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Distilled water (1\u00a0mL\/rat), corn oil (1\u00a0mL\/rat), 10\u00a0mg CQ10\/kg b.wt, 50\u00a0mg TNP\/kg b.wt, 5\u00a0mg Cd\/kg b.wt, TNP\u2009+\u2009Cd, or TNP\u2009+\u2009Cd\u2009+\u2009CQ10 was administered orally to seven groups of 70 male Sprague Dawley rats for 60\u00a0days. The findings demonstrated that TNP and\/or Cd exposure considerably raised serum levels of several renal damage products, disturbed electrolyte balance including sodium, potassium, and calcium, decreased antioxidant enzyme concentration in the kidneys, and elevated malondialdehyde. In addition, rats exposed to TNP and\/or Cd had significantly higher levels of renal titanium and Cd. In addition, rats exposed to TNP and\/or Cd showed significant histopathological lesions and collagen deposition as revealed by H and E and Masson trichrome staining, respectively. The kidneys were severely damaged by the combined effects of TNP and Cd, although CQ10 greatly mitigated these effects. According to the study, exposure to TNP and Cd can damage the kidneys\u2019 function and structure, especially when combined. However, CQ10 can protect against TNP and Cd\u2019s nephrotoxic effects.<\/jats:p>","DOI":"10.1007\/s12011-024-04469-x","type":"journal-article","created":{"date-parts":[[2024,12,21]],"date-time":"2024-12-21T02:52:20Z","timestamp":1734749540000},"page":"4183-4197","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Coenzyme Q10 Attenuates Kidney Injury Induced by Titanium Dioxide Nanoparticles and Cadmium Co-exposure in Rats"],"prefix":"10.1007","volume":"203","author":[{"given":"Yasmina M.","family":"Abd-Elhakim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed M. 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