{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:58:15Z","timestamp":1789469895204,"version":"build-2803163510"},"reference-count":75,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["U22A20361"],"award-info":[{"award-number":["U22A20361"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Postgraduate Innovation Research and Practice Program of Anhui Medical University","award":["YJS20230151"],"award-info":[{"award-number":["YJS20230151"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biol Trace Elem Res"],"DOI":"10.1007\/s12011-025-04525-0","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T08:58:49Z","timestamp":1738832329000},"page":"4543-4560","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Placental Ferroptosis May Be Involved in Prenatal Arsenic Exposure Induced Cognitive Impairment in Offspring"],"prefix":"10.1007","volume":"203","author":[{"given":"Mengzhu","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajing","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anni","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyou","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangbiao","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmei","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,6]]},"reference":[{"issue":"1\u20132","key":"4525_CR1","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1023\/A:1026001024578","volume":"253","author":"R Bhattacharyya","year":"2003","unstructured":"Bhattacharyya R, Chatterjee D, Nath B, Jana J, Jacks G, Vahter M (2003) High arsenic groundwater: mobilization, metabolism and mitigation\u2013an overview in the Bengal Delta Plain. Mol Cell Biochem 253(1\u20132):347\u2013355","journal-title":"Mol Cell Biochem"},{"issue":"7","key":"4525_CR2","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/j.ijheh.2014.03.004","volume":"217","author":"MS Bloom","year":"2014","unstructured":"Bloom MS, Surdu S, Neamtiu IA, Gurzau ES (2014) Maternal arsenic exposure and birth outcomes: a comprehensive review of the epidemiologic literature focused on drinking water. Int J Hyg Environ Health 217(7):709\u2013719","journal-title":"Int J Hyg Environ Health"},{"issue":"1","key":"4525_CR3","doi-asserted-by":"publisher","first-page":"18","DOI":"10.3390\/ijerph10010018","volume":"10","author":"J Jiang","year":"2012","unstructured":"Jiang J, Ashekuzzaman SM, Jiang A, Sharifuzzaman SM, Chowdhury SR (2012) Arsenic contaminated groundwater and its treatment options in Bangladesh. Int J Environ Res Public Health 10(1):18\u201346","journal-title":"Int J Environ Res Public Health"},{"issue":"1","key":"4525_CR4","doi-asserted-by":"publisher","first-page":"93","DOI":"10.17843\/rpmesp.2018.351.3604","volume":"35","author":"M Medina-Pizzali","year":"2018","unstructured":"Medina-Pizzali M, Robles P, Mendoza M, Torres C (2018) Arsenic intake: impact in human nutrition and health. Rev Peru Med Exp Salud Publica 35(1):93\u2013102","journal-title":"Rev Peru Med Exp Salud Publica"},{"key":"4525_CR5","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.watres.2013.09.016","volume":"48","author":"TJ Sorg","year":"2014","unstructured":"Sorg TJ, Chen ASC, Wang L (2014) Arsenic species in drinking water wells in the USA with high arsenic concentrations. Water Res 48:156\u2013169","journal-title":"Water Res"},{"issue":"8","key":"4525_CR6","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1007\/s00775-019-01740-8","volume":"24","author":"C Garza-Lombo","year":"2019","unstructured":"Garza-Lombo C, Pappa A, Panayiotidis MI, Gonsebatt ME, Franco R (2019) Arsenic-induced neurotoxicity: a mechanistic appraisal. J Biol Inorg Chem 24(8):1305\u20131316","journal-title":"J Biol Inorg Chem"},{"issue":"3","key":"4525_CR7","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1016\/j.etap.2015.09.016","volume":"40","author":"KSM Abdul","year":"2015","unstructured":"Abdul KSM, Jayasinghe SS, Chandana EPS, Jayasumana C, De Silva PMCS (2015) Arsenic and human health effects: a review. Environ Toxicol Pharmacol 40(3):828\u2013846","journal-title":"Environ Toxicol Pharmacol"},{"issue":"1","key":"4525_CR8","doi-asserted-by":"publisher","first-page":"46","DOI":"10.2337\/dc16-0810","volume":"40","author":"M Grau-Perez","year":"2017","unstructured":"Grau-Perez M, Kuo C, Spratlen M, Thayer KA, Mendez MA, Hamman RF, Dabelea D, Adgate JL, Knowler WC, Bell RA, Miller FW, Liese AD, Zhang C, Douillet C, Drobna Z, Mayer-Davis EJ, Styblo M, Navas-Acien A (2017) The association of arsenic exposure and metabolism with type 1 and type 2 diabetes in youth: the search case-control study. Diabetes Care 40(1):46\u201353","journal-title":"Diabetes Care"},{"key":"4525_CR9","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.envres.2016.02.009","volume":"147","author":"TR Sanchez","year":"2016","unstructured":"Sanchez TR, Perzanowski M, Graziano JH (2016) Inorganic arsenic and respiratory health, from early life exposure to sex-specific effects: a systematic review. Environ Res 147:537\u2013555","journal-title":"Environ Res"},{"issue":"6","key":"4525_CR10","doi-asserted-by":"publisher","first-page":"556","DOI":"10.3390\/ijerph14060556","volume":"14","author":"AH Milton","year":"2017","unstructured":"Milton AH, Hussain S, Akter S, Rahman M, Mouly TA, Mitchell K (2017) A review of the effects of chronic arsenic exposure on adverse pregnancy outcomes. Int J Environ Res Public Health 14(6):556","journal-title":"Int J Environ Res Public Health"},{"key":"4525_CR11","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/j.envres.2017.07.004","volume":"158","author":"Y Shih","year":"2017","unstructured":"Shih Y, Islam T, Hore SK, Sarwar G, Shahriar MH, Yunus M, Graziano JH, Harjes J, Baron JA, Parvez F, Ahsan H, Argos M (2017) Associations between prenatal arsenic exposure with adverse pregnancy outcome and child mortality. Environ Res 158:456\u2013461","journal-title":"Environ Res"},{"key":"4525_CR12","doi-asserted-by":"publisher","first-page":"116833","DOI":"10.1016\/j.ecoenv.2024.116833","volume":"283","author":"X Yang","year":"2024","unstructured":"Yang X, Chu F, Jiao Z, Yu H, Yang W, Li Y, Lu C, Ma H, Wang S, Liu Z, Qin S, Sun H (2024) Ellagic acid ameliorates arsenic-induced neuronal ferroptosis and cognitive impairment via nrf2\/gpx4 signaling pathway. Ecotoxicol Environ Saf 283:116833","journal-title":"Ecotoxicol Environ Saf"},{"issue":"10","key":"4525_CR13","first-page":"CD12649","volume":"10","author":"S Bae","year":"2021","unstructured":"Bae S, Kamynina E, Guetterman HM, Farinola AF, Caudill MA, Berry RJ, Cassano PA, Stover PJ (2021) Provision of folic acid for reducing arsenic toxicity in arsenic-exposed children and adults. Cochrane Database Syst Rev 10(10):CD12649","journal-title":"Cochrane Database Syst Rev"},{"issue":"9553","key":"4525_CR14","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.1016\/S0140-6736(06)69665-7","volume":"368","author":"P Grandjean","year":"2006","unstructured":"Grandjean P, Landrigan PJ (2006) Developmental neurotoxicity of industrial chemicals. Lancet 368(9553):2167\u20132178","journal-title":"Lancet"},{"issue":"5","key":"4525_CR15","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1007\/s00204-020-02725-2","volume":"94","author":"S Guth","year":"2020","unstructured":"Guth S, Huser S, Roth A, Degen G, Diel P, Edlund K, Eisenbrand G, Engel K, Epe B, Grune T, Heinz V, Henle T, Humpf H, Jager H, Joost H, Kulling SE, Lampen A, Mally A, Marchan R, Marko D, Muhle E, Nitsche MA, Rohrdanz E, Stadler R, van Thriel C, Vieths S, Vogel RF, Wascher E, Watzl C, Nothlings U, Hengstler JG (2020) Toxicity of fluoride: critical evaluation of evidence for human developmental neurotoxicity in epidemiological studies, animal experiments and in vitro analyses. Arch Toxicol 94(5):1375\u20131415","journal-title":"Arch Toxicol"},{"key":"4525_CR16","doi-asserted-by":"publisher","first-page":"103604","DOI":"10.1016\/j.etap.2021.103604","volume":"84","author":"X Liu","year":"2021","unstructured":"Liu X, Gao Y, Liu Y, Zhang W, Yang Y, Fu X, Sun D, Wang J (2021) Neuroglobin alleviates arsenic-induced neuronal damage. Environ Toxicol Pharmacol 84:103604","journal-title":"Environ Toxicol Pharmacol"},{"key":"4525_CR17","doi-asserted-by":"publisher","first-page":"116107","DOI":"10.1016\/j.ecoenv.2024.116107","volume":"273","author":"H Ma","year":"2024","unstructured":"Ma H, Yang W, Li Y, Li J, Yang X, Chen Y, Ma Y, Sun D, Sun H (2024) Effects of sodium arsenite exposure on behavior, ultrastructure and gene expression of brain in adult zebrafish (Danio rerio). Ecotoxicol Environ Saf 273:116107","journal-title":"Ecotoxicol Environ Saf"},{"issue":"12","key":"4525_CR18","doi-asserted-by":"publisher","first-page":"953","DOI":"10.3390\/toxics11120953","volume":"11","author":"F Chu","year":"2023","unstructured":"Chu F, Lu C, Jiao Z, Yang W, Yang X, Ma H, Yu H, Wang S, Li Y, Sun D, Sun H (2023) Unveiling the LncRNA-miRNA-mRNA regulatory network in arsenic-induced nerve injury in rats through high-throughput sequencing. Toxics 11(12):953","journal-title":"Toxics"},{"issue":"Pt 1","key":"4525_CR19","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.envint.2018.09.031","volume":"121","author":"B Wang","year":"2018","unstructured":"Wang B, Liu J, Liu B, Liu X, Yu X (2018) Prenatal exposure to arsenic and neurobehavioral development of newborns in China. Environ Int 121(Pt 1):421\u2013427","journal-title":"Environ Int"},{"key":"4525_CR20","doi-asserted-by":"publisher","first-page":"105112","DOI":"10.1016\/j.envint.2019.105112","volume":"135","author":"C Liang","year":"2020","unstructured":"Liang C, Wu X, Huang K, Yan S, Li Z, Xia X, Pan W, Sheng J, Tao R, Tao Y, Xiang H, Hao J, Wang Q, Tong S, Tao F (2020) Domain- and sex-specific effects of prenatal exposure to low levels of arsenic on children\u2019s development at 6 months of age: findings from the Ma\u2019anshan birth cohort study in China. Environ Int 135:105112","journal-title":"Environ Int"},{"key":"4525_CR21","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.neuro.2021.02.004","volume":"84","author":"S Dominguez","year":"2021","unstructured":"Dominguez S, Lencinas I, Bartos M, Gallegos C, Bras C, Monaco N, Minetti A, Gumilar F (2021) Neurobehavioral and neurochemical effects in rats offspring co-exposed to arsenic and fluoride during development. Neurotoxicology 84:30\u201340","journal-title":"Neurotoxicology"},{"key":"4525_CR22","doi-asserted-by":"publisher","first-page":"111617","DOI":"10.1016\/j.jinorgbio.2021.111617","volume":"225","author":"H Lu","year":"2021","unstructured":"Lu H, Zhao H, Wang Y, Guo M, Mu M, Liu Y, Nie X, Huang P, Xing M (2021) Arsenic (III) induces oxidative stress and inflammation in the gills of common carp, which is ameliorated by zinc (II). J Inorg Biochem 225:111617","journal-title":"J Inorg Biochem"},{"key":"4525_CR23","doi-asserted-by":"publisher","first-page":"117940","DOI":"10.1016\/j.envpol.2021.117940","volume":"289","author":"MS Rahaman","year":"2021","unstructured":"Rahaman MS, Rahman MM, Mise N, Sikder MT, Ichihara G, Uddin MK, Kurasaki M, Ichihara S (2021) Environmental arsenic exposure and its contribution to human diseases, toxicity mechanism and management. Environ Pollut 289:117940","journal-title":"Environ Pollut"},{"issue":"11","key":"4525_CR24","doi-asserted-by":"publisher","first-page":"3929","DOI":"10.1007\/s10653-021-01141-4","volume":"44","author":"M Saeed","year":"2022","unstructured":"Saeed M, Rehman MYA, Farooqi A, Malik RN (2022) Arsenic and fluoride co-exposure through drinking water and their impacts on intelligence and oxidative stress among rural school-aged children of Lahore and Kasur districts. Pakistan Environ Geochem Health 44(11):3929\u20133951","journal-title":"Pakistan Environ Geochem Health"},{"issue":"2","key":"4525_CR25","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1002\/jat.1649","volume":"31","author":"K Jomova","year":"2011","unstructured":"Jomova K, Jenisova Z, Feszterova M, Baros S, Liska J, Hudecova D, Rhodes CJ, Valko M (2011) Arsenic: toxicity, oxidative stress and human disease. J Appl Toxicol 31(2):95\u2013107","journal-title":"J Appl Toxicol"},{"issue":"1","key":"4525_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00204-015-1579-5","volume":"90","author":"M Valko","year":"2016","unstructured":"Valko M, Jomova K, Rhodes CJ, Kuca K, Musilek K (2016) Redox- and non-redox-metal-induced formation of free radicals and their role in human disease. Arch Toxicol 90(1):1\u201337","journal-title":"Arch Toxicol"},{"issue":"8","key":"4525_CR27","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1016\/S0143-4004(05)80188-2","volume":"15","author":"S Tabacova","year":"1994","unstructured":"Tabacova S, Baird DD, Balabaeva L, Lolova D, Petrov I (1994) Placental arsenic and cadmium in relation to lipid peroxides and glutathione levels in maternal-infant pairs from a copper smelter area. Placenta 15(8):873\u2013881","journal-title":"Placenta"},{"issue":"1","key":"4525_CR28","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/nchembio.1416","volume":"10","author":"SJ Dixon","year":"2014","unstructured":"Dixon SJ, Stockwell BR (2014) The role of iron and reactive oxygen species in cell death. Nat Chem Biol 10(1):9\u201317","journal-title":"Nat Chem Biol"},{"issue":"3","key":"4525_CR29","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.tcb.2015.10.014","volume":"26","author":"WS Yang","year":"2016","unstructured":"Yang WS, Stockwell BR (2016) Ferroptosis: death by lipid peroxidation. Trends Cell Biol 26(3):165\u2013176","journal-title":"Trends Cell Biol"},{"issue":"5","key":"4525_CR30","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.tips.2017.02.005","volume":"38","author":"JPF Angeli","year":"2017","unstructured":"Angeli JPF, Shah R, Pratt DA, Conrad M (2017) Ferroptosis inhibition: mechanisms and opportunities. Trends Pharmacol Sci 38(5):489\u2013498","journal-title":"Trends Pharmacol Sci"},{"issue":"12","key":"4525_CR31","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1016\/j.molcel.2022.03.022","volume":"82","author":"D Liang","year":"2022","unstructured":"Liang D, Minikes AM, Jiang X (2022) Ferroptosis at the intersection of lipid metabolism and cellular signaling. Mol Cell 82(12):2215\u20132227","journal-title":"Mol Cell"},{"key":"4525_CR32","doi-asserted-by":"publisher","first-page":"121390","DOI":"10.1016\/j.jhazmat.2019.121390","volume":"384","author":"S Wei","year":"2020","unstructured":"Wei S, Qiu T, Yao X, Wang N, Jiang L, Jia X, Tao Y, Wang Z, Pei P, Zhang J, Zhu Y, Yang G, Liu X, Liu S, Sun X (2020) Arsenic induces pancreatic dysfunction and ferroptosis via mitochondrial ROS-autophagy-lysosomal pathway. J Hazard Mater 384:121390","journal-title":"J Hazard Mater"},{"key":"4525_CR33","doi-asserted-by":"publisher","first-page":"118545","DOI":"10.1016\/j.envpol.2021.118545","volume":"293","author":"J Tong","year":"2022","unstructured":"Tong J, Liang C, Wu X, Huang K, Zhu B, Gao H, Zhu Y, Li Z, Qi J, Han Y, Ding P, Zhu Y, Tao F (2022) Prenatal serum thallium exposure and cognitive development among preschool-aged children: a prospective cohort study in China. Environ Pollut 293:118545","journal-title":"Environ Pollut"},{"key":"4525_CR34","doi-asserted-by":"publisher","first-page":"105882","DOI":"10.1016\/j.envint.2020.105882","volume":"142","author":"Y Zhu","year":"2020","unstructured":"Zhu Y, Wu X, Yan S, Huang K, Tong J, Gao H, Xie Y, Tao S, Ding P, Zhu P, Tao F (2020) Domain- and trimester-specific effect of prenatal phthalate exposure on preschooler cognitive development in the Ma\u2019anshan birth cohort (MABC) study. Environ Int 142:105882","journal-title":"Environ Int"},{"key":"4525_CR35","first-page":"11","volume":"849","author":"C Liang","year":"2022","unstructured":"Liang C, Zhang Z, Cao Y, Wang J, Shen L, Jiang T, Li D, Zou W, Zong K, Liang D, Xu X, Liu Y, Tao F, Luo G, Ji D, Cao Y (2022) Exposure to multiple toxic metals and polycystic ovary syndrome risk: endocrine disrupting effect from As. Pb and Ba Sci Total Environ 849:11","journal-title":"Pb and Ba Sci Total Environ"},{"issue":"2","key":"4525_CR36","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/pcn.12014","volume":"67","author":"P Yang","year":"2013","unstructured":"Yang P, Cheng C, Chang C, Liu T, Hsu H, Yen C (2013) Wechsler intelligence scale for children 4th edition-Chinese version index scores in Taiwanese children with attention-deficit\/hyperactivity disorder. Psychiatry Clin Neurosci 67(2):83\u201391","journal-title":"Psychiatry Clin Neurosci"},{"issue":"Pt 2","key":"4525_CR37","doi-asserted-by":"publisher","first-page":"160029","DOI":"10.1016\/j.scitotenv.2022.160029","volume":"858","author":"J Tong","year":"2023","unstructured":"Tong J, Liang C, Tao S, Geng M, Gan H, Yan S, Cao H, Xie L, Huang K, Tao F, Wu X (2023) Association of maternal and cord blood barium exposure with preschoolers\u2019 intellectual function: evidence from the Ma\u2019anshan birth cohort (MABC) study. Sci Total Environ 858(Pt 2):160029","journal-title":"Sci Total Environ"},{"issue":"9","key":"4525_CR38","doi-asserted-by":"publisher","first-page":"97004","DOI":"10.1289\/EHP12207","volume":"131","author":"Y Song","year":"2023","unstructured":"Song Y, Lv J, Zhang Z, Qian Q, Fan Y, Chen D, Zhang H, Xu F, Zhang C, Huang Y, Wang H, Wei W, Xu D (2023) Effects of gestational arsenic exposures on placental and fetal development in mice: the role of cyr61 m6a. Environ Health Perspect 131(9):97004","journal-title":"Environ Health Perspect"},{"key":"4525_CR39","doi-asserted-by":"publisher","first-page":"112901","DOI":"10.1016\/j.ecoenv.2021.112901","volume":"227","author":"J Lv","year":"2021","unstructured":"Lv J, Song Y, Zhang Z, Fan Y, Xu F, Gao L, Zhang X, Zhang C, Wang H, Xu D (2021) Gestational arsenic exposure induces anxiety-like behaviors in adult offspring by reducing DNA hydroxymethylation in the developing brain. Ecotoxicol Environ Saf 227:112901","journal-title":"Ecotoxicol Environ Saf"},{"key":"4525_CR40","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.taap.2018.07.030","volume":"356","author":"H Wang","year":"2018","unstructured":"Wang H, Li J, Zhang X, Zhu P, Hao J, Tao F, Xu D (2018) Maternal serum arsenic level during pregnancy is positively associated with adverse pregnant outcomes in a Chinese population. Toxicol Appl Pharmacol 356:114\u2013119","journal-title":"Toxicol Appl Pharmacol"},{"key":"4525_CR41","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.envres.2016.11.008","volume":"153","author":"AS Ettinger","year":"2017","unstructured":"Ettinger AS, Arbuckle TE, Fisher M, Liang CL, Davis K, Cirtiu C, Belanger P, Leblanc A, Fraser WD (2017) Arsenic levels among pregnant women and newborns in Canada: results from the maternal-infant research on environmental chemicals (MIREC) cohort. Environ Res 153:8\u201316","journal-title":"Environ Res"},{"issue":"6","key":"4525_CR42","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1007\/s10653-008-9245-y","volume":"31","author":"FM Francisca","year":"2009","unstructured":"Francisca FM, Carro Perez ME (2009) Assessment of natural arsenic in groundwater in Cordoba Province. Argentina Environ Geochem Health 31(6):673\u2013682","journal-title":"Argentina Environ Geochem Health"},{"key":"4525_CR43","doi-asserted-by":"publisher","first-page":"124861","DOI":"10.1016\/j.chemosphere.2019.124861","volume":"241","author":"Q Guo","year":"2020","unstructured":"Guo Q, Sun Z, Niu R, Manthari RK, Yuan M, Yang K, Cheng M, Gong Z, Wang J (2020) Effect of arsenic and\/or fluoride gestational exposure on renal autophagy in offspring mice. Chemosphere 241:124861","journal-title":"Chemosphere"},{"key":"4525_CR44","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.ecoenv.2018.08.109","volume":"165","author":"X Li","year":"2018","unstructured":"Li X, Yi H, Wang H (2018) Sulphur dioxide and arsenic affect male reproduction via interfering with spermatogenesis in mice. Ecotoxicol Environ Saf 165:164\u2013173","journal-title":"Ecotoxicol Environ Saf"},{"issue":"5868","key":"4525_CR45","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1038\/297681a0","volume":"297","author":"RG Morris","year":"1982","unstructured":"Morris RG, Garrud P, Rawlins JN, O\u2019Keefe J (1982) Place navigation impaired in rats with hippocampal lesions. Nature 297(5868):681\u2013683","journal-title":"Nature"},{"issue":"3","key":"4525_CR46","doi-asserted-by":"publisher","first-page":"279","DOI":"10.9758\/cpn.2016.14.3.279","volume":"14","author":"JC Song","year":"2016","unstructured":"Song JC, Seo MK, Park SW, Lee JG, Kim YH (2016) Differential effects of olanzapine and haloperidol on MK-801-induced memory impairment in mice. Clin Psychopharmacol Neurosci 14(3):279\u2013285","journal-title":"Clin Psychopharmacol Neurosci"},{"key":"4525_CR47","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.brainresbull.2020.06.011","volume":"162","author":"Q Xiao","year":"2020","unstructured":"Xiao Q, Wen S, Zhang X, Xue L, Zhang Z, Tan Y, Du R, Zhu Z, Zhu Y, Wang T, Yu C, Xiong L (2020) MiR-410-3p overexpression ameliorates neurological deficits in rats with hypoxic-ischemic brain damage. Brain Res Bull 162:218\u2013230","journal-title":"Brain Res Bull"},{"issue":"12","key":"4525_CR48","doi-asserted-by":"publisher","first-page":"970","DOI":"10.3390\/toxics11120970","volume":"11","author":"F Chu","year":"2023","unstructured":"Chu F, Yang W, Li Y, Lu C, Jiao Z, Bu K, Liu Z, Sun H, Sun D (2023) Subchronic arsenic exposure induces behavioral impairments and hippocampal damage in rats. Toxics 11(12):970","journal-title":"Toxics"},{"issue":"2","key":"4525_CR49","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1093\/toxsci\/kfy172","volume":"165","author":"L Bai","year":"2018","unstructured":"Bai L, Tang Q, Zou Z, Meng P, Tu B, Xia Y, Cheng S, Zhang L, Yang K, Mu S, Wang X, Qin X, Lv B, Cao X, Qin Q, Jiang X, Chen C (2018) m6A demethylase FTO regulates dopaminergic neurotransmission deficits caused by arsenite. Toxicol Sci 165(2):431\u2013446","journal-title":"Toxicol Sci"},{"key":"4525_CR50","doi-asserted-by":"publisher","first-page":"102689","DOI":"10.1016\/j.redox.2023.102689","volume":"62","author":"M Kannan","year":"2023","unstructured":"Kannan M, Sil S, Oladapo A, Thangaraj A, Periyasamy P, Buch S (2023) HIV-1 Tat-mediated microglial ferroptosis involves the miR-204-ACSL4 signaling axis. Redox Biol 62:102689","journal-title":"Redox Biol"},{"issue":"11","key":"4525_CR51","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.1080\/15548627.2018.1493043","volume":"14","author":"Y Urano","year":"2018","unstructured":"Urano Y, Mori C, Fuji A, Konno K, Yamamoto T, Yashirogi S, Ando M, Saito Y, Noguchi N (2018) 6-Hydroxydopamine induces secretion of PARK7\/DJ-1 via autophagy-based unconventional secretory pathway. Autophagy 14(11):1943\u20131958","journal-title":"Autophagy"},{"key":"4525_CR52","doi-asserted-by":"publisher","first-page":"112632","DOI":"10.1016\/j.ecoenv.2021.112632","volume":"224","author":"X Shi","year":"2021","unstructured":"Shi X, Zhu H, Xu X, Xiong Y, Dai L, Zhou G, Liu W, Zhang Y, Xu D, Wang H (2021) Gestational cadmium exposure impairs placental angiogenesis via activating GC\/GR signaling. Ecotoxicol Environ Saf 224:112632","journal-title":"Ecotoxicol Environ Saf"},{"key":"4525_CR53","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.neuro.2018.04.012","volume":"67","author":"Q Tang","year":"2018","unstructured":"Tang Q, Bai L, Zou Z, Meng P, Xia Y, Cheng S, Mu S, Zhou J, Wang X, Qin X, Cao X, Jiang X, Chen C (2018) Ferroptosis is newly characterized form of neuronal cell death in response to arsenite exposure. Neurotoxicology 67:27\u201336","journal-title":"Neurotoxicology"},{"key":"4525_CR54","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.toxlet.2016.04.023","volume":"254","author":"Y Gao","year":"2016","unstructured":"Gao Y, Yin Y, Xing X, Zhao Z, Lu Y, Sun Y, Zhuang Z, Wang M, Ji W, He Y (2016) Arsenic-induced anti-angiogenesis via miR-425-5p-regulated CCM3. Toxicol Lett 254:22\u201331","journal-title":"Toxicol Lett"},{"key":"4525_CR55","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/s12967-015-0430-3","volume":"13","author":"TK Dua","year":"2015","unstructured":"Dua TK, Dewanjee S, Gangopadhyay M, Khanra R, Zia-Ul-Haq M, De Feo V (2015) Ameliorative effect of water spinach, Ipomea aquatica (Convolvulaceae), against experimentally induced arsenic toxicity. J Transl Med 13:81","journal-title":"J Transl Med"},{"key":"4525_CR56","doi-asserted-by":"publisher","first-page":"133338","DOI":"10.1016\/j.chemosphere.2021.133338","volume":"290","author":"X Zhang","year":"2022","unstructured":"Zhang X, Mei D, Li Y, You M, Wang D, Yao D, Xu Y, Zhai L, Wang Y (2022) Arsenic exposure via drinking water during pregnancy and lactation induces autism-like behaviors in male offspring mice. Chemosphere 290:133338","journal-title":"Chemosphere"},{"issue":"2","key":"4525_CR57","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1289\/ehp.9501","volume":"115","author":"GA Wasserman","year":"2007","unstructured":"Wasserman GA, Liu X, Parvez F, Ahsan H, Factor-Litvak P, Kline J, van Geen A, Slavkovich V, Loiacono NJ, Levy D, Cheng Z, Graziano JH (2007) Water arsenic exposure and intellectual function in 6-year-old children in Araihazar. Bangladesh Environ Health Perspect 115(2):285\u2013289","journal-title":"Bangladesh Environ Health Perspect"},{"key":"4525_CR58","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.neuro.2017.01.006","volume":"59","author":"Y Zhu","year":"2017","unstructured":"Zhu Y, Xi S, Li M, Ding T, Liu N, Cao F, Zeng Y, Liu X, Tong J, Jiang S (2017) Fluoride and arsenic exposure affects spatial memory and activates the ERK\/CREB signaling pathway in offspring rats. Neurotoxicology 59:56\u201364","journal-title":"Neurotoxicology"},{"issue":"5","key":"4525_CR59","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","volume":"149","author":"SJ Dixon","year":"2012","unstructured":"Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, Morrison BR, Stockwell BR (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149(5):1060\u20131072","journal-title":"Cell"},{"issue":"19","key":"4525_CR60","doi-asserted-by":"publisher","first-page":"14459","DOI":"10.3390\/ijms241914459","volume":"24","author":"SM Korotkov","year":"2023","unstructured":"Korotkov SM (2023) Mitochondrial oxidative stress is the general reason for apoptosis induced by different-valence heavy metals in cells and mitochondria. Int J Mol Sci 24(19):14459","journal-title":"Int J Mol Sci"},{"issue":"2\u20133","key":"4525_CR61","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.cbi.2011.02.001","volume":"190","author":"L Wang","year":"2011","unstructured":"Wang L, Weng C, Wang Y, Wu M (2011) Lipoic acid ameliorates arsenic trioxide-induced HO-1 expression and oxidative stress in THP-1 monocytes and macrophages. Chem Biol Interact 190(2\u20133):129\u2013138","journal-title":"Chem Biol Interact"},{"key":"4525_CR62","doi-asserted-by":"publisher","first-page":"101950","DOI":"10.1016\/j.redox.2021.101950","volume":"41","author":"D Ross","year":"2021","unstructured":"Ross D, Siegel D (2021) The diverse functionality of NQO1 and its roles in redox control. Redox Biol 41:101950","journal-title":"Redox Biol"},{"key":"4525_CR63","doi-asserted-by":"publisher","first-page":"100977","DOI":"10.1016\/j.drup.2023.100977","volume":"70","author":"J Yu","year":"2023","unstructured":"Yu J, Zhong B, Zhao L, Hou Y, Ai N, Lu J, Ge W, Chen X (2023) Fighting drug-resistant lung cancer by induction of NAD(P)H:quinone oxidoreductase 1 (NQO1)-mediated ferroptosis. Drug Resist Updat 70:100977","journal-title":"Drug Resist Updat"},{"issue":"2","key":"4525_CR64","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","volume":"11","author":"J Li","year":"2020","unstructured":"Li J, Cao F, Yin H, Huang Z, Lin Z, Mao N, Sun B, Wang G (2020) Ferroptosis: past, present and future. Cell Death Dis 11(2):88","journal-title":"Cell Death Dis"},{"issue":"2","key":"4525_CR65","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/s12192-022-01257-1","volume":"27","author":"H Tian","year":"2021","unstructured":"Tian H, Xiong Y, Zhang Y, Leng Y, Tao J, Li L, Qiu Z, Xia Z (2021) Activation of NRF2\/FPN1 pathway attenuates myocardial ischemia-reperfusion injury in diabetic rats by regulating iron homeostasis and ferroptosis. Cell Stress Chaperones 27(2):149\u2013164","journal-title":"Cell Stress Chaperones"},{"issue":"8","key":"4525_CR66","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1007\/s00125-020-05153-0","volume":"63","author":"Y Ikeda","year":"2020","unstructured":"Ikeda Y, Watanabe H, Shiuchi T, Hamano H, Horinouchi Y, Imanishi M, Goda M, Zamami Y, Takechi K, Izawa-Ishizawa Y, Miyamoto L, Ishizawa K, Aihara K, Tsuchiya K, Tamaki T (2020) Deletion of H-ferritin in macrophages alleviates obesity and diabetes induced by high-fat diet in mice. Diabetologia 63(8):1588\u20131602","journal-title":"Diabetologia"},{"issue":"4","key":"4525_CR67","doi-asserted-by":"publisher","first-page":"1796","DOI":"10.1007\/s13311-020-00929-z","volume":"17","author":"Y Tian","year":"2020","unstructured":"Tian Y, Lu J, Hao X, Li H, Zhang G, Liu X, Li X, Zhao C, Kuang W, Chen D, Zhu M (2020) FTH1 inhibits ferroptosis through ferritinophagy in the 6-OHDA model of Parkinson\u2019s disease. Neurotherapeutics 17(4):1796\u20131812","journal-title":"Neurotherapeutics"},{"issue":"9","key":"4525_CR68","doi-asserted-by":"publisher","first-page":"2054","DOI":"10.1080\/15548627.2020.1810918","volume":"17","author":"X Chen","year":"2021","unstructured":"Chen X, Li J, Kang R, Klionsky DJ, Tang D (2021) Ferroptosis: machinery and regulation. Autophagy 17(9):2054\u20132081","journal-title":"Autophagy"},{"issue":"3","key":"4525_CR69","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.chembiol.2008.02.010","volume":"15","author":"WS Yang","year":"2008","unstructured":"Yang WS, Stockwell BR (2008) Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells. Chem Biol 15(3):234\u2013245","journal-title":"Chem Biol"},{"issue":"6","key":"4525_CR70","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/j.cmet.2020.10.011","volume":"32","author":"J Zheng","year":"2020","unstructured":"Zheng J, Conrad M (2020) The metabolic underpinnings of ferroptosis. Cell Metab 32(6):920\u2013937","journal-title":"Cell Metab"},{"issue":"1","key":"4525_CR71","doi-asserted-by":"publisher","first-page":"10262","DOI":"10.1038\/s41598-022-14248-0","volume":"12","author":"VRS Monteiro","year":"2022","unstructured":"Monteiro VRS, Andrade CBV, Gomes HR, Reginatto MW, Imperio GE, Fontes KN, Spiess DA, Rangel-Junior WS, Nascimento VMO, Lima COS, Sousa RPC, Bloise FF, Matthews SG, Bloise E, Pimentel-Coelho PM, Ortiga-Carvalho TM (2022) Mid-pregnancy poly(I:C) viral mimic disrupts placental ABC transporter expression and leads to long-term offspring motor and cognitive dysfunction. Sci Rep 12(1):10262","journal-title":"Sci Rep"},{"issue":"Pt 1","key":"4525_CR72","doi-asserted-by":"publisher","first-page":"135668","DOI":"10.1016\/j.chemosphere.2022.135668","volume":"307","author":"W Liu","year":"2022","unstructured":"Liu W, Zhu H, Xiong Y, Lv J, Huang Y, Wang H (2022) Environmental cadmium exposure during gestation impairs fetal brain and cognitive function of adult offspring via reducing placenta-derived e2 level. Chemosphere 307(Pt 1):135668","journal-title":"Chemosphere"},{"issue":"10","key":"4525_CR73","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1038\/s41593-021-00896-4","volume":"24","author":"C Vacher","year":"2021","unstructured":"Vacher C, Lacaille H, O\u2019Reilly JJ, Salzbank J, Bakalar D, Sebaoui S, Liere P, Clarkson-Paredes C, Sasaki T, Sathyanesan A, Kratimenos P, Ellegood J, Lerch JP, Imamura Y, Popratiloff A, Hashimoto-Torii K, Gallo V, Schumacher M, Penn AA (2021) Placental endocrine function shapes cerebellar development and social behavior. Nat Neurosci 24(10):1392\u20131401","journal-title":"Nat Neurosci"},{"key":"4525_CR74","doi-asserted-by":"publisher","first-page":"147918","DOI":"10.1016\/j.scitotenv.2021.147918","volume":"788","author":"C Zhang","year":"2021","unstructured":"Zhang C, Wu X, Li S, Dou L, Zhou L, Wang F, Ma K, Huang D, Pan Y, Gu J, Cao J, Wang H, Hao J (2021) Perinatal low-dose bisphenol AF exposure impairs synaptic plasticity and cognitive function of adult offspring in a sex-dependent manner. Sci Total Environ 788:147918","journal-title":"Sci Total Environ"},{"key":"4525_CR75","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.scitotenv.2019.134036","volume":"697","author":"H Zhang","year":"2019","unstructured":"Zhang H, Kuang H, Luo Y, Liu S, Meng L, Pang Q, Fan R (2019) Low-dose bisphenol A exposure impairs learning and memory ability with alterations of neuromorphology and neurotransmitters in rats. Sci Total Environ 697:11","journal-title":"Sci Total Environ"}],"container-title":["Biological Trace Element Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-025-04525-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12011-025-04525-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-025-04525-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T05:38:26Z","timestamp":1757137106000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12011-025-04525-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,6]]},"references-count":75,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["4525"],"URL":"https:\/\/doi.org\/10.1007\/s12011-025-04525-0","relation":{},"ISSN":["1559-0720"],"issn-type":[{"value":"1559-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,6]]},"assertion":[{"value":"26 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}