{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T20:11:40Z","timestamp":1778271100482,"version":"3.51.4"},"reference-count":96,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T00:00:00Z","timestamp":1715904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T00:00:00Z","timestamp":1715904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN 250139"],"award-info":[{"award-number":["RGPIN 250139"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biol Trace Elem Res"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1007\/s12011-024-04225-1","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T06:01:51Z","timestamp":1715925711000},"page":"1000-1015","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Alteration of Hepatic Cytochrome P450 Expression and Arachidonic Acid Metabolism by Arsenic Trioxide (ATO) in C57BL\/6 Mice"],"prefix":"10.1007","volume":"203","author":[{"given":"Mahmoud A.","family":"El-Ghiaty","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed A.","family":"Alqahtani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara R.","family":"El-Mahrouk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fadumo A.","family":"Isse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad H.","family":"Alammari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayman O. S.","family":"El-Kadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,5,17]]},"reference":[{"key":"4225_CR1","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1007\/s00775-018-1537-9","volume":"23","author":"M Hoonjan","year":"2018","unstructured":"Hoonjan M, Jadhav V, Bhatt P (2018) Arsenic trioxide: insights into its evolution to an anticancer agent. J Biol Inorg Chem 23:313\u2013329. https:\/\/doi.org\/10.1007\/s00775-018-1537-9","journal-title":"J Biol Inorg Chem"},{"issue":"Suppl 2","key":"4225_CR2","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1634\/theoncologist.6-suppl_2-22","volume":"6","author":"AJ Murgo","year":"2001","unstructured":"Murgo AJ (2001) Clinical trials of arsenic trioxide in hematologic and solid tumors: overview of the National Cancer Institute Cooperative Research and Development Studies. Oncologist 6(Suppl 2):22\u201328. https:\/\/doi.org\/10.1634\/theoncologist.6-suppl_2-22","journal-title":"Oncologist"},{"key":"4225_CR3","doi-asserted-by":"publisher","first-page":"115299","DOI":"10.1016\/j.taap.2020.115299","volume":"409","author":"QQ Wang","year":"2020","unstructured":"Wang QQ, Hua HY, Naranmandura H, Zhu HH (2020) Balance between the toxicity and anticancer activity of arsenic trioxide in treatment of acute promyelocytic leukemia. Toxicol Appl Pharmacol 409:115299. https:\/\/doi.org\/10.1016\/j.taap.2020.115299","journal-title":"Toxicol Appl Pharmacol"},{"key":"4225_CR4","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-023-03676-2","author":"Z Zhang","year":"2023","unstructured":"Zhang Z, Zhang S, Zhang F, Zhang Q, Wei H et al (2023) Clinical Indicators of Hepatotoxicity in Newly Diagnosed Acute Promyelocytic Leukemia Patients Undergoing Arsenic Trioxide Treatment. Biol Trace Elem Res. https:\/\/doi.org\/10.1007\/s12011-023-03676-2","journal-title":"Biol Trace Elem Res"},{"key":"4225_CR5","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1111\/j.1745-7254.2008.00771.x","volume":"29","author":"WY Au","year":"2008","unstructured":"Au WY, Kwong YL (2008) Arsenic trioxide: safety issues and their management. Acta Pharmacol Sin 29:296\u2013304. https:\/\/doi.org\/10.1111\/j.1745-7254.2008.00771.x","journal-title":"Acta Pharmacol Sin"},{"key":"4225_CR6","doi-asserted-by":"publisher","first-page":"119030","DOI":"10.1016\/j.ica.2019.119030","volume":"496","author":"\u00d0 Miodragovi\u0107","year":"2019","unstructured":"Miodragovi\u0107 \u00d0, Swindell EP, Waxali ZS, Bogachkov A, O\u2019Halloran TV (2019) Beyond cisplatin: combination therapy with arsenic trioxide. Inorganica Chim Acta 496:119030. https:\/\/doi.org\/10.1016\/j.ica.2019.119030","journal-title":"Inorganica Chim Acta"},{"key":"4225_CR7","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1080\/01635581.2018.1460676","volume":"70","author":"RC Vineetha","year":"2018","unstructured":"Vineetha RC, Archana V, Binu P, Arathi P, Nair RH (2018) L-ascorbic acid and \u03b1-tocopherol reduces hepatotoxicity associated with arsenic trioxide chemotherapy by modulating Nrf2 and Bcl2 transcription factors in chang liver cells. Nutr Cancer 70:684\u2013696. https:\/\/doi.org\/10.1080\/01635581.2018.1460676","journal-title":"Nutr Cancer"},{"key":"4225_CR8","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1007\/s12011-016-0821-1","volume":"176","author":"D Yang","year":"2017","unstructured":"Yang D, Lv Z, Zhang H, Liu B, Jiang H et al (2017) Activation of the Nrf2 Signaling Pathway Involving KLF9 Plays a Critical Role in Allicin Resisting Against Arsenic Trioxide-Induced Hepatotoxicity in Rats. Biol Trace Elem Res 176:192\u2013200. https:\/\/doi.org\/10.1007\/s12011-016-0821-1","journal-title":"Biol Trace Elem Res"},{"key":"4225_CR9","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.exphem.2006.10.004","volume":"35","author":"A Sasaki","year":"2007","unstructured":"Sasaki A, Oshima Y, Fujimura A (2007) An approach to elucidate potential mechanism of renal toxicity of arsenic trioxide. Exp Hematol 35:252\u2013262. https:\/\/doi.org\/10.1016\/j.exphem.2006.10.004","journal-title":"Exp Hematol"},{"key":"4225_CR10","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/s12012-018-09504-7","volume":"19","author":"VP Vineetha","year":"2019","unstructured":"Vineetha VP, Raghu KG (2019) An overview on arsenic trioxide-induced cardiotoxicity. Cardiovasc Toxicol 19:105\u2013119. https:\/\/doi.org\/10.1007\/s12012-018-09504-7","journal-title":"Cardiovasc Toxicol"},{"key":"4225_CR11","doi-asserted-by":"publisher","first-page":"534769","DOI":"10.1155\/2015\/534769","volume":"2015","author":"VK Gupta","year":"2015","unstructured":"Gupta VK, Singh S, Agrawal A, Siddiqi NJ, Sharma B (2015) Phytochemicals mediated remediation of neurotoxicity induced by heavy metals. Biochem Res Int 2015:534769. https:\/\/doi.org\/10.1155\/2015\/534769","journal-title":"Biochem Res Int"},{"key":"4225_CR12","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1146\/annurev-pharmtox-051921-020936","volume":"63","author":"MA El-Ghiaty","year":"2023","unstructured":"El-Ghiaty MA, El-Kadi AOS (2023) The duality of arsenic metabolism: impact on human health. Annu Rev Pharmacol Toxicol 63:341\u2013358. https:\/\/doi.org\/10.1146\/annurev-pharmtox-051921-020936","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"4225_CR13","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1007\/s12011-019-01957-3","volume":"196","author":"A Kumar","year":"2020","unstructured":"Kumar A, Khushboo PR, Sharma B (2020) Modulation of superoxide dismutase activity by mercury, lead, and arsenic. Biol Trace Elem Res 196:654\u2013661. https:\/\/doi.org\/10.1007\/s12011-019-01957-3","journal-title":"Biol Trace Elem Res"},{"key":"4225_CR14","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1021\/tx700079z","volume":"21","author":"FP Guengerich","year":"2008","unstructured":"Guengerich FP (2008) Cytochrome p450 and chemical toxicology. Chem Res Toxicol 21:70\u201383. https:\/\/doi.org\/10.1021\/tx700079z","journal-title":"Chem Res Toxicol"},{"key":"4225_CR15","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1021\/acs.chemrestox.6b00226","volume":"30","author":"FP Guengerich","year":"2017","unstructured":"Guengerich FP (2017) Intersection of the Roles of Cytochrome P450 Enzymes with Xenobiotic and Endogenous Substrates: Relevance to Toxicity and Drug Interactions. Chem Res Toxicol 30:2\u201312. https:\/\/doi.org\/10.1021\/acs.chemrestox.6b00226","journal-title":"Chem Res Toxicol"},{"key":"4225_CR16","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.17179\/excli2021-3890","volume":"20","author":"MA El-Ghiaty","year":"2021","unstructured":"El-Ghiaty MA, El-Kadi AOS (2021) Arsenic: Various species with different effects on cytochrome P450 regulation in humans. Excli j 20:1184\u2013242. https:\/\/doi.org\/10.17179\/excli2021-3890","journal-title":"Excli j"},{"key":"4225_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/03602532.2023.2254525","volume":"55","author":"MA El-Ghiaty","year":"2023","unstructured":"El-Ghiaty MA, El-Mahrouk SR, Alqahtani MA, El-Kadi AOS (2023) Differential modulation of cytochrome P450 enzymes by arsenicals in non-human experimental models. Drug Metab Rev 55:1\u201323. https:\/\/doi.org\/10.1080\/03602532.2023.2254525","journal-title":"Drug Metab Rev"},{"key":"4225_CR18","doi-asserted-by":"publisher","first-page":"110049","DOI":"10.1016\/j.cbi.2022.110049","volume":"364","author":"MA El-Ghiaty","year":"2022","unstructured":"El-Ghiaty MA, Alqahtani MA, El-Kadi AOS (2022) Down-regulation of hepatic cytochromes P450 1A1 and 1A2 by arsenic trioxide (ATO) in vivo and in vitro: A role of heme oxygenase 1. Chem Biol Interact 364:110049. https:\/\/doi.org\/10.1016\/j.cbi.2022.110049","journal-title":"Chem Biol Interact"},{"key":"4225_CR19","doi-asserted-by":"publisher","first-page":"104214","DOI":"10.1016\/j.etap.2023.104214","volume":"101","author":"MA El-Ghiaty","year":"2023","unstructured":"El-Ghiaty MA, Alqahtani MA, El-Kadi AOS (2023) Arsenic trioxide (ATO) up-regulates cytochrome P450 1A (CYP1A) enzymes in murine hepatoma Hepa-1c1c7 cell line. Environ Toxicol Pharmacol 101:104214. https:\/\/doi.org\/10.1016\/j.etap.2023.104214","journal-title":"Environ Toxicol Pharmacol"},{"key":"4225_CR20","doi-asserted-by":"publisher","first-page":"106400","DOI":"10.1016\/j.prostaglandins.2019.106400","volume":"147","author":"SM Shoieb","year":"2020","unstructured":"Shoieb SM, El-Ghiaty MA, Alqahtani MA, El-Kadi AOS (2020) Cytochrome P450-derived eicosanoids and inflammation in liver diseases. Prostaglandins Other Lipid Mediat 147:106400. https:\/\/doi.org\/10.1016\/j.prostaglandins.2019.106400","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"4225_CR21","doi-asserted-by":"publisher","first-page":"828","DOI":"10.3389\/fphar.2020.00828","volume":"11","author":"EA Evangelista","year":"2020","unstructured":"Evangelista EA, Cho CW, Aliwarga T, Totah RA (2020) Expression and function of eicosanoid-producing cytochrome P450 enzymes in solid tumors. Front Pharmacol 11:828. https:\/\/doi.org\/10.3389\/fphar.2020.00828","journal-title":"Front Pharmacol"},{"key":"4225_CR22","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.bbalip.2014.10.008","volume":"1851","author":"WS Powell","year":"2015","unstructured":"Powell WS, Rokach J (2015) Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid. Biochim Biophys Acta 1851:340\u2013355. https:\/\/doi.org\/10.1016\/j.bbalip.2014.10.008","journal-title":"Biochim Biophys Acta"},{"key":"4225_CR23","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1038\/s41392-020-00443-w","volume":"6","author":"B Wang","year":"2021","unstructured":"Wang B, Wu L, Chen J, Dong L, Chen C et al (2021) Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets. Signal Transduct Target Ther 6:94. https:\/\/doi.org\/10.1038\/s41392-020-00443-w","journal-title":"Signal Transduct Target Ther"},{"key":"4225_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/03602532.2016.1257021","volume":"49","author":"AA El-Sherbeni","year":"2017","unstructured":"El-Sherbeni AA, El-Kadi AO (2017) Microsomal cytochrome P450 as a target for drug discovery and repurposing. Drug Metab Rev 49:1\u201317. https:\/\/doi.org\/10.1080\/03602532.2016.1257021","journal-title":"Drug Metab Rev"},{"key":"4225_CR25","doi-asserted-by":"publisher","first-page":"106701","DOI":"10.1016\/j.prostaglandins.2022.106701","volume":"165","author":"FA Isse","year":"2023","unstructured":"Isse FA, Alammari AH, El-Sherbeni AA, Brocks DR, El-Kadi AOS (2023) The enantioselective separation and quantitation of the hydroxy-metabolites of arachidonic acid by liquid chromatography - tandem mass spectrometry. Prostaglandins Other Lipid Mediat 165:106701. https:\/\/doi.org\/10.1016\/j.prostaglandins.2022.106701","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"4225_CR26","doi-asserted-by":"publisher","first-page":"3285","DOI":"10.3390\/ijms19113285","volume":"19","author":"T Sonnweber","year":"2018","unstructured":"Sonnweber T, Pizzini A, Nairz M, Weiss G, Tancevski I (2018) Arachidonic acid metabolites in cardiovascular and metabolic diseases. Int J Mol Sci 19:3285. https:\/\/doi.org\/10.3390\/ijms19113285","journal-title":"Int J Mol Sci"},{"key":"4225_CR27","doi-asserted-by":"publisher","first-page":"113981","DOI":"10.1016\/j.biopha.2022.113981","volume":"156","author":"L Dong","year":"2022","unstructured":"Dong L, Wang H, Chen K, Li Y (2022) Roles of hydroxyeicosatetraenoic acids in diabetes (HETEs and diabetes). Biomed Pharmacother 156:113981. https:\/\/doi.org\/10.1016\/j.biopha.2022.113981","journal-title":"Biomed Pharmacother"},{"key":"4225_CR28","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.molmed.2008.08.005","volume":"14","author":"H Harizi","year":"2008","unstructured":"Harizi H, Corcuff JB, Gualde N (2008) Arachidonic-acid-derived eicosanoids: roles in biology and immunopathology. Trends Mol Med 14:461\u2013469. https:\/\/doi.org\/10.1016\/j.molmed.2008.08.005","journal-title":"Trends Mol Med"},{"key":"4225_CR29","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1111\/all.14295","volume":"76","author":"M Sokolowska","year":"2021","unstructured":"Sokolowska M, Rovati GE, Diamant Z, Untersmayr E, Schwarze J et al (2021) Current perspective on eicosanoids in asthma and allergic diseases: EAACI Task Force consensus report, part I. Allergy 76:114\u2013130. https:\/\/doi.org\/10.1111\/all.14295","journal-title":"Allergy"},{"key":"4225_CR30","doi-asserted-by":"publisher","first-page":"716801","DOI":"10.3389\/fphar.2021.716801","volume":"12","author":"KD Ni","year":"2021","unstructured":"Ni KD, Liu JY (2021) The Functions of Cytochrome P450 \u03c9-hydroxylases and the associated eicosanoids in inflammation-related diseases. Front Pharmacol 12:716801. https:\/\/doi.org\/10.3389\/fphar.2021.716801","journal-title":"Front Pharmacol"},{"key":"4225_CR31","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.3390\/ijms17091583","volume":"17","author":"B Titz","year":"2016","unstructured":"Titz B, Luettich K, Leroy P, Boue S, Vuillaume G et al (2016) Alterations in serum polyunsaturated fatty acids and eicosanoids in patients with mild to moderate chronic obstructive pulmonary disease (COPD). Int J Mol Sci 17:1583. https:\/\/doi.org\/10.3390\/ijms17091583","journal-title":"Int J Mol Sci"},{"key":"4225_CR32","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1042\/cs20050012","volume":"108","author":"RP Charbeneau","year":"2005","unstructured":"Charbeneau RP, Peters-Golden M (2005) Eicosanoids: mediators and therapeutic targets in fibrotic lung disease. Clin Sci (Lond) 108:479\u2013491. https:\/\/doi.org\/10.1042\/cs20050012","journal-title":"Clin Sci (Lond)"},{"key":"4225_CR33","doi-asserted-by":"publisher","first-page":"114732","DOI":"10.1016\/j.bcp.2021.114732","volume":"192","author":"ML Alvarez","year":"2021","unstructured":"Alvarez ML, Lorenzetti F (2021) Role of eicosanoids in liver repair, regeneration and cancer. Biochem Pharmacol 192:114732. https:\/\/doi.org\/10.1016\/j.bcp.2021.114732","journal-title":"Biochem Pharmacol"},{"key":"4225_CR34","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1097\/mnh.0000000000000088","volume":"24","author":"F Fan","year":"2015","unstructured":"Fan F, Muroya Y, Roman RJ (2015) Cytochrome P450 eicosanoids in hypertension and renal disease. Curr Opin Nephrol Hypertens 24:37\u201346. https:\/\/doi.org\/10.1097\/mnh.0000000000000088","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"4225_CR35","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.prostaglandins.2018.10.001","volume":"139","author":"C Fava","year":"2018","unstructured":"Fava C, Bonafini S (2018) Eicosanoids via CYP450 and cardiovascular disease: Hints from genetic and nutrition studies. Prostaglandins Other Lipid Mediat 139:41\u201347. https:\/\/doi.org\/10.1016\/j.prostaglandins.2018.10.001","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"4225_CR36","doi-asserted-by":"publisher","first-page":"173","DOI":"10.3109\/03602532.2012.754460","volume":"45","author":"AM Alsaad","year":"2013","unstructured":"Alsaad AM, Zordoky BN, Tse MM, El-Kadi AO (2013) Role of cytochrome P450-mediated arachidonic acid metabolites in the pathogenesis of cardiac hypertrophy. Drug Metab Rev 45:173\u2013195. https:\/\/doi.org\/10.3109\/03602532.2012.754460","journal-title":"Drug Metab Rev"},{"key":"4225_CR37","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1007\/s10555-010-9264-x","volume":"29","author":"D Panigrahy","year":"2010","unstructured":"Panigrahy D, Kaipainen A, Greene ER, Huang S (2010) Cytochrome P450-derived eicosanoids: the neglected pathway in cancer. Cancer Metastasis Rev 29:723\u2013735. https:\/\/doi.org\/10.1007\/s10555-010-9264-x","journal-title":"Cancer Metastasis Rev"},{"key":"4225_CR38","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25:402\u2013408. https:\/\/doi.org\/10.1006\/meth.2001.1262","journal-title":"Methods"},{"key":"4225_CR39","doi-asserted-by":"publisher","first-page":"110447","DOI":"10.1016\/j.cbi.2023.110447","volume":"376","author":"MA El-Ghiaty","year":"2023","unstructured":"El-Ghiaty MA, Alqahtani MA, El-Kadi AOS (2023) Modulation of cytochrome P450 1A (CYP1A) enzymes by monomethylmonothioarsonic acid (MMMTA(V)) in vivo and in vitro. Chem Biol Interact 376:110447. https:\/\/doi.org\/10.1016\/j.cbi.2023.110447","journal-title":"Chem Biol Interact"},{"key":"4225_CR40","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265\u2013275","journal-title":"J Biol Chem"},{"key":"4225_CR41","doi-asserted-by":"publisher","first-page":"27","DOI":"10.4103\/0976-0105.177703","volume":"7","author":"AB Nair","year":"2016","unstructured":"Nair AB, Jacob S (2016) A simple practice guide for dose conversion between animals and human. J Basic Clin Pharm 7:27\u201331. https:\/\/doi.org\/10.4103\/0976-0105.177703","journal-title":"J Basic Clin Pharm"},{"key":"4225_CR42","first-page":"6033","volume":"59","author":"YS Lew","year":"1999","unstructured":"Lew YS, Brown SL, Griffin RJ, Song CW, Kim JH (1999) Arsenic trioxide causes selective necrosis in solid murine tumors by vascular shutdown. Cancer Res 59:6033\u20136037","journal-title":"Cancer Res"},{"key":"4225_CR43","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1080\/0265673031000124316","volume":"19","author":"RJ Griffin","year":"2003","unstructured":"Griffin RJ, Monzen H, Williams BW, Park H, Lee SH, Song CW (2003) Arsenic trioxide induces selective tumour vascular damage via oxidative stress and increases thermosensitivity of tumours. Int J Hyperthermia 19:575\u2013589. https:\/\/doi.org\/10.1080\/0265673031000124316","journal-title":"Int J Hyperthermia"},{"key":"4225_CR44","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1016\/j.ijrobp.2004.12.058","volume":"61","author":"RJ Griffin","year":"2005","unstructured":"Griffin RJ, Williams BW, Park HJ, Song CW (2005) Preferential action of arsenic trioxide in solid-tumor microenvironment enhances radiation therapy. Int J Radiat Oncol Biol Phys 61:1516\u20131522. https:\/\/doi.org\/10.1016\/j.ijrobp.2004.12.058","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"4225_CR45","first-page":"4202","volume":"62","author":"YS Lew","year":"2002","unstructured":"Lew YS, Kolozsvary A, Brown SL, Kim JH (2002) Synergistic interaction with arsenic trioxide and fractionated radiation in locally advanced murine tumor. Cancer Res 62:4202\u20134205","journal-title":"Cancer Res"},{"key":"4225_CR46","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1038\/sj.neo.7900123","volume":"2","author":"RJ Griffin","year":"2000","unstructured":"Griffin RJ, Lee SH, Rood KL, Stewart MJ, Lyons JC et al (2000) Use of arsenic trioxide as an antivascular and thermosensitizing agent in solid tumors. Neoplasia 2:555\u2013560. https:\/\/doi.org\/10.1038\/sj.neo.7900123","journal-title":"Neoplasia"},{"key":"4225_CR47","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/934918","volume":"2012","author":"RJ Griffin","year":"2012","unstructured":"Griffin RJ, Williams BW, Koonce NA, Bischof JC, Song CW et al (2012) Vascular disrupting agent arsenic trioxide enhances thermoradiotherapy of solid tumors. J Oncol 2012:934918. https:\/\/doi.org\/10.1155\/2012\/934918","journal-title":"J Oncol"},{"key":"4225_CR48","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1139\/cjpp-2014-0136","volume":"92","author":"A Anwar-Mohamed","year":"2014","unstructured":"Anwar-Mohamed A, Elshenawy OH, El-Sherbeni AA, Abdelrady M, El-Kadi AO (2014) Acute arsenic treatment alters arachidonic acid and its associated metabolite levels in the brain of C57Bl\/6 mice. Can J Physiol Pharmacol 92:693\u2013702. https:\/\/doi.org\/10.1139\/cjpp-2014-0136","journal-title":"Can J Physiol Pharmacol"},{"key":"4225_CR49","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1152\/physrev.00021.2001","volume":"82","author":"RJ Roman","year":"2002","unstructured":"Roman RJ (2002) P-450 metabolites of arachidonic acid in the control of cardiovascular function. Physiol Rev 82:131\u2013185. https:\/\/doi.org\/10.1152\/physrev.00021.2001","journal-title":"Physiol Rev"},{"key":"4225_CR50","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.3109\/00498254.2012.693971","volume":"42","author":"A Anwar-Mohamed","year":"2012","unstructured":"Anwar-Mohamed A, El-Sherbeni AA, Kim SH, Althurwi HN, Zordoky BN, El-Kadi AO (2012) Acute arsenic toxicity alters cytochrome P450 and soluble epoxide hydrolase and their associated arachidonic acid metabolism in C57Bl\/6 mouse heart. Xenobiotica 42:1235\u20131247. https:\/\/doi.org\/10.3109\/00498254.2012.693971","journal-title":"Xenobiotica"},{"key":"4225_CR51","doi-asserted-by":"publisher","first-page":"5271","DOI":"10.3892\/mmr.2020.11587","volume":"22","author":"Z Zhao","year":"2020","unstructured":"Zhao Z, Li J, Zheng B, Liang Y, Shi J et al (2020) Ameliorative effects and mechanism of crocetin in arsenic trioxide-induced cardiotoxicity in rats. Mol Med Rep 22:5271\u20135281. https:\/\/doi.org\/10.3892\/mmr.2020.11587","journal-title":"Mol Med Rep"},{"key":"4225_CR52","doi-asserted-by":"publisher","first-page":"112167","DOI":"10.1016\/j.biopha.2021.112167","volume":"143","author":"M Zhang","year":"2021","unstructured":"Zhang M, Xue Y, Zheng B, Li L, Chu X et al (2021) Liquiritigenin protects against arsenic trioxide-induced liver injury by inhibiting oxidative stress and enhancing mTOR-mediated autophagy. Biomed Pharmacother 143:112167. https:\/\/doi.org\/10.1016\/j.biopha.2021.112167","journal-title":"Biomed Pharmacother"},{"key":"4225_CR53","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/s0006-2952(99)00066-0","volume":"58","author":"F Piscaglia","year":"1999","unstructured":"Piscaglia F, Knittel T, Kobold D, Barnikol-Watanabe S, Di Rocco P, Ramadori G (1999) Cellular localization of hepatic cytochrome 1B1 expression and its regulation by aromatic hydrocarbons and inflammatory cytokines. Biochem Pharmacol 58:157\u2013165. https:\/\/doi.org\/10.1016\/s0006-2952(99)00066-0","journal-title":"Biochem Pharmacol"},{"key":"4225_CR54","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1093\/toxsci\/kfm149","volume":"99","author":"L Umannov\u00e1","year":"2007","unstructured":"Umannov\u00e1 L, Zatloukalov\u00e1 J, Machala M, Krcm\u00e1r P, M\u00e1jkov\u00e1 Z et al (2007) Tumor necrosis factor-alpha modulates effects of aryl hydrocarbon receptor ligands on cell proliferation and expression of cytochrome P450 enzymes in rat liver \u201cstem-like\u201d cells. Toxicol Sci 99:79\u201389. https:\/\/doi.org\/10.1093\/toxsci\/kfm149","journal-title":"Toxicol Sci"},{"key":"4225_CR55","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/s0378-4274(02)00417-4","volume":"138","author":"C Malaplate-Armand","year":"2003","unstructured":"Malaplate-Armand C, Ferrari L, Masson C, Siest G, Batt AM (2003) Astroglial CYP1B1 up-regulation in inflammatory\/oxidative toxic conditions: IL-1beta effect and protection by N-acetylcysteine. Toxicol Lett 138:243\u2013251. https:\/\/doi.org\/10.1016\/s0378-4274(02)00417-4","journal-title":"Toxicol Lett"},{"key":"4225_CR56","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1124\/mol.62.3.638","volume":"62","author":"JM Maglich","year":"2002","unstructured":"Maglich JM, Stoltz CM, Goodwin B, Hawkins-Brown D, Moore JT, Kliewer SA (2002) Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification. Mol Pharmacol 62:638\u2013646. https:\/\/doi.org\/10.1124\/mol.62.3.638","journal-title":"Mol Pharmacol"},{"key":"4225_CR57","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.bcp.2008.05.020","volume":"77","author":"C K\u00f6hle","year":"2009","unstructured":"K\u00f6hle C, Bock KW (2009) Coordinate regulation of human drug-metabolizing enzymes, and conjugate transporters by the Ah receptor, pregnane X receptor and constitutive androstane receptor. Biochem Pharmacol 77:689\u2013699. https:\/\/doi.org\/10.1016\/j.bcp.2008.05.020","journal-title":"Biochem Pharmacol"},{"key":"4225_CR58","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/j.bcp.2014.06.003","volume":"90","author":"Y Wang","year":"2014","unstructured":"Wang Y, Masuyama H, Nobumoto E, Zhang G, Hiramatsu Y (2014) The inhibition of constitutive androstane receptor-mediated pathway enhances the effects of anticancer agents in ovarian cancer cells. Biochem Pharmacol 90:356\u2013366. https:\/\/doi.org\/10.1016\/j.bcp.2014.06.003","journal-title":"Biochem Pharmacol"},{"key":"4225_CR59","doi-asserted-by":"publisher","first-page":"165977","DOI":"10.1016\/j.bbadis.2020.165977","volume":"1867","author":"M Cornejo","year":"2021","unstructured":"Cornejo M, Mieres-Castro D, Blanco EH, Beltr\u00e1n AR, Araya JE et al (2021) Arsenic trioxide-increased MDCK cells proliferation requires activator protein 1-mediated increase of the sodium\/proton exchanger 1 activity. Biochim Biophys Acta Mol Basis Dis 1867:165977. https:\/\/doi.org\/10.1016\/j.bbadis.2020.165977","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"4225_CR60","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/j.phrs.2009.12.015","volume":"61","author":"A Anwar-mohamed","year":"2010","unstructured":"Anwar-mohamed A, Zordoky BN, Aboutabl ME, El-Kadi AO (2010) Alteration of cardiac cytochrome P450-mediated arachidonic acid metabolism in response to lipopolysaccharide-induced acute systemic inflammation. Pharmacol Res 61:410\u2013418. https:\/\/doi.org\/10.1016\/j.phrs.2009.12.015","journal-title":"Pharmacol Res"},{"key":"4225_CR61","first-page":"17","volume":"29","author":"SR Mitchell","year":"2001","unstructured":"Mitchell SR, Sewer MB, Kardar SS, Morgan ET (2001) Characterization of CYP4A induction in rat liver by inflammatory stimuli: dependence on sex, strain, and inflammation-evoked hypophagia. Drug Metab Dispos 29:17\u201322","journal-title":"Drug Metab Dispos"},{"key":"4225_CR62","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1124\/dmd.110.035287","volume":"39","author":"KN Theken","year":"2011","unstructured":"Theken KN, Deng Y, Kannon MA, Miller TM, Poloyac SM, Lee CR (2011) Activation of the acute inflammatory response alters cytochrome P450 expression and eicosanoid metabolism. Drug Metab Dispos 39:22\u201329. https:\/\/doi.org\/10.1124\/dmd.110.035287","journal-title":"Drug Metab Dispos"},{"key":"4225_CR63","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1038\/leu.2008.59","volume":"22","author":"A Habib","year":"2008","unstructured":"Habib A, Hamade E, Mahfouz R, Nasrallah MS, de Th\u00e9 H, Bazarbachi A (2008) Arsenic trioxide inhibits ATRA-induced prostaglandin E2 and cyclooxygenase-1 in NB4 cells, a model of acute promyelocytic leukemia. Leukemia 22:1125\u20131130. https:\/\/doi.org\/10.1038\/leu.2008.59","journal-title":"Leukemia"},{"key":"4225_CR64","doi-asserted-by":"publisher","first-page":"2661","DOI":"10.3390\/ijms18122661","volume":"18","author":"TF Borin","year":"2017","unstructured":"Borin TF, Angara K, Rashid MH, Achyut BR, Arbab AS (2017) Arachidonic acid metabolite as a novel therapeutic target in breast cancer metastasis. Int J Mol Sci 18:2661. https:\/\/doi.org\/10.3390\/ijms18122661","journal-title":"Int J Mol Sci"},{"key":"4225_CR65","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.prostaglandins.2015.12.007","volume":"122","author":"H Huang","year":"2016","unstructured":"Huang H, Al-Shabrawey M, Wang MH (2016) Cyclooxygenase- and cytochrome P450-derived eicosanoids in stroke. Prostaglandins Other Lipid Mediat 122:45\u201353. https:\/\/doi.org\/10.1016\/j.prostaglandins.2015.12.007","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"4225_CR66","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1042\/bj20061328","volume":"403","author":"DN Muller","year":"2007","unstructured":"Muller DN, Schmidt C, Barbosa-Sicard E, Wellner M, Gross V et al (2007) Mouse Cyp4a isoforms: enzymatic properties, gender- and strain-specific expression, and role in renal 20-hydroxyeicosatetraenoic acid formation. Biochem J 403:109\u2013118. https:\/\/doi.org\/10.1042\/bj20061328","journal-title":"Biochem J"},{"key":"4225_CR67","doi-asserted-by":"publisher","first-page":"719","DOI":"10.3109\/00498254.2012.754113","volume":"43","author":"A Anwar-Mohamed","year":"2013","unstructured":"Anwar-Mohamed A, El-Sherbeni A, Kim SH, Elshenawy OH, Althurwi HN et al (2013) Acute arsenic treatment alters cytochrome P450 expression and arachidonic acid metabolism in lung, liver and kidney of C57Bl\/6 mice. Xenobiotica 43:719\u2013729. https:\/\/doi.org\/10.3109\/00498254.2012.754113","journal-title":"Xenobiotica"},{"key":"4225_CR68","doi-asserted-by":"publisher","first-page":"8921","DOI":"10.1523\/jneurosci.0148-16.2016","volume":"36","author":"N Ziegler","year":"2016","unstructured":"Ziegler N, Awwad K, Fisslthaler B, Reis M, Devraj K et al (2016) \u03b2-Catenin Is Required for Endothelial Cyp1b1 Regulation Influencing Metabolic Barrier Function. J Neurosci 36:8921\u20138935. https:\/\/doi.org\/10.1523\/jneurosci.0148-16.2016","journal-title":"J Neurosci"},{"key":"4225_CR69","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.vph.2016.04.002","volume":"83","author":"L Chen","year":"2016","unstructured":"Chen L, Joseph G, Zhang FF, Nguyen H, Jiang H et al (2016) 20-HETE contributes to ischemia-induced angiogenesis. Vascul Pharmacol 83:57\u201365. https:\/\/doi.org\/10.1016\/j.vph.2016.04.002","journal-title":"Vascul Pharmacol"},{"key":"4225_CR70","doi-asserted-by":"publisher","first-page":"R71","DOI":"10.1152\/ajpregu.00039.2015","volume":"309","author":"V Garcia","year":"2015","unstructured":"Garcia V, Joseph G, Shkolnik B, Ding Y, Zhang FF et al (2015) Angiotensin II receptor blockade or deletion of vascular endothelial ACE does not prevent vascular dysfunction and remodeling in 20-HETE-dependent hypertension. Am J Physiol Regul Integr Comp Physiol 309:R71\u2013R78. https:\/\/doi.org\/10.1152\/ajpregu.00039.2015","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"4225_CR71","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1248\/bpb.28.1651","volume":"28","author":"T Seki","year":"2005","unstructured":"Seki T, Wang MH, Miyata N, Laniado-Schwartzman M (2005) Cytochrome P450 4A isoform inhibitory profile of N-hydroxy-N\u2019-(4-butyl-2-methylphenyl)-formamidine (HET0016), a selective inhibitor of 20-HETE synthesis. Biol Pharm Bull 28:1651\u20131654. https:\/\/doi.org\/10.1248\/bpb.28.1651","journal-title":"Biol Pharm Bull"},{"key":"4225_CR72","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1124\/jpet.115.229377","volume":"356","author":"V Garcia","year":"2016","unstructured":"Garcia V, Shkolnik B, Milhau L, Falck JR, Schwartzman ML (2016) 20-HETE Activates the Transcription of Angiotensin-Converting Enzyme via Nuclear Factor-\u03baB Translocation and Promoter Binding. J Pharmacol Exp Ther 356:525\u2013533. https:\/\/doi.org\/10.1124\/jpet.115.229377","journal-title":"J Pharmacol Exp Ther"},{"key":"4225_CR73","doi-asserted-by":"publisher","unstructured":"Moore GY, Pidgeon GP (2017) Cross-talk between cancer cells and the tumour microenvironment: the role of the 5-Lipoxygenase Pathway. Int J Mol Sci 18(2):236. https:\/\/doi.org\/10.3390\/ijms18020236","DOI":"10.3390\/ijms18020236"},{"key":"4225_CR74","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/1476-4598-2-10","volume":"2","author":"XZ Ding","year":"2003","unstructured":"Ding XZ, Hennig R, Adrian TE (2003) Lipoxygenase and cyclooxygenase metabolism: new insights in treatment and chemoprevention of pancreatic cancer. Mol Cancer 2:10. https:\/\/doi.org\/10.1186\/1476-4598-2-10","journal-title":"Mol Cancer"},{"key":"4225_CR75","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.prostaglandins.2011.08.004","volume":"96","author":"ER Greene","year":"2011","unstructured":"Greene ER, Huang S, Serhan CN, Panigrahy D (2011) Regulation of inflammation in cancer by eicosanoids. Prostaglandins Other Lipid Mediat 96:27\u201336. https:\/\/doi.org\/10.1016\/j.prostaglandins.2011.08.004","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"4225_CR76","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/978-1-4615-4861-4_17","volume":"447","author":"K Tang","year":"1999","unstructured":"Tang K, Honn KV (1999) 12(S)-HETE in cancer metastasis. Adv Exp Med Biol 447:181\u2013191. https:\/\/doi.org\/10.1007\/978-1-4615-4861-4_17","journal-title":"Adv Exp Med Biol"},{"key":"4225_CR77","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1016\/j.bbrc.2004.03.003","volume":"316","author":"Z Liu","year":"2004","unstructured":"Liu Z, Carbrey JM, Agre P, Rosen BP (2004) Arsenic trioxide uptake by human and rat aquaglyceroporins. Biochem Biophys Res Commun 316:1178\u20131185. https:\/\/doi.org\/10.1016\/j.bbrc.2004.03.003","journal-title":"Biochem Biophys Res Commun"},{"key":"4225_CR78","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.jes.2016.10.001","volume":"49","author":"BA Roggenbeck","year":"2016","unstructured":"Roggenbeck BA, Banerjee M, Leslie EM (2016) Cellular arsenic transport pathways in mammals. J Environ Sci (China) 49:38\u201358. https:\/\/doi.org\/10.1016\/j.jes.2016.10.001","journal-title":"J Environ Sci (China)"},{"key":"4225_CR79","doi-asserted-by":"publisher","first-page":"e26753","DOI":"10.7759\/cureus.26753","volume":"14","author":"D Yao","year":"2022","unstructured":"Yao D, Liu S, Lian F, Xu X, Yang J et al (2022) AQP9 (Aquaporin 9) Determines Arsenic Uptake and Tolerance in Human Hepatocellular Carcinoma Cells In Vitro. Cureus 14:e26753. https:\/\/doi.org\/10.7759\/cureus.26753","journal-title":"Cureus"},{"key":"4225_CR80","doi-asserted-by":"publisher","first-page":"17523","DOI":"10.1038\/s41598-021-96822-6","volume":"11","author":"S Yu","year":"2021","unstructured":"Yu S, Li LH, Lee CH, Jeyakannu P, Wang JJ, Hong CH (2021) Arsenic leads to autophagy of keratinocytes by increasing aquaporin 3 expression. Sci Rep 11:17523. https:\/\/doi.org\/10.1038\/s41598-021-96822-6","journal-title":"Sci Rep"},{"key":"4225_CR81","doi-asserted-by":"publisher","first-page":"e2894","DOI":"10.1038\/cddis.2017.282","volume":"8","author":"D Huang","year":"2017","unstructured":"Huang D, Feng X, Liu Y, Deng Y, Chen H et al (2017) AQP9-induced cell cycle arrest is associated with RAS activation and improves chemotherapy treatment efficacy in colorectal cancer. Cell Death Dis 8:e2894. https:\/\/doi.org\/10.1038\/cddis.2017.282","journal-title":"Cell Death Dis"},{"key":"4225_CR82","doi-asserted-by":"publisher","first-page":"6053","DOI":"10.1073\/pnas.092131899","volume":"99","author":"Z Liu","year":"2002","unstructured":"Liu Z, Shen J, Carbrey JM, Mukhopadhyay R, Agre P, Rosen BP (2002) Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9. Proc Natl Acad Sci U S A 99:6053\u20136058. https:\/\/doi.org\/10.1073\/pnas.092131899","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4225_CR83","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1016\/j.bbrc.2004.08.002","volume":"322","author":"H Bhattacharjee","year":"2004","unstructured":"Bhattacharjee H, Carbrey J, Rosen BP, Mukhopadhyay R (2004) Drug uptake and pharmacological modulation of drug sensitivity in leukemia by AQP9. Biochem Biophys Res Commun 322:836\u2013841. https:\/\/doi.org\/10.1016\/j.bbrc.2004.08.002","journal-title":"Biochem Biophys Res Commun"},{"key":"4225_CR84","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s13045-015-0143-3","volume":"8","author":"D Chau","year":"2015","unstructured":"Chau D, Ng K, Chan TS, Cheng YY, Fong B et al (2015) Azacytidine sensitizes acute myeloid leukemia cells to arsenic trioxide by up-regulating the arsenic transporter aquaglyceroporin 9. J Hematol Oncol 8:46. https:\/\/doi.org\/10.1186\/s13045-015-0143-3","journal-title":"J Hematol Oncol"},{"key":"4225_CR85","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.envint.2019.02.058","volume":"126","author":"LD Garbinski","year":"2019","unstructured":"Garbinski LD, Rosen BP, Chen J (2019) Pathways of arsenic uptake and efflux. Environ Int 126:585\u2013597. https:\/\/doi.org\/10.1016\/j.envint.2019.02.058","journal-title":"Environ Int"},{"key":"4225_CR86","doi-asserted-by":"publisher","first-page":"33404","DOI":"10.1074\/jbc.M007030200","volume":"275","author":"SV Kala","year":"2000","unstructured":"Kala SV, Neely MW, Kala G, Prater CI, Atwood DW et al (2000) The MRP2\/cMOAT transporter and arsenic-glutathione complex formation are required for biliary excretion of arsenic. J Biol Chem 275:33404\u201333408. https:\/\/doi.org\/10.1074\/jbc.M007030200","journal-title":"J Biol Chem"},{"key":"4225_CR87","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1124\/pr.109.002014","volume":"62","author":"CD Klaassen","year":"2010","unstructured":"Klaassen CD, Aleksunes LM (2010) Xenobiotic, bile acid, and cholesterol transporters: function and regulation. Pharmacol Rev 62:1\u201396. https:\/\/doi.org\/10.1124\/pr.109.002014","journal-title":"Pharmacol Rev"},{"key":"4225_CR88","doi-asserted-by":"publisher","first-page":"32700","DOI":"10.1074\/jbc.M404912200","volume":"279","author":"EM Leslie","year":"2004","unstructured":"Leslie EM, Haimeur A, Waalkes MP (2004) Arsenic transport by the human multidrug resistance protein 1 (MRP1\/ABCC1). Evidence that a tri-glutathione conjugate is required. J Biol Chem 279:32700\u201332708. https:\/\/doi.org\/10.1074\/jbc.M404912200","journal-title":"J Biol Chem"},{"key":"4225_CR89","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1124\/dmd.105.003780","volume":"33","author":"JM Maher","year":"2005","unstructured":"Maher JM, Slitt AL, Cherrington NJ, Cheng X, Klaassen CD (2005) Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (Mrp) family in mice. Drug Metab Dispos 33:947\u2013955. https:\/\/doi.org\/10.1124\/dmd.105.003780","journal-title":"Drug Metab Dispos"},{"key":"4225_CR90","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1002\/path.1379","volume":"200","author":"JE Ros","year":"2003","unstructured":"Ros JE, Libbrecht L, Geuken M, Jansen PL, Roskams TA (2003) High expression of MDR1, MRP1, and MRP3 in the hepatic progenitor cell compartment and hepatocytes in severe human liver disease. J Pathol 200:553\u2013560. https:\/\/doi.org\/10.1002\/path.1379","journal-title":"J Pathol"},{"key":"4225_CR91","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1515\/bc.2004.029","volume":"385","author":"MG Donner","year":"2004","unstructured":"Donner MG, Warskulat U, Saha N, H\u00e4ussinger D (2004) Enhanced expression of basolateral multidrug resistance protein isoforms Mrp3 and Mrp5 in rat liver by LPS. Biol Chem 385:331\u2013339. https:\/\/doi.org\/10.1515\/bc.2004.029","journal-title":"Biol Chem"},{"key":"4225_CR92","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.taap.2004.10.012","volume":"204","author":"EM Leslie","year":"2005","unstructured":"Leslie EM, Deeley RG, Cole SP (2005) Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense. Toxicol Appl Pharmacol 204:216\u2013237. https:\/\/doi.org\/10.1016\/j.taap.2004.10.012","journal-title":"Toxicol Appl Pharmacol"},{"key":"4225_CR93","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/0005-2736(76)90160-7","volume":"455","author":"RL Juliano","year":"1976","unstructured":"Juliano RL, Ling V (1976) A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochim Biophys Acta 455:152\u2013162. https:\/\/doi.org\/10.1016\/0005-2736(76)90160-7","journal-title":"Biochim Biophys Acta"},{"key":"4225_CR94","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1517\/17425255.4.7.895","volume":"4","author":"X Ma","year":"2008","unstructured":"Ma X, Idle JR, Gonzalez FJ (2008) The pregnane X receptor: from bench to bedside. Expert Opin Drug Metab Toxicol 4:895\u2013908. https:\/\/doi.org\/10.1517\/17425255.4.7.895","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"4225_CR95","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/s0300-483x(01)00532-7","volume":"170","author":"J Liu","year":"2002","unstructured":"Liu J, Liu Y, Powell DA, Waalkes MP, Klaassen CD (2002) Multidrug-resistance mdr1a\/1b double knockout mice are more sensitive than wild type mice to acute arsenic toxicity, with higher arsenic accumulation in tissues. Toxicology 170:55\u201362. https:\/\/doi.org\/10.1016\/s0300-483x(01)00532-7","journal-title":"Toxicology"},{"key":"4225_CR96","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1023\/b:mcbi.0000007256.44450.8c","volume":"255","author":"Y Xie","year":"2004","unstructured":"Xie Y, Liu J, Liu Y, Klaassen CD, Waalkes MP (2004) Toxicokinetic and genomic analysis of chronic arsenic exposure in multidrug-resistance mdr1a\/1b(-\/-) double knockout mice. Mol Cell Biochem 255:11\u201318. https:\/\/doi.org\/10.1023\/b:mcbi.0000007256.44450.8c","journal-title":"Mol Cell Biochem"}],"container-title":["Biological Trace Element Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-024-04225-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12011-024-04225-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-024-04225-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T20:35:14Z","timestamp":1737491714000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12011-024-04225-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,17]]},"references-count":96,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["4225"],"URL":"https:\/\/doi.org\/10.1007\/s12011-024-04225-1","relation":{},"ISSN":["0163-4984","1559-0720"],"issn-type":[{"value":"0163-4984","type":"print"},{"value":"1559-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,17]]},"assertion":[{"value":"3 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The authors declare that they have no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}