{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:56:16Z","timestamp":1786982176760,"version":"build-2736575974"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T00:00:00Z","timestamp":1712534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T00:00:00Z","timestamp":1712534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biol Trace Elem Res"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1007\/s12011-024-04171-y","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T15:01:26Z","timestamp":1712588486000},"page":"291-304","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of Zinc Combined with Metformin on Zinc Homeostasis, Blood-Epididymal Barrier, and Epididymal Absorption in Male Diabetic Mice"],"prefix":"10.1007","volume":"203","author":[{"given":"Menghui","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanhuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoju","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bangrong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqing","family":"Tie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0217-2490","authenticated-orcid":false,"given":"Shusong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,8]]},"reference":[{"key":"4171_CR1","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.diabres.2018.02.023","volume":"138","author":"NH Cho","year":"2018","unstructured":"Cho NH, Shaw JE, Karuranga S, Huang Y, da Rocha Fernandes JD, Ohlrogge AW, Malanda B (2018) IDF Diabetes Atlas: global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract 138:271\u2013281","journal-title":"Diabetes Res Clin Pract"},{"issue":"3","key":"4171_CR2","doi-asserted-by":"publisher","first-page":"950","DOI":"10.3390\/molecules27030950","volume":"27","author":"A Singh","year":"2022","unstructured":"Singh A, Kukreti R, Saso L, Kukreti S (2022) Mechanistic insight into oxidative stress-triggered signaling pathways and type 2 diabetes. Molecules 27(3):950","journal-title":"Molecules"},{"issue":"2","key":"4171_CR3","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1007\/s12011-016-0674-7","volume":"173","author":"KP Maremanda","year":"2016","unstructured":"Maremanda KP, Khan S, Jena GB (2016) Role of zinc supplementation in testicular and epididymal damages in diabetic rat: involvement of Nrf2, SOD1, and GPX5. Biol Trace Elem Res 173(2):452\u2013464","journal-title":"Biol Trace Elem Res"},{"issue":"7","key":"4171_CR4","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1007\/s00125-010-1722-z","volume":"53","author":"N Karachalias","year":"2010","unstructured":"Karachalias N, Babaei-Jadidi R, Rabbani N, Thornalley PJ (2010) Increased protein damage in renal glomeruli, retina, nerve, plasma and urine and its prevention by thiamine and benfotiamine therapy in a rat model of diabetes. Diabetologia 53(7):1506\u20131516","journal-title":"Diabetologia"},{"issue":"5","key":"4171_CR5","first-page":"403","volume":"5","author":"S Asri-Rezaei","year":"2015","unstructured":"Asri-Rezaei S, Tamaddonfard E, Ghasemsoltani-Momtaz B, Erfanparast A, Gholamalipour S (2015) Effects of crocin and zinc chloride on blood levels of zinc and metabolic and oxidative parameters in streptozotocin-induced diabetic rats. Avicenna J Phytomed 5(5):403\u2013412","journal-title":"Avicenna J Phytomed"},{"issue":"8","key":"4171_CR6","doi-asserted-by":"publisher","first-page":"e0136390","DOI":"10.1371\/journal.pone.0136390","volume":"10","author":"C Qian","year":"2015","unstructured":"Qian C, Zhu C, Yu W, Jiang X, Zhang F (2015) High-fat diet\/low-dose streptozotocin-induced type 2 diabetes in rats impacts osteogenesis and Wnt signaling in bone marrow stromal cells. PLoS One 10(8):e0136390","journal-title":"PLoS One"},{"issue":"9","key":"4171_CR7","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1007\/s00125-017-4318-z","volume":"60","author":"CJ Bailey","year":"2017","unstructured":"Bailey CJ (2017) Metformin: historical overview. Diabetologia 60(9):1566\u20131576","journal-title":"Diabetologia"},{"issue":"2","key":"4171_CR8","first-page":"69","volume":"19","author":"A Fallah","year":"2018","unstructured":"Fallah A, Mohammad-Hasani A, Colagar AH (2018) Zinc is an essential element for male fertility: a review of zn roles in men\u2019s health, germination, sperm quality, and fertilization. J Reprod Infertil 19(2):69\u201381","journal-title":"J Reprod Infertil"},{"issue":"2","key":"4171_CR9","doi-asserted-by":"publisher","first-page":"176","DOI":"10.3945\/an.112.003210","volume":"4","author":"AS Prasad","year":"2013","unstructured":"Prasad AS (2013) Discovery of human zinc deficiency: its impact on human health and disease. Adv Nutr 4(2):176\u2013190","journal-title":"Adv Nutr"},{"issue":"1","key":"4171_CR10","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s40199-015-0127-4","volume":"23","author":"P Ranasinghe","year":"2015","unstructured":"Ranasinghe P, Pigera S, Galappatthy P, Katulanda P, Constantine GR (2015) Zinc and diabetes mellitus: understanding molecular mechanisms and clinical implications. Daru 23(1):44","journal-title":"Daru"},{"issue":"2","key":"4171_CR11","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.repbio.2020.03.002","volume":"20","author":"KP Maremanda","year":"2020","unstructured":"Maremanda KP, Srivalliputturu SB, Jena G (2020) Zinc deficient diet exacerbates the testicular and epididymal damage in type 2 diabetic rat: studies on oxidative stress-related mechanisms. Reprod Biol 20(2):191\u2013201","journal-title":"Reprod Biol"},{"issue":"5","key":"4171_CR12","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.3390\/nu11051027","volume":"11","author":"JC Fern\u00e1ndez-Cao","year":"2019","unstructured":"Fern\u00e1ndez-Cao JC, Warthon-Medina M, Moran H, Arija V, Doepking C, Serra-Majem L, Lowe NM (2019) Zinc intake and status and risk of type 2 diabetes mellitus: a systematic review and meta-analysis. Nutrients 11(5):1027","journal-title":"Nutrients"},{"issue":"2","key":"4171_CR13","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1007\/s12011-019-01810-7","volume":"194","author":"S Qi","year":"2020","unstructured":"Qi S, He J, Zheng H, Chen C, Jiang H, Lan S (2020) Zinc supplementation increased bone mineral density, improves bone histomorphology, and prevents bone loss in diabetic rat. Biol Trace Elem Res 194(2):493\u2013501","journal-title":"Biol Trace Elem Res"},{"issue":"10","key":"4171_CR14","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1139\/apnm-2018-0070","volume":"43","author":"NM Aziz","year":"2018","unstructured":"Aziz NM, Kamel MY, Mohamed MS, Ahmed SM (2018) Antioxidant, anti-inflammatory, and anti-apoptotic effects of zinc supplementation in testes of rats with experimentally induced diabetes. Appl Physiol Nutr Metab 43(10):1010\u20131018","journal-title":"Appl Physiol Nutr Metab"},{"issue":"3","key":"4171_CR15","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.52711\/0974-360X.2022.00198","volume":"15","author":"HY Younis","year":"2022","unstructured":"Younis HY, Thanoon IA, Fadhil NN, Merkhan MM (2022) Effect of zinc as an add-on to metformin therapy on glycemic control, serum insulin, and c-peptide levels and insulin resistance in type 2 diabetes mellitus patient. Res J Pharm Technol 15(3):1184\u20131188","journal-title":"Res J Pharm Technol"},{"key":"4171_CR16","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.vascn.2016.10.007","volume":"84","author":"S Nath","year":"2017","unstructured":"Nath S, Ghosh SK, Choudhury Y (2017) A murine model of type 2 diabetes mellitus developed using a combination of high fat diet and multiple low doses of streptozotocin treatment mimics the metabolic characteristics of type 2 diabetes mellitus in humans. J Pharmacol Toxicol Methods 84:20\u201330","journal-title":"J Pharmacol Toxicol Methods"},{"issue":"8","key":"4171_CR17","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.3390\/molecules24081454","volume":"24","author":"FR Cheng","year":"2019","unstructured":"Cheng FR, Cui HX, Fang JL, Yuan K, Guo Y (2019) Ameliorative effect and mechanism of the purified anthraquinone-glycoside preparation from Rheum Palmatum L. on Type 2 Diabetes Mellitus. Molecules 24(8):1454","journal-title":"Molecules"},{"issue":"2","key":"4171_CR18","first-page":"151","volume":"53","author":"L Li","year":"2023","unstructured":"Li L, Bowei Z, Qing L, Qiuyue L, Yanqing B, Baohua Z (2023) The effect of Lactobacillus plantarum on rats with type 2 diabetes mellitus and the mechanism of the effect. Industr Microbiol 53(2):151\u2013162","journal-title":"Industr Microbiol"},{"issue":"8","key":"4171_CR19","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1007\/s11626-023-00804-z","volume":"59","author":"H Li","year":"2023","unstructured":"Li H, Li Y, Liu J, Liu X, Li Y, Wang S, Ma J (2023) Knockdown of ZnT4 induced apoptosis, inhibited proliferation and testosterone synthesis of TM3 cells. In Vitro Cell Dev Biol Anim 59(8):565\u2013574","journal-title":"In Vitro Cell Dev Biol Anim"},{"issue":"5","key":"4171_CR20","doi-asserted-by":"publisher","first-page":"2396","DOI":"10.1007\/s12011-022-03324-1","volume":"201","author":"B Sun","year":"2023","unstructured":"Sun B, Ma J, Te L, Zuo X, Liu J, Li Y, Bi J, Wang S (2023) Zinc-deficient diet causes imbalance in zinc homeostasis and impaired autophagy and impairs semen quality in mice. Biol Trace Elem Res 201(5):2396\u20132406","journal-title":"Biol Trace Elem Res"},{"key":"4171_CR21","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1007\/BF02917357","volume":"43-45","author":"R Dams","year":"1994","unstructured":"Dams R (1994) RNAA as compared to ICP-MS for the analysis of normal human serum. Biol Trace Elem Res 43-45:539\u2013548","journal-title":"Biol Trace Elem Res"},{"issue":"6","key":"4171_CR22","doi-asserted-by":"publisher","first-page":"BSR20171059","DOI":"10.1042\/BSR20171059","volume":"37","author":"F Fang","year":"2017","unstructured":"Fang F, Ni K, Cai Y, Zhao Q, Shang J, Zhang X, Shen S, Xiong C (2017) Busulfan administration produces toxic effects on epididymal morphology and inhibits the expression of ZO-1 and vimentin in the mouse epididymis. Biosci Rep 37(6):BSR20171059","journal-title":"Biosci Rep"},{"issue":"1","key":"4171_CR23","first-page":"231","volume":"32","author":"AK Baltaci","year":"2019","unstructured":"Baltaci AK, Mogulkoc R, Baltaci SB (2019) Review: the role of zinc in the endocrine system. Pak J Pharm Sci 32(1):231\u2013239","journal-title":"Pak J Pharm Sci"},{"issue":"6","key":"4171_CR24","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1093\/humrep\/deu075","volume":"29","author":"C Foresta","year":"2014","unstructured":"Foresta C, Garolla A, Cosci I, Menegazzo M, Ferigo M, Gandin V, De Toni L (2014) Role of zinc trafficking in male fertility: from germ to sperm. Hum Reprod 29(6):1134\u20131145","journal-title":"Hum Reprod"},{"issue":"1","key":"4171_CR25","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1186\/s12864-017-4119-2","volume":"18","author":"R Lawson","year":"2017","unstructured":"Lawson R, Maret W, Hogstrand C (2017) Expression of the ZIP\/SLC39A transporters in \u03b2-cells: a systematic review and integration of multiple datasets. BMC Genomics 18(1):719","journal-title":"BMC Genomics"},{"issue":"2","key":"4171_CR26","doi-asserted-by":"publisher","first-page":"476","DOI":"10.3390\/ijms19020476","volume":"19","author":"A Fukunaka","year":"2018","unstructured":"Fukunaka A, Fujitani Y (2018) Role of zinc homeostasis in the pathogenesis of diabetes and obesity. Int J Mol Sci 19(2):476","journal-title":"Int J Mol Sci"},{"issue":"1","key":"4171_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ymgme.2008.01.010","volume":"94","author":"W Maret","year":"2008","unstructured":"Maret W (2008) A role for metallothionein in the pathogenesis of diabetes and its cardiovascular complications. Mol Genet Metab 94(1):1\u20133","journal-title":"Mol Genet Metab"},{"issue":"3","key":"4171_CR28","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.3892\/mmr.2014.2969","volume":"11","author":"G Dong","year":"2015","unstructured":"Dong G, Chen H, Qi M, Dou Y, Wang Q (2015) Balance between metallothionein and metal response element binding transcription factor 1 is mediated by zinc ions (review). Mol Med Rep 11(3):1582\u20131586","journal-title":"Mol Med Rep"},{"issue":"10","key":"4171_CR29","doi-asserted-by":"publisher","first-page":"e1036","DOI":"10.1002\/iid3.1036","volume":"11","author":"S Wang","year":"2023","unstructured":"Wang S, Lu Y, Chi T, Zhang Y, Zhao Y, Guo H, Feng L (2023) Identification of ferroptosis-related genes in type 2 diabetes mellitus based on machine learning. Immun Inflamm Dis 11(10):e1036","journal-title":"Immun Inflamm Dis"},{"issue":"5","key":"4171_CR30","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1111\/andr.12638","volume":"7","author":"M Weigel Mu\u00f1oz","year":"2019","unstructured":"Weigel Mu\u00f1oz M, Carvajal G, Curci L, Gonzalez SN, Cuasnicu PS (2019) Relevance of CRISP proteins for epididymal physiology, fertilization, and fertility. Andrology 7(5):610\u2013617","journal-title":"Andrology"},{"issue":"4","key":"4171_CR31","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1111\/j.1745-7262.2007.00308.x","volume":"9","author":"DG Cyr","year":"2007","unstructured":"Cyr DG, Gregory M, Dub\u00e9 E, Dufresne J, Chan PT, Hermo L (2007) Orchestration of occludins, claudins, catenins and cadherins as players involved in maintenance of the blood-epididymal barrier in animals and humans. Asian J Androl 9(4):463\u2013475","journal-title":"Asian J Androl"},{"issue":"06","key":"4171_CR32","first-page":"1195","volume":"41","author":"Z Wenqian","year":"2021","unstructured":"Wenqian Z, Xueming Z (2021) Progress in epididymal structure and function. Chin J Prev Vet Med 41(06):1195\u20131199 + 1209","journal-title":"Chin J Prev Vet Med"},{"issue":"2","key":"4171_CR33","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1093\/toxsci\/kft106","volume":"134","author":"J Cai","year":"2013","unstructured":"Cai J, Wang C, Huang L, Chen M, Zuo Z (2013) A novel effect of polychlorinated biphenyls: impairment of the tight junctions in the mouse epididymis. Toxicol Sci 134(2):382\u2013390","journal-title":"Toxicol Sci"},{"issue":"17","key":"4171_CR34","doi-asserted-by":"publisher","first-page":"3930","DOI":"10.1091\/mbc.e09-04-0320","volume":"20","author":"CM Van Itallie","year":"2009","unstructured":"Van Itallie CM, Fanning AS, Bridges A, Anderson JM (2009) ZO-1 stabilizes the tight junction solute barrier through coupling to the perijunctional cytoskeleton. Mol Biol Cell 20(17):3930\u20133940","journal-title":"Mol Biol Cell"},{"issue":"4","key":"4171_CR35","doi-asserted-by":"publisher","first-page":"894","DOI":"10.2337\/diabetes.55.04.06.db05-0355","volume":"55","author":"H Rincon-Choles","year":"2006","unstructured":"Rincon-Choles H, Vasylyeva TL, Pergola PE, Bhandari B, Bhandari K, Zhang JH, Wang W, Gorin Y, Barnes JL, Abboud HE (2006) ZO-1 expression and phosphorylation in diabetic nephropathy. Diabetes 55(4):894\u2013900","journal-title":"Diabetes"},{"issue":"2","key":"4171_CR36","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1002\/jemt.24436","volume":"87","author":"FM Abdel-Maksoud","year":"2024","unstructured":"Abdel-Maksoud FM, Zayed AE, Abdelhafez EA, Hussein MT (2024) Seasonal variations of the epididymis in donkeys (Equus asinus) with special reference to blood epididymal barrier. Microsc Res Tech 87(2):326\u2013338","journal-title":"Microsc Res Tech"},{"issue":"4","key":"4171_CR37","doi-asserted-by":"publisher","first-page":"325","DOI":"10.4161\/spmg.1.4.18948","volume":"1","author":"DG Cyr","year":"2011","unstructured":"Cyr DG (2011) Connexins and pannexins: coordinating cellular communication in the testis and epididymis. Spermatogenesis 1(4):325\u2013338","journal-title":"Spermatogenesis"},{"key":"4171_CR38","doi-asserted-by":"publisher","first-page":"603813","DOI":"10.1155\/2013\/603813","volume":"2013","author":"H Aktu\u011f","year":"2013","unstructured":"Aktu\u011f H, Bozok \u00c7etinta\u015f V, Uysal A, Oltulu F, Yava\u015fo\u011flu A, Akarca S\u00d6, Kosova B (2013) Evaluation of the effects of STZ-induced diabetes on in vitro fertilization and early embryogenesis processes. J Diabetes Res 2013:603813","journal-title":"J Diabetes Res"},{"issue":"2","key":"4171_CR39","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1039\/C4MT00300D","volume":"7","author":"E Heiliger","year":"2015","unstructured":"Heiliger E, Osmanagic A, Haase H, Golenhofen N, Grabrucker AM, Weth A, Baumgartner W (2015) N-cadherin-mediated cell adhesion is regulated by extracellular Zn (2+). Metallomics 7(2):355\u2013362","journal-title":"Metallomics"},{"key":"4171_CR40","doi-asserted-by":"publisher","first-page":"117759","DOI":"10.1016\/j.lfs.2020.117759","volume":"254","author":"J Li","year":"2020","unstructured":"Li J, Li B, Bai F, Ma Y, Liu N, Liu Y, Wang Y, Liu Q (2020) Metformin therapy confers cardioprotection against the remodeling of gap junction in tachycardia-induced atrial fibrillation dog model. Life Sci 254:117759","journal-title":"Life Sci"},{"issue":"8","key":"4171_CR41","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1071\/RD13301","volume":"26","author":"S Arrighi","year":"2014","unstructured":"Arrighi S (2014) Are the basal cells of the mammalian epididymis still an enigma? Reprod Fertil Dev 26(8):1061\u20131071","journal-title":"Reprod Fertil Dev"},{"key":"4171_CR42","doi-asserted-by":"publisher","first-page":"102027","DOI":"10.1016\/j.redox.2021.102027","volume":"44","author":"M Galli","year":"2021","unstructured":"Galli M, Hameed A, \u017bbikowski A, Zabielski P (2021) Aquaporins in insulin resistance and diabetes: more than channels! Redox Biol 44:102027","journal-title":"Redox Biol"},{"issue":"8","key":"4171_CR43","doi-asserted-by":"publisher","first-page":"e14119","DOI":"10.1111\/and.14119","volume":"53","author":"P Mohammadi","year":"2021","unstructured":"Mohammadi P, Mesbah-Namin SA, Movahedin M (2021) Attenuation of aquaporin-3 may be contributing to low sperm motility and is associated with activated caspase-3 in asthenozoospermic individuals. Andrologia 53(8):e14119","journal-title":"Andrologia"},{"issue":"5","key":"4171_CR44","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1248\/bpb.29.991","volume":"29","author":"M Asai","year":"2006","unstructured":"Asai M, Higuchi S, Kubota M, Iguchi K, Usui S, Hirano K (2006) Regulators for blood glucose level affect gene expression of aquaporin 3. Biol Pharm Bull 29(5):991\u2013996","journal-title":"Biol Pharm Bull"},{"issue":"15","key":"4171_CR45","doi-asserted-by":"publisher","first-page":"3782","DOI":"10.3390\/ijms20153782","volume":"20","author":"N Ikarashi","year":"2019","unstructured":"Ikarashi N, Mizukami N, Kon R, Kaneko M, Uchino R, Fujisawa I, Fukuda N, Sakai H, Kamei J (2019) Study of the mechanism underlying the onset of diabetic xeroderma focusing on an aquaporin-3 in a streptozotocin-induced diabetic mouse model. Int J Mol Sci 20(15):3782","journal-title":"Int J Mol Sci"},{"issue":"4","key":"4171_CR46","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1111\/rda.12957","volume":"52","author":"BC Schimming","year":"2017","unstructured":"Schimming BC, Baumam C, Pinheiro P, de Matteis R, Domeniconi RF (2017) Aquaporin 9 is expressed in the epididymis of immature and mature pigs. Reprod Domest Anim 52(4):617\u2013624","journal-title":"Reprod Domest Anim"},{"issue":"3","key":"4171_CR47","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1080\/19396368.2022.2033350","volume":"68","author":"A Kannan","year":"2022","unstructured":"Kannan A, Mariajoseph-Antony LF, Panneerselvam A, Loganathan C, Kiduva Jothiraman D, Anbarasu K, Prahalathan C (2022) Aquaporin 9 regulates Leydig cell steroidogenesis in diabetes. Syst Biol Reprod Med 68(3):213\u2013226","journal-title":"Syst Biol Reprod Med"},{"issue":"6","key":"4171_CR48","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1071\/RD14237","volume":"28","author":"N Prieto-Mart\u00ednez","year":"2016","unstructured":"Prieto-Mart\u00ednez N, Vilagran I, Morat\u00f3 R, Rodr\u00edguez-Gil JE, Yeste M, Bonet S (2016) Aquaporins 7 and 11 in boar spermatozoa: detection, localisation and relationship with sperm quality. Reprod Fertil Dev 28(6):663\u2013672","journal-title":"Reprod Fertil Dev"},{"issue":"5","key":"4171_CR49","doi-asserted-by":"publisher","first-page":"F416","DOI":"10.1152\/ajprenal.00295.2015","volume":"310","author":"DP Choma","year":"2016","unstructured":"Choma DP, Vanacore R, Naylor H, Zimmerman IA, Pavlichenko A, Pavlichenko A, Foye L, Carbone DP, Harris RC, Dikov MM, Tchekneva EE (2016) Aquaporin 11 variant associates with kidney disease in type 2 diabetic patients. Am J Physiol Renal Physiol 310(5):F416\u2013F425","journal-title":"Am J Physiol Renal Physiol"},{"issue":"6","key":"4171_CR50","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1093\/ndt\/gfy219","volume":"34","author":"B Han","year":"2019","unstructured":"Han B, Wu X, Huang PP, Zhu FX, Liu S (2019) Aquaporin 11 rs2276415 variant and progression of chronic kidney disease. Nephrol Dial Transplant 34(6):970\u2013973","journal-title":"Nephrol Dial Transplant"}],"container-title":["Biological Trace Element Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-024-04171-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12011-024-04171-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-024-04171-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T11:25:30Z","timestamp":1736162730000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12011-024-04171-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,8]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["4171"],"URL":"https:\/\/doi.org\/10.1007\/s12011-024-04171-y","relation":{},"ISSN":["0163-4984","1559-0720"],"issn-type":[{"value":"0163-4984","type":"print"},{"value":"1559-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,8]]},"assertion":[{"value":"7 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 April 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments were conducted in accordance with the ethical guidelines of the Ethics Committee of Hebei Reproductive Health Hospital (Hebei Reproductive Health Research Institute).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}