{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T08:15:27Z","timestamp":1793261727932,"version":"4.5.0"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biol Trace Elem Res"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1007\/s12011-023-04022-2","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T07:02:43Z","timestamp":1703228563000},"page":"4605-4617","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Carvacrol Reduces Mercuric Chloride-Induced Testicular Toxicity by Regulating Oxidative Stress, Inflammation, Apoptosis, Autophagy, and Histopathological Changes"],"prefix":"10.1007","volume":"202","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5573-4923","authenticated-orcid":false,"given":"Hasan","family":"\u015eim\u015fek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cihan","family":"G\u00fcr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sefa","family":"K\u00fc\u00e7\u00fckler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"\u0130lerit\u00fcrk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurhan","family":"Akaras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"\u00d6z","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih Mehmet","family":"Kandemir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,12,22]]},"reference":[{"key":"4022_CR1","doi-asserted-by":"publisher","first-page":"109542","DOI":"10.1016\/j.ecoenv.2019.109542","volume":"183","author":"F Safari","year":"2019","unstructured":"Safari F, Akramian M, Salehi-arjmand H, Khadivi A (2019) Physiological and molecular mechanisms underlying salicylic acid-mitigated mercury toxicity in lemon balm (Melissa officinalis L.). Ecotoxicol Environ Saf 183:109542","journal-title":"Ecotoxicol Environ Saf"},{"issue":"3","key":"4022_CR2","doi-asserted-by":"publisher","first-page":"3401","DOI":"10.1007\/s11356-019-07237-w","volume":"27","author":"RS Almeer","year":"2020","unstructured":"Almeer RS, Albasher G, Kassab RB, Ibrahim SR, Alotibi F, Alarifi S et al (2020) Ziziphus spina-christi leaf extract attenuates mercury chloride-induced testicular dysfunction in rats. Environ Sci Pollut Res Int 27(3):3401\u20133412","journal-title":"Environ Sci Pollut Res Int"},{"issue":"9","key":"4022_CR3","doi-asserted-by":"publisher","first-page":"e13385","DOI":"10.1111\/jfbc.13385","volume":"44","author":"G Albasher","year":"2020","unstructured":"Albasher G, Alkahtani S, Alarifi S (2020) Berberine mitigates oxidative damage associated with testicular impairment following mercury chloride intoxication. J Food Biochem 44(9):e13385","journal-title":"J Food Biochem"},{"issue":"2","key":"4022_CR4","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.bj.2019.07.004","volume":"43","author":"SA Adelakun","year":"2020","unstructured":"Adelakun SA, Ukwenya VO, Akingbade GT, Omotoso OD, Aniah JA (2020) Interventions of aqueous extract of Solanum melongena fruits (garden eggs) on mercury chloride induced testicular toxicity in adult male Wistar rats. Biomed J 43(2):174\u2013182","journal-title":"Biomed J"},{"key":"4022_CR5","unstructured":"World Health Organization (WHO) (2017) Mercury and health. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/mercury-and-health. Accessed 05 Jun 2023"},{"key":"4022_CR6","doi-asserted-by":"publisher","first-page":"113018","DOI":"10.1016\/j.ecoenv.2021.113018","volume":"228","author":"PC Gao","year":"2021","unstructured":"Gao PC, Chu JH, Chen XW, Li LX, Fan RF (2021) Selenium alleviates mercury chloride-induced liver injury by regulating mitochondrial dynamics to inhibit the crosstalk between energy metabolism disorder and NF-\u03baB\/NLRP3 inflammasome-mediated inflammation. Ecotoxicol Environ Saf 228:113018","journal-title":"Ecotoxicol Environ Saf"},{"issue":"4","key":"4022_CR7","doi-asserted-by":"publisher","first-page":"94","DOI":"10.3390\/toxics8040094","volume":"8","author":"P Mass\u00e1nyi","year":"2020","unstructured":"Mass\u00e1nyi P, Mass\u00e1nyi M, Madeddu R, Stawarz R, Luk\u00e1\u010d N (2020) Effects of cadmium, lead, and mercury on the structure and function of reproductive organs. Toxics 8(4):94","journal-title":"Toxics"},{"issue":"1","key":"4022_CR8","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1002\/tox.23378","volume":"37","author":"S Li","year":"2022","unstructured":"Li S, Han B, Wu P, Yang Q, Wang X, Li J et al (2022) Effect of inorganic mercury exposure on reproductive system of male mice: immunosuppression and fibrosis in testis. Environ Toxicol 37(1):69\u201378","journal-title":"Environ Toxicol"},{"key":"4022_CR9","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.reprotox.2019.02.012","volume":"85","author":"MC Henriques","year":"2019","unstructured":"Henriques MC, Loureiro S, Fardilha M, Herdeiro MT (2019) Exposure to mercury and human reproductive health: a systematic review. Reprod Toxicol 85:93\u2013103","journal-title":"Reprod Toxicol"},{"issue":"3","key":"4022_CR10","doi-asserted-by":"publisher","first-page":"199","DOI":"10.4274\/jtgga.galenos.2022.2022-2-6","volume":"23","author":"S Kumar","year":"2022","unstructured":"Kumar S, Sharma A, Sedha S (2022) Occupational and environmental mercury exposure and human reproductive health - a review. J Turk Ger Gynecol Assoc 23(3):199\u2013210","journal-title":"J Turk Ger Gynecol Assoc"},{"key":"4022_CR11","doi-asserted-by":"publisher","unstructured":"Ruyani A, Muthmainnah D, Simatupang MB, Ramadhanti AP, Putri SR, Parlindungan D (2022) Etlingera hemisphaerica Blume attenuates male reproductive toxicity due to mercury chloride in Mus musculus. PREPRINT (Version 1) available at Research Square. https:\/\/doi.org\/10.21203\/rs.3.rs-2022132\/v1","DOI":"10.21203\/rs.3.rs-2022132\/v1"},{"issue":"4","key":"4022_CR12","doi-asserted-by":"publisher","first-page":"157","DOI":"10.9734\/jocamr\/2021\/v16i430305","volume":"16","author":"JD Nwahiri","year":"2021","unstructured":"Nwahiri JD, Tamuno-Emine DG, Nwachuku EO, Bartimaeus ES (2021) Antioxidant potentials of Pentaclethra macrophylla seed (Ugba) on mercury toxicity induced hepatic, renal and testicular oxidative stress in male albino rats. JOCAMR 16(4):157\u2013167","journal-title":"JOCAMR"},{"key":"4022_CR13","doi-asserted-by":"publisher","first-page":"119610","DOI":"10.1016\/j.lfs.2021.119610","volume":"277","author":"FM Kandemir","year":"2021","unstructured":"Kandemir FM, Caglayan C, Darendelio\u011flu E, K\u00fc\u00e7\u00fckler S, \u0130zol E, Kandemir \u00d6 (2021) Modulatory effects of carvacrol against cadmium-induced hepatotoxicity and nephrotoxicity by molecular targeting regulation. Life Sci 277:119610","journal-title":"Life Sci"},{"issue":"6","key":"4022_CR14","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1002\/tox.23762","volume":"38","author":"C Gur","year":"2023","unstructured":"Gur C, Akarsu SA, Akaras N, Tuncer SC, Kandemir FM (2023) Carvacrol reduces abnormal and dead sperm counts by attenuating sodium arsenite-induced oxidative stress, inflammation, apoptosis, and autophagy in the testicular tissues of rats. Environ Toxicol 38(6):1265\u20131276","journal-title":"Environ Toxicol"},{"key":"4022_CR15","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.jtemb.2019.07.011","volume":"56","author":"C Caglayan","year":"2019","unstructured":"Caglayan C, Kandemir FM, Darendelio\u011flu E, Y\u0131ld\u0131r\u0131m S, Kucukler S, Dortbudak MB (2019) Rutin ameliorates mercuric chloride-induced hepatotoxicity in rats via interfering with oxidative stress, inflammation and apoptosis. J Trace Elem Med Biol 56:60\u201368","journal-title":"J Trace Elem Med Biol"},{"issue":"2","key":"4022_CR16","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/0003-2697(66)90167-9","volume":"16","author":"ZA Placer","year":"1966","unstructured":"Placer ZA, Cushman LL, Johnson BC (1966) Estimation of product of lipid peroxidation (malonyl dialdehyde) in biochemical systems. Anal Biochem 16(2):359\u2013364","journal-title":"Anal Biochem"},{"key":"4022_CR17","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","volume":"105","author":"H Aebi","year":"1984","unstructured":"Aebi H (1984) Catalase in vitro. Methods Enzymol 105:121\u2013126","journal-title":"Methods Enzymol"},{"issue":"3","key":"4022_CR18","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1093\/clinchem\/34.3.497","volume":"34","author":"Y Sun","year":"1988","unstructured":"Sun Y, Oberley LW, Li Y (1988) A simple method for clinical assay of superoxide dismutase. Clin Chem 34(3):497\u2013500","journal-title":"Clin Chem"},{"issue":"3","key":"4022_CR19","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.bbrc.2012.08.016","volume":"425","author":"RA Lawrence","year":"2012","unstructured":"Lawrence RA, Burk RF (2012) Glutathione peroxidase activity in selenium-deficient rat liver. 1976. Biochem Biophys Res Commun 425(3):503\u2013509","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"4022_CR20","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/0003-2697(68)90092-4","volume":"25","author":"J Sedlak","year":"1968","unstructured":"Sedlak J, Lindsay RH (1968) Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman\u2019s reagent. Anal Biochem 25(1):192\u2013205","journal-title":"Anal Biochem"},{"issue":"1","key":"4022_CR21","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193(1):265\u2013275","journal-title":"J Biol Chem"},{"key":"4022_CR22","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method. Methods 25:402\u2013408","journal-title":"Methods"},{"issue":"11","key":"4022_CR23","doi-asserted-by":"publisher","first-page":"2639","DOI":"10.1002\/tox.23624","volume":"37","author":"M Ileriturk","year":"2022","unstructured":"Ileriturk M, Kandemir O, Kandemir FM (2022) Evaluation of protective effects of quercetin against cypermethrin-induced lung toxicity in rats via oxidative stress, inflammation, apoptosis, autophagy, and endoplasmic reticulum stress pathway. Environ Toxicol 37(11):2639\u20132650","journal-title":"Environ Toxicol"},{"issue":"3","key":"4022_CR24","doi-asserted-by":"publisher","first-page":"e13524","DOI":"10.1111\/and.13524","volume":"52","author":"FM Kandemir","year":"2020","unstructured":"Kandemir FM, Caglayan C, Aksu EH, Yildirim S, Kucukler S, Gur C et al (2020) Protective effect of rutin on mercuric chloride-induced reproductive damage in male rats. Andrologia 52(3):e13524","journal-title":"Andrologia"},{"issue":"18","key":"4022_CR25","doi-asserted-by":"publisher","first-page":"51531","DOI":"10.1007\/s11356-023-25970-1","volume":"30","author":"PC Gao","year":"2023","unstructured":"Gao PC, Wang AQ, Chen XW, Cui H, Li Y, Fan RF (2023) Selenium alleviates endoplasmic reticulum calcium depletion-induced endoplasmic reticulum stress and apoptosis in chicken myocardium after mercuric chloride exposure. Environ Sci Pollut Res Int 30(18):51531\u201351541","journal-title":"Environ Sci Pollut Res Int"},{"key":"4022_CR26","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.jtemb.2019.04.007","volume":"54","author":"C Caglayan","year":"2019","unstructured":"Caglayan C, Kandemir FM, Yildirim S, Kucukler S, Eser G (2019) Rutin protects mercuric chloride-induced nephrotoxicity via targeting of aquaporin 1 level, oxidative stress, apoptosis and inflammation in rats. J Trace Elem Med Biol 54:69\u201378","journal-title":"J Trace Elem Med Biol"},{"issue":"1","key":"4022_CR27","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1038\/s41598-020-79713-0","volume":"11","author":"NM Wijesundara","year":"2021","unstructured":"Wijesundara NM, Lee SF, Cheng Z, Davidson R, Rupasinghe HPV (2021) Carvacrol exhibits rapid bactericidal activity against Streptococcus pyogenes through cell membrane damage. Sci Rep 11(1):1487","journal-title":"Sci Rep"},{"issue":"1","key":"4022_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/10715762.2019.1702656","volume":"54","author":"GBN Chainy","year":"2020","unstructured":"Chainy GBN, Sahoo DK (2020) Hormones and oxidative stress: an overview. Free Radic Res 54(1):1\u201326","journal-title":"Free Radic Res"},{"key":"4022_CR29","doi-asserted-by":"publisher","first-page":"110410","DOI":"10.1016\/j.cbi.2023.110410","volume":"374","author":"N Akaras","year":"2023","unstructured":"Akaras N, Gur C, Kucukler S, Kandemir FM (2023) Zingerone reduces sodium arsenite-induced nephrotoxicity by regulating oxidative stress, inflammation, apoptosis and histopathological changes. Chem Biol Interact 374:110410","journal-title":"Chem Biol Interact"},{"issue":"16","key":"4022_CR30","doi-asserted-by":"publisher","first-page":"19783","DOI":"10.1007\/s11356-020-11509-1","volume":"28","author":"M Seif","year":"2021","unstructured":"Seif M, Abd El-Aziz T, Sayed M, Wang Z (2021) Zingiber officinale ethanolic extract attenuates oxidative stress, steroidogenic gene expression alterations, and testicular histopathology induced by sodium arsenite in male rats. Environ Sci Pollut Res Int 28(16):19783\u201319798","journal-title":"Environ Sci Pollut Res Int"},{"issue":"2","key":"4022_CR31","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1002\/bab.1830","volume":"67","author":"L Panneerselvam","year":"2020","unstructured":"Panneerselvam L, Raghunath A, Ravi MS, Vetrivel A, Subramaniam V, Sundarraj K, Perumal E (2020) Ferulic acid attenuates arsenic-induced cardiotoxicity in rats. Biotechnol Appl Biochem 67(2):186\u2013195","journal-title":"Biotechnol Appl Biochem"},{"issue":"1","key":"4022_CR32","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1081\/IPH-51757","volume":"27","author":"SH Kim","year":"2005","unstructured":"Kim SH, Sharma RP (2005) Mercury alters endotoxin-induced inflammatory cytokine expression in liver: differential roles of p38 and extracellular signal-regulated mitogen-activated protein kinases. Immunopharmacol Immunotoxicol 27(1):123\u2013135","journal-title":"Immunopharmacol Immunotoxicol"},{"issue":"12","key":"4022_CR33","doi-asserted-by":"publisher","first-page":"2412","DOI":"10.1016\/j.fct.2007.06.023","volume":"45","author":"MK Sharma","year":"2007","unstructured":"Sharma MK, Sharma A, Kumar A, Kumar M (2007) Spirulina fusiformis provides protection against mercuric chloride induced oxidative stress in Swiss albino mice. Food Chem Toxicol 45(12):2412\u20132419","journal-title":"Food Chem Toxicol"},{"key":"4022_CR34","doi-asserted-by":"publisher","first-page":"111716","DOI":"10.1016\/j.jinorgbio.2022.111716","volume":"229","author":"LX Li","year":"2022","unstructured":"Li LX, Chu JH, Chen XW, Gao PC, Wang ZY, Liu C, Fan RF (2022) Selenium ameliorates mercuric chloride-induced brain damage through activating BDNF\/TrKB\/PI3K\/AKT and inhibiting NF-\u03baB signaling pathways. J Inorg Biochem 229:111716. https:\/\/doi.org\/10.1016\/j.jinorgbio.2022.111716","journal-title":"J Inorg Biochem"},{"key":"4022_CR35","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.theriogenology.2022.05.007","volume":"187","author":"XW Chen","year":"2022","unstructured":"Chen XW, Chu JH, Li LX, Gao PC, Wang ZY, Fan RF (2022) Protective mechanism of selenium on mercuric chloride-induced testis injury in chicken via p38 MAPK\/ATF2\/iNOS signaling pathway. Theriogenology 187:188\u2013194","journal-title":"Theriogenology"},{"key":"4022_CR36","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/j.tifs.2021.08.023","volume":"116","author":"NB Rathod","year":"2021","unstructured":"Rathod NB, Kulawik P, Ozogul F, Regenstein JM, Ozogul Y (2021) Biological activity of plant-based carvacrol and thymol and their impact on human health and food quality. Trends Food Sci Technol 116:733\u2013748","journal-title":"Trends Food Sci Technol"},{"key":"4022_CR37","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1016\/j.biopha.2018.12.054","volume":"111","author":"H Shoorei","year":"2019","unstructured":"Shoorei H, Khaki A, Khaki AA, Hemmati AA, Moghimian M, Shokoohi M (2019) The ameliorative effect of carvacrol on oxidative stress and germ cell apoptosis in testicular tissue of adult diabetic rats. Biomed Pharmacother 111:568\u2013578","journal-title":"Biomed Pharmacother"},{"issue":"36","key":"4022_CR38","doi-asserted-by":"publisher","first-page":"49808","DOI":"10.1007\/s11356-021-14049-4","volume":"28","author":"C Gur","year":"2021","unstructured":"Gur C, Kandemir FM, Darendelioglu E, Caglayan C, Kucukler S, Kandemir O et al (2021) Morin protects against acrylamide-induced neurotoxicity in rats: an investigation into different signal pathways. Environ Sci Pollut Res Int 28(36):49808\u201349819","journal-title":"Environ Sci Pollut Res Int"},{"key":"4022_CR39","doi-asserted-by":"publisher","first-page":"118301","DOI":"10.1016\/j.lfs.2020.118301","volume":"261","author":"S Kucukler","year":"2020","unstructured":"Kucukler S, Caglayan C, Darendelio\u011flu E, Kandemir FM (2020) Morin attenuates acrylamide-induced testicular toxicity in rats by regulating the NF-\u03baB, Bax\/Bcl-2 and PI3K\/Akt\/mTOR signaling pathways. Life Sci 261:118301","journal-title":"Life Sci"},{"issue":"2","key":"4022_CR40","first-page":"96","volume":"6","author":"H Simsek","year":"2023","unstructured":"Simsek H, Akaras N (2023) Acacetin ameliorates acetylsalicylic acid-induced gastric ulcer in rats by interfering with oxidative stress, inflammation, and apoptosis. Int J Med Biochem 6(2):96\u2013103","journal-title":"Int J Med Biochem"},{"key":"4022_CR41","doi-asserted-by":"publisher","first-page":"147502","DOI":"10.1016\/j.gene.2023.147502","volume":"875","author":"H \u015eim\u015fek","year":"2023","unstructured":"\u015eim\u015fek H, Akaras N, G\u00fcr C, K\u00fc\u00e7\u00fckler S, Kandemir FM (2023) Beneficial effects of chrysin on cadmium-induced nephrotoxicity in rats: modulating the levels of Nrf2\/HO-1, RAGE\/NLRP3, and Caspase-3\/Bax\/Bcl-2 signaling pathways. Gene 875:147502","journal-title":"Gene"},{"key":"4022_CR42","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.jphotobiol.2019.01.006","volume":"192","author":"OE Elshawi","year":"2019","unstructured":"Elshawi OE, Nabeel AI (2019) Modulatory effect of a new benzopyran derivative via COX-2 blocking and down regulation of NF-\u03baB against \u03b3-radiation induced- intestinal inflammation. J Photochem Photobiol B 192:90\u201396","journal-title":"J Photochem Photobiol B"},{"issue":"2","key":"4022_CR43","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1007\/s11033-021-06948-z","volume":"49","author":"K Yesildag","year":"2022","unstructured":"Yesildag K, Gur C, Ileriturk M, Kandemir FM (2022) Evaluation of oxidative stress, inflammation, apoptosis, oxidative DNA damage and metalloproteinases in the lungs of rats treated with cadmium and carvacrol. Mol Biol Rep 49(2):1201\u20131211","journal-title":"Mol Biol Rep"},{"key":"4022_CR44","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.neuro.2020.10.009","volume":"81","author":"H \u00c7elik","year":"2020","unstructured":"\u00c7elik H, Kucukler S, \u00c7omakl\u0131 S, Caglayan C, \u00d6zdemir S, Yard\u0131m A, Karaman M, Kandemir FM (2020) Neuroprotective effect of chrysin on isoniazid-induced neurotoxicity via suppression of oxidative stress, inflammation and apoptosis in rats. Neurotoxicology 81:197\u2013208","journal-title":"Neurotoxicology"},{"key":"4022_CR45","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.plgene.2017.12.001","volume":"13","author":"A Singh","year":"2018","unstructured":"Singh A, Nath O, Singh S, Kumar S, Singh IK (2018) Genome-wide identification of the MAPK gene family in chickpea and expression analysis during development and stress response. Plant Gene 13:25\u201335","journal-title":"Plant Gene"},{"key":"4022_CR46","doi-asserted-by":"publisher","first-page":"113216","DOI":"10.1016\/j.ejmech.2021.113216","volume":"213","author":"MM Madkour","year":"2021","unstructured":"Madkour MM, Anbar HS, El-Gamal MI (2021) Current status and future prospects of p38\u03b1\/MAPK14 kinase and its inhibitors. Eur J Med Chem 213:113216","journal-title":"Eur J Med Chem"},{"key":"4022_CR47","doi-asserted-by":"publisher","first-page":"108369","DOI":"10.1016\/j.reprotox.2023.108369","volume":"118","author":"M Ileriturk","year":"2023","unstructured":"Ileriturk M, Kandemir O, Akaras N, Simsek H, Genc A, Kandemir FM (2023) Hesperidin has a protective effect on paclitaxel-induced testicular toxicity through regulating oxidative stress, apoptosis, inflammation and endoplasmic reticulum stress. Reprod Toxicol 118:108369","journal-title":"Reprod Toxicol"},{"issue":"3","key":"4022_CR48","doi-asserted-by":"publisher","first-page":"e13155","DOI":"10.1111\/jfbc.13155","volume":"44","author":"N Akaras","year":"2020","unstructured":"Akaras N, Abuc OO, Koc K, Bal T, Geyikoglu F, Atilay H, Erol HS, Yigit S, Gul M (2020) (1 \u2192 3)-\u03b2-d-glucan enhances the toxicity induced by Bortezomib in rat testis. J Food Biochem 44(3):e13155","journal-title":"J Food Biochem"},{"issue":"8","key":"4022_CR49","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1080\/10520295.2017.1350748","volume":"92","author":"N Akaras","year":"2017","unstructured":"Akaras N, Bal T, Atilay H, Selli J, Halici MB (2017) Protective effects of agomelatine on testicular damage caused by bortezomib. Biotech Histochem 92(8):552\u2013559","journal-title":"Biotech Histochem"},{"issue":"9","key":"4022_CR50","doi-asserted-by":"publisher","first-page":"5555","DOI":"10.1039\/C9FO01152H","volume":"10","author":"B Han","year":"2019","unstructured":"Han B, Li S, Lv Y, Yang D, Li J, Yang Q, Wu P, Lv Z, Zhang Z (2019) Dietary melatonin attenuates chromium-induced lung injury via activating the Sirt1\/Pgc-1\u03b1\/Nrf2 pathway. Food Funct 10(9):5555\u20135565","journal-title":"Food Funct"},{"issue":"4","key":"4022_CR51","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1007\/s12011-021-02766-3","volume":"200","author":"B Han","year":"2022","unstructured":"Han B, Lv Z, Han X, Li S, Han B, Yang Q, Wang X, Wu P, Li J, Deng N, Zhang Z (2022) Harmful effects of inorganic mercury exposure on kidney cells: mitochondrial dynamics disorder and excessive oxidative stress. Biol Trace Elem Res 200(4):1591\u20131597","journal-title":"Biol Trace Elem Res"},{"key":"4022_CR52","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1016\/j.chemosphere.2019.06.096","volume":"234","author":"S Li","year":"2019","unstructured":"Li S, Baiyun R, Lv Z, Li J, Han D, Zhao W, Yu L, Deng N, Liu Z, Zhang Z (2019) Exploring the kidney hazard of exposure to mercuric chloride in mice:disorder of mitochondrial dynamics induces oxidative stress and results in apoptosis. Chemosphere 234:822\u2013829","journal-title":"Chemosphere"},{"issue":"12","key":"4022_CR53","first-page":"22158","volume":"8","author":"R Akc\u0131lar","year":"2015","unstructured":"Akc\u0131lar R, Akc\u0131lar A, Ko\u00e7ak C, Ko\u00e7ak FE, Bayat Z, \u015eim\u015fek H et al (2015) Effects of Ukrain on intestinal apoptosis caused by ischemia-reperfusion injury in rats. Int J Clin Exp Med 8(12):22158\u201322166","journal-title":"Int J Clin Exp Med"},{"issue":"2","key":"4022_CR54","first-page":"209","volume":"19","author":"H \u015eim\u015fek","year":"2016","unstructured":"\u015eim\u015fek H, Demiry\u00fcrek \u015e, Demir T, Atabay HD, \u00c7eribasi AO, Bayraktar R et al (2016) Assessment of expressions of Bcl-XL, b-FGF, Bmp-2, Caspase-3, PDGFR-\u03b1, Smad1 and TGF-\u03b21 genes in a rat model of lung ischemia\/reperfusion. Iran J Basic Med Sci 19(2):209\u2013214","journal-title":"Iran J Basic Med Sci"},{"issue":"45","key":"4022_CR55","doi-asserted-by":"publisher","first-page":"101208","DOI":"10.1007\/s11356-023-29410-y","volume":"30","author":"H \u015eim\u015fek","year":"2023","unstructured":"\u015eim\u015fek H, K\u00fc\u00e7\u00fckler S, G\u00fcr C, Akaras N, Kandemir FM (2023) Protective effects of sinapic acid against lead acetate-induced nephrotoxicity: a multi-biomarker approach. Environ Sci Pollut Res Int 30(45):101208\u2013101222","journal-title":"Environ Sci Pollut Res Int"},{"issue":"9","key":"4022_CR56","first-page":"1098","volume":"26","author":"H \u015eim\u015fek","year":"2023","unstructured":"\u015eim\u015fek H, K\u00fc\u00e7\u00fckler S, G\u00fcr C, \u0130lerit\u00fcrk M, Ayg\u00f6rmez S, Kandemir FM (2023) Protective effects of zingerone against sodium arsenite-induced lung toxicity: a multi-biomarker approach. Iran J Basic Med Sci 26(9):1098\u20131106","journal-title":"Iran J Basic Med Sci"},{"issue":"14","key":"4022_CR57","doi-asserted-by":"publisher","first-page":"12767","DOI":"10.1007\/s11356-016-6209-0","volume":"24","author":"XS Wang","year":"2017","unstructured":"Wang XS, Liu C, Khoso PA, Zheng W, Li M, Li S (2017) Autophagy response in the liver of pigeon exposed to avermectin. Environ Sci Pollut Res Int 24(14):12767\u201312777","journal-title":"Environ Sci Pollut Res Int"},{"issue":"2","key":"4022_CR58","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.jtos.2019.01.008","volume":"17","author":"LM Martin","year":"2019","unstructured":"Martin LM, Jeyabalan N, Tripathi R, Panigrahi T, Johnson PJ, Ghosh A et al (2019) Autophagy in corneal health and disease: a concise review. Ocul Surf 17(2):186\u2013197","journal-title":"Ocul Surf"},{"issue":"3","key":"4022_CR59","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1177\/0748233709102717","volume":"25","author":"M Aydin","year":"2009","unstructured":"Aydin M, Cevik A, Kandemir FM, Yuksel M, Apaydin AM (2009) Evaluation of hormonal change, biochemical parameters, and histopathological status of uterus in rats exposed to 50-Hz electromagnetic field. Toxicol Ind Health 25(3):153\u2013158","journal-title":"Toxicol Ind Health"},{"issue":"1","key":"4022_CR60","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1007\/s12011-015-0449-6","volume":"170","author":"R Li","year":"2016","unstructured":"Li R, Luo X, Li L, Peng Q, Yang Y, Zhao L et al (2016) The protective effects of melatonin against oxidative stress and inflammation induced by acute cadmium exposure in mice testis. Biol Trace Elem Res 170(1):152\u2013164","journal-title":"Biol Trace Elem Res"},{"issue":"5","key":"4022_CR61","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.joim.2022.07.001","volume":"20","author":"DE Rotimi","year":"2022","unstructured":"Rotimi DE, Olaolu TD, Adeyemi OS (2022) Pharmacological action of quercetin against testicular dysfunction: a mini review. J Integr Med 20(5):396\u2013401","journal-title":"J Integr Med"},{"key":"4022_CR62","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.envpol.2016.01.059","volume":"212","author":"S Zhang","year":"2016","unstructured":"Zhang S, Niu Q, Gao H, Ma R, Lei R, Zhang C et al (2016) Excessive apoptosis and defective autophagy contribute to developmental testicular toxicity induced by fluoride. Environ Pollut 212:97\u2013104","journal-title":"Environ Pollut"},{"issue":"9","key":"4022_CR63","doi-asserted-by":"publisher","first-page":"e13697","DOI":"10.1111\/and.13697","volume":"52","author":"BO Anyanwu","year":"2020","unstructured":"Anyanwu BO, Ezejiofor AN, Nwaogazie IL, Akaranta O, Orisakwe OE (2020) Low-dose heavy metal mixture (lead, cadmium and mercury)-induced testicular injury and protective effect of zinc and Costus afer in Wistar albino rats. Andrologia 52(9):e13697","journal-title":"Andrologia"}],"container-title":["Biological Trace Element Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-023-04022-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12011-023-04022-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-023-04022-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T10:42:33Z","timestamp":1724409753000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12011-023-04022-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,22]]},"references-count":63,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["4022"],"URL":"https:\/\/doi.org\/10.1007\/s12011-023-04022-2","relation":{},"ISSN":["0163-4984","1559-0720"],"issn-type":[{"value":"0163-4984","type":"print"},{"value":"1559-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,22]]},"assertion":[{"value":"9 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 December 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethics committee approval was received for this study from the ethics committee of Necmettin Erbakan University KONUDAM Experimental Medicine Research and Study Center\u2019s (No: 2022\/048, Date: 25 Aug 2022).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"The authors gave their explicit consent to publish the manuscript. Hasan \u015eim\u015fek is free to contact any of the people involved in the research to seek further clarification and information.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Publish"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}