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In an experiment conducted on female Wistar rats, the animals were divided into groups receiving control, 3-NPA, 3-NPA\u2009+\u2009BA, and BA only. 3-NPA triggers oxidative stress in the body by inducing excessive production of reactive oxygen species (ROS), leading to cellular damage and apoptosis. Experimental results showed that oxidative stress markers (MDA, GSH, and GSH-Px) increased in the group treated with 3-NPA, along with elevated inflammatory and apoptotic indicators (TNF-\u03b1, IL-6, NF-\u03baB, caspase 3, and 9). Moreover, significant histopathological findings such as degeneration, necrosis, and oocyte loss in follicles were observed. Boric acid application significantly reduced these adverse effects, enhancing antioxidant defense and providing protective effects on ovarian tissue. In conclusion, it was observed that BA\u2019s antioxidant and anti-apoptotic properties exhibited protective potential against 3-NPA-related ovarian damage, with a positive impact on reproductive health. 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