{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:34:31Z","timestamp":1759970071362,"version":"build-2065373602"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biol Trace Elem Res"],"DOI":"10.1007\/s12011-025-04576-3","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T04:52:36Z","timestamp":1742359956000},"page":"5127-5136","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Iron as a Modifiable Factor for Adverse Pregnancy Outcomes: Refining and Understanding Causal Estimates Using Mendelian Randomization"],"prefix":"10.1007","volume":"203","author":[{"given":"Yuhang","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linbin","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziye","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lizhang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,3,19]]},"reference":[{"key":"4576_CR1","volume":"385","author":"A Robinson","year":"2024","unstructured":"Robinson A (2024) The future health risks of adverse pregnancy outcomes \u2026 and other research. BMJ (Clinical research ed) 385:q917","journal-title":"BMJ (Clinical research ed)"},{"key":"4576_CR2","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1001\/jamainternmed.2024.0276","volume":"184","author":"C Crump","year":"2024","unstructured":"Crump C, Sundquist J, Sundquist K (2024) Adverse pregnancy outcomes and long-term mortality in women. JAMA Intern Med 184:631\u2013640","journal-title":"JAMA Intern Med"},{"key":"4576_CR3","doi-asserted-by":"publisher","first-page":"1655s","DOI":"10.3945\/ajcn.117.156000","volume":"106","author":"N Milman","year":"2017","unstructured":"Milman N, Taylor CL, Merkel J, Brannon PM (2017) Iron status in pregnant women and women of reproductive age in Europe. Am J Clin Nutr 106:1655s-s1662","journal-title":"Am J Clin Nutr"},{"key":"4576_CR4","doi-asserted-by":"crossref","unstructured":"Pai RD, Chong YS, Clemente-Chua LR, Irwinda R, Huynh TNK, Wibowo N, et al. Prevention and management of iron deficiency\/iron-deficiency anemia in women: an Asian expert consensus. Nutrients. 2023;15:","DOI":"10.3390\/nu15143125"},{"key":"4576_CR5","doi-asserted-by":"publisher","first-page":"e151111738965","DOI":"10.33448\/rsd-v11i17.38965","volume":"11","author":"LdS Borba","year":"2022","unstructured":"Borba LdS, Lima LBd, Silva GVd, Salles SWE, Bandeira ARG, Lima SHPd (2022) Importance of iron in the human body: an integrative literature review. Research, Society and Development. 11:e151111738965","journal-title":"Research, Society and Development."},{"key":"4576_CR6","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1146\/annurev-nutr-061021-030404","volume":"43","author":"V Sangkhae","year":"2023","unstructured":"Sangkhae V, Fisher AL, Ganz T, Nemeth E (2023) Iron homeostasis during pregnancy: maternal, placental, and fetal regulatory mechanisms. Annu Rev Nutr 43:279\u2013300","journal-title":"Annu Rev Nutr"},{"key":"4576_CR7","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.ajog.2020.03.006","volume":"223","author":"MK Georgieff","year":"2020","unstructured":"Georgieff MK (2020) Iron deficiency in pregnancy. Am J Obstet Gynecol 223:516\u2013524","journal-title":"Am J Obstet Gynecol"},{"key":"4576_CR8","doi-asserted-by":"crossref","unstructured":"Means RT. Iron deficiency and iron deficiency anemia: implications and impact in pregnancy, fetal development, and early childhood parameters. Nutrients. 2020;12:","DOI":"10.3390\/nu12020447"},{"key":"4576_CR9","doi-asserted-by":"crossref","unstructured":"Santander Ballest\u00edn S, Gim\u00e9nez Campos MI, Ballest\u00edn Ballest\u00edn J, Luesma Bartolom\u00e9 MJ. Is supplementation with micronutrients still necessary during pregnancy? A review. Nutrients. 2021;13:","DOI":"10.3390\/nu13093134"},{"key":"4576_CR10","doi-asserted-by":"publisher","first-page":"2206","DOI":"10.1182\/blood.2020005745","volume":"136","author":"V Sangkhae","year":"2020","unstructured":"Sangkhae V, Fisher AL, Chua KJ, Ruchala P, Ganz T, Nemeth E (2020) Maternal hepcidin determines embryo iron homeostasis in mice. Blood 136:2206\u20132216","journal-title":"Blood"},{"key":"4576_CR11","doi-asserted-by":"publisher","first-page":"4127","DOI":"10.1002\/fsn3.2373","volume":"9","author":"H Zulfiqar","year":"2021","unstructured":"Zulfiqar H, Shah IU, Sheas MN, Ahmed Z, Ejaz U, Ullah I et al (2021) Dietary association of iron deficiency anemia and related pregnancy outcomes. Food Sci Nutr 9:4127\u20134133","journal-title":"Food Sci Nutr"},{"key":"4576_CR12","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/s41430-019-0464-3","volume":"74","author":"JL Finkelstein","year":"2020","unstructured":"Finkelstein JL, Kurpad AV, Bose B, Thomas T, Srinivasan K, Duggan C (2020) Anaemia and iron deficiency in pregnancy and adverse perinatal outcomes in Southern India. Eur J Clin Nutr 74:112\u2013125","journal-title":"Eur J Clin Nutr"},{"key":"4576_CR13","first-page":"1177","volume":"50","author":"Y Shao","year":"2021","unstructured":"Shao Y, Mao B, Qiu J, Bai Y, Lin R, He X et al (2021) Association between iron supplementation, dietary iron intake and risk of moderate preterm birth: a birth cohort study in China. Iran J Public Health 50:1177\u20131187","journal-title":"Iran J Public Health"},{"key":"4576_CR14","doi-asserted-by":"publisher","first-page":"e0221299","DOI":"10.1371\/journal.pone.0221299","volume":"14","author":"EA Symington","year":"2019","unstructured":"Symington EA, Baumgartner J, Malan L, Wise AJ, Ricci C, Zandberg L et al (2019) Maternal iron-deficiency is associated with premature birth and higher birth weight despite routine antenatal iron supplementation in an urban South African setting: the NuPED prospective study. PLoS ONE 14:e0221299","journal-title":"PLoS ONE"},{"key":"4576_CR15","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1002\/ajh.25341","volume":"94","author":"Y Guo","year":"2019","unstructured":"Guo Y, Zhang N, Zhang D, Ren Q, Ganz T, Liu S et al (2019) Iron homeostasis in pregnancy and spontaneous abortion. Am J Hematol 94:184\u2013188","journal-title":"Am J Hematol"},{"key":"4576_CR16","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1111\/bjh.17049","volume":"192","author":"S Wei","year":"2021","unstructured":"Wei S, Liu W, Qi Y, Guo Y, Zhang S, Wang L et al (2021) Disordered serum erythroferrone and hepcidin levels as indicators of the spontaneous abortion occurrence during early pregnancy in humans. Br J Haematol 192:643\u2013651","journal-title":"Br J Haematol"},{"key":"4576_CR17","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.jtemb.2019.08.009","volume":"56","author":"MG Skalnaya","year":"2019","unstructured":"Skalnaya MG, Tinkov AA, Lobanova YN, Chang JS, Skalny AV (2019) Serum levels of copper, iron, and manganese in women with pregnancy, miscarriage, and primary infertility. Journal of trace elements in medicine and biology\u202f: organ of the Society for Minerals and Trace Elements (GMS) 56:124\u2013130","journal-title":"Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)"},{"key":"4576_CR18","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1007\/s12291-022-01043-x","volume":"38","author":"Prabhu K Sairoz","year":"2023","unstructured":"Sairoz Prabhu K, Poojari VG, Shetty S, Rao M, Kamath A (2023) Maternal serum zinc, copper, magnesium, and iron in spontaneous abortions. Indian journal of clinical biochemistry\u202f: IJCB. 38:128\u201331","journal-title":"Indian journal of clinical biochemistry : IJCB."},{"key":"4576_CR19","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1055\/s-2000-9508","volume":"17","author":"X Xiong","year":"2000","unstructured":"Xiong X, Buekens P, Alexander S, Demianczuk N, Wollast E (2000) Anemia during pregnancy and birth outcome: a meta-analysis. Am J Perinatol 17:137\u2013146","journal-title":"Am J Perinatol"},{"key":"4576_CR20","doi-asserted-by":"publisher","first-page":"1280s","DOI":"10.1093\/ajcn\/71.5.1280s","volume":"71","author":"LH Allen","year":"2000","unstructured":"Allen LH (2000) Anemia and iron deficiency: effects on pregnancy outcome. Am J Clin Nutr 71:1280s-s1284","journal-title":"Am J Clin Nutr"},{"key":"4576_CR21","doi-asserted-by":"publisher","first-page":"1672s","DOI":"10.3945\/ajcn.117.156034","volume":"106","author":"C Zhang","year":"2017","unstructured":"Zhang C, Rawal S (2017) Dietary iron intake, iron status, and gestational diabetes. Am J Clin Nutr 106:1672s-s1680","journal-title":"Am J Clin Nutr"},{"key":"4576_CR22","doi-asserted-by":"crossref","unstructured":"Kataria Y, Wu Y, Horskj\u00e6r PH, Mandrup-Poulsen T, Ellervik C. Iron status and gestational diabetes-a meta-analysis. Nutrients. 2018;10:","DOI":"10.3390\/nu10050621"},{"key":"4576_CR23","doi-asserted-by":"crossref","unstructured":"Birney E. Mendelian randomization. Cold Spring Harbor perspectives in medicine. 2022;12:","DOI":"10.1101\/cshperspect.a041302"},{"key":"4576_CR24","first-page":"n2233","volume":"375","author":"VW Skrivankova","year":"2021","unstructured":"Skrivankova VW, Richmond RC, Woolf BAR, Davies NM, Swanson SA, VanderWeele TJ et al (2021) Strengthening the reporting of observational studies in epidemiology using Mendelian randomisation (STROBE-MR): explanation and elaboration. BMJ (Clinical research ed) 375:n2233","journal-title":"BMJ (Clinical research ed)"},{"key":"4576_CR25","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1002\/jrsm.1346","volume":"10","author":"J Bowden","year":"2019","unstructured":"Bowden J, Holmes MV (2019) Meta-analysis and Mendelian randomization: a review. Research synthesis methods 10:486\u2013496","journal-title":"Research synthesis methods"},{"key":"4576_CR26","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/s42003-020-01575-z","volume":"4","author":"S Bell","year":"2021","unstructured":"Bell S, Rigas AS, Magnusson MK, Ferkingstad E, Allara E, Bjornsdottir G et al (2021) A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis. Communications biology 4:156","journal-title":"Communications biology"},{"key":"4576_CR27","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1038\/s41586-022-05473-8","volume":"613","author":"MI Kurki","year":"2023","unstructured":"Kurki MI, Karjalainen J, Palta P, Sipil\u00e4 TP, Kristiansson K, Donner KM et al (2023) FinnGen provides genetic insights from a well-phenotyped isolated population. Nature 613:508\u2013518","journal-title":"Nature"},{"key":"4576_CR28","doi-asserted-by":"publisher","first-page":"157","DOI":"10.3389\/fgene.2020.00157","volume":"11","author":"TA Myers","year":"2020","unstructured":"Myers TA, Chanock SJ, Machiela MJ (2020) LDlinkR: an R package for rapidly calculating linkage disequilibrium statistics in diverse populations. Front Genet 11:157","journal-title":"Front Genet"},{"key":"4576_CR29","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.1177\/0962280215597579","volume":"26","author":"S Burgess","year":"2017","unstructured":"Burgess S, Small DS, Thompson SG (2017) A review of instrumental variable estimators for Mendelian randomization. Stat Methods Med Res 26:2333\u20132355","journal-title":"Stat Methods Med Res"},{"key":"4576_CR30","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/s41467-020-14389-8","volume":"11","author":"N Papadimitriou","year":"2020","unstructured":"Papadimitriou N, Dimou N, Tsilidis KK, Banbury B, Martin RM, Lewis SJ et al (2020) Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis. Nat Commun 11:597","journal-title":"Nat Commun"},{"key":"4576_CR31","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1002\/gepi.21758","volume":"37","author":"S Burgess","year":"2013","unstructured":"Burgess S, Butterworth A, Thompson SG (2013) Mendelian randomization analysis with multiple genetic variants using summarized data. Genet Epidemiol 37:658\u2013665","journal-title":"Genet Epidemiol"},{"key":"4576_CR32","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.jclinepi.2014.09.005","volume":"68","author":"JF Cohen","year":"2015","unstructured":"Cohen JF, Chalumeau M, Cohen R, Korevaar DA, Khoshnood B, Bossuyt PM (2015) Cochran\u2019s Q test was useful to assess heterogeneity in likelihood ratios in studies of diagnostic accuracy. J Clin Epidemiol 68:299\u2013306","journal-title":"J Clin Epidemiol"},{"key":"4576_CR33","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/s10654-017-0255-x","volume":"32","author":"S Burgess","year":"2017","unstructured":"Burgess S, Thompson SG (2017) Interpreting findings from Mendelian randomization using the MR-Egger method. Eur J Epidemiol 32:377\u2013389","journal-title":"Eur J Epidemiol"},{"key":"4576_CR34","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","volume":"50","author":"M Verbanck","year":"2018","unstructured":"Verbanck M, Chen CY, Neale B, Do R (2018) Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Nat Genet 50:693\u2013698","journal-title":"Nat Genet"},{"key":"4576_CR35","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1002\/gepi.22207","volume":"43","author":"JS Ong","year":"2019","unstructured":"Ong JS, MacGregor S (2019) Implementing MR-PRESSO and GCTA-GSMR for pleiotropy assessment in Mendelian randomization studies from a practitioner\u2019s perspective. Genet Epidemiol 43:609\u2013616","journal-title":"Genet Epidemiol"},{"key":"4576_CR36","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.nutres.2018.03.005","volume":"53","author":"F Brunacci","year":"2018","unstructured":"Brunacci F, Rocha VS, De Carli E, Esp\u00f3sito BP, Ruano R, Colli C (2018) Increased serum iron in preeclamptic women is likely due to low hepcidin levels. Nutrition research (New York, NY) 53:32\u201339","journal-title":"Nutrition research (New York, NY)"},{"key":"4576_CR37","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/S0002-9378(87)80037-6","volume":"157","author":"P Samuels","year":"1987","unstructured":"Samuels P, Main EK, Mennuti MT, Gabbe SG (1987) The origin of increased serum iron in pregnancy-induced hypertension. Am J Obstet Gynecol 157:721\u2013725","journal-title":"Am J Obstet Gynecol"},{"key":"4576_CR38","doi-asserted-by":"crossref","unstructured":"Lubi\u0144ski J, Lener MR, Marciniak W, Pietrzak S, Derkacz R, Cybulski C, et al. Serum essential elements and survival after cancer diagnosis. Nutrients. 2023;15:","DOI":"10.3390\/nu15112611"},{"key":"4576_CR39","doi-asserted-by":"publisher","first-page":"7038","DOI":"10.1111\/febs.16059","volume":"289","author":"J Liu","year":"2022","unstructured":"Liu J, Kang R, Tang D (2022) Signaling pathways and defense mechanisms of ferroptosis. FEBS J 289:7038\u20137050","journal-title":"FEBS J"},{"key":"4576_CR40","doi-asserted-by":"publisher","first-page":"115466","DOI":"10.1016\/j.biopha.2023.115466","volume":"167","author":"Y Shan","year":"2023","unstructured":"Shan Y, Guan C, Wang J, Qi W, Chen A, Liu S (2023) Impact of ferroptosis on preeclampsia: a review. Biomedicine & pharmacotherapy Biomedecine & pharmacotherapie 167:115466","journal-title":"Biomedicine & pharmacotherapy Biomedecine & pharmacotherapie"},{"key":"4576_CR41","doi-asserted-by":"publisher","first-page":"178","DOI":"10.2174\/1389557518666181015151350","volume":"19","author":"S Taysi","year":"2019","unstructured":"Taysi S, Tascan AS, Ugur MG, Demir M (2019) Radicals, oxidative\/nitrosative stress and preeclampsia. Mini Rev Med Chem 19:178\u2013193","journal-title":"Mini Rev Med Chem"},{"key":"4576_CR42","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1146\/annurev-med-043021-032816","volume":"74","author":"E Nemeth","year":"2023","unstructured":"Nemeth E, Ganz T (2023) Hepcidin and iron in health and disease. Annu Rev Med 74:261\u2013277","journal-title":"Annu Rev Med"},{"key":"4576_CR43","doi-asserted-by":"publisher","first-page":"109875","DOI":"10.1016\/j.cbi.2022.109875","volume":"356","author":"SA Salama","year":"2022","unstructured":"Salama SA, Abdel-Bakky MS, Mohamed AA (2022) Upregulation of Nrf2 signaling and suppression of ferroptosis and NF-\u03baB pathway by leonurine attenuate iron overload-induced hepatotoxicity. Chem Biol Interact 356:109875","journal-title":"Chem Biol Interact"},{"key":"4576_CR44","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/s41572-023-00417-6","volume":"9","author":"E Dimitriadis","year":"2023","unstructured":"Dimitriadis E, Rolnik DL, Zhou W, Estrada-Gutierrez G, Koga K, Francisco RPV et al (2023) Pre-eclampsia Nature reviews Disease primers 9:8","journal-title":"Pre-eclampsia Nature reviews Disease primers"},{"key":"4576_CR45","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1007\/s00005-010-0095-9","volume":"58","author":"BJ Cherayil","year":"2010","unstructured":"Cherayil BJ (2010) Iron and immunity: immunological consequences of iron deficiency and overload. Arch Immunol Ther Exp 58:407\u2013415","journal-title":"Arch Immunol Ther Exp"},{"key":"4576_CR46","doi-asserted-by":"crossref","unstructured":"Zhang Y, Lu Y, Jin L. Iron metabolism and ferroptosis in physiological and pathological pregnancy. International journal of molecular sciences. 2022;23:","DOI":"10.3390\/ijms23169395"},{"key":"4576_CR47","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1182\/blood-2013-11-539718","volume":"124","author":"X Wang","year":"2014","unstructured":"Wang X, Mendelsohn L, Rogers H, Leitman S, Raghavachari N, Yang Y et al (2014) Heme-bound iron activates placenta growth factor in erythroid cells via erythroid Kr\u00fcppel-like factor. Blood 124:946\u2013954","journal-title":"Blood"},{"issue":"Suppl 2","key":"4576_CR48","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1002\/ijgo.14944","volume":"162","author":"R Ataide","year":"2023","unstructured":"Ataide R, Fielding K, Pasricha SR, Bennett C (2023) Iron deficiency, pregnancy, and neonatal development. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 162(Suppl 2):14\u201322","journal-title":"International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics"},{"key":"4576_CR49","doi-asserted-by":"publisher","first-page":"103073","DOI":"10.1016\/j.redox.2024.103073","volume":"70","author":"P Tian","year":"2024","unstructured":"Tian P, Xu Z, Guo J, Zhao J, Chen W, Huang W et al (2024) Hypoxia causes trophoblast cell ferroptosis to induce miscarriage through lnc-HZ06\/HIF1\u03b1-SUMO\/NCOA4 axis. Redox Biol 70:103073","journal-title":"Redox Biol"},{"key":"4576_CR50","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1146\/annurev.nutr.012809.104804","volume":"30","author":"M Wessling-Resnick","year":"2010","unstructured":"Wessling-Resnick M (2010) Iron homeostasis and the inflammatory response. Annu Rev Nutr 30:105\u2013122","journal-title":"Annu Rev Nutr"},{"key":"4576_CR51","doi-asserted-by":"crossref","unstructured":"Pandur E, Pap R, J\u00e1nosa G, Horv\u00e1th A, Sipos K. The role of fractalkine in the regulation of endometrial iron metabolism in iron deficiency. International journal of molecular sciences. 2023;24:","DOI":"10.3390\/ijms24129917"},{"key":"4576_CR52","doi-asserted-by":"publisher","first-page":"112583","DOI":"10.1016\/j.yexcr.2021.112583","volume":"403","author":"E Pandur","year":"2021","unstructured":"Pandur E, Pap R, Montsk\u00f3 G, J\u00e1nosa G, Sipos K, Kov\u00e1cs GL (2021) Fractalkine enhances endometrial receptivity and activates iron transport towards trophoblast cells in an in vitro co-culture system of HEC-1A and JEG-3 cells. Exp Cell Res 403:112583","journal-title":"Exp Cell Res"},{"key":"4576_CR53","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1007\/s10534-024-00586-1","volume":"37","author":"D Shan","year":"2024","unstructured":"Shan D, Chen Q, Xie Y, Dai S, Hu Y (2024) Current understanding of essential trace elements in intrahepatic cholestasis of pregnancy. Biometals\u202f: an international journal on the role of metal ions in biology, biochemistry, and medicine 37:943\u2013953","journal-title":"Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine"},{"key":"4576_CR54","doi-asserted-by":"publisher","first-page":"3735","DOI":"10.1007\/s10620-015-3791-9","volume":"60","author":"D Letner","year":"2015","unstructured":"Letner D, Peloquin J, Durand J, Rutherford A, Yajnik V, Khalili H et al (2015) Elevated total iron-binding capacity is associated with an increased risk of celiac disease. Dig Dis Sci 60:3735\u20133742","journal-title":"Dig Dis Sci"},{"key":"4576_CR55","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1111\/j.1440-1797.2008.01004.x","volume":"14","author":"YC Cheng","year":"2009","unstructured":"Cheng YC, Kuo WW, Wu CH, Shu WT, Kuo CH, Hwang JM et al (2009) Iron status and cardiovascular risk factors in patients with haemodialysis versus patients with ischaemic heart disease. Nephrology (Carlton) 14:65\u201369","journal-title":"Nephrology (Carlton)"},{"key":"4576_CR56","doi-asserted-by":"crossref","unstructured":"Fillebeen C, Lam NH, Chow S, Botta A, Sweeney G, Pantopoulos K. Regulatory connections between iron and glucose metabolism. International journal of molecular sciences. 2020;21:","DOI":"10.3390\/ijms21207773"},{"key":"4576_CR57","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.jtemb.2013.09.009","volume":"28","author":"S Zein","year":"2014","unstructured":"Zein S, Rachidi S, Hininger-Favier I (2014) Is oxidative stress induced by iron status associated with gestational diabetes mellitus? Journal of trace elements in medicine and biology\u202f: organ of the Society for Minerals and Trace Elements (GMS) 28:65\u201369","journal-title":"Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)"},{"key":"4576_CR58","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1038\/s41430-022-01086-6","volume":"76","author":"TT Lao","year":"2022","unstructured":"Lao TT, Hui SYA, Wong LL, Sahota DS (2022) Iron deficiency anaemia associated with increased placenta praevia and placental abruption: a retrospective case-control study. Eur J Clin Nutr 76:1172\u20131177","journal-title":"Eur J Clin Nutr"},{"key":"4576_CR59","doi-asserted-by":"publisher","first-page":"20220827","DOI":"10.1515\/biol-2022-0827","volume":"19","author":"S Lai","year":"2024","unstructured":"Lai S, Yu W, Liu Y, Yang Y, Zhang X (2024) Current research and evidence gaps on placental development in iron deficiency anemia. Open life sciences 19:20220827","journal-title":"Open life sciences"},{"key":"4576_CR60","doi-asserted-by":"publisher","first-page":"297","DOI":"10.17219\/acem\/154858","volume":"32","author":"\u00c7 \u00d6zg\u00f6k\u00e7e","year":"2023","unstructured":"\u00d6zg\u00f6k\u00e7e \u00c7, \u00d6cal A, Ermi\u015f IS (2023) Expression of NF-\u03baB and VEGF in normal placenta and placenta previa patients. Advances in clinical and experimental medicine\u202f: official organ Wroclaw Medical University 32:297\u2013306","journal-title":"Advances in clinical and experimental medicine : official organ Wroclaw Medical University"}],"container-title":["Biological Trace Element Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-025-04576-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12011-025-04576-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-025-04576-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:04:39Z","timestamp":1759917879000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12011-025-04576-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,19]]},"references-count":60,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["4576"],"URL":"https:\/\/doi.org\/10.1007\/s12011-025-04576-3","relation":{},"ISSN":["1559-0720"],"issn-type":[{"type":"electronic","value":"1559-0720"}],"subject":[],"published":{"date-parts":[[2025,3,19]]},"assertion":[{"value":"22 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study is a secondary analysis of publicly available GWAS summary data. Ethical approval was obtained for each of the original GWAS studies. Therefore, no further ethical approval or participant consent was required.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent or Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}