{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:48:58Z","timestamp":1792183738611,"version":"4.4.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T00:00:00Z","timestamp":1726876800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T00:00:00Z","timestamp":1726876800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No: 81872976"],"award-info":[{"award-number":["No: 81872976"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No: 81872976"],"award-info":[{"award-number":["No: 81872976"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No: 81872976"],"award-info":[{"award-number":["No: 81872976"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No: 81872976"],"award-info":[{"award-number":["No: 81872976"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No: 81872976"],"award-info":[{"award-number":["No: 81872976"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No: 81872976"],"award-info":[{"award-number":["No: 81872976"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No: 81872976"],"award-info":[{"award-number":["No: 81872976"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Health and wellness research projects of Anhui Province","award":["No: AHWJ2022b062"],"award-info":[{"award-number":["No: AHWJ2022b062"]}]},{"name":"Health and wellness research projects of Anhui Province","award":["No: AHWJ2022b062"],"award-info":[{"award-number":["No: AHWJ2022b062"]}]},{"name":"Health and wellness research projects of Anhui Province","award":["No: AHWJ2022b062"],"award-info":[{"award-number":["No: AHWJ2022b062"]}]},{"name":"Health and wellness research projects of Anhui Province","award":["No: AHWJ2022b062"],"award-info":[{"award-number":["No: AHWJ2022b062"]}]},{"name":"Health and wellness research projects of Anhui Province","award":["No: AHWJ2022b062"],"award-info":[{"award-number":["No: AHWJ2022b062"]}]},{"name":"Health and wellness research projects of Anhui Province","award":["No: AHWJ2022b062"],"award-info":[{"award-number":["No: AHWJ2022b062"]}]},{"name":"Health and wellness research projects of Anhui Province","award":["No: AHWJ2022b062"],"award-info":[{"award-number":["No: AHWJ2022b062"]}]},{"name":"Chinese Medicine Inheritance Innovation and Development Research Project of Anhui Red Cross Society","award":["No: 2022ZYYD06"],"award-info":[{"award-number":["No: 2022ZYYD06"]}]},{"name":"Chinese Medicine Inheritance Innovation and Development Research Project of Anhui Red Cross Society","award":["No: 2022ZYYD06"],"award-info":[{"award-number":["No: 2022ZYYD06"]}]},{"name":"Chinese Medicine Inheritance Innovation and Development Research Project of Anhui Red Cross Society","award":["No: 2022ZYYD06"],"award-info":[{"award-number":["No: 2022ZYYD06"]}]},{"name":"Chinese Medicine Inheritance Innovation and Development Research Project of Anhui Red Cross Society","award":["No: 2022ZYYD06"],"award-info":[{"award-number":["No: 2022ZYYD06"]}]},{"name":"Chinese Medicine Inheritance Innovation and Development Research Project of Anhui Red Cross Society","award":["No: 2022ZYYD06"],"award-info":[{"award-number":["No: 2022ZYYD06"]}]},{"name":"Chinese Medicine Inheritance Innovation and Development Research Project of Anhui Red Cross Society","award":["No: 2022ZYYD06"],"award-info":[{"award-number":["No: 2022ZYYD06"]}]},{"name":"Chinese Medicine Inheritance Innovation and Development Research Project of Anhui Red Cross Society","award":["No: 2022ZYYD06"],"award-info":[{"award-number":["No: 2022ZYYD06"]}]},{"name":"Key Research and Development Plan Projects of Anhui Province","award":["202204295107020043"],"award-info":[{"award-number":["202204295107020043"]}]},{"name":"Key Research and Development Plan Projects of Anhui Province","award":["202204295107020043"],"award-info":[{"award-number":["202204295107020043"]}]},{"name":"Key Research and Development Plan Projects of Anhui Province","award":["202204295107020043"],"award-info":[{"award-number":["202204295107020043"]}]},{"name":"Key Research and Development Plan Projects of Anhui Province","award":["202204295107020043"],"award-info":[{"award-number":["202204295107020043"]}]},{"name":"Key Research and Development Plan Projects of Anhui Province","award":["202204295107020043"],"award-info":[{"award-number":["202204295107020043"]}]},{"name":"Key Research and Development Plan Projects of Anhui Province","award":["202204295107020043"],"award-info":[{"award-number":["202204295107020043"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biol Trace Elem Res"],"DOI":"10.1007\/s12011-024-04384-1","type":"journal-article","created":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T23:32:19Z","timestamp":1726875139000},"page":"3123-3131","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Glutathione Attenuates Copper Levels and Alleviates Hepatic Injury in TX Mice"],"prefix":"10.1007","volume":"203","author":[{"given":"Mengzhen","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ni","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuge","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijian","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,21]]},"reference":[{"key":"4384_CR1","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1016\/j.biochi.2009.07.012","volume":"91","author":"ML Schilsky","year":"2009","unstructured":"Schilsky ML (2009) Wilson disease: current status and the future. Biochimie 91:1278\u20131281. https:\/\/doi.org\/10.1016\/j.biochi.2009.07.012","journal-title":"Biochimie"},{"key":"4384_CR2","doi-asserted-by":"publisher","first-page":"5659","DOI":"10.1038\/s41598-021-84894-3","volume":"11","author":"A Muchenditsi","year":"2021","unstructured":"Muchenditsi A, Talbot CC Jr, Gottlieb A et al (2021) Systemic deletion of Atp7b modifies the hepatocytes\u2019 response to copper overload in the mouse models of Wilson disease. Sci Rep 11:5659. https:\/\/doi.org\/10.1038\/s41598-021-84894-3","journal-title":"Sci Rep"},{"key":"4384_CR3","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1016\/j.freeradbiomed.2004.09.010","volume":"37","author":"SS Leonard","year":"2004","unstructured":"Leonard SS, Harris GK, Shi X (2004) Metal-induced oxidative stress and signal transduction. Free Radical Biol Med 37:1921\u20131942. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2004.09.010","journal-title":"Free Radical Biol Med"},{"issue":"1","key":"4384_CR4","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/S1474-4422(14)70190-5","volume":"14","author":"O Bandmann","year":"2015","unstructured":"Bandmann O, Weiss KH, Kaler SG (2015) Wilson\u2019s disease and other neurological copper disorders. The Lancet Neurology 14(1):103\u2013113. https:\/\/doi.org\/10.1016\/S1474-4422(14)70190-5","journal-title":"The Lancet Neurology"},{"issue":"3","key":"4384_CR5","doi-asserted-by":"publisher","first-page":"e243","DOI":"10.1212\/NXG.0000000000000243","volume":"4","author":"R Uerlings","year":"2018","unstructured":"Uerlings R, Moreno D, Murillo O et al (2018) Brain copper storage after genetic long-term correction in a mouse model of Wilson disease. Neurology Genetics 4(3):e243. https:\/\/doi.org\/10.1212\/NXG.0000000000000243","journal-title":"Neurology Genetics"},{"key":"4384_CR6","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.jtemb.2014.06.016","volume":"28","author":"ML Schilsky","year":"2014","unstructured":"Schilsky ML (2014) A century for progress in the diagnosis of Wilson disease. J Trace Elem Med Biol: Organ Soc Miner Trace Elem (GMS) 28:492\u2013494. https:\/\/doi.org\/10.1016\/j.jtemb.2014.06.016","journal-title":"J Trace Elem Med Biol: Organ Soc Miner Trace Elem (GMS)"},{"issue":"3","key":"4384_CR7","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/s12264-017-0107-4","volume":"33","author":"JJ Xie","year":"2017","unstructured":"Xie JJ, Wu ZY (2017) Wilson\u2019s Disease in China. Neurosci Bull 33(3):323\u2013330. https:\/\/doi.org\/10.1007\/s12264-017-0107-4","journal-title":"Neurosci Bull"},{"key":"4384_CR8","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1039\/b906712b","volume":"40","author":"WB Dunn","year":"2011","unstructured":"Dunn WB, Broadhurst DI, Atherton HJ et al (2011) Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy. Chem Soc Rev 40:387\u2013426. https:\/\/doi.org\/10.1039\/b906712b","journal-title":"Chem Soc Rev"},{"key":"4384_CR9","doi-asserted-by":"publisher","unstructured":"Lindon JC, Nicholson JK (2008) Spectroscopic and statistical techniques for information recovery in metabonomics and metabolomics.\u00a0Annual review of analytical chemistry (Palo Alto, Calif.),\u00a01, 45\u201369. https:\/\/doi.org\/10.1146\/annurev.anchem.1.031207.113026","DOI":"10.1146\/annurev.anchem.1.031207.113026"},{"issue":"11","key":"4384_CR10","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.4254\/wjh.v13.i11.1552","volume":"13","author":"J Seetharaman","year":"2021","unstructured":"Seetharaman J, Sarma MS (2021) Chelation therapy in liver diseases of childhood: current status and response. World J Hepatol 13(11):1552\u20131567. https:\/\/doi.org\/10.4254\/wjh.v13.i11.1552","journal-title":"World J Hepatol"},{"key":"4384_CR11","doi-asserted-by":"publisher","first-page":"e64381","DOI":"10.1371\/journal.pone.0064381","volume":"8","author":"A Zhang","year":"2013","unstructured":"Zhang A, Sun H, Han Y et al (2013) Urinary metabolic biomarker and pathway study of hepatitis B virus infected patients based on UPLC-MS system. PLoS ONE 8:e64381. https:\/\/doi.org\/10.1371\/journal.pone.0064381","journal-title":"PLoS ONE"},{"key":"4384_CR12","doi-asserted-by":"publisher","first-page":"805812","DOI":"10.3389\/fcvm.2021.80581","volume":"8","author":"X Hu","year":"2022","unstructured":"Hu X, Zhou R, Li H et al (2022) Alterations of gut microbiome and serum metabolome in coronary artery disease patients complicated with non-alcoholic fatty liver disease are associated with adverse cardiovascular outcomes. Frontiers in cardiovascular medicine 8:805812. https:\/\/doi.org\/10.3389\/fcvm.2021.80581","journal-title":"Frontiers in cardiovascular medicine"},{"key":"4384_CR13","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/0891-5849(89)90160-3","volume":"6","author":"HC Sutton","year":"1989","unstructured":"Sutton HC, Winterbourn CC (1989) On the participation of higher oxidation states of iron and copper in Fenton reactions. Free Radical Biol Med 6:53\u201360. https:\/\/doi.org\/10.1016\/0891-5849(89)90160-3","journal-title":"Free Radical Biol Med"},{"key":"4384_CR14","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1385\/BTER:96:1-3:209","volume":"96","author":"D Ozcelik","year":"2003","unstructured":"Ozcelik D, Ozaras R, Gurel Z et al (2003) Copper-mediated oxidative stress in rat liver. Biol Trace Elem Res 96:209\u2013215. https:\/\/doi.org\/10.1385\/BTER:96:1-3:209","journal-title":"Biol Trace Elem Res"},{"key":"4384_CR15","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1007\/s12011-016-0627-1","volume":"173","author":"Y Yang","year":"2016","unstructured":"Yang Y, Wang H, Guo Y et al (2016) Metal ion imbalance-related oxidative stress is involved in the mechanisms of liver injury in a rat model of chronic aluminum exposure. Biol Trace Elem Res 173:126\u2013131. https:\/\/doi.org\/10.1007\/s12011-016-0627-1","journal-title":"Biol Trace Elem Res"},{"key":"4384_CR16","doi-asserted-by":"publisher","first-page":"8082","DOI":"10.3748\/wjg.v20.i25.8082","volume":"20","author":"H Cicho\u017c-Lach","year":"2014","unstructured":"Cicho\u017c-Lach H, Michalak A (2014) Oxidative stress as a crucial factor in liver diseases. World J Gastroenterol 20:8082\u20138091. https:\/\/doi.org\/10.3748\/wjg.v20.i25.8082","journal-title":"World J Gastroenterol"},{"key":"4384_CR17","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1007\/s12011-021-02672-8","volume":"200","author":"H Guo","year":"2022","unstructured":"Guo H, Wang Y, Cui H et al (2022) Copper induces spleen damage through modulation of oxidative stress, apoptosis, DNA damage, and inflammation. Biol Trace Elem Res 200:669\u2013677. https:\/\/doi.org\/10.1007\/s12011-021-02672-8","journal-title":"Biol Trace Elem Res"},{"key":"4384_CR18","doi-asserted-by":"publisher","first-page":"124888","DOI":"10.1016\/j.jhazmat.2020.124888","volume":"408","author":"F Yang","year":"2021","unstructured":"Yang F, Liao J, Yu W et al (2021) Exposure to copper induces mitochondria-mediated apoptosis by inhibiting mitophagy and the PINK1\/parkin pathway in chicken (Gallus gallus) livers. J Hazard Mater 408:124888. https:\/\/doi.org\/10.1016\/j.jhazmat.2020.124888","journal-title":"J Hazard Mater"},{"issue":"4","key":"4384_CR19","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1007\/s12011-022-03277-5","volume":"201","author":"G Gromadzka","year":"2023","unstructured":"Gromadzka G, Przyby\u0142kowski A, Litwin T (2023) Karpi\u0144ska A (2023) Antioxidant capacity is decreased in Wilson\u2019s disease and correlates to liver function. Biol Trace Elem Res 201(4):1582\u20131587. https:\/\/doi.org\/10.1007\/s12011-022-03277-5","journal-title":"Biol Trace Elem Res"},{"issue":"3","key":"4384_CR20","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1007\/s10545-011-9422-5","volume":"35","author":"R Bruha","year":"2012","unstructured":"Bruha R, Vitek L, Marecek Z et al (2012) (2012) Decreased serum antioxidant capacity in patients with Wilson disease is associated with neurological symptoms. J Inherit Metab Dis 35(3):541\u2013548. https:\/\/doi.org\/10.1007\/s10545-011-9422-5","journal-title":"J Inherit Metab Dis"},{"key":"4384_CR21","doi-asserted-by":"publisher","unstructured":"Pak K, Ordway S, Sadowski B, et al (2021) Wilson's disease and iron overload: pathophysiology and therapeutic implications. Clin Liver Dis (Hoboken). 2021;17(2):61\u201366. Published 2021 Feb 28. https:\/\/doi.org\/10.1002\/cld.986","DOI":"10.1002\/cld.986"},{"key":"4384_CR22","doi-asserted-by":"publisher","first-page":"5028181","DOI":"10.1155\/2019\/5028181","volume":"2019","author":"VP Bajic","year":"2019","unstructured":"Bajic VP, Van Neste C, Obradovic M et al (2019) Glutathione \u201credox homeostasis\u201d and its relation to cardiovascular disease. Oxid Med Cell Longev 2019:5028181. https:\/\/doi.org\/10.1155\/2019\/5028181","journal-title":"Oxid Med Cell Longev"},{"key":"4384_CR23","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1080\/15592294.2020.1781024","volume":"15","author":"A Mungala Lengo","year":"2020","unstructured":"Mungala Lengo A, Guiraut C, Mohamed I et al (2020) Relationship between redox potential of glutathione and DNA methylation level in liver of newborn guinea pigs. Epigenetics 15:1348\u20131360. https:\/\/doi.org\/10.1080\/15592294.2020.1781024","journal-title":"Epigenetics"},{"key":"4384_CR24","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1146\/annurev.bi.45.070176.003015","volume":"45","author":"A Meister","year":"1976","unstructured":"Meister A, Tate SS (1976) Glutathione and related gamma-glutamyl compounds: biosynthesis and utilization. Annu Rev Biochem 45:559\u2013604. https:\/\/doi.org\/10.1146\/annurev.bi.45.070176.003015","journal-title":"Annu Rev Biochem"},{"key":"4384_CR25","unstructured":"Zhang B, Yang XJ, Fang YY et al (2011) Clinical study of glutathione tablets in the treatment of hepatoblastic nuclear degeneration.Chinese Journal of New Drugs and Clinical Remedies,2011,30(03):199\u2013202."},{"key":"4384_CR26","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.cld.2017.06.011","volume":"21","author":"ML Schilsky","year":"2017","unstructured":"Schilsky ML (2017) Wilson disease: diagnosis, treatment, and follow-up. Clin Liver Dis 21:755\u2013767. https:\/\/doi.org\/10.1016\/j.cld.2017.06.011","journal-title":"Clin Liver Dis"},{"key":"4384_CR27","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1038\/nchembio.72","volume":"4","author":"BE Kim","year":"2008","unstructured":"Kim BE, Nevitt T, Thiele DJ (2008) Mechanisms for copper acquisition, distribution and regulation. Nat Chem Biol 4:176\u2013185. https:\/\/doi.org\/10.1038\/nchembio.72","journal-title":"Nat Chem Biol"},{"key":"4384_CR28","doi-asserted-by":"publisher","first-page":"2721","DOI":"10.1172\/JCI85226","volume":"126","author":"J Lichtmannegger","year":"2016","unstructured":"Lichtmannegger J, Leitzinger C, Wimmer R et al (2016) Methanobactin reverses acute liver failure in a rat model of Wilson disease. J Clin Investig 126:2721\u20132735. https:\/\/doi.org\/10.1172\/JCI85226","journal-title":"J Clin Investig"},{"issue":"9559","key":"4384_CR29","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/S0140-6736(07)60196-2","volume":"369","author":"A Ala","year":"2007","unstructured":"Ala A, Walker AP, Ashkan K et al (2007) (2007) Wilson\u2019s disease. Lancet 369(9559):397\u2013408. https:\/\/doi.org\/10.1016\/S0140-6736(07)60196-2","journal-title":"Lancet"},{"key":"4384_CR30","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1345\/aph.17075","volume":"32","author":"LA Anderson","year":"1998","unstructured":"Anderson LA, Hakojarvi SL, Boudreaux SK (1998) Zinc acetate treatment in Wilson\u2019s disease. Ann Pharmacother 32:78\u201387. https:\/\/doi.org\/10.1345\/aph.17075","journal-title":"Ann Pharmacother"},{"issue":"4","key":"4384_CR31","doi-asserted-by":"publisher","first-page":"465","DOI":"10.2174\/1570159X18666200429233517","volume":"19","author":"XZ Yuan","year":"2021","unstructured":"Yuan XZ, Yang RM (2021) Wang XP (2021) Management perspective of Wilson\u2019s disease: early diagnosis and individualized therapy. Curr Neuropharmacol 19(4):465\u2013485. https:\/\/doi.org\/10.2174\/1570159X18666200429233517","journal-title":"Curr Neuropharmacol"},{"key":"4384_CR32","doi-asserted-by":"publisher","unstructured":"M Guindi 2019 Wilson disease Seminars in diagnostic pathology 36 415 422 https:\/\/doi.org\/10.1053\/j.semdp.2019.07.008","DOI":"10.1053\/j.semdp.2019.07.008"},{"issue":"4","key":"4384_CR33","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1097\/WCO.0000000000000837","volume":"33","author":"A Aggarwal","year":"2020","unstructured":"Aggarwal A (2020) Bhatt M (2020) Wilson disease. Curr Opin Neurol 33(4):534\u2013542. https:\/\/doi.org\/10.1097\/WCO.0000000000000837","journal-title":"Curr Opin Neurol"},{"key":"4384_CR34","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.pneurobio.2014.01.002","volume":"116","author":"IF Scheiber","year":"2014","unstructured":"Scheiber IF, Mercer JF, Dringen R (2014) Metabolism and functions of copper in brain. Prog Neurobiol 116:33\u201357. https:\/\/doi.org\/10.1016\/j.pneurobio.2014.01.002","journal-title":"Prog Neurobiol"},{"key":"4384_CR35","doi-asserted-by":"publisher","first-page":"33","DOI":"10.3389\/fphar.2014.00033","volume":"5","author":"L Zhao","year":"2014","unstructured":"Zhao L, Xia Z, Wang F (2014) Zebrafish in the sea of mineral (iron, zinc, and copper) metabolism. Front Pharmacol 5:33. https:\/\/doi.org\/10.3389\/fphar.2014.00033","journal-title":"Front Pharmacol"},{"key":"4384_CR36","doi-asserted-by":"publisher","first-page":"108529","DOI":"10.1016\/j.pharmthera.2023.108529","volume":"251","author":"CR Wooton-Kee","year":"2023","unstructured":"Wooton-Kee CR (2023) Therapeutic implications of impaired nuclear receptor function and dysregulated metabolism in Wilson\u2019s disease. Pharmacol Ther 251:108529. https:\/\/doi.org\/10.1016\/j.pharmthera.2023.108529","journal-title":"Pharmacol Ther"},{"key":"4384_CR37","doi-asserted-by":"publisher","unstructured":"Shribman S, Poujois A, Bandmann O et al (2021) Warner TT. Wilson's disease: update on pathogenesis, biomarkers and treatments. J Neurol Neurosurg Psychiatry. 2021;92(10):1053\u20131061. https:\/\/doi.org\/10.1136\/jnnp-2021-326123","DOI":"10.1136\/jnnp-2021-326123"},{"key":"4384_CR38","doi-asserted-by":"publisher","first-page":"110799","DOI":"10.1016\/j.jinorgbio.2019.110799","volume":"199","author":"RM Sebio","year":"2019","unstructured":"Sebio RM, Ferrarotti N, Lairion F et al (2019) (2019) Brain oxidative stress in rat with chronic iron or copper overload. J Inorg Biochem 199:110799. https:\/\/doi.org\/10.1016\/j.jinorgbio.2019.110799","journal-title":"J Inorg Biochem"},{"issue":"2","key":"4384_CR39","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1007\/s10534-021-00289-x","volume":"34","author":"G Gromadzka","year":"2021","unstructured":"Gromadzka G, Wierzbicka D, Litwin T, Przyby\u0142kowski A (2021) Iron metabolism is disturbed and anti-copper treatment improves but does not normalize iron metabolism in Wilson\u2019s disease. Biometals 34(2):407\u2013414. https:\/\/doi.org\/10.1007\/s10534-021-00289-x","journal-title":"Biometals"},{"issue":"9","key":"4384_CR40","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1111\/hepr.13200","volume":"48","author":"Y Tatsumi","year":"2018","unstructured":"Tatsumi Y, Kato A, Kato K, Hayashi H (2018) The interactions between iron and copper in genetic iron overload syndromes and primary copper toxicoses in Japan. Hepatol Res 48(9):679\u2013691. https:\/\/doi.org\/10.1111\/hepr.13200","journal-title":"Hepatol Res"},{"key":"4384_CR41","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.jtemb.2014.05.007","volume":"31","author":"P Dusek","year":"2015","unstructured":"Dusek P, Roos PM, Litwin T et al (2015) (2015) The neurotoxicity of iron, copper and manganese in Parkinson\u2019s and Wilson\u2019s diseases. J Trace Elem Med Biol 31:193\u2013203. https:\/\/doi.org\/10.1016\/j.jtemb.2014.05.007","journal-title":"J Trace Elem Med Biol"},{"key":"4384_CR42","doi-asserted-by":"publisher","unstructured":"Gromadzka G, Czerwi\u0144ska J, Krzemi\u0144ska E, et al (2024) Wilson's disease-crossroads of genetics, inflammation and immunity\/autoimmunity: clinical and molecular issues. Int J Mol Sci. 2024;25(16):9034. Published 2024 Aug 20. https:\/\/doi.org\/10.3390\/ijms25169034","DOI":"10.3390\/ijms25169034"},{"issue":"3","key":"4384_CR43","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s00795-006-0326-7","volume":"39","author":"H Hayashi","year":"2006","unstructured":"Hayashi H, Yano M, Fujita Y (2006) Wakusawa S (2006) Compound overload of copper and iron in patients with Wilson\u2019s disease. Med Mol Morphol 39(3):121\u2013126. https:\/\/doi.org\/10.1007\/s00795-006-0326-7","journal-title":"Med Mol Morphol"},{"key":"4384_CR44","doi-asserted-by":"publisher","first-page":"154539","DOI":"10.1016\/j.phymed.2022.154539","volume":"113","author":"X Sun","year":"2023","unstructured":"Sun X, Zhang X, Yan H et al (2023) (2023) Protective effect of curcumin on hepatolenticular degeneration through copper excretion and inhibition of ferroptosis. Phytomedicine 113:154539. https:\/\/doi.org\/10.1016\/j.phymed.2022.154539","journal-title":"Phytomedicine"},{"key":"4384_CR45","unstructured":"Zhang B, Jang TZ, Wang XY et al (2010) Study of Gandouling tablet and glutathione on hepatoblastic degeneration. Journal of Emergency in Traditional Chinese Medicine,2010,19(05):760\u2013761+763"},{"key":"4384_CR46","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1016\/s0305-0491(98)10001-9","volume":"119","author":"E Chiaradia","year":"1998","unstructured":"Chiaradia E, Avellini L, Rueca F et al (1998) Physical exercise, oxidative stress and muscle damage in racehorses. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 119:833\u2013836. https:\/\/doi.org\/10.1016\/s0305-0491(98)10001-9","journal-title":"Part B, Biochemistry & molecular biology"},{"key":"4384_CR47","doi-asserted-by":"publisher","first-page":"3397","DOI":"10.2174\/0929867311320270005","volume":"20","author":"V Bocci","year":"2013","unstructured":"Bocci V, Valacchi G (2013) Free radicals and antioxidants: how to reestablish redox homeostasis in chronic diseases? Curr Med Chem 20:3397\u20133415. https:\/\/doi.org\/10.2174\/0929867311320270005","journal-title":"Curr Med Chem"},{"key":"4384_CR48","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1248\/cpb.34.409","volume":"34","author":"T Kamei","year":"1986","unstructured":"Kamei T, Asano K, Nakamura S (1986) Determination of serum glutamate oxaloacetate transaminase and glutamate pyruvate transaminase by using L-glutamate oxidase. Chem Pharm Bull 34:409\u2013412. https:\/\/doi.org\/10.1248\/cpb.34.409","journal-title":"Chem Pharm Bull"},{"key":"4384_CR49","doi-asserted-by":"publisher","first-page":"582390","DOI":"10.3389\/fphar.2020.582390","volume":"11","author":"N Wang","year":"2020","unstructured":"Wang N, Cheng M, Zhang X et al (2020) Gandou decoction decreases copper levels and alleviates hepatic injury in copper-laden hepatolenticular degeneration model rats. Front Pharmacol 11:582390. https:\/\/doi.org\/10.3389\/fphar.2020.582390","journal-title":"Front Pharmacol"}],"container-title":["Biological Trace Element Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-024-04384-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12011-024-04384-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-024-04384-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T12:02:20Z","timestamp":1749470540000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12011-024-04384-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,21]]},"references-count":49,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["4384"],"URL":"https:\/\/doi.org\/10.1007\/s12011-024-04384-1","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4742084\/v1","asserted-by":"object"}]},"ISSN":["1559-0720"],"issn-type":[{"value":"1559-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,21]]},"assertion":[{"value":"15 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}