{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T16:51:45Z","timestamp":1768409505755,"version":"3.49.0"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T00:00:00Z","timestamp":1732924800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T00:00:00Z","timestamp":1732924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003121","name":"Ferdowsi university of mashhad","doi-asserted-by":"crossref","award":["2\/42932"],"award-info":[{"award-number":["2\/42932"]}],"id":[{"id":"10.13039\/501100003121","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biol Trace Elem Res"],"DOI":"10.1007\/s12011-024-04452-6","type":"journal-article","created":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T02:57:12Z","timestamp":1732935432000},"page":"3793-3802","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of Zinc on Blood Biochemical and mTOR Gene Expression in Rats with Polycystic Ovarian"],"prefix":"10.1007","volume":"203","author":[{"given":"Faeze Fazel","family":"Torshizi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1948-9734","authenticated-orcid":false,"given":"Reza Majidzadeh","family":"Heravi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Javadmanesh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,11,30]]},"reference":[{"key":"4452_CR1","unstructured":"Wourld Health Organization (2023) A report about polycystic ovary syndrome. Available from: https:\/\/www.who.int\/newsroom\/factsheets\/detail\/polycystic-ovary-syndrome. Accessed 27 Oct 2024"},{"issue":"1","key":"4452_CR2","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1089\/imr.2023.0045","volume":"3","author":"S Mohammed","year":"2024","unstructured":"Mohammed S, Cockburn BN, Sundaram V (2024) Exploring the novel alternative and modern treatment options for polycystic ovary syndrome-a review. Integrat Med Rep 3(1):33\u201342","journal-title":"Integrat Med Rep"},{"issue":"4","key":"4452_CR3","first-page":"279","volume":"80","author":"AT Ali","year":"2015","unstructured":"Ali AT (2015) Polycystic ovary syndrome and metabolic syndrome. Ceska gynekol 80(4):279\u2013289","journal-title":"Ceska gynekol"},{"issue":"2","key":"4452_CR4","doi-asserted-by":"publisher","first-page":"E392","DOI":"10.1152\/ajpendo.2001.281.2.E392","volume":"281","author":"A Dunaif","year":"2001","unstructured":"Dunaif A, Wu X, Lee A, Diamanti-Kandarakis E (2001) Defects in insulin receptor signaling in vivo in the polycystic ovary syndrome (PCOS). Am J Physiol Endocrinol 281(2):E392\u2013E399","journal-title":"Am J Physiol Endocrinol"},{"key":"4452_CR5","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/S1472-6483(11)60393-3","volume":"10","author":"JM Weiss","year":"2005","unstructured":"Weiss JM, Tauchert S, Ludwig AK, Diedrich K (2005) Treatment strategies in PCOS patients. Rep biomed online 10:67\u201374","journal-title":"Rep biomed online"},{"issue":"10","key":"4452_CR6","doi-asserted-by":"publisher","first-page":"801","DOI":"10.3109\/09513590.2015.1075497","volume":"31","author":"NA Desai","year":"2015","unstructured":"Desai NA, Patel SS (2015) Increased insulin-like growth factor-1 in relation to cardiovascular function in polycystic ovary syndrome: friend or foe? Gynecol Endocrinol 31(10):801\u2013807","journal-title":"Gynecol Endocrinol"},{"issue":"3","key":"4452_CR7","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.cell.2006.01.016","volume":"124","author":"S Wullschleger","year":"2006","unstructured":"Wullschleger S, Loewith R, Hall MN (2006) TOR signaling in growth and metabolism. Cell 124(3):471\u2013484","journal-title":"Cell"},{"issue":"10","key":"4452_CR8","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.molmed.2007.08.001","volume":"13","author":"GG Chiang","year":"2007","unstructured":"Chiang GG, Abraham RT (2007) Targeting the mTOR signaling network in cancer. Trends mol med 13(10):433\u2013442","journal-title":"Trends mol med"},{"issue":"11","key":"4452_CR9","doi-asserted-by":"publisher","first-page":"5016","DOI":"10.1210\/en.2009-0096","volume":"150","author":"J Roa","year":"2009","unstructured":"Roa J, Garcia-Galiano D, Varela L et al (2009) The mammalian target of rapamycin as novel central regulator of puberty onset via modulation of hypothalamic Kiss1 system. Endocrinol 150(11):5016\u20135026","journal-title":"Endocrinol"},{"issue":"10","key":"4452_CR10","doi-asserted-by":"publisher","first-page":"1732","DOI":"10.1210\/me.2012-1106","volume":"26","author":"M Palaniappan","year":"2012","unstructured":"Palaniappan M, Menon KMJ (2012) Luteinizing hormone\/human chorionic gonadotropin-mediated activation of mTORC1 signaling is required for androgen synthesis by theca-interstitial cells. Mol Endocrinol 26(10):1732\u20131742","journal-title":"Mol Endocrinol"},{"issue":"1","key":"4452_CR11","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.gene.2013.03.039","volume":"523","author":"X-M Zhang","year":"2013","unstructured":"Zhang X-M, Li L, Xu J-J et al (2013) Rapamycin preserves the follicle pool reserve and prolongs the ovarian lifespan of female rats via modulating mTOR activation and sirtuin expression. Gene 523(1):82\u201387","journal-title":"Gene"},{"issue":"11","key":"4452_CR12","doi-asserted-by":"publisher","first-page":"E1382","DOI":"10.1073\/pnas.1418973112","volume":"112","author":"Y Wang","year":"2015","unstructured":"Wang Y, Zhu L, Kuokkanen S, Pollard JW (2015) Activation of protein synthesis in mouse uterine epithelial cells by estradiol-17\u03b2 is mediated by a PKC\u2013ERK1\/2\u2013mTOR signaling pathway. Proc Natl Acad Sci U S A 112(11):E1382\u2013E1391","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"15","key":"4452_CR13","doi-asserted-by":"publisher","first-page":"6710","DOI":"10.1128\/MCB.24.15.6710-6718.2004","volume":"24","author":"M Murakami","year":"2004","unstructured":"Murakami M, Ichisaka T, Maeda M et al (2004) mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells. Mol Cell Biol 24(15):6710\u20136718","journal-title":"Mol Cell Biol"},{"key":"4452_CR14","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1177\/1933719107312037","volume":"15","author":"A Yaba","year":"2008","unstructured":"Yaba A, Bianchi V, Borini A, Johnson J (2008) A putative mitotic checkpoint dependent on mTOR function controls cell proliferation and survival in ovarian granulosa cells. Rep Sci 15:128\u2013138","journal-title":"Rep Sci"},{"key":"4452_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1757-2215-5-38","volume":"5","author":"A Yaba","year":"2012","unstructured":"Yaba A, Demir N (2012) The mechanism of mTOR (mammalian target of rapamycin) in a mouse model of polycystic ovary syndrome (PCOS). J Ovarian Res 5:1\u201312","journal-title":"J Ovarian Res"},{"issue":"3","key":"4452_CR16","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1042\/BJ20070540","volume":"405","author":"LR Pearce","year":"2007","unstructured":"Pearce LR, Huang X, Boudeau J et al (2007) Identification of Protor as a novel Rictor-binding component of mTOR complex-2. Biochem J 405(3):513\u2013522","journal-title":"Biochem J"},{"issue":"35","key":"4452_CR17","doi-asserted-by":"publisher","first-page":"25604","DOI":"10.1074\/jbc.M704343200","volume":"282","author":"S Woo","year":"2007","unstructured":"Woo S, Kim D, Jun C et al (2007) PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor \u03b2 expression and signaling. J Biol Chem 282(35):25604\u201325612","journal-title":"J Biol Chem"},{"issue":"5","key":"4452_CR18","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1093\/biolre\/ioab023","volume":"104","author":"TB Garner","year":"2021","unstructured":"Garner TB, Hester JM, Carothers A, Diaz F (2021) Role of zinc in female reproduction. Biol Reprod 104(5):976\u2013994","journal-title":"Biol Reprod"},{"issue":"4","key":"4452_CR19","doi-asserted-by":"publisher","first-page":"2188","DOI":"10.3390\/ijms22042188","volume":"22","author":"S Vickram","year":"2021","unstructured":"Vickram S, Rohini K, Srinivasan S et al (2021) Role of zinc (Zn) in human reproduction: a journey from initial spermatogenesis to childbirth. Int J Mol Sci 22(4):2188","journal-title":"Int J Mol Sci"},{"issue":"1","key":"4452_CR20","doi-asserted-by":"publisher","first-page":"2162609","DOI":"10.1080\/26895293.2022.2162609","volume":"16","author":"A Niknia","year":"2023","unstructured":"Niknia A, Vakili R, Tahmasbi AM (2023) Role of zinc-methionine chelate on bone health and eggshell quality in late\u2013phase laying hens. All life 16(1):2162609","journal-title":"All life"},{"key":"4452_CR21","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1007\/s12011-015-0535-9","volume":"171","author":"D Huang","year":"2016","unstructured":"Huang D, Hu Q, Fang S, Feng J (2016) Dosage effect of zinc glycine chelate on zinc metabolism and gene expression of zinc transporter in intestinal segments on rat. Biol Trace Elem Res 171:363\u2013370","journal-title":"Biol Trace Elem Res"},{"issue":"6","key":"4452_CR22","first-page":"825","volume":"26","author":"AR de Souza","year":"2007","unstructured":"de Souza AR, Martins LP, de Faria LC et al (2007) Studies on the bioavailability of zinc in rats supplementated with two different zinc-methionine compounds. Latin Am J Pharm 26(6):825","journal-title":"Latin Am J Pharm"},{"issue":"2","key":"4452_CR23","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1177\/156482651303400210","volume":"34","author":"M Ruz","year":"2013","unstructured":"Ruz M, Carrasco F, Rojas P et al (2013) Zinc as a potential coadjuvant in therapy for type 2 diabetes. Food nutr bull 34(2):215\u2013221","journal-title":"Food nutr bull"},{"key":"4452_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1758-5996-2-70","volume":"2","author":"N Wiernsperger","year":"2010","unstructured":"Wiernsperger N, Rapin J (2010) Trace elements in glucometabolic disorders: an update. Diabetol Metab Syndr 2:1\u20139","journal-title":"Diabetol Metab Syndr"},{"key":"4452_CR25","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1007\/s12011-014-9941-7","volume":"158","author":"I Guler","year":"2014","unstructured":"Guler I, Himmetoglu O, Turp A et al (2014) Zinc and homocysteine levels in polycystic ovarian syndrome patients with insulin resistance. Biol Trace Elem Res 158:297\u2013304","journal-title":"Biol Trace Elem Res"},{"issue":"11","key":"4452_CR26","doi-asserted-by":"publisher","first-page":"4071","DOI":"10.1210\/en.2015-1159","volume":"156","author":"A Hurliman","year":"2015","unstructured":"Hurliman A, Keller Brown J, Maille N, Mandala M, Casson P, Osol G (2015) Hyperandrogenism and insulin resistance, not changes in body weight, mediate the development of endothelial dysfunction in a female rat model of polycystic ovary syndrome (PCOS). Endocrinol 156(11):4071\u20134080","journal-title":"Endocrinol"},{"key":"4452_CR27","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s12011-017-1085-0","volume":"182","author":"M Maktabi","year":"2018","unstructured":"Maktabi M, Jamilian M, Asemi Z (2018) Magnesium-zinc-calcium-vitamin D co-supplementation improves hormonal profiles, biomarkers of inflammation and oxidative stress in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Biol Trace Elem Res 182:21\u201328","journal-title":"Biol Trace Elem Res"},{"issue":"8","key":"4452_CR28","doi-asserted-by":"publisher","first-page":"2464","DOI":"10.3390\/nu12082464","volume":"12","author":"M Nasiadek","year":"2020","unstructured":"Nasiadek M, Stragierowicz J, Klimczak M, Kilanowicz AJN (2020) The role of zinc in selected female reproductive system disorders. Nutirents 12(8):2464","journal-title":"Nutirents"},{"issue":"1","key":"4452_CR29","doi-asserted-by":"publisher","first-page":"E25","DOI":"10.1152\/ajpendo.2001.281.1.E25","volume":"281","author":"CJ Lynch","year":"2001","unstructured":"Lynch CJ, Patson BJ, Goodman SA, Trapolsi D, Kimball SR (2001) Zinc stimulates the activity of the insulin-and nutrient-regulated protein kinase mTOR. Am J Physiol Endocrinol Metabol 281(1):E25\u2013E34","journal-title":"Am J Physiol Endocrinol Metabol"},{"key":"4452_CR30","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s12011-007-0018-8","volume":"118","author":"JP McClung","year":"2007","unstructured":"McClung JP, Tarr TN, Barnes BR, Scrimgeour AG, Young A (2007) Effect of supplemental dietary zinc on the mammalian target of rapamycin (mTOR) signaling pathway in skeletal muscle and liver from post-absorptive mice. Biol Trace Elem Res 118:65\u201376","journal-title":"Biol Trace Elem Res"},{"issue":"1","key":"4452_CR31","first-page":"36","volume":"23","author":"FF Torshizi","year":"2020","unstructured":"Torshizi FF, Chamani M, Khodaei HR, Sadeghi AA, Hejazi SH, Heravi RM (2020) Therapeutic effects of organic zinc on reproductive hormones, insulin resistance and mTOR expression, as a novel component, in a rat model of polycystic ovary syndrome. Iran J Basic Med Sci 23(1):36","journal-title":"Iran J Basic Med Sci"},{"issue":"18","key":"4452_CR32","doi-asserted-by":"publisher","first-page":"9972","DOI":"10.3390\/ijms22189972","volume":"22","author":"E Przygrodzka","year":"2021","unstructured":"Przygrodzka E, Plewes MR, Davis JS (2021) Luteinizing hormone regulation of inter-organelle communication and fate of the corpus luteum. Inter J Mol Sci 22(18):9972","journal-title":"Inter J Mol Sci"},{"issue":"5","key":"4452_CR33","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1530\/EJE-11-1070","volume":"166","author":"J Ott","year":"2012","unstructured":"Ott J, Wattar L, Kurz C, Seemann R, Huber J, Mayerhofer K, Vytiska-Binstorfer E (2012) Parameters for calcium metabolism in women with polycystic ovary syndrome who undergo clomiphene citrate stimulation: a prospective cohort study. Eur J Endocrinol 166(5):897\u2013902","journal-title":"Eur J Endocrinol"},{"key":"4452_CR34","doi-asserted-by":"publisher","unstructured":"Legro RS (2012) of Conference Obesity and PCOS: implications for diagnosis and treatment. In Seminars in reproductive medicine. Thieme Medical Publishers. https:\/\/doi.org\/10.1055\/s-0032-1328878","DOI":"10.1055\/s-0032-1328878"},{"issue":"6","key":"4452_CR35","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.jnutbio.2009.01.009","volume":"20","author":"J Jansen","year":"2009","unstructured":"Jansen J, Karges W, Rink L (2009) Zinc and diabetes\u2014clinical links and molecular mechanisms. J Nutr Biochem 20(6):399\u2013417","journal-title":"J Nutr Biochem"},{"issue":"3","key":"4452_CR36","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.mefs.2017.11.003","volume":"23","author":"M Kanafchian","year":"2018","unstructured":"Kanafchian M, Mahjoub S, Esmaeilzadeh S, Rahsepar M, Mosapour A (2018) Status of serum selenium and zinc in patients with the polycystic ovary syndrome with and without insulin resistance. Middle East Fertil Soc J 23(3):241\u2013245","journal-title":"Middle East Fertil Soc J"},{"key":"4452_CR37","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1007\/s00404-009-0955-x","volume":"280","author":"HI Afridi","year":"2009","unstructured":"Afridi HI, Kazi TG, Kazi N et al (2009) Status of essential trace metals in biological samples of diabetic mother and their neonates. Arch Gynecol Obstetrics 280:415\u2013423","journal-title":"Arch Gynecol Obstetrics"},{"issue":"11","key":"4452_CR38","first-page":"1109","volume":"28","author":"Y Tamura","year":"2021","unstructured":"Tamura Y (2021) The role of zinc homeostasis in the prevention of diabetes mellitus and cardiovascular diseases. J Atherosclerosis 28(11):1109\u20131122","journal-title":"J Atherosclerosis"},{"issue":"1","key":"4452_CR39","first-page":"231","volume":"32","author":"AK Baltaci","year":"2019","unstructured":"Baltaci AK, Mogulkoc R, Baltaci SB (2019) The role of zinc in the endocrine system. Pakistan J Pharma Sci 32(1):231\u2013239","journal-title":"Pakistan J Pharma Sci"},{"issue":"Suppl 3","key":"4452_CR40","doi-asserted-by":"publisher","first-page":"S611","DOI":"10.4103\/2230-8210.105579","volume":"16","author":"AK Baltaci","year":"2012","unstructured":"Baltaci AK, Mogulkoc R (2012) Leptin and zinc relation: in regulation of food intake and immunity. Indian J Endocrinol Metab 16(Suppl 3):S611\u2013S616","journal-title":"Indian J Endocrinol Metab"},{"issue":"7","key":"4452_CR41","doi-asserted-by":"publisher","first-page":"2402","DOI":"10.1210\/jcem.85.7.6661","volume":"85","author":"A Katz","year":"2000","unstructured":"Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, Sullivan G, Quon M (2000) Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metabol 85(7):2402\u20132410","journal-title":"J Clin Endocrinol Metabol"},{"issue":"7","key":"4452_CR42","first-page":"423","volume":"15","author":"BN Jahromi","year":"2017","unstructured":"Jahromi BN, Dabaghmanesh MH, Parsanezhad ME, Fatehpoor F (2017) Association of leptin and insulin resistance in PCOS: a case-controlled study. Int J Rep BioMed 15(7):423","journal-title":"Int J Rep BioMed"},{"issue":"1","key":"4452_CR43","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s12576-017-0571-7","volume":"68","author":"J Olechnowicz","year":"2018","unstructured":"Olechnowicz J, Tinkov A, Skalny A, Suliburska J (2018) Zinc status is associated with inflammation, oxidative stress, lipid, and glucose metabolism. J Physiol Sci 68(1):19\u201331","journal-title":"J Physiol Sci"},{"issue":"1","key":"4452_CR44","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1093\/ajcn\/nqz041","volume":"110","author":"X Wang","year":"2019","unstructured":"Wang X, Wu W, Zheng W et al (2019) Zinc supplementation improves glycemic control for diabetes prevention and management: a systematic review and meta-analysis of randomized controlled trials. Am J Clin Nutr 110(1):76\u201390","journal-title":"Am J Clin Nutr"},{"issue":"5","key":"4452_CR45","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1093\/jn\/131.5.1414","volume":"131","author":"X Tang","year":"2001","unstructured":"Tang X, Shay N (2001) Zinc has an insulin-like effect on glucose transport mediated by phosphoinositol-3-kinase and Akt in 3T3-L1 fibroblasts and adipocytes. J Nutr 131(5):1414\u20131420","journal-title":"J Nutr"},{"key":"4452_CR46","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s10534-005-3686-x","volume":"18","author":"CG Taylor","year":"2005","unstructured":"Taylor CG (2005) Zinc, the pancreas, and diabetes: insights from rodent studies and future directions. Biometals 18:305\u2013312","journal-title":"Biometals"},{"issue":"1","key":"4452_CR47","first-page":"e12470","volume":"12","author":"S Thathapudi","year":"2014","unstructured":"Thathapudi S, Kodati V, Erukkambattu J, Katragadda A, Addepally U, Hasan Q (2014) Anthropometric and biochemical characteristics of polycystic ovarian syndrome in South Indian women using AES-2006 criteria. Int J Endocrin 12(1):e12470","journal-title":"Int J Endocrin"},{"issue":"2","key":"4452_CR48","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1530\/eje.1.02207","volume":"155","author":"D Glintborg","year":"2006","unstructured":"Glintborg D, Andersen M, Hagen C, Frystyk J, Hulstr\u00f8m V, Flyvbjerg A, Hermann AP (2006) Evaluation of metabolic risk markers in polycystic ovary syndrome (PCOS). Adiponectin, ghrelin, leptin and body composition in hirsute PCOS patients and controls. Eur J Endocrinol 155(2):337\u2013345","journal-title":"Eur J Endocrinol"},{"issue":"2","key":"4452_CR49","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1530\/REP-17-0584","volume":"155","author":"R Patel","year":"2018","unstructured":"Patel R, Shah G (2018) High-fat diet exposure from pre-pubertal age induces polycystic ovary syndrome (PCOS) in rats. Rep 155(2):139\u2013149","journal-title":"Rep"},{"issue":"8","key":"4452_CR50","first-page":"2694","volume":"83","author":"RS Legro","year":"1998","unstructured":"Legro RS, Finegood D, Dunaif A (1998) A fasting glucose to insulin ratio is a useful measure of insulin sensitivity in women with polycystic ovary syndrome. J Clin Endocrinol Metabol 83(8):2694\u20132698","journal-title":"J Clin Endocrinol Metabol"},{"issue":"5","key":"4452_CR51","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/j.bpobgyn.2004.05.004","volume":"18","author":"A Balen","year":"2004","unstructured":"Balen A (2004) The pathophysiology of polycystic ovary syndrome: trying to understand PCOS and its endocrinology. Best Pract Res Clin Obstet Gynaecol 18(5):685\u2013706","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"5","key":"4452_CR52","doi-asserted-by":"publisher","first-page":"265","DOI":"10.18632\/aging.100149","volume":"2","author":"MV Blagosklonny","year":"2010","unstructured":"Blagosklonny MV (2010) Why men age faster but reproduce longer than women: mTOR and evolutionary perspectives. Aging 2(5):265","journal-title":"Aging"},{"issue":"19","key":"4452_CR53","doi-asserted-by":"publisher","first-page":"9461","DOI":"10.1158\/0008-5472.CAN-06-1895","volume":"66","author":"J Yu","year":"2006","unstructured":"Yu J, Henske E (2006) Estrogen-induced activation of mammalian target of rapamycin is mediated via tuberin and the small GTPase Ras homologue enriched in brain. Cancer Res 66(19):9461\u20139466","journal-title":"Cancer Res"},{"issue":"6","key":"4452_CR54","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1002\/ca.23211","volume":"31","author":"J Liu","year":"2018","unstructured":"Liu J, Wu D, Qu L, Liao H, Li M (2018) The role of mTOR in ovarian neoplasms, polycystic ovary syndrome, and ovarian aging. Clin Anat 31(6):891\u2013898","journal-title":"Clin Anat"},{"issue":"5","key":"4452_CR55","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1177\/1933719116667606","volume":"24","author":"T Li","year":"2017","unstructured":"Li T, Mo H, Chen W et al (2017) Role of the PI3K-Akt signaling pathway in the pathogenesis of polycystic ovary syndrome. Rep Sci 24(5):646\u2013655","journal-title":"Rep Sci"},{"issue":"2","key":"4452_CR56","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/nrm1837","volume":"7","author":"CM Taniguchi","year":"2006","unstructured":"Taniguchi CM, Emanuelli B, Kahn CR (2006) Critical nodes in signalling pathways: insights into insulin action. Nat Rev Cell Biol 7(2):85\u201396","journal-title":"Nat Rev Cell Biol"},{"issue":"34","key":"4452_CR57","doi-asserted-by":"publisher","first-page":"25979","DOI":"10.1074\/jbc.M001975200","volume":"275","author":"S Kim","year":"2000","unstructured":"Kim S, Jung Y, Kim D, Koh H, Chung J (2000) Extracellular zinc activates p70 S6 kinase through the phosphatidylinositol 3-kinase signaling pathway. J Biol Chem 275(34):25979\u201325984","journal-title":"J Biol Chem"},{"issue":"3","key":"4452_CR58","doi-asserted-by":"publisher","first-page":"2282","DOI":"10.1074\/jbc.M412179200","volume":"280","author":"I Briaud","year":"2005","unstructured":"Briaud I, Dickson LM, Lingohr MK, McCuaig JF, Lawrence JC, Rhodes C (2005) Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in \u03b2-cells. J Biol Chem 280(3):2282\u20132293","journal-title":"J Biol Chem"}],"container-title":["Biological Trace Element Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-024-04452-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12011-024-04452-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-024-04452-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T15:01:55Z","timestamp":1750172515000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12011-024-04452-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,30]]},"references-count":58,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["4452"],"URL":"https:\/\/doi.org\/10.1007\/s12011-024-04452-6","relation":{},"ISSN":["1559-0720"],"issn-type":[{"value":"1559-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,30]]},"assertion":[{"value":"22 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All methods in the study were in accordance to the ethics guidelines on the animal experiments at the Ferdowsi University of Mashhad. The committee on the ethics of animal experiments approved the protocols by certificate number IR.UM.REC.1401.286.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}