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Smoking-related elevations in serum and seminal lead (Pb) and arsenic (As) may play a role in mediating the toxic effects of smoking on seminogram. This research aims to determine whether smoking has any significant impact on Pb and As levels in the seminal plasma and serum, as well as on the various semen parameters, when compared to nonsmokers. In total, 80 adult males were included: 60 smokers and 20 age-matched nonsmokers. Based on the number of cigarettes smoked\/day (CPD), the smokers were categorized into mild (1\u201310), moderate (11\u201320), and severe (&gt;\u200920). The analysis of semen was conducted in accordance with the 2010 WHO laboratory manual. Using an atomic absorption spectrophotometer, Pb and As concentrations in the serum and seminal plasma of all groups were determined. Compared to nonsmokers, smokers had a significantly reduced sperm count, motility, and viability, as well as a larger percentage of aberrant forms (<jats:italic>P<\/jats:italic>\u2009=\u20090.001, 0.025, 0.034, 0.002 respectively). Smokers had higher Pb concentrations in their serum and seminal fluid than nonsmokers (<jats:italic>P<\/jats:italic>\u2009=\u20090.002, 0.001 respectively). Seminal Pb had a significant negative correlation with sperm count (<jats:italic>P<\/jats:italic>\u2009=\u20090.004, r\u2009=\u2009-0.320). Serum Pb levels were found to positively correlate with seminal Pb levels (<jats:italic>P<\/jats:italic> 0.001, r\u2009=\u20090.648), and cigarette smokers had substantially greater seminal As levels than nonsmokers (<jats:italic>P<\/jats:italic>\u2009=\u20090.024). Sperm viability was strongly inversely related to seminal As (<jats:italic>P<\/jats:italic>\u2009=\u20090.042, r\u2009=\u2009-0.264). Seminal As levels and aberrant sperm shapes were found to be significantly correlated (<jats:italic>P<\/jats:italic>\u2009=\u20090.001, r\u2009=\u20090.414). In smokers, a significant positive relationship between seminal As and seminal Pb was observed. Therefore, semen parameters could be adversely affected by smoking through high levels of Pb and As (<jats:italic>P<\/jats:italic>\u2009=\u20090.012, r\u2009=\u20090.298).<\/jats:p>","DOI":"10.1007\/s12011-023-04039-7","type":"journal-article","created":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T05:01:48Z","timestamp":1704430908000},"page":"4450-4458","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Serum and Seminal Plasma Levels of Lead and Arsenic in Cigarette Smokers and Their Relation to the Semen Parameters"],"prefix":"10.1007","volume":"202","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0333-5506","authenticated-orcid":false,"given":"Azza Gaber Antar","family":"Farag","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9724-1596","authenticated-orcid":false,"given":"Eman Abd-Elfatah","family":"Badr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2167-2981","authenticated-orcid":false,"given":"Alaa Osama Ali","family":"Kholif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1646-1853","authenticated-orcid":false,"given":"Mostafa Nabil","family":"Khalifa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3572-4653","authenticated-orcid":false,"given":"Mai Medhat Mohamed","family":"Ghanem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,5]]},"reference":[{"issue":"6","key":"4039_CR1","doi-asserted-by":"publisher","first-page":"954","DOI":"10.4103\/1008-682X.150847","volume":"17","author":"JB Dai","year":"2015","unstructured":"Dai JB, Wang ZX, Qiao ZD (2015) The hazardous effects of tobacco smoking on male fertility. 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