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The relationship between the changes in the levels of plasma trace elements of patients with AV after 3\u00a0months of isotretinoin treatment and the side effects was investigated in the study. Plasma samples of 35 patients were collected before and after isotretinoin treatment. Samples were analyzed by Inductively Coupled Plasma\u2013Mass Spectrometer. After treatment, the levels of phosphorus, magnesium, and zinc in plasma increased statistically, while the level of potassium decreased (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The treatment had differing effects on zinc levels based on the gender of the individuals. With treatment, the levels of zinc in the plasma of men showed a greater increase compared to women (<jats:italic>p<\/jats:italic>\u2009=\u20097.3e-04). Additionally, the correlation matrix analysis revealed a strong correlation (<jats:italic>R<\/jats:italic>\u2009&gt;\u20090.8) between magnesium and calcium. According to the study results, the change in phosphorus and potassium levels shows that isotretinoin affects kidney functions. The results suggest that phosphorus, potassium, magnesium, and zinc are associated with fatigue, dry skin and chapped lips, hair loss, and sebum secretion, respectively. Consequently, the study emphasizes the need for a comprehensive pre-treatment assessment, including monitoring of liver and kidney function as well as the levels of phosphorus and potassium in patients.<\/jats:p>","DOI":"10.1007\/s12011-023-04053-9","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T10:02:11Z","timestamp":1704880931000},"page":"4858-4868","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Analysis of Isotretinoin-Induced Alterations in the Levels of Plasma Trace Elements: Investigation of the Relationship Between Magnesium, Phosphorus, Potassium, Zinc, and Treatment-Related Side Effects"],"prefix":"10.1007","volume":"202","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5439-950X","authenticated-orcid":false,"given":"Tugrul Cagri","family":"Akman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Yazici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7027-809X","authenticated-orcid":false,"given":"Alptug","family":"Atila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3497-4092","authenticated-orcid":false,"given":"Cuma","family":"Mertoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,10]]},"reference":[{"key":"4053_CR1","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1111\/JOCD.13595","volume":"20","author":"MA Ibrahim","year":"2021","unstructured":"Ibrahim MA, Mohammed SA, Elhabak DM (2021) Role of KLF2: new insight in inflammatory acne pathogenesis. 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Approval was granted by the Ethics Committee of Erzincan Binali Y\u0131ld\u0131r\u0131m University (Date 26.04.2021\/ Permit Number: E-21142744\u2013804-0.99\u201377978, Decision No: 06\/29).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}