{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T02:52:27Z","timestamp":1785898347882,"version":"3.56.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T00:00:00Z","timestamp":1733443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T00:00:00Z","timestamp":1733443200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"The Government clinical medical talent training program","award":["ZF2023175, ZF2024192"],"award-info":[{"award-number":["ZF2023175, ZF2024192"]}]},{"name":"The Government clinical medical talent training program","award":["ZF2023175, ZF2024192"],"award-info":[{"award-number":["ZF2023175, ZF2024192"]}]},{"name":"The Government clinical medical talent training program","award":["ZF2023175, ZF2024192"],"award-info":[{"award-number":["ZF2023175, ZF2024192"]}]},{"name":"The Government clinical medical talent training program","award":["ZF2023175, ZF2024192"],"award-info":[{"award-number":["ZF2023175, ZF2024192"]}]},{"name":"The Government clinical medical talent training program","award":["ZF2023175, ZF2024192"],"award-info":[{"award-number":["ZF2023175, ZF2024192"]}]},{"name":"The Government clinical medical talent training program","award":["ZF2023175, ZF2024192"],"award-info":[{"award-number":["ZF2023175, ZF2024192"]}]},{"name":"The Government clinical medical talent training program","award":["ZF2023175, ZF2024192"],"award-info":[{"award-number":["ZF2023175, ZF2024192"]}]},{"name":"The Government clinical medical talent training program","award":["ZF2023175, ZF2024192"],"award-info":[{"award-number":["ZF2023175, ZF2024192"]}]},{"DOI":"10.13039\/501100003787","name":"Hebei Natural Science Foundation","doi-asserted-by":"crossref","award":["H2022314001"],"award-info":[{"award-number":["H2022314001"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003787","name":"Hebei Natural Science Foundation","doi-asserted-by":"crossref","award":["H2022314001"],"award-info":[{"award-number":["H2022314001"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003787","name":"Hebei Natural Science Foundation","doi-asserted-by":"crossref","award":["H2022314001"],"award-info":[{"award-number":["H2022314001"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003787","name":"Hebei Natural Science Foundation","doi-asserted-by":"crossref","award":["H2022314001"],"award-info":[{"award-number":["H2022314001"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003787","name":"Hebei Natural Science Foundation","doi-asserted-by":"crossref","award":["H2022314001"],"award-info":[{"award-number":["H2022314001"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003787","name":"Hebei Natural Science Foundation","doi-asserted-by":"crossref","award":["H2022314001"],"award-info":[{"award-number":["H2022314001"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003787","name":"Hebei Natural Science Foundation","doi-asserted-by":"crossref","award":["H2022314001"],"award-info":[{"award-number":["H2022314001"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003787","name":"Hebei Natural Science Foundation","doi-asserted-by":"crossref","award":["H2022314001"],"award-info":[{"award-number":["H2022314001"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biol Trace Elem Res"],"DOI":"10.1007\/s12011-024-04464-2","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T01:12:43Z","timestamp":1733447563000},"page":"4153-4163","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["BPA Exacerbates Zinc Deficiency\u2013Induced Testicular Tissue Inflammation in Male Mice Through the TNF-\u03b1\/NF-\u03baB\/Caspase8 Signaling Pathway"],"prefix":"10.1007","volume":"203","author":[{"given":"Xinying","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanhuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanjing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0217-2490","authenticated-orcid":false,"given":"Shusong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqing","family":"Tie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,6]]},"reference":[{"key":"4464_CR1","doi-asserted-by":"publisher","first-page":"11101","DOI":"10.3390\/ijerph120911101","volume":"12","author":"X Huo","year":"2015","unstructured":"Huo X, Chen D, He Y et al (2015) Bisphenol-A and Female infertility: a possible role of gene-environment interactions. Int J Environ Res Public Health 12:11101\u201311116","journal-title":"Int J Environ Res Public Health"},{"key":"4464_CR2","doi-asserted-by":"publisher","first-page":"2515","DOI":"10.1007\/s11356-012-0827-y","volume":"19","author":"W Xi","year":"2011","unstructured":"Xi W, Wan HT, Zhao YG et al (2011) Effects of perinatal exposure to bisphenol A and di(2-ethylhexyl)-phthalate on gonadal development of male mice. Environ Sci Pollut R 19:2515\u20132527","journal-title":"Environ Sci Pollut R"},{"key":"4464_CR3","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1385\/ENDO:25:2:163","volume":"25","author":"CB Herath","year":"2004","unstructured":"Herath CB, Jin W, Watanabe G et al (2004) Adverse effects of environmental toxicants, octylphenol and bisphenol A, on male reproductive functions in pubertal rats. Endocrine 25:163\u2013172","journal-title":"Endocrine"},{"key":"4464_CR4","first-page":"57","volume":"228","author":"FP Manfo","year":"2014","unstructured":"Manfo FP, Jubendradass R, Nantia EA et al (2014) Adverse effects of bisphenol A on male reproductive function. Rev Environ Contam T 228:57\u201382","journal-title":"Rev Environ Contam T"},{"key":"4464_CR5","doi-asserted-by":"crossref","unstructured":"Melebary SJ, AlGhamdi MS, Elhalwagy MEA et al (2022) Disturbance in some fertility biomarkers induced and changes in testis architecture by chronic exposure to various dosages of each of nonylphenol or bisphenol A and their mix. Life (Basel) 12:1555","DOI":"10.3390\/life12101555"},{"key":"4464_CR6","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.reprotox.2020.07.001","volume":"96","author":"Y Meng","year":"2020","unstructured":"Meng Y, Yannan Z, Ren L et al (2020) Adverse reproductive function induced by maternal BPA exposure is associated with abnormal autophagy and activating inflamation via mTOR and TLR4\/NF-\u03baB signaling pathways in female offspring rats. Reprod Toxicol 96:185\u2013194","journal-title":"Reprod Toxicol"},{"key":"4464_CR7","doi-asserted-by":"crossref","unstructured":"Costa MI, Sarmento-Ribeiro AB, Gon\u00e7alves AC (2023) Zinc: from biological functions to therapeutic potential. Int J Mol Sci 24:4822","DOI":"10.3390\/ijms24054822"},{"key":"4464_CR8","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1017\/S0029665100000781","volume":"59","author":"L Rink","year":"2000","unstructured":"Rink L, Gabriel P (2000) Zinc and the immune system. P Nutr Soc 59:541\u2013552","journal-title":"P Nutr Soc"},{"key":"4464_CR9","doi-asserted-by":"publisher","first-page":"4682","DOI":"10.1021\/cr800556u","volume":"109","author":"W Maret","year":"2009","unstructured":"Maret W, Li Y (2009) Coordination dynamics of zinc in proteins. Chem Rev 109:4682\u20134707","journal-title":"Chem Rev"},{"key":"4464_CR10","doi-asserted-by":"publisher","first-page":"110173","DOI":"10.1016\/j.cbi.2022.110173","volume":"367","author":"K Jomova","year":"2022","unstructured":"Jomova K, Makova M, Alomar SY et al (2022) Essential metals in health and disease. Chem-Biol Interact 367:110173","journal-title":"Chem-Biol Interact"},{"key":"4464_CR11","doi-asserted-by":"publisher","first-page":"1656","DOI":"10.1007\/s12011-023-03789-8","volume":"202","author":"X Zeng","year":"2024","unstructured":"Zeng X, Wang Z, Yu L et al (2024) Zinc supplementation reduces testicular cell apoptosis in mice and improves spermatogenic dysfunction caused by marginal zinc deficiency. Biol Trace Elem Res 202:1656\u20131668","journal-title":"Biol Trace Elem Res"},{"key":"4464_CR12","doi-asserted-by":"publisher","first-page":"e22549","DOI":"10.1002\/jbt.22549","volume":"34","author":"C Sahu","year":"2020","unstructured":"Sahu C, Charaya A, Singla S et al (2020) Zinc deficient diet increases the toxicity of bisphenol A in rat testis. J Biochem Mol Toxic 34:e22549","journal-title":"J Biochem Mol Toxic"},{"key":"4464_CR13","doi-asserted-by":"publisher","first-page":"343","DOI":"10.3945\/ajcn.116.135327","volume":"105","author":"SJ Zyba","year":"2017","unstructured":"Zyba SJ, Shenvi SV, Killilea DW et al (2017) A moderate increase in dietary zinc reduces DNA strand breaks in leukocytes and alters plasma proteins without changing plasma zinc concentrations. Am J Clin Nutr 105:343\u2013351","journal-title":"Am J Clin Nutr"},{"key":"4464_CR14","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1007\/s12011-020-02163-2","volume":"199","author":"KR Wessells","year":"2021","unstructured":"Wessells KR, Brown KH, Arnold CD et al (2021) Plasma and nail zinc concentrations, but not hair zinc, respond positively to two different forms of preventive zinc supplementation in young Laotian children: a randomized controlled trial. Biol Trace Elem Res 199:442\u2013452","journal-title":"Biol Trace Elem Res"},{"key":"4464_CR15","doi-asserted-by":"publisher","first-page":"359","DOI":"10.3945\/jn.110.131318","volume":"141","author":"TP Croxford","year":"2011","unstructured":"Croxford TP, McCormick NH, Kelleher SL (2011) Moderate zinc deficiency reduces testicular Zip6 and Zip10 abundance and impairs spermatogenesis in mice. J Nutr 141:359\u2013365","journal-title":"J Nutr"},{"key":"4464_CR16","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1177\/0960327118816134","volume":"38","author":"AA Khalaf","year":"2019","unstructured":"Khalaf AA, Ahmed W, Moselhy WA et al (2019) Protective effects of selenium and nano-selenium on bisphenol-induced reproductive toxicity in male rats. Hum Exp Toxicol 38:398\u2013408","journal-title":"Hum Exp Toxicol"},{"key":"4464_CR17","first-page":"1043","volume":"32","author":"S Kalender","year":"2019","unstructured":"Kalender S, Apaydin FG, Kalender Y (2019) Testicular toxicity of orally administrated bisphenol A in rats and protective role of taurine and curcumin. Pak J Pharm Sci 32:1043\u20131047","journal-title":"Pak J Pharm Sci"},{"key":"4464_CR18","doi-asserted-by":"publisher","first-page":"2396","DOI":"10.1007\/s12011-022-03324-1","volume":"201","author":"B Sun","year":"2023","unstructured":"Sun B, Ma J, Te L et al (2023) Zinc-deficient diet causes imbalance in zinc homeostasis and impaired autophagy and impairs semen quality in mice. Biol Trace Elem Res 201:2396\u20132406","journal-title":"Biol Trace Elem Res"},{"key":"4464_CR19","first-page":"2","volume":"1","author":"SG Johnsen","year":"1970","unstructured":"Johnsen SG (1970) Testicular biopsy score count\u2013a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males. Hormones 1:2\u201325","journal-title":"Hormones"},{"key":"4464_CR20","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1007\/BF02917357","volume":"43\u201345","author":"R Dams","year":"1994","unstructured":"Dams R (1994) RNAA as compared to ICP-MS for the analysis of normal human serum. Biol Trace Elem Res 43\u201345:539\u2013548","journal-title":"Biol Trace Elem Res"},{"key":"4464_CR21","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.2174\/1570159X17666190726112101","volume":"17","author":"A Santoro","year":"2019","unstructured":"Santoro A, Chianese R, Troisi J et al (2019) Neuro-toxic and reproductive effects of BPA. Curr Neuropharmacol 17:1109\u20131132","journal-title":"Curr Neuropharmacol"},{"key":"4464_CR22","doi-asserted-by":"publisher","first-page":"130518","DOI":"10.1016\/j.bbagen.2023.130518","volume":"1868","author":"R Luan","year":"2024","unstructured":"Luan R, Luo M, Ding D et al (2024) Zinc deficiency increases lung inflammation and fibrosis in obese mice by promoting oxidative stress. Bba-Gen Subj 1868:130518","journal-title":"Bba-Gen Subj"},{"key":"4464_CR23","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1211\/jpp.60.9.0017","volume":"60","author":"MM El-Seweidy","year":"2008","unstructured":"El-Seweidy MM, Hashem RM, Abo-El-matty DM et al (2008) Frequent inadequate supply of micronutrients in fast food induces oxidative stress and inflammation in testicular tissues of weanling rats. J Pharm Pharmacol 60:1237\u20131242","journal-title":"J Pharm Pharmacol"},{"key":"4464_CR24","doi-asserted-by":"publisher","first-page":"729539","DOI":"10.3389\/fimmu.2021.729539","volume":"12","author":"Y Fang","year":"2021","unstructured":"Fang Y, Su Y, Xu J et al (2021) Varicocele-mediated male infertility: from the perspective of testicular immunity and inflammation. Front Immunol 12:729539","journal-title":"Front Immunol"},{"key":"4464_CR25","doi-asserted-by":"publisher","first-page":"228","DOI":"10.3109\/19396368.2011.574248","volume":"57","author":"Y Izumi","year":"2011","unstructured":"Izumi Y, Yamaguchi K, Ishikawa T et al (2011) Molecular changes induced by bisphenol-A in rat Sertoli cell culture. Syst Biol Reprod Med 57:228\u2013232","journal-title":"Syst Biol Reprod Med"},{"key":"4464_CR26","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1111\/bcpt.12894","volume":"122","author":"FM Ogo","year":"2018","unstructured":"Ogo FM, de Lion Siervo GEM, Staurengo-Ferrari L et al (2018) Bisphenol A exposure impairs epididymal development during the peripubertal period of rats: inflammatory profile and tissue changes. Basic Clin Pharmacol 122:262\u2013270","journal-title":"Basic Clin Pharmacol"},{"key":"4464_CR27","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1080\/14647273.2018.1494390","volume":"23","author":"A BeigiHarchegani","year":"2020","unstructured":"BeigiHarchegani A, Dahan H, Tahmasbpour E et al (2020) Effects of zinc deficiency on impaired spermatogenesis and male infertility: the role of oxidative stress, inflammation and apoptosis. Hum Fertil 23:5\u201316","journal-title":"Hum Fertil"},{"key":"4464_CR28","doi-asserted-by":"publisher","first-page":"127501","DOI":"10.1016\/j.ijbiomac.2023.127501","volume":"253","author":"L Peng","year":"2023","unstructured":"Peng L, Chen S, Lin H et al (2023) Bisphenol A exposure exacerbates tracheal inflammatory injury in selenium-deficient chickens by regulating the miR-155\/TRAF3\/ROS pathway. Int J Biol Macromol 253:127501","journal-title":"Int J Biol Macromol"},{"key":"4464_CR29","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1007\/s13224-023-01767-7","volume":"73","author":"H Akbari","year":"2023","unstructured":"Akbari H, Elyasi L, Khaleghi AA et al (2023) The effect of zinc supplementation on improving sperm parameters in infertile diabetic men. J Obstet Gyn India 73:316\u2013321","journal-title":"J Obstet Gyn India"},{"key":"4464_CR30","first-page":"69","volume":"19","author":"A Fallah","year":"2018","unstructured":"Fallah A, Mohammad-Hasani A, Colagar AH (2018) Zinc is an essential element for male fertility: a review of Zn roles in men\u2019s health, germination, sperm quality, and fertilization. J Reprod Infertil 19:69\u201381","journal-title":"J Reprod Infertil"},{"key":"4464_CR31","doi-asserted-by":"publisher","first-page":"82","DOI":"10.3945\/an.112.003038","volume":"4","author":"W Maret","year":"2013","unstructured":"Maret W (2013) Zinc biochemistry: from a single zinc enzyme to a key element of life. Adv Nutr 4:82\u201391","journal-title":"Adv Nutr"},{"key":"4464_CR32","doi-asserted-by":"publisher","first-page":"100320","DOI":"10.1016\/j.jbc.2021.100320","volume":"296","author":"T Kambe","year":"2021","unstructured":"Kambe T, Taylor KM, Fu D (2021) Zinc transporters and their functional integration in mammalian cells. J Biol Chem 296:100320","journal-title":"J Biol Chem"},{"key":"4464_CR33","doi-asserted-by":"publisher","first-page":"15456","DOI":"10.1074\/jbc.M412188200","volume":"280","author":"L Huang","year":"2005","unstructured":"Huang L, Kirschke CP, Zhang Y et al (2005) The ZIP7 gene (Slc39a7) encodes a zinc transporter involved in zinc homeostasis of the Golgi apparatus. J Biol Chem 280:15456\u201315463","journal-title":"J Biol Chem"},{"key":"4464_CR34","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1073\/pnas.0510407103","volume":"103","author":"TB Aydemir","year":"2006","unstructured":"Aydemir TB, Blanchard RK, Cousins RJ (2006) Zinc supplementation of young men alters metallothionein, zinc transporter, and cytokine gene expression in leukocyte populations. P Natl Acad Sci USA 103:1699\u20131704","journal-title":"P Natl Acad Sci USA"},{"key":"4464_CR35","doi-asserted-by":"publisher","first-page":"e18059","DOI":"10.1371\/journal.pone.0018059","volume":"6","author":"S Hojyo","year":"2011","unstructured":"Hojyo S, Fukada T, Shimoda S et al (2011) The zinc transporter SLC39A14\/ZIP14 controls G-protein coupled receptor-mediated signaling required for systemic growth. PLoS One 6:e18059","journal-title":"PLoS One"},{"key":"4464_CR36","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1152\/japplphysiol.01123.2014","volume":"119","author":"V Adams","year":"2015","unstructured":"Adams V, Alves M, Fischer T et al (2015) High-intensity interval training attenuates endothelial dysfunction in a Dahl salt-sensitive rat model of heart failure with preserved ejection fraction. J Appl Physiol 119:745\u2013752","journal-title":"J Appl Physiol"},{"key":"4464_CR37","doi-asserted-by":"publisher","first-page":"6135","DOI":"10.1021\/ic200270p","volume":"50","author":"S Potocki","year":"2011","unstructured":"Potocki S, Rowinska-Zyrek M, Valensin D et al (2011) Metal binding ability of cysteine-rich peptide domain of ZIP13 Zn2+ ions transporter. Inorg Chem 50:6135\u20136145","journal-title":"Inorg Chem"},{"key":"4464_CR38","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1007\/s12011-019-01671-0","volume":"192","author":"S Thokala","year":"2019","unstructured":"Thokala S, Bodiga VL, Kudle MR et al (2019) Comparative response of cardiomyocyte ZIPs and ZnTs to extracellular zinc and TPEN. Biol Trace Elem Res 192:297\u2013307","journal-title":"Biol Trace Elem Res"},{"key":"4464_CR39","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.jcmgh.2014.11.006","volume":"1","author":"MJ Waldner","year":"2015","unstructured":"Waldner MJ, Neurath MF (2015) Mechanisms of immune signaling in colitis-associated cancer. Cell Mol Gastroenterol Hepatol 1:6\u201316","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"4464_CR40","doi-asserted-by":"publisher","first-page":"64","DOI":"10.3748\/wjg.v20.i1.64","volume":"20","author":"J Pedersen","year":"2014","unstructured":"Pedersen J, Coskun M, Soendergaard C et al (2014) Inflammatory pathways of importance for management of inflammatory bowel disease. World J Gastroentero 20:64\u201377","journal-title":"World J Gastroentero"},{"key":"4464_CR41","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1002\/tox.22702","volume":"34","author":"FM Huang","year":"2019","unstructured":"Huang FM, Chang YC, Lee SS et al (2019) Expression of pro-inflammatory cytokines and mediators induced by Bisphenol A via ERK-NF\u03baB and JAK1\/2-STAT3 pathways in macrophages. Environ Toxicol 34:486\u2013494","journal-title":"Environ Toxicol"},{"key":"4464_CR42","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1007\/s12011-022-03166-x","volume":"201","author":"Y Xu","year":"2023","unstructured":"Xu Y, Li A, Li X et al (2023) Zinc deficiency induces inflammation and apoptosis via oxidative stress in the kidneys of mice. Biol Trace Elem Res 201:739\u2013750","journal-title":"Biol Trace Elem Res"},{"key":"4464_CR43","doi-asserted-by":"publisher","first-page":"1290100","DOI":"10.3389\/fimmu.2023.1290100","volume":"14","author":"K Kijima","year":"2023","unstructured":"Kijima K, Ono G, Kobayakawa K et al (2023) Zinc deficiency impairs axonal regeneration and functional recovery after spinal cord injury by modulating macrophage polarization via NF-\u03baB pathway. Front Immunol 14:1290100","journal-title":"Front Immunol"},{"key":"4464_CR44","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.celrep.2013.01.009","volume":"3","author":"MJ Liu","year":"2013","unstructured":"Liu MJ, Bao S, G\u00e1lvez-Peralta M et al (2013) ZIP8 regulates host defense through zinc-mediated inhibition of NF-\u03baB. Cell Rep 3:386\u2013400","journal-title":"Cell Rep"},{"key":"4464_CR45","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1067\/mlc.2001.118108","volume":"138","author":"AS Prasad","year":"2001","unstructured":"Prasad AS, Bao B, Beck FW et al (2001) Zinc activates NF-kappaB in HUT-78 cells. J Lab Clin Med 138:250\u2013256","journal-title":"J Lab Clin Med"}],"container-title":["Biological Trace Element Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-024-04464-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12011-024-04464-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-024-04464-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T04:02:15Z","timestamp":1750132935000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12011-024-04464-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,6]]},"references-count":45,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["4464"],"URL":"https:\/\/doi.org\/10.1007\/s12011-024-04464-2","relation":{},"ISSN":["1559-0720"],"issn-type":[{"value":"1559-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,6]]},"assertion":[{"value":"22 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experimental procedures were approved by the Ethics Committee of Hebei General Hospital (Animal ethics approval number: 2024-DW-048).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"All authors have agreed for publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}