast growth factor 2 expression in rat chondrocytes cultured in vitro. Biol Trace Elem Res 190(2):466\u2013471. https:\/\/doi.org\/10.1007\/s12011-018-1564-y","journal-title":"Biol Trace Elem Res"},{"key":"3772_CR17","doi-asserted-by":"publisher","first-page":"112482","DOI":"10.1016\/j.msec.2021.112482","volume":"131","author":"Y Sun","year":"2021","unstructured":"Sun Y et al (2021) A polydopamine-assisted strontium-substituted apatite coating for titanium promotes osteogenesis and angiogenesis via FAK\/MAPK and PI3K\/AKT signaling pathways. Materials Science and Engineering: C 131:112482. https:\/\/doi.org\/10.1016\/j.msec.2021.112482","journal-title":"Materials Science and Engineering: C"},{"key":"3772_CR18","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.bone.2015.11.011","volume":"83","author":"S Almubarak","year":"2016","unstructured":"Almubarak S et al (2016) Tissue engineering strategies for promoting vascularized bone regeneration. Bone 83:197\u2013209. https:\/\/doi.org\/10.1016\/j.bone.2015.11.011","journal-title":"Bone"},{"issue":"3","key":"3772_CR19","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/s10456-017-9541-1","volume":"20","author":"J Filipowska","year":"2017","unstructured":"Filipowska J et al (2017) The role of vasculature in bone development, regeneration and proper systemic functioning. Angiogenesis 20(3):291\u2013302. https:\/\/doi.org\/10.1007\/s10456-017-9541-1","journal-title":"Angiogenesis"},{"key":"3772_CR20","doi-asserted-by":"publisher","first-page":"110430","DOI":"10.1016\/j.compositesb.2022.110430","volume":"250","author":"F Yang","year":"2023","unstructured":"Yang F et al (2023) Biodegradable magnesium incorporated microspheres enable immunomodulation and spatiotemporal drug release for the treatment of osteonecrosis of the femoral head. Composites Part B: Engineering 250:110430. https:\/\/doi.org\/10.1016\/j.compositesb.2022.110430","journal-title":"Composites Part B: Engineering"},{"issue":"7","key":"3772_CR21","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1359\/jbmr.070321","volume":"22","author":"S Choudhary","year":"2007","unstructured":"Choudhary S et al (2007) Strontium ranelate promotes osteoblastic differentiation and mineralization of murine bone marrow stromal cells: involvement of prostaglandins. J Bone Miner Res 22(7):1002\u20131010. https:\/\/doi.org\/10.1359\/jbmr.070321","journal-title":"J Bone Miner Res"},{"issue":"1","key":"3772_CR22","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.bone.2007.08.043","volume":"42","author":"E Bonnelye","year":"2008","unstructured":"Bonnelye E et al (2008) Dual effect of strontium ranelate: stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitro. Bone 42(1):129\u2013138. https:\/\/doi.org\/10.1016\/j.bone.2007.08.043","journal-title":"Bone"},{"key":"3772_CR23","doi-asserted-by":"publisher","first-page":"499","DOI":"10.3389\/fbioe.2020.00499","volume":"8","author":"G Montagna","year":"2020","unstructured":"Montagna G et al (2020) An in vivo comparison study between strontium nanoparticles and rhBMP2. Front Bioeng Biotechnol 8:499. https:\/\/doi.org\/10.3389\/fbioe.2020.00499","journal-title":"Front Bioeng Biotechnol"},{"issue":"12","key":"3772_CR24","doi-asserted-by":"publisher","first-page":"6654","DOI":"10.3390\/ijms22126564","volume":"22","author":"B Ko\u0142odziejska","year":"2021","unstructured":"Ko\u0142odziejska B, St\u0119pie\u0144 N, Kolmas J (2021) The influence of strontium on bone tissue metabolism and its application in osteoporosis treatment. Int J Mol Sci 22(12):6654. https:\/\/doi.org\/10.3390\/ijms22126564","journal-title":"Int J Mol Sci"},{"key":"3772_CR25","doi-asserted-by":"publisher","unstructured":"Barbeck M, et al. (2022) In vivo analysis of the immune response to strontium- and copper-doped bioglass. In Vivo 36(5): 2149\u20132165. https:\/\/doi.org\/10.21873\/invivo.12941","DOI":"10.21873\/invivo.12941"},{"issue":"5","key":"3772_CR26","doi-asserted-by":"publisher","first-page":"735.e1","DOI":"10.1016\/j.ajog.2022.06.052","volume":"227","author":"C Fotopoulou","year":"2022","unstructured":"Fotopoulou C et al (2022) Outcomes of gynecologic cancer surgery during the COVID-19 pandemic: an international, multicenter, prospective CovidSurg-Gynecologic Oncology Cancer study. Am J Obstet Gynecol 227(5):735.e1-735.e25. https:\/\/doi.org\/10.1016\/j.ajog.2022.06.052","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"3772_CR27","doi-asserted-by":"publisher","first-page":"233","DOI":"10.11005\/jbm.2014.21.4.233","volume":"21","author":"KJ Ha","year":"2014","unstructured":"Ha KJ, Kim N (2014) Regulation of NFATc1 in osteoclast differentiation. J Bone Metab 21(4):233\u2013241","journal-title":"J Bone Metab"},{"key":"3772_CR28","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.msec.2018.04.012","volume":"89","author":"W Zhang","year":"2018","unstructured":"Zhang W et al (2018) Synergistic effect of strontium and silicon in strontium-substituted sub-micron bioactive glass for enhanced osteogenesis. Mater Sci Eng C Mater Biol Appl 89:245\u2013255. https:\/\/doi.org\/10.1016\/j.msec.2018.04.012","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"3772_CR29","first-page":"729352","volume":"2015","author":"T Yuichiro","year":"2015","unstructured":"Yuichiro T, Tomoko M, Yuji Y (2015) Functional diversity of fibroblast growth factors in bone formation. Int J Endocrinol 2015:729352","journal-title":"Int J Endocrinol"},{"issue":"11","key":"3772_CR30","doi-asserted-by":"publisher","first-page":"2048","DOI":"10.1002\/jbmr.3537","volume":"33","author":"M Saito","year":"2018","unstructured":"Saito M et al (2018) Platelet-derived TGF-\u03b2 induces tissue factor expression via the smad3 pathway in osteosarcoma cells. J Bone Miner Res 33(11):2048\u20132058","journal-title":"J Bone Miner Res"}],"container-title":["Biological Trace Element Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-023-03772-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12011-023-03772-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-023-03772-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T21:22:26Z","timestamp":1708032146000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12011-023-03772-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,26]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["3772"],"URL":"https:\/\/doi.org\/10.1007\/s12011-023-03772-3","relation":{},"ISSN":["0163-4984","1559-0720"],"issn-type":[{"value":"0163-4984","type":"print"},{"value":"1559-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,26]]},"assertion":[{"value":"20 April 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 July 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"NA. There is no human or animal subject involved in the research.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}