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A total of 122 participants, including 61 periodontitis patients and 61 periodontally healthy individuals, were included. Serum TOS, TAS, and selenium levels were measured, and the biochemical and clinical parameters were compared. The relationship between selenium levels and periodontitis was assessed through univariate analysis and multivariate logistic regression. Compared with the healthy group, the periodontitis group had significantly higher TOS and significantly lower TAS and selenium levels (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Logistic regression analysis also revealed a significant correlation between selenium levels and periodontitis (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Our study demonstrated that periodontitis was related to TOS, TAS, and selenium levels. The present study investigated the relationships of periodontitis with TOS, TAS, and selenium levels. Selenium levels could serve as an important biomarker for periodontal disease, as they are strongly correlated with the TOS value, the TAS value, and clinical parameters. Furthermore, lower selenium levels were observed in periodontitis patients than in healthy individuals.\n                  <\/jats:p>","DOI":"10.1007\/s12011-025-04649-3","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T12:02:22Z","timestamp":1746446542000},"page":"6415-6425","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Potential Relationship Between Decreased Serum Selenium Levels and Oxidative Stress in Periodontitis Stage III-IV"],"prefix":"10.1007","volume":"203","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2986-6740","authenticated-orcid":false,"given":"Mehmetcan","family":"Uytun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2398-9291","authenticated-orcid":false,"given":"Recep","family":"Orbak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7536-8921","authenticated-orcid":false,"given":"Ahmet","family":"K\u0131z\u0131ltun\u00e7","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,5]]},"reference":[{"issue":"9499","key":"4649_CR1","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1016\/S0140-6736(05)67728-8","volume":"366","author":"BL Pihlstrom","year":"2005","unstructured":"Pihlstrom BL, Michalowicz BS, Johnson NW (2005) Periodontal diseases. 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