{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T13:29:48Z","timestamp":1783690188470,"version":"3.55.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T00:00:00Z","timestamp":1716249600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T00:00:00Z","timestamp":1716249600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biol Trace Elem Res"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1007\/s12011-024-04233-1","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T17:01:52Z","timestamp":1716310912000},"page":"766-774","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Bedsore Healing Using Selenium-Enriched Lactobacillus brevis LSe: A Randomized, Double-Blind, Controlled Clinical Trial"],"prefix":"10.1007","volume":"203","author":[{"given":"Farshid","family":"Ataollahi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bagher","family":"Amirheidari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Ahmadinejad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Khoshnam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojtaba","family":"Shakibaie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Forootanfar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Nooshadokht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Shabani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Ramezani Nejad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeleh","family":"Khodabakhshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zohreh","family":"Amirheidari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,21]]},"reference":[{"issue":"5","key":"4233_CR1","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1111\/iwj.13390","volume":"17","author":"M El Genedy","year":"2020","unstructured":"El Genedy M, Hahnel E, Tomova-Simitchieva T, Padula WV, Hauss A, Lober N et al (2020) Cost-effectiveness of multi-layered silicone foam dressings for prevention of sacral and heel pressure ulcers in high-risk intensive care unit patients: an economic analysis of a randomised controlled trial. Int Wound J. 17(5):1291\u20139","journal-title":"Int Wound J."},{"issue":"3","key":"4233_CR2","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1111\/iwj.12101","volume":"12","author":"N Santamaria","year":"2015","unstructured":"Santamaria N, Gerdtz M, Sage S, McCann J, Freeman A, Vassiliou T et al (2015) A randomised controlled trial of the effectiveness of soft silicone multi-layered foam dressings in the prevention of sacral and heel pressure ulcers in trauma and critically ill patients: the border trial. Int Wound J. 12(3):302\u20138","journal-title":"Int Wound J."},{"issue":"1","key":"4233_CR3","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1186\/s13063-016-1313-5","volume":"17","author":"D Pickham","year":"2016","unstructured":"Pickham D, Ballew B, Ebong K, Shinn J, Lough ME, Mayer B (2016) Evaluating optimal patient-turning procedures for reducing hospital-acquired pressure ulcers (LS-HAPU): study protocol for a randomized controlled trial. Trials 17(1):190","journal-title":"Trials"},{"key":"4233_CR4","doi-asserted-by":"publisher","first-page":"68","DOI":"10.4103\/abr.abr_207_19","volume":"8","author":"E Poursadra","year":"2019","unstructured":"Poursadra E, Anvari-Tafti M, Dehghani A, Eghbali-Babadi M, Rafiei Z (2019) Comparing the effect of henna oil and olive oil on pressure ulcer grade one in intensive care units patients. Adv Biomed Res 8:68","journal-title":"Adv Biomed Res"},{"issue":"1","key":"4233_CR5","first-page":"1","volume":"2020","author":"M Rizwanullah","year":"2020","unstructured":"Rizwanullah M, Alam S, Ahmad W (2020) Pressure Ulcer (Bed Sore) Treated with Unani formulation \u201cZaroor-E-Qawi\u201d\u2013a case report. J Clin Case Rep Med Res 2020(1):1","journal-title":"J Clin Case Rep Med Res"},{"issue":"6","key":"4233_CR6","doi-asserted-by":"publisher","first-page":"409","DOI":"10.12968\/jowc.2019.28.6.409","volume":"28","author":"M Stolt","year":"2019","unstructured":"Stolt M, Hjerppe A, Hietanen H, Puukka P, Haavisto E (2019) Local treatment of pressure ulcers in long-term care: a correlational cross-sectional study. J Wound Care 28(6):409\u201315","journal-title":"J Wound Care"},{"issue":"15","key":"4233_CR7","doi-asserted-by":"publisher","first-page":"2439","DOI":"10.3390\/cells11152439","volume":"11","author":"P Kolimi","year":"2022","unstructured":"Kolimi P, Narala S, Nyavanandi D, Youssef AAA, Dudhipala N (2022) Innovative treatment strategies to accelerate wound healing: trajectory and recent advancements. Cells 11(15):2439","journal-title":"Cells"},{"issue":"2","key":"4233_CR8","first-page":"152","volume":"4","author":"M Fang","year":"2023","unstructured":"Fang M, Zhang H, Wang Y, Zhang H, Zhang D, Xu P (2023) Biomimetic selenium nanosystems for infectious wound healing. Eng Regen 4(2):152\u201360","journal-title":"Eng Regen"},{"issue":"3","key":"4233_CR9","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1007\/s10787-020-00690-x","volume":"28","author":"S Hariharan","year":"2020","unstructured":"Hariharan S, Dharmaraj S (2020) Selenium and selenoproteins: it\u2019s role in regulation of inflammation. Inflammopharmacology 28(3):667\u201395","journal-title":"Inflammopharmacology"},{"issue":"3","key":"4233_CR10","doi-asserted-by":"publisher","first-page":"284","DOI":"10.29252\/beat-0703012","volume":"7","author":"A Abbaszadeh","year":"2019","unstructured":"Abbaszadeh A, Tehmasebi-Foolad A, Rajabzadeh A, Beigi-Brojeni N, Zarei L (2019) Effects of chitosan\/nano selenium biofilm on infected wound healing in rats; an experimental study. Bull Emerg Trauma 7(3):284\u201391","journal-title":"Bull Emerg Trauma"},{"issue":"3","key":"4233_CR11","doi-asserted-by":"publisher","first-page":"62","DOI":"10.3390\/biomedicines8030062","volume":"8","author":"P Tran","year":"2020","unstructured":"Tran P, Enos T, Luth K, Hamood A, Ray C, Mitchell K, Reid TW (2020) Organo-selenium-containing polyester bandage inhibits bacterial biofilm growth on the bandage and in the wound. Biomedicines 8(3):62","journal-title":"Biomedicines"},{"key":"4233_CR12","doi-asserted-by":"crossref","unstructured":"Cavalu S, Kamel E, Laslo V, Fritea L, Costea T, Antoniac IV, Vasile E, Antoniac A, Semenescu A, Mohan A, Saceleanu V (2017) Eco-friendly, facile and rapid way for synthesis of selenium nanoparticles production, structural and morphological characterisation. Revista de Chimie 68(12):2963\u20132966","DOI":"10.37358\/RC.17.12.6017"},{"issue":"2","key":"4233_CR13","first-page":"148","volume":"1","author":"P Eszenyi","year":"2011","unstructured":"Eszenyi P, Sztrik A, Babka B, Prokisch J (2011) Elemental, nano-sized (100\u2013500 nm) selenium production by probiotic lactic acid bacteria. Int J Biosci Biochem Bioinforma 1(2):148","journal-title":"Int J Biosci Biochem Bioinforma"},{"issue":"1","key":"4233_CR14","doi-asserted-by":"publisher","first-page":"11572","DOI":"10.1038\/s41598-020-68483-4","volume":"10","author":"J Brandi","year":"2020","unstructured":"Brandi J, Cheri S, Manfredi M, Di Carlo C, Vita Vanella V, Federici F et al (2020) Exploring the wound healing, anti-inflammatory, anti-pathogenic and proteomic effects of lactic acid bacteria on keratinocytes. Sci Rep 10(1):11572","journal-title":"Sci Rep"},{"issue":"1","key":"4233_CR15","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1111\/j.1742-481X.2008.00577.x","volume":"6","author":"MC Peral","year":"2009","unstructured":"Peral MC, Martinez MA, Valdez JC (2009) Bacteriotherapy with Lactobacillus plantarum in burns. Int Wound J 6(1):73\u201381","journal-title":"Int Wound J"},{"issue":"1","key":"4233_CR16","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s13287-020-1569-2","volume":"11","author":"N Han","year":"2020","unstructured":"Han N, Jia L, Guo L, Su Y, Luo Z, Du J et al (2020) Balanced oral pathogenic bacteria and probiotics promoted wound healing via maintaining mesenchymal stem cell homeostasis. Stem Cell Res Ther 11(1):61","journal-title":"Stem Cell Res Ther"},{"issue":"6","key":"4233_CR17","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1111\/iwj.13451","volume":"17","author":"R Knackstedt","year":"2020","unstructured":"Knackstedt R, Knackstedt T, Gatherwright J (2020) The role of topical probiotics on wound healing: a review of animal and human studies. Int Wound J 17(6):1687\u201394","journal-title":"Int Wound J"},{"issue":"2","key":"4233_CR18","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.anai.2014.05.002","volume":"113","author":"M Matsumoto","year":"2014","unstructured":"Matsumoto M, Ebata T, Hirooka J, Hosoya R, Inoue N, Itami S et al (2014) Antipruritic effects of the probiotic strain LKM512 in adults with atopic dermatitis. Ann Allergy Asthma Immunol 113(2):209\u201316.e7","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"4","key":"4233_CR19","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1177\/039463201102400421","volume":"24","author":"L Drago","year":"2011","unstructured":"Drago L, Iemoli E, Rodighiero V, Nicola L, De Vecchi E, Piconi S (2011) Effects of Lactobacillus salivarius LS01 (DSM 22775) treatment on adult atopic dermatitis: a randomized placebo-controlled study. Int J Immunopathol Pharmacol 24(4):1037\u201348","journal-title":"Int J Immunopathol Pharmacol"},{"key":"4233_CR20","doi-asserted-by":"crossref","unstructured":"Edsberg LE, Black JM, Goldberg M, McNichol L, Moore L, Sieggreen M (2016) Revised national pressure ulcer advisory panel pressure injury staging system: revised pressure injury staging system. J Wound Ostomy Continence Nurs 43(6):585\u201397","DOI":"10.1097\/WON.0000000000000281"},{"key":"4233_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jtemb.2016.11.013","volume":"40","author":"M Shakibaie","year":"2017","unstructured":"Shakibaie M, Mohammadi-Khorsand T, Adeli-Sardou M, Jafari M, Amirpour-Rostami S, Ameri A, Forootanfar H (2017) Probiotic and antioxidant properties of selenium-enriched Lactobacillus brevis LSe isolated from an Iranian traditional dairy product. J Trace Elem Med Biol 40:1\u20139","journal-title":"J Trace Elem Med Biol"},{"issue":"3","key":"4233_CR22","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","volume":"215","author":"SF Altschul","year":"1990","unstructured":"Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ (1990) Basic local alignment search tool. J Mol Biol 215(3):403\u201310","journal-title":"J Mol Biol"},{"key":"4233_CR23","unstructured":"Armstrong D, Meyr A (2018) Risk factors for impaired wound healing and wound complications 4. UpToDate Retrieved December"},{"issue":"1","key":"4233_CR24","doi-asserted-by":"publisher","first-page":"64","DOI":"10.3390\/ijms22010064","volume":"22","author":"SM Niemiec","year":"2020","unstructured":"Niemiec SM, Louiselle AE, Liechty KW, Zgheib C (2020) Role of microRNAs in pressure ulcer immune response, pathogenesis, and treatment. Int J Mol Sci 22(1):64","journal-title":"Int J Mol Sci"},{"issue":"1","key":"4233_CR25","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1111\/bjd.18659","volume":"182","author":"Y Yu","year":"2020","unstructured":"Yu Y, Dunaway S, Champer J, Kim J, Alikhan A (2020) Changing our microbiome: probiotics in dermatology. Br J Dermatol 182(1):39\u201346","journal-title":"Br J Dermatol"},{"issue":"3","key":"4233_CR26","first-page":"193","volume":"15","author":"L Brognara","year":"2020","unstructured":"Brognara L, Salmaso L, Mazzotti A, Di Martino A, Faldini C, Cauli O (2020) Effects of probiotics in the management of infected chronic wounds: from cell culture to human studies. Curr Clin Pharmacol 15(3):193\u2013206","journal-title":"Curr Clin Pharmacol"},{"issue":"6","key":"4233_CR27","first-page":"520","volume":"29","author":"S Mahpishanian","year":"2022","unstructured":"Mahpishanian S, Fatemi M, Ghandehari F (2022) The Effect of Lactobacillus plantarum and Selenium-enriched Lactobacillus plantarum on Staphylococcus aureus-Induced Osteomyelitis. J Kerman Univ Med Sci 29(6):520\u20138","journal-title":"J Kerman Univ Med Sci"},{"issue":"3","key":"4233_CR28","doi-asserted-by":"publisher","first-page":"e2970","DOI":"10.1002\/dmrr.2970","volume":"34","author":"S Mohseni","year":"2018","unstructured":"Mohseni S, Bayani M, Bahmani F, Tajabadi-Ebrahimi M, Bayani MA, Jafari P, Asemi Z (2018) The beneficial effects of probiotic administration on wound healing and metabolic status in patients with diabetic foot ulcer: a randomized, double-blind, placebo-controlled trial. Diabetes Metab Res Rev 34(3):e2970","journal-title":"Diabetes Metab Res Rev"},{"issue":"4","key":"4233_CR29","first-page":"268","volume":"29","author":"MH El-Ghazely","year":"2016","unstructured":"El-Ghazely MH, Mahmoud WH, Atia MA, Eldip EM (2016) Effect of probiotic administration in the therapy of pediatric thermal burn. Ann Burns Fire Disasters 29(4):268\u201372","journal-title":"Ann Burns Fire Disasters"},{"issue":"1","key":"4233_CR30","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1097\/BCR.0000000000000139","volume":"36","author":"T Mayes","year":"2015","unstructured":"Mayes T, Gottschlich MM, James LE, Allgeier C, Weitz J, Kagan RJ (2015) Clinical safety and efficacy of probiotic administration following burn injury. J Burn Care Res. 36(1):92\u20139","journal-title":"J Burn Care Res."},{"key":"4233_CR31","doi-asserted-by":"crossref","unstructured":"Hackshaw A (2008) Small studies: strengths and limitations. Eur Respiratory J 32(5):1141\u20131143","DOI":"10.1183\/09031936.00136408"},{"issue":"1","key":"4233_CR32","doi-asserted-by":"publisher","first-page":"111","DOI":"10.3390\/nu14010111","volume":"14","author":"C Togo","year":"2021","unstructured":"Togo C, Zidorio AP, Goncalves V, Botelho P, de Carvalho K, Dutra E (2021) Does probiotic consumption enhance wound healing? A systematic review. Nutrients 14(1):111","journal-title":"Nutrients"},{"issue":"18","key":"4233_CR33","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1001\/jama.2012.3507","volume":"307","author":"S Hempel","year":"2012","unstructured":"Hempel S, Newberry SJ, Maher AR, Wang Z, Miles JN, Shanman R et al (2012) Probiotics for the prevention and treatment of antibiotic-associated diarrhea: a systematic review and meta-analysis. JAMA 307(18):1959\u201369","journal-title":"JAMA"},{"issue":"2","key":"4233_CR34","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/s12602-017-9324-4","volume":"10","author":"C Esposito","year":"2018","unstructured":"Esposito C, Roberti A, Turra F, Cerulo M, Severino G, Settimi A, Escolino M (2018) Frequency of antibiotic-associated diarrhea and related complications in pediatric patients who underwent hypospadias repair: a comparative study using probiotics vs placebo. Probiotics Antimicrob Proteins 10(2):323\u20138","journal-title":"Probiotics Antimicrob Proteins"}],"container-title":["Biological Trace Element Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-024-04233-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12011-024-04233-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-024-04233-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T20:20:44Z","timestamp":1737490844000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12011-024-04233-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,21]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["4233"],"URL":"https:\/\/doi.org\/10.1007\/s12011-024-04233-1","relation":{},"ISSN":["0163-4984","1559-0720"],"issn-type":[{"value":"0163-4984","type":"print"},{"value":"1559-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,21]]},"assertion":[{"value":"13 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 May 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This research was a randomized, double-blind, controlled clinical trial. It was verified on the Iranian website for registration of clinical trials (IRCT20221221056887N2). The research was also approved by the ethics committee of Kerman University of Medical Sciences (IR.KMU.REC.1402.038), Kerman, Iran. The trial was carried out in the ICU wards of Bahonar Medical Center, Kerman, Iran. Informed consent was received, and all personal details are treated as private and are not published. Trial registration: IRCT, IRCT20221221056887N2. Registered 15 May 2023, .","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval and Consent to participate"}},{"value":"All authors expressed their consent for publication of the project results.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Authors have no conflicts of interest to declare.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}