{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T13:56:02Z","timestamp":1772718962757,"version":"3.50.1"},"reference-count":160,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:00:00Z","timestamp":1736380800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:00:00Z","timestamp":1736380800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biol Trace Elem Res"],"DOI":"10.1007\/s12011-025-04513-4","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T05:28:20Z","timestamp":1736400500000},"page":"4489-4505","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Could the Effect of Arsenic on the Testis be Reversed after Removing the Insult? A Meta-analysis Study"],"prefix":"10.1007","volume":"203","author":[{"given":"Luiz Ot\u00e1vio","family":"Guimar\u00e3es-Ervilha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00edrian Quint\u00e3o","family":"Assis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thain\u00e1","family":"Iasbik-Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabela Pereira","family":"da Silva Bento","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7416-3529","authenticated-orcid":false,"given":"Mariana","family":"Machado-Neves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,1,9]]},"reference":[{"key":"4513_CR1","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s10565-022-09710-8","volume":"39","author":"S Muzaffar","year":"2023","unstructured":"Muzaffar S, Khan J, Srivastava R et al (2023) Mechanistic understanding of the toxic effects of arsenic and warfare arsenicals on human health and environment. Cell Biol Toxicol 39:85\u2013110. https:\/\/doi.org\/10.1007\/s10565-022-09710-8","journal-title":"Cell Biol Toxicol"},{"key":"4513_CR2","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1080\/10915810600840776","volume":"25","author":"A Wang","year":"2006","unstructured":"Wang A, Holladay SD, Wolf DC et al (2006) Reproductive and developmental toxicity of arsenic in rodents: A review. Int J Toxicol 25:319\u2013331. https:\/\/doi.org\/10.1080\/10915810600840776","journal-title":"Int J Toxicol"},{"key":"4513_CR3","first-page":"9275","volume":"26","author":"M Perrelli","year":"2022","unstructured":"Perrelli M, Wu R, Liu DJ et al (2022) Heavy metals as risk factors for human diseases - a Bayesian network approach. Eur Rev Med Pharmacol Sci 26:9275\u20139310","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"4513_CR4","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.aogh.2014.09.005","volume":"80","author":"M Tolins","year":"2014","unstructured":"Tolins M, Ruchirawat M, Landrigan P (2014) The developmental neurotoxicity of arsenic: Cognitive and behavioral consequences of early life exposure. Ann Glob Heal 80:303\u2013314. https:\/\/doi.org\/10.1016\/j.aogh.2014.09.005","journal-title":"Ann Glob Heal"},{"key":"4513_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/toxres\/tfad111","volume":"13","author":"SY Ganie","year":"2024","unstructured":"Ganie SY, Javaid D, Hajam YA, Reshi MS (2024) Arsenic toxicity: sources, pathophysiology and mechanism. Toxicol Res (Camb) 13:1\u201320. https:\/\/doi.org\/10.1093\/toxres\/tfad111","journal-title":"Toxicol Res (Camb)"},{"key":"4513_CR6","doi-asserted-by":"publisher","first-page":"8803","DOI":"10.1039\/d3ra00789h","volume":"13","author":"KS Patel","year":"2023","unstructured":"Patel KS, Pandey PK, Mart\u00edn-Ramos P et al (2023) A review on arsenic in the environment: contamination, mobility, sources, and exposure. RSC Adv 13:8803\u20138821. https:\/\/doi.org\/10.1039\/d3ra00789h","journal-title":"RSC Adv"},{"key":"4513_CR7","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1016\/j.scitotenv.2015.08.070","volume":"538","author":"AE Bardach","year":"2015","unstructured":"Bardach AE, Ciapponi A, Soto N et al (2015) Epidemiology of chronic disease related to arsenic in Argentina: A systematic review. Sci Total Environ 538:802\u2013816. https:\/\/doi.org\/10.1016\/j.scitotenv.2015.08.070","journal-title":"Sci Total Environ"},{"key":"4513_CR8","doi-asserted-by":"publisher","first-page":"18200","DOI":"10.1007\/s11356-016-6870-3","volume":"23","author":"PR Guvvala","year":"2016","unstructured":"Guvvala PR, Sellappan S, Parameswaraiah RJ (2016) Impact of arsenic(V) on testicular oxidative stress and sperm functional attributes in Swiss albino mice. Environ Sci Pollut Res 23:18200\u201318210. https:\/\/doi.org\/10.1007\/s11356-016-6870-3","journal-title":"Environ Sci Pollut Res"},{"key":"4513_CR9","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.scitotenv.2017.08.216","volume":"612","author":"S Bhowmick","year":"2018","unstructured":"Bhowmick S, Pramanik S, Singh P et al (2018) Arsenic in groundwater of West Bengal, India: A review of human health risks and assessment of possible intervention options. Sci Total Environ 612:148\u2013169. https:\/\/doi.org\/10.1016\/j.scitotenv.2017.08.216","journal-title":"Sci Total Environ"},{"key":"4513_CR10","doi-asserted-by":"publisher","first-page":"105883","DOI":"10.1016\/j.envint.2020.105883","volume":"142","author":"G Desai","year":"2020","unstructured":"Desai G, Barg G, Vahter M et al (2020) Executive functions in school children from Montevideo, Uruguay and their associations with concurrent low-level arsenic exposure. Environ Int 142:105883. https:\/\/doi.org\/10.1016\/j.envint.2020.105883","journal-title":"Environ Int"},{"key":"4513_CR11","doi-asserted-by":"publisher","first-page":"117940","DOI":"10.1016\/j.envpol.2021.117940","volume":"289","author":"MS Rahaman","year":"2021","unstructured":"Rahaman MS, Rahman MM, Mise N et al (2021) Environmental arsenic exposure and its contribution to human diseases, toxicity mechanism and management. Environ Pollut 289:117940. https:\/\/doi.org\/10.1016\/j.envpol.2021.117940","journal-title":"Environ Pollut"},{"key":"4513_CR12","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1080\/09603123.2019.1674255","volume":"31","author":"W Zhang","year":"2021","unstructured":"Zhang W, Gao Y, Yu G et al (2021) Progress in the prevention and control of water-borne arsenicosis in China. Int J Environ Health Res 31:548\u2013557. https:\/\/doi.org\/10.1080\/09603123.2019.1674255","journal-title":"Int J Environ Health Res"},{"key":"4513_CR13","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.taap.2003.10.023","volume":"198","author":"S Hirano","year":"2004","unstructured":"Hirano S, Kobayashi Y, Cui X et al (2004) The accumulation and toxicity of methylated arsenicals in endothelial cells: Important roles of thiol compounds. Toxicol Appl Pharmacol 198:458\u2013467. https:\/\/doi.org\/10.1016\/j.taap.2003.10.023","journal-title":"Toxicol Appl Pharmacol"},{"key":"4513_CR14","doi-asserted-by":"crossref","unstructured":"Machado-Neves M, Souza ACF (2023) 17 - The effect of arsenical compounds on mitochondrial metabolism. In: de Oliveira MRBT-MI (ed). Academic Press, pp 379\u2013407","DOI":"10.1016\/B978-0-323-88462-4.00006-7"},{"key":"4513_CR15","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.mrgentox.2008.09.020","volume":"674","author":"A De Vizcaya-Ruiz","year":"2009","unstructured":"De Vizcaya-Ruiz A, Barbier O, Ruiz-Ramos R, Cebrian ME (2009) Biomarkers of oxidative stress and damage in human populations exposed to arsenic. Mutat Res - Genet Toxicol Environ Mutagen 674:85\u201392. https:\/\/doi.org\/10.1016\/j.mrgentox.2008.09.020","journal-title":"Mutat Res - Genet Toxicol Environ Mutagen"},{"key":"4513_CR16","doi-asserted-by":"publisher","unstructured":"Zubair M, Ahmad M, Qureshi ZI (2017) Review on arsenic-induced toxicity in male reproductive system and its amelioration. Andrologia 49:. https:\/\/doi.org\/10.1111\/and.12791","DOI":"10.1111\/and.12791"},{"key":"4513_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/antiox12081559","volume":"12","author":"E Monageng","year":"2023","unstructured":"Monageng E, Offor U, Takalani NB et al (2023) A Review on the Impact of Oxidative Stress and Medicinal Plants on Leydig Cells. Antioxidants 12:1\u201329. https:\/\/doi.org\/10.3390\/antiox12081559","journal-title":"Antioxidants"},{"key":"4513_CR18","doi-asserted-by":"publisher","first-page":"166742","DOI":"10.1016\/j.bbadis.2023.166742","volume":"1869","author":"P Sharma","year":"2023","unstructured":"Sharma P, Kaushal N, Saleth LR et al (2023) Oxidative stress-induced apoptosis and autophagy: Balancing the contrary forces in spermatogenesis. Biochim Biophys Acta - Mol Basis Dis 1869:166742. https:\/\/doi.org\/10.1016\/j.bbadis.2023.166742","journal-title":"Biochim Biophys Acta - Mol Basis Dis"},{"key":"4513_CR19","unstructured":"Eaton D, Gilbert S (2013) Principles of toxicology. In: Casarett & Doull\u2019s Toxicology, 8th ed. New York, pp 13\u201348"},{"key":"4513_CR20","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.freeradbiomed.2011.04.008","volume":"51","author":"SJS Flora","year":"2011","unstructured":"Flora SJS (2011) Arsenic-induced oxidative stress and its reversibility. Free Radic Biol Med 51:257\u2013281. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2011.04.008","journal-title":"Free Radic Biol Med"},{"key":"4513_CR21","doi-asserted-by":"publisher","unstructured":"Machado-Neves M (2022) Arsenic exposure and its implications in male fertility. Anim Reprod 19:. https:\/\/doi.org\/10.1590\/1984-3143-AR2022-0119","DOI":"10.1590\/1984-3143-AR2022-0119"},{"key":"4513_CR22","doi-asserted-by":"publisher","unstructured":"Kim Y-J, Kim J-M (2015) Arsenic Toxicity in Male Reproduction and Development. Dev Reprod 19:167\u2013180. https:\/\/doi.org\/10.12717\/DR.2015.19.4.167","DOI":"10.12717\/DR.2015.19.4.167"},{"key":"4513_CR23","doi-asserted-by":"publisher","first-page":"256","DOI":"10.5958\/0973-9130.2018.00112.3","volume":"12","author":"AEA Fouad","year":"2018","unstructured":"Fouad AEA, Fouad AA, Al-Melhim WN (2018) Protective effect of baicalin in rats exposed to arsenic-induced testicular toxicity. Indian J Forensic Med Toxicol 12:256\u2013261. https:\/\/doi.org\/10.5958\/0973-9130.2018.00112.3","journal-title":"Indian J Forensic Med Toxicol"},{"key":"4513_CR24","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.lfs.2018.09.045","volume":"212","author":"K Renu","year":"2018","unstructured":"Renu K, Madhyastha H, Madhyastha R et al (2018) Review on molecular and biochemical insights of arsenic-mediated male reproductive toxicity. Life Sci 212:37\u201358. https:\/\/doi.org\/10.1016\/j.lfs.2018.09.045","journal-title":"Life Sci"},{"key":"4513_CR25","doi-asserted-by":"publisher","unstructured":"Hu Y, Li J, Lou B, et al (2020) The role of reactive oxygen species in arsenic toxicity. Biomolecules 10:. https:\/\/doi.org\/10.3390\/biom10020240","DOI":"10.3390\/biom10020240"},{"key":"4513_CR26","first-page":"27","volume":"5","author":"M Sarkar","year":"2003","unstructured":"Sarkar M, Chaudhuri GR, Chattopadhyay A, Biswas NM (2003) Effect of sodium arsenite on spermatogenesis, plasma gonadotrophins andtestosterone in rats. Asian J Androl 5:27\u201331","journal-title":"Asian J Androl"},{"key":"4513_CR27","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1191\/0960327104ht467oa","volume":"23","author":"N Pant","year":"2004","unstructured":"Pant N, Murthy RC, Srivastava SP (2004) Male reproductive toxicity of sodium arsenite in mice. Hum Exp Toxicol 23:399\u2013403. https:\/\/doi.org\/10.1191\/0960327104ht467oa","journal-title":"Hum Exp Toxicol"},{"key":"4513_CR28","first-page":"249","volume":"10","author":"HR Momeni","year":"2012","unstructured":"Momeni HR, Eskandari N (2012) Effect of vitamin E on sperm parameters and DNA integrity in sodium arsenite-treated rats. Iran J Reprod Med 10:249\u2013256","journal-title":"Iran J Reprod Med"},{"key":"4513_CR29","doi-asserted-by":"publisher","first-page":"152886","DOI":"10.1016\/j.tox.2021.152886","volume":"460","author":"F Couto-Santos","year":"2021","unstructured":"Couto-Santos F, Viana AGDA, Souza ACF et al (2021) Prepubertal arsenic exposure alters phosphoproteins profile, quality, and fertility of epididymal spermatozoa in sexually mature rats. Toxicology 460:152886. https:\/\/doi.org\/10.1016\/j.tox.2021.152886","journal-title":"Toxicology"},{"key":"4513_CR30","first-page":"154","volume-title":"Molecular mechanisms in spermatogenesis","author":"RJ Aitken","year":"2008","unstructured":"Aitken RJ, Roman SD (2008) antioxidant systems and oxidative stress in the testes. In: Cheng CY (ed) Molecular mechanisms in spermatogenesis. Springer, New York, New York, NY, pp 154\u2013171"},{"key":"4513_CR31","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1093\/humupd\/dmk001","volume":"12","author":"J Ehmcke","year":"2006","unstructured":"Ehmcke J, Wistuba J, Schlatt S (2006) Spermatogonial stem cells: questions, models and perspectives. Hum Reprod Update 12:275\u2013282. https:\/\/doi.org\/10.1093\/humupd\/dmk001","journal-title":"Hum Reprod Update"},{"key":"4513_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12915-017-0357-7","volume":"15","author":"S Nakagawa","year":"2017","unstructured":"Nakagawa S, Noble DWA, Senior AM, Lagisz M (2017) Meta-evaluation of meta-analysis: Ten appraisal questions for biologists. BMC Biol 15:1\u201314. https:\/\/doi.org\/10.1186\/s12915-017-0357-7","journal-title":"BMC Biol"},{"key":"4513_CR33","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/nature25753","volume":"555","author":"J Gurevitch","year":"2018","unstructured":"Gurevitch J, Koricheva J, Nakagawa S, Stewart G (2018) Meta-analysis and the science of research synthesis. Nature 555:175\u2013182. https:\/\/doi.org\/10.1038\/nature25753","journal-title":"Nature"},{"key":"4513_CR34","doi-asserted-by":"publisher","first-page":"214","DOI":"10.3390\/jox12030016","volume":"12","author":"F Zargari","year":"2022","unstructured":"Zargari F, Rahaman MS, KazemPour R, Hajirostamlou M (2022) Arsenic, oxidative stress and reproductive system. J Xenobiotics 12:214\u2013222. https:\/\/doi.org\/10.3390\/jox12030016","journal-title":"J Xenobiotics"},{"key":"4513_CR35","doi-asserted-by":"publisher","first-page":"115304","DOI":"10.1016\/j.taap.2020.115304","volume":"409","author":"F Couto-Santos","year":"2020","unstructured":"Couto-Santos F, Souza ACF, Bastos DSS et al (2020) Prepubertal exposure to arsenic alters male reproductive parameters in pubertal and adult rats. Toxicol Appl Pharmacol 409:115304. https:\/\/doi.org\/10.1016\/j.taap.2020.115304","journal-title":"Toxicol Appl Pharmacol"},{"key":"4513_CR36","doi-asserted-by":"publisher","first-page":"e1000100","DOI":"10.1371\/journal.pmed.1000100","volume":"6","author":"A Liberati","year":"2009","unstructured":"Liberati A, Altman DG, Tetzlaff J et al (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: Explanation and elaboration. PLoS Med 6:e1000100. https:\/\/doi.org\/10.1371\/journal.pmed.1000100","journal-title":"PLoS Med"},{"key":"4513_CR37","unstructured":"Rosenberg M, Adams D, Gurevitch J (2000) MetaWin: Statistical software for meta-analysis. Version 2.0. Sinauer Assoc"},{"key":"4513_CR38","doi-asserted-by":"publisher","first-page":"e14347","DOI":"10.1111\/and.14347","volume":"54","author":"I Fatima","year":"2022","unstructured":"Fatima I, Qureshi IZ (2022) Intraperitoneal kisspeptin-10 administration ameliorates sodium arsenite-induced reproductive toxicity in adult male mice. Andrologia 54:e14347. https:\/\/doi.org\/10.1111\/and.14347","journal-title":"Andrologia"},{"key":"4513_CR39","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.ecoenv.2018.12.035","volume":"170","author":"A Alamdar","year":"2019","unstructured":"Alamdar A, Tian M, Huang Q et al (2019) Enhanced histone H3K9 tri-methylation suppresses steroidogenesis in rat testis chronically exposed to arsenic. Ecotoxicol Environ Saf 170:513\u2013520. https:\/\/doi.org\/10.1016\/j.ecoenv.2018.12.035","journal-title":"Ecotoxicol Environ Saf"},{"key":"4513_CR40","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1111\/and.12561","volume":"48","author":"BB Baltaci","year":"2016","unstructured":"Baltaci BB, Uygur R, Caglar V et al (2016) Protective effects of quercetin against arsenic-induced testiculardamage in rats. Andrologia 48:1202\u20131213. https:\/\/doi.org\/10.1111\/and.12561","journal-title":"Andrologia"},{"key":"4513_CR41","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1615\/JEnvironPatholToxicolOncol.v26.i1.40","volume":"26","author":"R Biswas","year":"2007","unstructured":"Biswas R, Poddar S, Mukherjee A (2007) Investigation on the genotoxic effects of long-term administration ofsodium arsenite in bone marrow and testicular cells in vivo using thecomet assay. J Environ Pathol Toxicol Oncol 26:29\u201337. https:\/\/doi.org\/10.1615\/JEnvironPatholToxicolOncol.v26.i1.40","journal-title":"J Environ Pathol Toxicol Oncol"},{"key":"4513_CR42","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.1021\/tx700366x","volume":"21","author":"T-J Chiou","year":"2008","unstructured":"Chiou T-J, Chu S-T, Tzeng W-F et al (2008) Arsenic trioxide impairs spermatogenesis via reducing gene expression levels in testosterone synthesis pathway. Chem Res Toxicol 21:1562\u20131569. https:\/\/doi.org\/10.1021\/tx700366x","journal-title":"Chem Res Toxicol"},{"key":"4513_CR43","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1002\/tox.22660","volume":"34","author":"P da Cunha de Medeiros","year":"2019","unstructured":"da Cunha de Medeiros P, Samelo RR, Silva APG et al (2019) Prepubertal exposure to low doses of sodium arsenite impairs spermatogenesis and epididymal histophysiology in rats. Environ Toxicol 34:83\u201391. https:\/\/doi.org\/10.1002\/tox.22660","journal-title":"Environ Toxicol"},{"key":"4513_CR44","doi-asserted-by":"publisher","first-page":"4257498","DOI":"10.1155\/2016\/4257498","volume":"2016","author":"RF da Silva","year":"2016","unstructured":"da Silva RF, dos Borges C et al (2016) The coadministration of N-Acetylcysteine ameliorates the effects of arsenic trioxide on the male mouse genital system. Oxid Med Cell Longev 2016:4257498. https:\/\/doi.org\/10.1155\/2016\/4257498","journal-title":"Oxid Med Cell Longev"},{"key":"4513_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.reprotox.2021.03.005","volume":"102","author":"AT de Ara\u00fajo-Ramos","year":"2021","unstructured":"de Ara\u00fajo-Ramos AT, Basso CG, Passoni MT et al (2021) The endocrine disrupting effects of sodium arsenite in the rat testis is not mediated through macrophage activation. Reprod Toxicol 102:1\u20139. https:\/\/doi.org\/10.1016\/j.reprotox.2021.03.005","journal-title":"Reprod Toxicol"},{"key":"4513_CR46","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.fct.2008.11.013","volume":"47","author":"FM El-Demerdash","year":"2009","unstructured":"El-Demerdash FM, Yousef MI, Radwan FME (2009) Ameliorating effect of curcumin on sodium arsenite-induced oxidative damage and lipid peroxidation in different rat organs. Food Chem Toxicol 47:249\u2013254. https:\/\/doi.org\/10.1016\/j.fct.2008.11.013","journal-title":"Food Chem Toxicol"},{"key":"4513_CR47","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1177\/0960327111405862","volume":"31","author":"M Ferreira","year":"2012","unstructured":"Ferreira M, Matos RC, Oliveira H et al (2012) Impairment of mice spermatogenesis by sodium arsenite. Hum Exp Toxicol 31:290\u2013302. https:\/\/doi.org\/10.1177\/0960327111405862","journal-title":"Hum Exp Toxicol"},{"key":"4513_CR48","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1177\/0960327115595682","volume":"35","author":"SG Li","year":"2016","unstructured":"Li SG, Xu SZ, Niu Q et al (2016) Lutein alleviates arsenic-induced reproductive toxicity in male mice via Nrf2 signaling. Hum Exp Toxicol 35:491\u2013500. https:\/\/doi.org\/10.1177\/0960327115595682","journal-title":"Hum Exp Toxicol"},{"key":"4513_CR49","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.ecoenv.2018.08.109","volume":"165","author":"X Li","year":"2018","unstructured":"Li X, Yi H, Wang H (2018) Sulphur dioxide and arsenic affect male reproduction via interfering with spermatogenesis in mice. Ecotoxicol Environ Saf 165:164\u2013173. https:\/\/doi.org\/10.1016\/j.ecoenv.2018.08.109","journal-title":"Ecotoxicol Environ Saf"},{"key":"4513_CR50","doi-asserted-by":"publisher","first-page":"272","DOI":"10.3967\/bes2015.038","volume":"28","author":"S Li-Gang","year":"2015","unstructured":"Li-Gang S, Ding YS, Niu Q et al (2015) Grape seed proanthocyanidin extract alleviates arsenic-induced oxidative reproductive toxicity in male mice. Biomed Environ Sci 28:272\u2013280. https:\/\/doi.org\/10.3967\/bes2015.038","journal-title":"Biomed Environ Sci"},{"key":"4513_CR51","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1177\/0748233711433934","volume":"29","author":"M Messarah","year":"2013","unstructured":"Messarah M, Saoudi M, Boumendjel A et al (2013) Green tea extract alleviates arsenic-induced biochemical toxicity and lipid peroxidation in rats. Toxicol Ind Health 29:349\u2013359. https:\/\/doi.org\/10.1177\/0748233711433934","journal-title":"Toxicol Ind Health"},{"key":"4513_CR52","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1515\/jbcpp-2012-0039","volume":"24","author":"PK Mukhopadhyay","year":"2013","unstructured":"Mukhopadhyay PK, Dey A, Mukherjee S, Pradhan NK (2013) The effect of coadministration of \u03b1-tocopherol and ascorbic acid on arsenic trioxide-induced testicular toxicity in adult rats. J Basic Clin Physiol Pharmacol 24:245\u2013253. https:\/\/doi.org\/10.1515\/jbcpp-2012-0039","journal-title":"J Basic Clin Physiol Pharmacol"},{"key":"4513_CR53","doi-asserted-by":"publisher","unstructured":"Prathima P, Pavani R, Sukeerthi S, Sainath SB (2018) \u03b1-Lipoic acid inhibits testicular and epididymal oxidative damage and improves fertility efficacy in arsenic-intoxicated rats. J Biochem Mol Toxicol 32:. https:\/\/doi.org\/10.1002\/jbt.22016","DOI":"10.1002\/jbt.22016"},{"key":"4513_CR54","doi-asserted-by":"publisher","first-page":"27905","DOI":"10.1007\/s11356-017-0200-2","volume":"24","author":"ATA Ramos","year":"2017","unstructured":"Ramos ATA, Diamante MAS, de Almeida LC et al (2017) Morphological and morphometrical changes on adult Wistar rat testis caused by chronic sodium arsenite exposure. Environ Sci Pollut Res 24:27905\u201327912. https:\/\/doi.org\/10.1007\/s11356-017-0200-2","journal-title":"Environ Sci Pollut Res"},{"key":"4513_CR55","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.jtemb.2011.08.145","volume":"25","author":"PS Reddy","year":"2011","unstructured":"Reddy PS, Rani GP, Sainath SB et al (2011) Protective effects of N-acetylcysteine against arsenic-induced oxidative stress and reprotoxicity in male mice. J Trace Elem Med Biol 25:247\u2013253. https:\/\/doi.org\/10.1016\/j.jtemb.2011.08.145","journal-title":"J Trace Elem Med Biol"},{"key":"4513_CR56","doi-asserted-by":"publisher","first-page":"127271","DOI":"10.1016\/j.jtemb.2023.127271","volume":"80","author":"F de Santana","year":"2023","unstructured":"de Santana F et al (2023) Toxicology of arsenate, arsenite, cadmium, lead, chromium, and nickel in testes of adult Swiss mice after chronic exposure by intraperitoneal route. J Trace Elem Med Biol 80:127271. https:\/\/doi.org\/10.1016\/j.jtemb.2023.127271","journal-title":"J Trace Elem Med Biol"},{"key":"4513_CR57","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1007\/s12011-015-0523-0","volume":"171","author":"ACF Souza","year":"2016","unstructured":"Souza ACF, Marchesi SC, de AlmeidaLima GD et al (2016) Effects of sodium arsenite and arsenate in testicular histomorphometryand antioxidants enzymes activities in rats. Biol Trace Elem Res 171:354\u2013362. https:\/\/doi.org\/10.1007\/s12011-015-0523-0","journal-title":"Biol Trace Elem Res"},{"key":"4513_CR58","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1111\/andr.12613","volume":"7","author":"ACF Souza","year":"2019","unstructured":"Souza ACF, Bastos DSS, Sertorio MN et al (2019) Combined effects of arsenic exposure and diabetes on male reproductive functions. Andrology 7:730\u2013740. https:\/\/doi.org\/10.1111\/andr.12613","journal-title":"Andrology"},{"key":"4513_CR59","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1177\/0748233713512891","volume":"32","author":"R Uygur","year":"2016","unstructured":"Uygur R, Aktas C, Caglar V et al (2016) Protective effects of melatonin against arsenic-induced apoptosis and oxidative stress in rat testes. Toxicol Ind Health 32:848\u2013859. https:\/\/doi.org\/10.1177\/0748233713512891","journal-title":"Toxicol Ind Health"},{"key":"4513_CR60","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1093\/toxres\/tfac022","volume":"11","author":"K Venkaiah","year":"2022","unstructured":"Venkaiah K, Daveedu T, Prathima P et al (2022) Immobilization stress exacerbates arsenic-induced reprotoxic effects in adult rats. Toxicol Res (Camb) 11:426\u2013436. https:\/\/doi.org\/10.1093\/toxres\/tfac022","journal-title":"Toxicol Res (Camb)"},{"key":"4513_CR61","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.etap.2018.08.012","volume":"63","author":"Q Zeng","year":"2018","unstructured":"Zeng Q, Yi H, Huang L et al (2018) Reduced testosterone and Ddx3y expression caused by long-term exposure to arsenic and its effect on spermatogenesis in mice. Environ Toxicol Pharmacol 63:84\u201391. https:\/\/doi.org\/10.1016\/j.etap.2018.08.012","journal-title":"Environ Toxicol Pharmacol"},{"key":"4513_CR62","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/s12967-015-0430-3","volume":"13","author":"TK Dua","year":"2015","unstructured":"Dua TK, Dewanjee S, Gangopadhyay M et al (2015) Ameliorative effect of water spinach, Ipomea aquatica (Convolvulaceae), against experimentally induced arsenic toxicity. J Transl Med 13:81. https:\/\/doi.org\/10.1186\/s12967-015-0430-3","journal-title":"J Transl Med"},{"key":"4513_CR63","doi-asserted-by":"publisher","first-page":"113079","DOI":"10.1016\/j.envpol.2019.113079","volume":"254","author":"IA Adedara","year":"2019","unstructured":"Adedara IA, Adebowale AA, Atanda OE, Fabunmi AT et al (2019) Selenium abates reproductive dysfunction via attenuation of biometalaccumulation, oxido-inflammatory stress and caspase-3 activation in malerats exposed to arsenic. Environ Pollut 254:113079. https:\/\/doi.org\/10.1016\/j.envpol.2019.113079","journal-title":"Environ Pollut"},{"key":"4513_CR64","doi-asserted-by":"publisher","first-page":"7174351","DOI":"10.1155\/2016\/7174351","volume":"2016","author":"SAE Bashandy","year":"2016","unstructured":"Bashandy SAE, El Awdan SA, Ebaid H, Alhazza IM (2016) Antioxidant potential of spirulina platensis mitigates oxidative stressand reprotoxicity induced by sodium arsenite in male rats. Oxid Med Cell Longev 2016:7174351. https:\/\/doi.org\/10.1155\/2016\/7174351","journal-title":"Oxid Med Cell Longev"},{"key":"4513_CR65","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.toxlet.2009.03.001","volume":"187","author":"J Das","year":"2009","unstructured":"Das J, Ghosh J, Manna P et al (2009) Taurine protects rat testes against NaAsO2-induced oxidative stress and apoptosis via mitochondrial dependent and independent pathways. Toxicol Lett 187:201\u2013210. https:\/\/doi.org\/10.1016\/j.toxlet.2009.03.001","journal-title":"Toxicol Lett"},{"key":"4513_CR66","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.ejphar.2010.12.045","volume":"655","author":"AA Fouad","year":"2011","unstructured":"Fouad AA, Al-Sultan AI, Yacoubi MT (2011) Coenzyme Q10 counteracts testicular injury induced by sodium arsenite in rats. Eur J Pharmacol 655:91\u201398. https:\/\/doi.org\/10.1016\/j.ejphar.2010.12.045","journal-title":"Eur J Pharmacol"},{"key":"4513_CR67","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.tox.2018.11.012","volume":"413","author":"PR Guvvala","year":"2019","unstructured":"Guvvala PR, Parameswaraiah RJ, Sellappan S et al (2019) Ellagic and ferulic acids protect arsenic-induced male reproductivetoxicity via regulating Nfe2l2, Ppargc1a and StAR expressions in testis. Toxicology 413:1\u201312. https:\/\/doi.org\/10.1016\/j.tox.2018.11.012","journal-title":"Toxicology"},{"key":"4513_CR68","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1590\/1984-3143-AR2021-0035","volume":"18","author":"A Khair","year":"2021","unstructured":"Khair A, Awal MA, Hoque MN et al (2021) Spirulina ameliorates arsenic induced reproductive toxicity in male rats. Anim Reprod 18:1\u201319. https:\/\/doi.org\/10.1590\/1984-3143-AR2021-0035","journal-title":"Anim Reprod"},{"key":"4513_CR69","doi-asserted-by":"publisher","first-page":"114914","DOI":"10.1016\/j.ecoenv.2023.114914","volume":"257","author":"X Li","year":"2023","unstructured":"Li X, Wang W, Hou Y et al (2023) Arsenic interferes with spermatogenesis involving Rictor\/mTORC2-mediated blood-testis barrier disruption in mice. Ecotoxicol Environ Saf 257:114914. https:\/\/doi.org\/10.1016\/j.ecoenv.2023.114914","journal-title":"Ecotoxicol Environ Saf"},{"key":"4513_CR70","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.reprotox.2018.04.015","volume":"78","author":"GDA Lima","year":"2018","unstructured":"Lima GDA, Sertorio MN, Ferreira Souza AC et al (2018) Fertility in male rats: Disentangling adverse effects of arsenic compounds. Reprod Toxicol 78:130\u2013140. https:\/\/doi.org\/10.1016\/j.reprotox.2018.04.015","journal-title":"Reprod Toxicol"},{"key":"4513_CR71","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1179\/135100008X259169","volume":"13","author":"P Manna","year":"2008","unstructured":"Manna P, Sinha M, Sil PC (2008) Protection of arsenic-induced testicular oxidative stress by arjunolic acid. Redox Rep 13:67\u201377. https:\/\/doi.org\/10.1179\/135100008X259169","journal-title":"Redox Rep"},{"key":"4513_CR72","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1016\/j.biopha.2018.04.194","volume":"103","author":"S Mehrzadi","year":"2018","unstructured":"Mehrzadi S, Bahrami N, Mehrabani M et al (2018) Ellagic acid: A promising protective remedy against testicular toxicity induced by arsenic. Biomed Pharmacother 103:1464\u20131472. https:\/\/doi.org\/10.1016\/j.biopha.2018.04.194","journal-title":"Biomed Pharmacother"},{"key":"4513_CR73","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1023\/A:1016686113763","volume":"14","author":"N Pant","year":"2001","unstructured":"Pant N, Kumar R, Murthy RC, Srivastava SP (2001) Male reproductive effect of arsenic in mice. Biometals 14:113\u2013117. https:\/\/doi.org\/10.1023\/A:1016686113763","journal-title":"Biometals"},{"key":"4513_CR74","doi-asserted-by":"publisher","first-page":"19783","DOI":"10.1007\/s11356-020-11509-1","volume":"28","author":"M Seif","year":"2021","unstructured":"Seif M, Abd El-Aziz T, Sayed M, Wang Z (2021) Zingiber officinale ethanolic extract attenuates oxidative stress, steroidogenic gene expression alterations, and testicular histopathology induced by sodium arsenite in male rats. Environ Sci Pollut Res 28:19783\u201319798. https:\/\/doi.org\/10.1007\/s11356-020-11509-1","journal-title":"Environ Sci Pollut Res"},{"key":"4513_CR75","doi-asserted-by":"publisher","first-page":"54647","DOI":"10.1007\/s11356-021-14486-1","volume":"28","author":"S Wu","year":"2021","unstructured":"Wu S, Zhong G, Wan F et al (2021) Evaluation of toxic effects induced by arsenic trioxide or\/and antimony on autophagy and apoptosis in testis of adult mice. Environ Sci Pollut Res 28:54647\u201354660. https:\/\/doi.org\/10.1007\/s11356-021-14486-1","journal-title":"Environ Sci Pollut Res"},{"key":"4513_CR76","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.jtemb.2016.07.001","volume":"39","author":"IA Adedara","year":"2017","unstructured":"Adedara IA, Abolaji AO, Awogbindin IO, Farombi EO (2017) Suppression of the brain-pituitary-testicular axis function following acute arsenic and manganese co-exposure and withdrawal in rats. J Trace Elem Med Biol 39:21\u201329. https:\/\/doi.org\/10.1016\/j.jtemb.2016.07.001","journal-title":"J Trace Elem Med Biol"},{"key":"4513_CR77","doi-asserted-by":"publisher","first-page":"153148","DOI":"10.1016\/j.tox.2022.153148","volume":"470","author":"S Akbari","year":"2022","unstructured":"Akbari S, Seyedabadi M, Amiri FT et al (2022) Sodium arsenite accelerates D-galactose-induced aging in the testis of the rat: Evidence for mitochondrial oxidative damage, NF-kB, JNK, and apoptosis pathways. Toxicology 470:153148. https:\/\/doi.org\/10.1016\/j.tox.2022.153148","journal-title":"Toxicology"},{"key":"4513_CR78","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1177\/0960327116679714","volume":"36","author":"LS Alto\u00e9","year":"2017","unstructured":"Alto\u00e9 LS, Reis IB, Gomes MLM et al (2017) Could vitamin C and zinc chloride protect the germ cells against sodium arsenite? Hum Exp Toxicol 36:1049\u20131058. https:\/\/doi.org\/10.1177\/0960327116679714","journal-title":"Hum Exp Toxicol"},{"key":"4513_CR79","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.taap.2006.11.009","volume":"218","author":"SI Chang","year":"2007","unstructured":"Chang SI, Jin B, Youn P et al (2007) Arsenic-induced toxicity and the protective role of ascorbic acid inmouse testis. Toxicol Appl Pharmacol 218:196\u2013203. https:\/\/doi.org\/10.1016\/j.taap.2006.11.009","journal-title":"Toxicol Appl Pharmacol"},{"key":"4513_CR80","doi-asserted-by":"publisher","first-page":"109333","DOI":"10.1016\/j.cbi.2020.109333","volume":"333","author":"MF El-Khadragy","year":"2021","unstructured":"El-Khadragy MF et al (2021) Chlorogenic acid abates male reproductive dysfunction in arsenic-exposed mice via attenuation of testicular oxido-inflammatory stress and apoptotic responses. Chem Biol Interact 333:109333. https:\/\/doi.org\/10.1016\/j.cbi.2020.109333","journal-title":"Chem Biol Interact"},{"key":"4513_CR81","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1477-7827-4-9","volume":"4","author":"K Jana","year":"2006","unstructured":"Jana K, Jana S, Samanta PK (2006) Effects of chronic exposure to sodium arsenite onhypothalamo-pituitary-testicular activities in adult rats: possible anestrogenic mode of action. Reprod Biol Endocrinol 4:9. https:\/\/doi.org\/10.1186\/1477-7827-4-9","journal-title":"Reprod Biol Endocrinol"},{"key":"4513_CR82","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1093\/toxsci\/kfs169","volume":"128","author":"Y Li","year":"2012","unstructured":"Li Y, Wang M, Piao F, Wang X (2012) Subchronic exposure to arsenic inhibits spermatogenesis and downregulates the expression of Ddx3y in testis and epididymis of mice. Toxicol Sci 128:482\u2013489. https:\/\/doi.org\/10.1093\/toxsci\/kfs169","journal-title":"Toxicol Sci"},{"key":"4513_CR83","doi-asserted-by":"publisher","first-page":"110360","DOI":"10.1016\/j.ecoenv.2020.110360","volume":"194","author":"P Meng","year":"2020","unstructured":"Meng P, Zhang S, Jiang X et al (2020) Arsenite induces testicular oxidative stress in vivo and in vitro leading to ferroptosis. Ecotoxicol Environ Saf 194:110360. https:\/\/doi.org\/10.1016\/j.ecoenv.2020.110360","journal-title":"Ecotoxicol Environ Saf"},{"key":"4513_CR84","doi-asserted-by":"publisher","unstructured":"Olfati A, Tvrda E (2021) Riboflavin recovery of spermatogenic dysfunction via a dual inhibition of oxidative changes and regulation of the PINK1-mediated pathway in arsenic-injured rat model. Physiol Res 70:591\u2013603. https:\/\/doi.org\/10.33549\/physiolres.934658","DOI":"10.33549\/physiolres.934658"},{"key":"4513_CR85","doi-asserted-by":"publisher","unstructured":"Quadri AL, Yakubu MT (2017) Fertility enhancing activity and toxicity profile of aqueous extract of Chasmanthera dependens roots in male rats. Andrologia 49:. https:\/\/doi.org\/10.1111\/and.12775","DOI":"10.1111\/and.12775"},{"key":"4513_CR86","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2021\/9589345","volume":"2021","author":"M Raeeszadeh","year":"2021","unstructured":"Raeeszadeh M, Karimfar B, Amiri AA, Akbari A (2021) Protective effect of nano-vitamin C on infertility due to oxidative stress induced by lead and arsenic in male rats. J Chem 2021:1\u201312. https:\/\/doi.org\/10.1155\/2021\/9589345","journal-title":"J Chem"},{"key":"4513_CR87","doi-asserted-by":"publisher","unstructured":"Ullah K, Jahan S, Aziz F, et al (2019) Ameliorative effect of Caryopteris grata benth. Against arsenic-induced enzymatic alterations in testis of albino balb\/c mice. Polish J Environ Stud 28:861\u2013866. https:\/\/doi.org\/10.15244\/pjoes\/84831","DOI":"10.15244\/pjoes\/84831"},{"key":"4513_CR88","doi-asserted-by":"publisher","first-page":"115253","DOI":"10.1016\/j.taap.2020.115253","volume":"408","author":"L Wu","year":"2020","unstructured":"Wu L, Wei Y, Li H et al (2020) The ubiquitination and acetylation of histones are associated with male reproductive disorders induced by chronic exposure to arsenite. Toxicol Appl Pharmacol 408:115253. https:\/\/doi.org\/10.1016\/j.taap.2020.115253","journal-title":"Toxicol Appl Pharmacol"},{"key":"4513_CR89","doi-asserted-by":"publisher","first-page":"121084","DOI":"10.1016\/j.envpol.2023.121084","volume":"320","author":"F Ye","year":"2023","unstructured":"Ye F, Wu L, Li H et al (2023) SIRT1\/PGC-1\u03b1 is involved in arsenic-induced male reproductive damage through mitochondrial dysfunction, which is blocked by the antioxidative effect of zinc. Environ Pollut 320:121084. https:\/\/doi.org\/10.1016\/j.envpol.2023.121084","journal-title":"Environ Pollut"},{"key":"4513_CR90","doi-asserted-by":"publisher","first-page":"e13754","DOI":"10.1111\/and.13754","volume":"52","author":"TO Ajibade","year":"2020","unstructured":"Ajibade TO, Olayemi FO (2020) Polyphenol-rich fraction of alchornea cordifolia leaf ameliorates arsenite-induced infertility in male rats. Andrologia 52:e13754. https:\/\/doi.org\/10.1111\/and.13754","journal-title":"Andrologia"},{"key":"4513_CR91","doi-asserted-by":"publisher","first-page":"89","DOI":"10.3109\/19396368.2014.998350","volume":"61","author":"S Jahan","year":"2015","unstructured":"Jahan S, Iftikhar N, Ullah H et al (2015) Alleviative effect of quercetin on rat testis against arsenic: a histological and biochemical study. Syst Biol Reprod Med 61:89\u201395. https:\/\/doi.org\/10.3109\/19396368.2014.998350","journal-title":"Syst Biol Reprod Med"},{"key":"4513_CR92","doi-asserted-by":"publisher","first-page":"155932581772926","DOI":"10.1177\/1559325817729260","volume":"15","author":"MB Omotola","year":"2017","unstructured":"Omotola MB, Adeosun IO, Obuotor EM et al (2017) Assessment of the effects of graded doses of polyphenolic-rich fraction of garcinia kola seeds on pituitary-testicular axis of male Wistar rats. Dose Response 15:1559325817729260. https:\/\/doi.org\/10.1177\/1559325817729260","journal-title":"Dose Response"},{"key":"4513_CR93","doi-asserted-by":"publisher","first-page":"e13091","DOI":"10.1111\/and.13091","volume":"50","author":"M Tazari","year":"2018","unstructured":"Tazari M, Baghshani H, Moosavi Z (2018) Effect of betaine versus arsenite-induced alterations of testicular oxidative stress and circulating androgenic indices in rats. Andrologia 50:e13091. https:\/\/doi.org\/10.1111\/and.13091","journal-title":"Andrologia"},{"key":"4513_CR94","doi-asserted-by":"publisher","unstructured":"Biswas S, Mukhopadhyay P (2020) Casein- and pea-enriched high-protein diet can take care of thereprotoxic effects of arsenic in male rats. Andrologia 52:. https:\/\/doi.org\/10.1111\/and.13560","DOI":"10.1111\/and.13560"},{"key":"4513_CR95","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2023\/7579366","volume":"2023","author":"F Solaimani","year":"2023","unstructured":"Solaimani F, Habibi E, Ghasemi M et al (2023) The protective effects of Trametes Versicolor on arsenic-induced male reproductive toxicity through regulation of oxidative stress: A biochemical and histopathological survey. Andrologia 2023:1\u201313. https:\/\/doi.org\/10.1155\/2023\/7579366","journal-title":"Andrologia"},{"key":"4513_CR96","doi-asserted-by":"publisher","first-page":"100171","DOI":"10.1016\/j.phyplu.2021.100171","volume":"2","author":"A Akinboro","year":"2022","unstructured":"Akinboro A, Adedosu OT, Badmus JA et al (2022) Aspalathus Linearis extract ameliorate haematological disorder, dyslipidaemia and tissue toxicity associated with arsenic exposure in rats. Phytomedicine Plus 2:100171. https:\/\/doi.org\/10.1016\/j.phyplu.2021.100171","journal-title":"Phytomedicine Plus"},{"key":"4513_CR97","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/0300-483X(90)90135-4","volume":"64","author":"F D\u00edaz-Barriga","year":"1990","unstructured":"D\u00edaz-Barriga F, Llamas E, de Jes\u00fas MJ et al (1990) Arsenic-cadmium interaction in rats. Toxicology 64:191\u2013203. https:\/\/doi.org\/10.1016\/0300-483X(90)90135-4","journal-title":"Toxicology"},{"key":"4513_CR98","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/j.biopha.2017.09.151","volume":"96","author":"PR Guvvala","year":"2017","unstructured":"Guvvala PR, Ravindra JP, Rajani CV et al (2017) Protective role of epigallocatechin-3-gallate on arsenic inducedtesticular toxicity in Swiss albino mice. Biomed Pharmacother 96:685\u2013694. https:\/\/doi.org\/10.1016\/j.biopha.2017.09.151","journal-title":"Biomed Pharmacother"},{"key":"4513_CR99","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1111\/and.12472","volume":"48","author":"S Ince","year":"2016","unstructured":"Ince S, Avdatek F, Demirel HH et al (2016) Ameliorative effect of polydatin on oxidative stress-mediated testicular damage by chronic arsenic exposure in rats. Andrologia 48:518\u2013524. https:\/\/doi.org\/10.1111\/and.12472","journal-title":"Andrologia"},{"key":"4513_CR100","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1080\/02772248.2013.866237","volume":"95","author":"Z Kaya","year":"2013","unstructured":"Kaya Z, Eraslan G (2013) The effects of evening primrose oil on arsenic-induced oxidative stress in rats. Toxicol Environ Chem 95:1416\u20131423. https:\/\/doi.org\/10.1080\/02772248.2013.866237","journal-title":"Toxicol Environ Chem"},{"key":"4513_CR101","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s40360-018-0239-9","volume":"19","author":"L Mahajan","year":"2018","unstructured":"Mahajan L, Verma PK, Raina R, Sood S (2018) Potentiating effect of imidacloprid on arsenic-induced testicular toxicity in Wistar rats. BMC Pharmacol Toxicol 19:48. https:\/\/doi.org\/10.1186\/s40360-018-0239-9","journal-title":"BMC Pharmacol Toxicol"},{"key":"4513_CR102","doi-asserted-by":"publisher","first-page":"3772","DOI":"10.1007\/s12011-020-02518-9","volume":"199","author":"M Dehdashti Moghadam","year":"2021","unstructured":"Dehdashti Moghadam M, Baghshani H, Ghodrati Azadi H, Moosavi Z (2021) Ameliorative effects of caffeic acid against arsenic-induced testicular injury in mice. Biol Trace Elem Res 199:3772\u20133780. https:\/\/doi.org\/10.1007\/s12011-020-02518-9","journal-title":"Biol Trace Elem Res"},{"key":"4513_CR103","doi-asserted-by":"publisher","first-page":"e12720","DOI":"10.1111\/jfbc.12720","volume":"43","author":"C Caglayan","year":"2019","unstructured":"Caglayan C, Demir Y, Kucukler S et al (2019) The effects of hesperidin on sodium arsenite-induced different organ toxicity in rats on metabolic enzymes as antidiabetic and anticholinergics potentials: A biochemical approach. J Food Biochem 43:e12720. https:\/\/doi.org\/10.1111\/jfbc.12720","journal-title":"J Food Biochem"},{"key":"4513_CR104","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1080\/15287394.2017.1376405","volume":"80","author":"RF da Silva","year":"2017","unstructured":"da Silva RF, dos Borges C et al (2017) Arsenic trioxide exposure impairs testicular morphology in adult malemice and consequent fetus viability. J Toxicol Environ Heal A-Current Issues 80:1166\u20131179. https:\/\/doi.org\/10.1080\/15287394.2017.1376405","journal-title":"J Toxicol Environ Heal A-Current Issues"},{"key":"4513_CR105","doi-asserted-by":"publisher","first-page":"124650","DOI":"10.1016\/j.chemosphere.2019.124650","volume":"238","author":"Y Han","year":"2020","unstructured":"Han Y, Liang C, Manthari RK et al (2020) Arsenic influences spermatogenesis by disorganizing the elongation ofspermatids in adult male mice. Chemosphere 238:124650. https:\/\/doi.org\/10.1016\/j.chemosphere.2019.124650","journal-title":"Chemosphere"},{"key":"4513_CR106","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.tox.2018.09.010","volume":"411","author":"Q Zeng","year":"2019","unstructured":"Zeng Q, Yi H, Huang L et al (2019) Long-term arsenite exposure induces testicular toxicity by redox imbalance, G2\/M cell arrest and apoptosis in mice. Toxicology 411:122\u2013132. https:\/\/doi.org\/10.1016\/j.tox.2018.09.010","journal-title":"Toxicology"},{"key":"4513_CR107","doi-asserted-by":"crossref","unstructured":"Cohen J (1992) A power primer. (power analysis) (Quantitative Methods in Psychology). Psychol Bull 112:155","DOI":"10.1037\/\/0033-2909.112.1.155"},{"key":"4513_CR108","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1037\/0033-2909.86.3.638","volume":"86","author":"R Rosenthal","year":"1979","unstructured":"Rosenthal R (1979) The \u2018File Drawer\u2019 problem and tolerance for null results. Psychol Bull 86:638\u2013641. https:\/\/doi.org\/10.1037\/0033-2909.86.3.638","journal-title":"Psychol Bull"},{"key":"4513_CR109","doi-asserted-by":"publisher","first-page":"684504","DOI":"10.1155\/2010\/684504","volume":"2010","author":"K Svechnikov","year":"2010","unstructured":"Svechnikov K, Izzo G, Landreh L et al (2010) Endocrine disruptors and Leydig cell function. J Biomed Biotechnol 2010:684504. https:\/\/doi.org\/10.1155\/2010\/684504","journal-title":"J Biomed Biotechnol"},{"key":"4513_CR110","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.taap.2006.06.014","volume":"216","author":"UK Chowdhury","year":"2006","unstructured":"Chowdhury UK, Zakharyan RA, Hernandez A et al (2006) Glutathione-S-transferase-omega [MMA(V) reductase] knockout mice: Enzyme and arsenic species concentrations in tissues after arsenate administration. Toxicol Appl Parmacol 216:446\u2013457. https:\/\/doi.org\/10.1016\/j.taap.2006.06.014","journal-title":"Toxicol Appl Parmacol"},{"key":"4513_CR111","doi-asserted-by":"publisher","first-page":"137","DOI":"10.5487\/TR.2013.29.2.137","volume":"29","author":"HS Bae","year":"2013","unstructured":"Bae HS, Ryu DY, Choi BS, Park JD (2013) Urinary arsenic concentrations and their associated factors in Korean adults. Toxicol Res 29:137\u2013142. https:\/\/doi.org\/10.5487\/TR.2013.29.2.137","journal-title":"Toxicol Res"},{"key":"4513_CR112","unstructured":"Rossman TG (2007) Arsenic. In: Environmental and Occupational Medicine, 4th ed. Lippincott Williams & Wilkins, pp 1007\u20131020"},{"key":"4513_CR113","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1289\/ehp.0800509","volume":"117","author":"A Navas-Acien","year":"2009","unstructured":"Navas-Acien A, Umans JG, Howard BV et al (2009) Urine arsenic concentrations and species excretion patterns in American Indian communities over a 10-year period: The strong heart study. Environ Health Perspect 117:1428\u20131433. https:\/\/doi.org\/10.1289\/ehp.0800509","journal-title":"Environ Health Perspect"},{"key":"4513_CR114","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/S0300-483X(02)00285-8","volume":"181\u2013182","author":"M Vahter","year":"2002","unstructured":"Vahter M (2002) Mechanisms of arsenic biotransformation. Toxicology 181\u2013182:211\u2013217. https:\/\/doi.org\/10.1016\/S0300-483X(02)00285-8","journal-title":"Toxicology"},{"key":"4513_CR115","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.envres.2015.03.019","volume":"140","author":"N Yoshida","year":"2015","unstructured":"Yoshida N, Inaoka T, Sultana N et al (2015) Non-monotonic relationships between arsenic and selenium excretion and its implication on arsenic methylation pattern in a Bangladeshi population. Environ Res 140:300\u2013307. https:\/\/doi.org\/10.1016\/j.envres.2015.03.019","journal-title":"Environ Res"},{"key":"4513_CR116","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/S0950-351X(87)80053-8","volume":"1","author":"AM Matsumoto","year":"1987","unstructured":"Matsumoto AM, Bremner WJ (1987) Endocrinology of the hypothalamic-pituitary-testicular axis with particular reference to the hormonal control of spermatogenesis. Baillieres Clin Endocrinol Metab 1:71\u201387. https:\/\/doi.org\/10.1016\/S0950-351X(87)80053-8","journal-title":"Baillieres Clin Endocrinol Metab"},{"key":"4513_CR117","doi-asserted-by":"publisher","first-page":"2604","DOI":"10.1074\/jbc.M114.605808","volume":"290","author":"M Prasad","year":"2015","unstructured":"Prasad M, Kaur J, Pawlak KJ et al (2015) Mitochondria-associated endoplasmic reticulum membrane (MAM) regulates steroidogenic activity via steroidogenic acute regulatory protein (StAR)-voltage-dependent anion channel 2 (VDAC2) interaction. J Biol Chem 290:2604\u20132616. https:\/\/doi.org\/10.1074\/jbc.M114.605808","journal-title":"J Biol Chem"},{"key":"4513_CR118","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1210\/er.2003-0030","volume":"25","author":"AH Payne","year":"2004","unstructured":"Payne AH, Hales DB (2004) Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Endocr Rev 25:947\u2013970. https:\/\/doi.org\/10.1210\/er.2003-0030","journal-title":"Endocr Rev"},{"key":"4513_CR119","doi-asserted-by":"publisher","first-page":"e22823","DOI":"10.1002\/jbt.22823","volume":"35","author":"JK Bhardwaj","year":"2021","unstructured":"Bhardwaj JK, Paliwal A, Saraf P (2021) Effects of heavy metals on reproduction owing to infertility. J Biochem Mol Toxicol 35:e22823. https:\/\/doi.org\/10.1002\/jbt.22823","journal-title":"J Biochem Mol Toxicol"},{"key":"4513_CR120","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1210\/me.2008-0235","volume":"23","author":"AE Rosenblatt","year":"2009","unstructured":"Rosenblatt AE, Burnstein KL (2009) Inhibition of androgen receptor transcriptional activity as a novelmechanism of action of arsenic. Mol Endocrinol 23:412\u2013421. https:\/\/doi.org\/10.1210\/me.2008-0235","journal-title":"Mol Endocrinol"},{"key":"4513_CR121","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.envint.2019.02.058","volume":"126","author":"LD Garbinski","year":"2019","unstructured":"Garbinski LD, Rosen BP, Chen J (2019) Pathways of arsenic uptake and efflux. Environ Int 126:585\u2013597. https:\/\/doi.org\/10.1016\/j.envint.2019.02.058","journal-title":"Environ Int"},{"key":"4513_CR122","doi-asserted-by":"publisher","first-page":"147","DOI":"10.3109\/19396360903582216","volume":"56","author":"JJ Wirth","year":"2010","unstructured":"Wirth JJ, Mijal RS (2010) Adverse effects of low level heavy metal exposure on male reproductive function. Syst Biol Reprod Med 56:147\u2013167. https:\/\/doi.org\/10.3109\/19396360903582216","journal-title":"Syst Biol Reprod Med"},{"key":"4513_CR123","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1006\/abbi.2000.2023","volume":"382","author":"S Ahmad","year":"2000","unstructured":"Ahmad S, Kitchin KT, Cullen WR (2000) Arsenic species that cause release of iron from ferritin and generation of activated oxygen. Arch Biochem Biophys 382:195\u2013202. https:\/\/doi.org\/10.1006\/abbi.2000.2023","journal-title":"Arch Biochem Biophys"},{"key":"4513_CR124","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.2174\/0929867053764635","volume":"12","author":"M Valko","year":"2005","unstructured":"Valko M, Morris H, Cronin M (2005) Metals, toxicity and oxidative stress. Curr Med Chem 12:1161\u20131208. https:\/\/doi.org\/10.2174\/0929867053764635","journal-title":"Curr Med Chem"},{"key":"4513_CR125","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/FPC.0b013e3282f29663","volume":"18","author":"L Paiva","year":"2008","unstructured":"Paiva L, Marcos R, Creus A et al (2008) Polymorphism of glutathione transferase omega 1 in a population exposed to a high environmental arsenic burden. Pharmacogenet Genomics 18:1\u201310. https:\/\/doi.org\/10.1097\/FPC.0b013e3282f29663","journal-title":"Pharmacogenet Genomics"},{"key":"4513_CR126","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1071\/RD9950659","volume":"7","author":"R John Aitken","year":"1995","unstructured":"John Aitken R (1995) Free radicals, lipid peroxidation and sperm function. Reprod Fertil Dev 7:659\u2013668. https:\/\/doi.org\/10.1071\/RD9950659","journal-title":"Reprod Fertil Dev"},{"key":"4513_CR127","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.reprotox.2012.06.007","volume":"34","author":"G Lavranos","year":"2012","unstructured":"Lavranos G, Balla M, Tzortzopoulou A et al (2012) Investigating ROS sources in male infertility: A common end for numerous pathways. Reprod Toxicol 34:298\u2013307. https:\/\/doi.org\/10.1016\/j.reprotox.2012.06.007","journal-title":"Reprod Toxicol"},{"key":"4513_CR128","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1016\/j.fertnstert.2014.10.020","volume":"102","author":"EY Ko","year":"2014","unstructured":"Ko EY, Sabanegh ES, Agarwal A (2014) Male infertility testing: Reactive oxygen species and antioxidant capacity. Fertil Steril 102:1518\u20131527. https:\/\/doi.org\/10.1016\/j.fertnstert.2014.10.020","journal-title":"Fertil Steril"},{"key":"4513_CR129","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/and.13126","volume":"50","author":"A Agarwal","year":"2018","unstructured":"Agarwal A, Rana M, Qiu E et al (2018) Role of oxidative stress, infection and inflammation in male infertility. Andrologia 50:1\u201313. https:\/\/doi.org\/10.1111\/and.13126","journal-title":"Andrologia"},{"key":"4513_CR130","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/S0015-0282(02)04948-8","volume":"79","author":"A Agarwal","year":"2003","unstructured":"Agarwal A, Saleh RA, Bedaiwy MA (2003) Role of reactive oxygen species in the pathophysiology of human reproduction. Fertil Steril 79:829\u2013843. https:\/\/doi.org\/10.1016\/S0015-0282(02)04948-8","journal-title":"Fertil Steril"},{"key":"4513_CR131","doi-asserted-by":"crossref","unstructured":"Hales DB, Allen JA, Shankara T, et al (2005) Mitochondrial function in Leydig cell steroidogenesis. In: Hardy MP, Griswold MD (eds) Testicular cell dynamics and endocrine signaling. pp 120\u2013134","DOI":"10.1196\/annals.1336.014"},{"key":"4513_CR132","doi-asserted-by":"publisher","first-page":"235","DOI":"10.3390\/biom10020235","volume":"10","author":"VM Nurchi","year":"2020","unstructured":"Nurchi VM, Djordjevic AB, Crisponi G et al (2020) Arsenic toxicity: Molecular targets and therapeutic agents. Biomolecules 10:235. https:\/\/doi.org\/10.3390\/biom10020235","journal-title":"Biomolecules"},{"key":"4513_CR133","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.etap.2016.10.020","volume":"48","author":"A Sattar","year":"2016","unstructured":"Sattar A, Xie S, Hafeez MA et al (2016) Metabolism and toxicity of arsenicals in mammals. Environ Toxicol Pharmacol 48:214\u2013224. https:\/\/doi.org\/10.1016\/j.etap.2016.10.020","journal-title":"Environ Toxicol Pharmacol"},{"key":"4513_CR134","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/S0040-8166(95)80016-6","volume":"27","author":"LD Russell","year":"1995","unstructured":"Russell LD, de Fran\u00e7a LR (1995) Building a testis. Tissue Cell 27:129\u2013147. https:\/\/doi.org\/10.1016\/S0040-8166(95)80016-6","journal-title":"Tissue Cell"},{"key":"4513_CR135","first-page":"185","volume":"3","author":"M Ali","year":"2013","unstructured":"Ali M, Khan SA, Dubey P et al (2013) Impact of arsenic on testosterone synthesis pathway and sperm production in mice. Innov J Med Heal Sci 3:185\u2013189","journal-title":"Innov J Med Heal Sci"},{"key":"4513_CR136","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s10495-005-3087-1","volume":"11","author":"DK Gautam","year":"2006","unstructured":"Gautam DK, Misro MM, Chaki SP, Sehgal N (2006) H2O2 at physiological concentrations modulates Leydig cell function inducing oxidative stress and apoptosis. Apoptosis 11:39\u201346. https:\/\/doi.org\/10.1007\/s10495-005-3087-1","journal-title":"Apoptosis"},{"key":"4513_CR137","first-page":"84","volume":"52","author":"S Sarkar","year":"2008","unstructured":"Sarkar S, Hazra J, Upadhyay SN et al (2008) Arsenic induced toxicity on testicular tissue of mice. Indian J Physiol Pharmacol 52:84\u201390","journal-title":"Indian J Physiol Pharmacol"},{"key":"4513_CR138","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1002\/j.1939-4640.1992.tb01653.x","volume":"13","author":"RM Sharpe","year":"1992","unstructured":"Sharpe RM, Maddocks S, Millar M et al (1992) Testosterone and spermatogenesis identification of stage-specific, androgen-regulated proteins secreted by adult rat seminiferous tubules. J Androl 13:172\u2013184. https:\/\/doi.org\/10.1002\/j.1939-4640.1992.tb01653.x","journal-title":"J Androl"},{"key":"4513_CR139","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1046\/j.1365-2605.1998.00109.x","volume":"21","author":"J Blanco-Rodr\u00edguez","year":"1998","unstructured":"Blanco-Rodr\u00edguez J, Mart\u00ednez-Garc\u00eda C (1998) Apoptosis precedes detachment of germ cells from the seminiferous epithelium after hormone suppression by short-term oestradiol treatment of rats. Int J Androl 21:109\u2013115. https:\/\/doi.org\/10.1046\/j.1365-2605.1998.00109.x","journal-title":"Int J Androl"},{"key":"4513_CR140","doi-asserted-by":"publisher","first-page":"3279","DOI":"10.1210\/en.2008-0086","volume":"149","author":"MH Abel","year":"2008","unstructured":"Abel MH, Baker PJ, Charlton HM et al (2008) Spermatogenesis and Sertoli cell activity in mice lacking Sertoli cell receptors for follicle-stimulating hormone and androgen. Endocrinology 149:3279\u20133285. https:\/\/doi.org\/10.1210\/en.2008-0086","journal-title":"Endocrinology"},{"key":"4513_CR141","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1530\/REP-09-0377","volume":"139","author":"PJ O\u2019Shaughnessy","year":"2010","unstructured":"O\u2019Shaughnessy PJ, Monteiro A, Verhoeven G et al (2010) Effect of FSH on testicular morphology and spermatogenesis in gonadotrophin-deficient hypogonadal mice lacking androgen receptors. Reproduction 139:177\u2013184. https:\/\/doi.org\/10.1530\/REP-09-0377","journal-title":"Reproduction"},{"key":"4513_CR142","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1089\/dna.2017.4081","volume":"37","author":"J Ramos-Trevi\u00f1o","year":"2018","unstructured":"Ramos-Trevi\u00f1o J, Bassol-Mayagoitia S, Hern\u00e1ndez-Ibarra JA et al (2018) Toxic effect of cadmium, lead, and arsenic on the Sertoli cell: Mechanisms of damage involved. DNA Cell Biol 37:600\u2013608. https:\/\/doi.org\/10.1089\/dna.2017.4081","journal-title":"DNA Cell Biol"},{"key":"4513_CR143","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1002\/mrd.23309","volume":"87","author":"YQ Wang","year":"2020","unstructured":"Wang YQ, Cheng JM, Wen Q et al (2020) An exploration of the role of Sertoli cells on fetal testis development using cell ablation strategy. Mol Reprod Dev 87:223\u2013230. https:\/\/doi.org\/10.1002\/mrd.23309","journal-title":"Mol Reprod Dev"},{"key":"4513_CR144","doi-asserted-by":"publisher","first-page":"32518","DOI":"10.1038\/srep32518","volume":"6","author":"Q Huang","year":"2016","unstructured":"Huang Q, Luo L, Alamdar A et al (2016) Integrated proteomics and metabolomics analysis of rat testis: Mechanism of arsenic-induced male reproductive toxicity. Sci Rep 6:32518. https:\/\/doi.org\/10.1038\/srep32518","journal-title":"Sci Rep"},{"key":"4513_CR145","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.cotox.2019.09.005","volume":"19","author":"B Tariba Lovakovi\u0107","year":"2020","unstructured":"Tariba Lovakovi\u0107 B (2020) Cadmium, arsenic, and lead: elements affecting male reproductive health. Curr Opin Toxicol 19:7\u201314. https:\/\/doi.org\/10.1016\/j.cotox.2019.09.005","journal-title":"Curr Opin Toxicol"},{"key":"4513_CR146","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1002\/jat.1649","volume":"31","author":"K Jomova","year":"2011","unstructured":"Jomova K, Jenisova Z, Feszterova M et al (2011) Arsenic: Toxicity, oxidative stress and human disease. J Appl Toxicol 31:95\u2013107. https:\/\/doi.org\/10.1002\/jat.1649","journal-title":"J Appl Toxicol"},{"key":"4513_CR147","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1002\/(SICI)1097-4652(199811)177:2<324::AID-JCP14>3.0.CO;2-9","volume":"177","author":"YC Chen","year":"1998","unstructured":"Chen YC, Lin-Shiau SYN, Lin JK (1998) Involvement of reactive oxygen species and caspase 3 activation in arsenite-induced apoptosis. J Cell Physiol 177:324\u2013333. https:\/\/doi.org\/10.1002\/(SICI)1097-4652(199811)177:2%3c324::AID-JCP14%3e3.0.CO;2-9","journal-title":"J Cell Physiol"},{"key":"4513_CR148","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/and.14042","volume":"53","author":"B Yaz\u011fan","year":"2021","unstructured":"Yaz\u011fan B, Baltaci AK, Mogulkoc R, Avunduk MC (2021) Zinc is a strong stimulant of metallothionein synthesis in the ischaemic testis tissue. Andrologia 53:1\u20137. https:\/\/doi.org\/10.1111\/and.14042","journal-title":"Andrologia"},{"key":"4513_CR149","doi-asserted-by":"publisher","first-page":"139233","DOI":"10.1016\/j.scitotenv.2020.139233","volume":"734","author":"Y Han","year":"2020","unstructured":"Han Y, Liang C, Yu Y et al (2020) Chronic arsenic exposure lowered sperm motility via impairing ultra-microstructure and key proteins expressions of sperm acrosome and flagellum formation during spermiogenesis in male mice. Sci Total Environ 734:139233. https:\/\/doi.org\/10.1016\/j.scitotenv.2020.139233","journal-title":"Sci Total Environ"},{"key":"4513_CR150","doi-asserted-by":"publisher","first-page":"124768","DOI":"10.1016\/j.jhazmat.2020.124768","volume":"406","author":"X-Y Zhang","year":"2021","unstructured":"Zhang X-Y, Wang B, Xu S et al (2021) Reactive oxygen species-evoked genotoxic stress mediates arsenic-inducedsuppression of male germ cell proliferation and decline in sperm quality. J Hazard Mater 406:124768. https:\/\/doi.org\/10.1016\/j.jhazmat.2020.124768","journal-title":"J Hazard Mater"},{"key":"4513_CR151","doi-asserted-by":"publisher","first-page":"110063","DOI":"10.1016\/j.ecoenv.2019.110063","volume":"190","author":"H Chen","year":"2020","unstructured":"Chen H, Liu G, Qiao N et al (2020) Toxic effects of arsenic trioxide on spermatogonia are associated withoxidative stress, mitochondrial dysfunction, autophagy and metabolomicalterations. Ecotoxicol Environ Saf 190:110063. https:\/\/doi.org\/10.1016\/j.ecoenv.2019.110063","journal-title":"Ecotoxicol Environ Saf"},{"key":"4513_CR152","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fendo.2022.897196","volume":"13","author":"VA Ruthig","year":"2022","unstructured":"Ruthig VA, Lamb DJ (2022) Updates in Sertoli Cell-mediated signaling during spermatogenesis and advances in restoring Sertoli cell function. Front Endocrinol (Lausanne) 13:1\u20138. https:\/\/doi.org\/10.3389\/fendo.2022.897196","journal-title":"Front Endocrinol (Lausanne)"},{"key":"4513_CR153","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.1126\/science.1144885","volume":"317","author":"S Yoshida","year":"2007","unstructured":"Yoshida S, Sukeno M, Nabeshima YI (2007) A vasculature-associated niche for undifferentiated spermatogonia in the mouse testis. Science 317:1722\u20131726. https:\/\/doi.org\/10.1126\/science.1144885","journal-title":"Science"},{"key":"4513_CR154","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1073\/pnas.1517994113","volume":"113","author":"LY Chen","year":"2016","unstructured":"Chen LY, Willis WD, Eddy EM (2016) Targeting the Gdnf Gene in peritubular myoid cells disrupts undifferentiated spermatogonial cell development. Proc Natl Acad Sci U S A 113:1829\u20131834. https:\/\/doi.org\/10.1073\/pnas.1517994113","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4513_CR155","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1093\/humrep\/der357","volume":"27","author":"K Zohni","year":"2012","unstructured":"Zohni K, Zhang X, Tan SL et al (2012) The efficiency of male fertility restoration is dependent on the recovery kinetics of spermatogonial stem cells after cytotoxic treatment with busulfan in mice. Hum Reprod 27:44\u201353. https:\/\/doi.org\/10.1093\/humrep\/der357","journal-title":"Hum Reprod"},{"key":"4513_CR156","doi-asserted-by":"crossref","unstructured":"La HM, Hobbs RM (2019) Mechanisms regulating mammalian spermatogenesis and fertility recovery following germ\u00a0cell depletion. Springer International Publishing","DOI":"10.1007\/s00018-019-03201-6"},{"key":"4513_CR157","unstructured":"Environmental Protection Agency (1996) Guidelines for reproductive toxicity risk assessment. https:\/\/www.epa.gov\/risk\/guidelines-reproductive-toxicity-risk-assessment. Accessed 20 Nov 2021"},{"key":"4513_CR158","unstructured":"Klinefelter GR, Veeramachaneni RD (2014) Assessment of male reproductive toxicity. In: Hayes\u2019 principles and methods of toxicology, 6th ed. Philadelphia, pp 1602\u20131626"},{"key":"4513_CR159","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1002\/j.1939-4640.1981.tb00595.x","volume":"2","author":"RP Amann","year":"1981","unstructured":"Amann RP (1981) A critical review of methods for evaluation of spermatogenesis from seminal characteristics. J Androl 2:37\u201358. https:\/\/doi.org\/10.1002\/j.1939-4640.1981.tb00595.x","journal-title":"J Androl"},{"key":"4513_CR160","doi-asserted-by":"publisher","first-page":"133020","DOI":"10.1016\/j.chemosphere.2021.133020","volume":"291","author":"M Machado-Neves","year":"2022","unstructured":"Machado-Neves M (2022) Effect of heavy metals on epididymal morphology and function: An integrative review. Chemosphere 291:133020. https:\/\/doi.org\/10.1016\/j.chemosphere.2021.133020","journal-title":"Chemosphere"}],"container-title":["Biological Trace Element Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-025-04513-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12011-025-04513-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-025-04513-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T01:09:59Z","timestamp":1754356199000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12011-025-04513-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,9]]},"references-count":160,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["4513"],"URL":"https:\/\/doi.org\/10.1007\/s12011-025-04513-4","relation":{},"ISSN":["1559-0720"],"issn-type":[{"value":"1559-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,9]]},"assertion":[{"value":"4 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}