{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T21:01:42Z","timestamp":1782853302266,"version":"3.54.5"},"reference-count":70,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Shanxi Medical University Provincial Doctoral Research Fund","award":["SD2417"],"award-info":[{"award-number":["SD2417"]}]},{"name":"Shanxi Medical University Doctoral Start-up Fund","award":["XD2312"],"award-info":[{"award-number":["XD2312"]}]},{"name":"the Shanxi Province Basic Research Program","award":["202403021212261"],"award-info":[{"award-number":["202403021212261"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No.82103961"],"award-info":[{"award-number":["No.82103961"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No.82173644"],"award-info":[{"award-number":["No.82173644"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shanxi Province Central-Guided Local Science and Technology Development Fund Project","award":["YDZJSX2024D064"],"award-info":[{"award-number":["YDZJSX2024D064"]}]},{"name":"Lvliang City Key Research and Development Project"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biol Trace Elem Res"],"DOI":"10.1007\/s12011-026-05016-6","type":"journal-article","created":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T16:26:34Z","timestamp":1772727994000},"page":"5062-5080","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gut Microbiota Remodeling after Fecal Microbiota Transplantation Is Associated with Reduced Inflammation and Cardiac Injury in Fluoride-Arsenic Co-Exposed Rats"],"prefix":"10.1007","volume":"204","author":[{"given":"Xiaoxuan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyu","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penghui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengyi","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyue","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijing","family":"Xuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulan","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,5]]},"reference":[{"key":"5016_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2020.126388","volume":"251","author":"D Haldar","year":"2020","unstructured":"Haldar D, Duarah P, Purkait MK (2020) MOFs for the treatment of arsenic, fluoride and iron contaminated drinking water: a review. Chemosphere 251:126388. https:\/\/doi.org\/10.1016\/j.chemosphere.2020.126388","journal-title":"Chemosphere"},{"key":"5016_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2023.117257","volume":"238","author":"T Biswas","year":"2023","unstructured":"Biswas T, Chandra Pal S, Saha A, Ruidas D (2023) Arsenic and fluoride exposure in drinking water caused human health risk in coastal groundwater aquifers. Environ Res 238:117257. https:\/\/doi.org\/10.1016\/j.envres.2023.117257","journal-title":"Environ Res"},{"key":"5016_CR3","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/s12403-020-00347-8","volume":"12","author":"X He","year":"2020","unstructured":"He X, Li P, Ji Y, Wang Y, Su Z, Elumalai V (2020) Groundwater arsenic and fluoride and associated arsenicosis and fluorosis in China: occurrence, distribution and management. Expo Health 12:355\u2013368. https:\/\/doi.org\/10.1007\/s12403-020-00347-8","journal-title":"Expo Health"},{"key":"5016_CR4","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.cca.2016.02.001","volume":"455","author":"S Iyer","year":"2016","unstructured":"Iyer S, Sengupta C, Velumani A (2016) Blood arsenic: pan-India prevalence. Clin Chim Acta 455:99\u2013101. https:\/\/doi.org\/10.1016\/j.cca.2016.02.001","journal-title":"Clin Chim Acta"},{"key":"5016_CR5","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1289\/ehp.99107727","volume":"107","author":"M Tondel","year":"1999","unstructured":"Tondel M, Rahman M, Magnuson A, Chowdhury IA, Faruquee MH, Ahmad SA (1999) The relationship of arsenic levels in drinking water and the prevalence rate of skin lesions in Bangladesh. Environ Health Perspect 107:727\u2013729. https:\/\/doi.org\/10.1289\/ehp.99107727","journal-title":"Environ Health Perspect"},{"key":"5016_CR6","unstructured":"WHO Guidelines Approved by the Guidelines Review Committee (2017) Geneva, 2017"},{"key":"5016_CR7","doi-asserted-by":"publisher","DOI":"10.1007\/s10653-025-02743-y","volume":"47","author":"X Wang","year":"2025","unstructured":"Wang X, Huq ME, Jiang G, Liu H, Su C, Li J, Li H, Al Dughairi AA, Wang C (2025) Spatial distribution and influencing factors, and health risks of high fluoride and arsenic groundwater in Eastern Henan Plain, Northern China. Environ Geochem Health 47:433. https:\/\/doi.org\/10.1007\/s10653-025-02743-y","journal-title":"Environ Geochem Health"},{"key":"5016_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2020.126126","volume":"249","author":"M Kumar","year":"2020","unstructured":"Kumar M, Goswami R, Patel AK, Srivastava M, Das N (2020) Scenario, perspectives and mechanism of arsenic and fluoride co-occurrence in the groundwater: a review. Chemosphere 249:126126. https:\/\/doi.org\/10.1016\/j.chemosphere.2020.126126","journal-title":"Chemosphere"},{"key":"5016_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2021.117940","author":"MS Rahaman","year":"2021","unstructured":"Rahaman MS, Rahman MM, Mise N, Sikder MT, Ichihara G, Uddin MK, Kurasaki M, Ichihara S (2021) Environmental arsenic exposure and its contribution to human diseases, toxicity mechanism and management. Environ Pollut. https:\/\/doi.org\/10.1016\/j.envpol.2021.117940","journal-title":"Environ Pollut"},{"key":"5016_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2020.124751","volume":"408","author":"AM Mawia","year":"2021","unstructured":"Mawia AM, Hui S, Zhou L, Li H, Tabassum J, Lai C, Wang J, Shao G, Wei X, Tang S, Luo J, Hu S, Hu P (2021) Inorganic arsenic toxicity and alleviation strategies in rice. J Hazard Mater 408:124751. https:\/\/doi.org\/10.1016\/j.jhazmat.2020.124751","journal-title":"J Hazard Mater"},{"key":"5016_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2022.114021","volume":"244","author":"C Ren","year":"2022","unstructured":"Ren C, Li HH, Zhang CY, Song XC (2022) Effects of chronic fluorosis on the brain. Ecotoxicol Environ Saf 244:114021. https:\/\/doi.org\/10.1016\/j.ecoenv.2022.114021","journal-title":"Ecotoxicol Environ Saf"},{"key":"5016_CR12","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.1111\/jcmm.14185","volume":"23","author":"W Wei","year":"2019","unstructured":"Wei W, Pang S, Sun D (2019) The pathogenesis of endemic fluorosis: research progress in the last 5 years. J Cell Mol Med 23:2333\u20132342. https:\/\/doi.org\/10.1111\/jcmm.14185","journal-title":"J Cell Mol Med"},{"key":"5016_CR13","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.addr.2020.07.019","volume":"159","author":"J Soppert","year":"2020","unstructured":"Soppert J, Lehrke M, Marx N, Jankowski J, Noels H (2020) Lipoproteins and lipids in cardiovascular disease: from mechanistic insights to therapeutic targeting. Adv Drug Deliv Rev 159:4\u201333. https:\/\/doi.org\/10.1016\/j.addr.2020.07.019","journal-title":"Adv Drug Deliv Rev"},{"key":"5016_CR14","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1007\/s12011-020-02232-6","volume":"199","author":"M Li","year":"2021","unstructured":"Li M, Zhao Y, Tian X, Liu P, Xie J, Dong N, Feng J, Gao Y, Fan Y, Qiu Y, Tian F, Yan X (2021) Fluoride exposure and blood pressure: a systematic review and meta-analysis. Biol Trace Elem Res 199:925\u2013934. https:\/\/doi.org\/10.1007\/s12011-020-02232-6","journal-title":"Biol Trace Elem Res"},{"key":"5016_CR15","doi-asserted-by":"publisher","first-page":"5033","DOI":"10.1021\/acs.jafc.9b00312","volume":"67","author":"X Yan","year":"2019","unstructured":"Yan X, Dong N, Hao X, Xing Y, Tian X, Feng J, Xie J, Lv Y, Wei C, Gao Y, Qiu Y, Wang T (2019) Comparative transcriptomics reveals the role of the Toll-Like receptor signaling pathway in fluoride-induced cardiotoxicity. J Agric Food Chem 67:5033\u20135042. https:\/\/doi.org\/10.1021\/acs.jafc.9b00312","journal-title":"J Agric Food Chem"},{"key":"5016_CR16","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.chemosphere.2017.05.002","volume":"182","author":"X Yan","year":"2017","unstructured":"Yan X, Wang L, Yang X, Qiu Y, Tian X, Lv Y, Tian F, Song G, Wang T (2017) Fluoride induces apoptosis in H9c2 cardiomyocytes via the mitochondrial pathway. Chemosphere 182:159\u2013165. https:\/\/doi.org\/10.1016\/j.chemosphere.2017.05.002","journal-title":"Chemosphere"},{"key":"5016_CR17","doi-asserted-by":"publisher","DOI":"10.1289\/ehp11981","volume":"131","author":"EX Jiang","year":"2023","unstructured":"Jiang EX, Domingo-Relloso A, Abuawad A, Haack K, Tellez-Plaza M, Fallin MD, Umans JG, Best LG, Zhang Y, Kupsco A, Belsky DW, Cole SA, Navas-Acien A (2023) Arsenic exposure and epigenetic aging: the association with cardiovascular disease and all-cause mortality in the Strong Heart Study. Environ Health Perspect 131:127016. https:\/\/doi.org\/10.1289\/ehp11981","journal-title":"Environ Health Perspect"},{"key":"5016_CR18","doi-asserted-by":"publisher","DOI":"10.1289\/ehp577","volume":"125","author":"CC Kuo","year":"2017","unstructured":"Kuo CC, Moon KA, Wang SL, Silbergeld E, Navas-Acien A (2017) The association of arsenic metabolism with cancer, cardiovascular disease, and diabetes: a systematic review of the epidemiological evidence. Environ Health Perspect 125:087001. https:\/\/doi.org\/10.1289\/ehp577","journal-title":"Environ Health Perspect"},{"key":"5016_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118132","volume":"257","author":"ACF Souza","year":"2020","unstructured":"Souza ACF, de Paiva Coimbra JL, Ervilha LOG, Bastos DSS, Cossolin JFS, Santos EC, de Oliveira LL, Machado-Neves M (2020) Arsenic induces dose-dependent structural and ultrastructural pathological remodeling in the heart of Wistar rats. Life Sci 257:118132. https:\/\/doi.org\/10.1016\/j.lfs.2020.118132","journal-title":"Life Sci"},{"key":"5016_CR20","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1093\/toxsci\/kfr097","volume":"122","author":"M Lemaire","year":"2011","unstructured":"Lemaire M, Lemari\u00e9 CA, Molina MF, Schiffrin EL, Lehoux S, Mann KK (2011) Exposure to moderate arsenic concentrations increases atherosclerosis in ApoE-\/- mouse model. Toxicol Sci 122:211\u2013221. https:\/\/doi.org\/10.1093\/toxsci\/kfr097","journal-title":"Toxicol Sci"},{"key":"5016_CR21","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.taap.2009.08.004","volume":"241","author":"S Srivastava","year":"2009","unstructured":"Srivastava S, Vladykovskaya EN, Haberzettl P, Sithu SD, D\u2019Souza SE, States JC (2009) Arsenic exacerbates atherosclerotic lesion formation and inflammation in ApoE-\/- mice. Toxicol Appl Pharmacol 241:90\u2013100. https:\/\/doi.org\/10.1016\/j.taap.2009.08.004","journal-title":"Toxicol Appl Pharmacol"},{"key":"5016_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2021.132518","volume":"288","author":"M Li","year":"2022","unstructured":"Li M, Feng J, Cheng Y, Dong N, Tian X, Liu P, Zhao Y, Qiu Y, Tian F, Lyu Y, Zhao Q, Wei C, Wang M, Yuan J, Ying X, Ren X, Yan X (2022) Arsenic-fluoride co-exposure induced endoplasmic reticulum stress resulting in apoptosis in rat heart and H9c2 cells. Chemosphere 288:132518. https:\/\/doi.org\/10.1016\/j.chemosphere.2021.132518","journal-title":"Chemosphere"},{"key":"5016_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2021.112506","volume":"222","author":"P Liu","year":"2021","unstructured":"Liu P, Li R, Tian X, Zhao Y, Li M, Wang M, Ying X, Yuan J, Xie J, Yan X, Lyu Y, Wei C, Qiu Y, Tian F, Zhao Q, Yan X (2021) Co-exposure to fluoride and arsenic disrupts intestinal flora balance and induces testicular autophagy in offspring rats. Ecotoxicol Environ Saf 222:112506. https:\/\/doi.org\/10.1016\/j.ecoenv.2021.112506","journal-title":"Ecotoxicol Environ Saf"},{"key":"5016_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2023.114647","volume":"253","author":"X Tian","year":"2023","unstructured":"Tian X, Wang M, Ying X, Dong N, Li M, Feng J, Zhao Y, Zhao Q, Tian F, Li B, Zhang W, Qiu Y, Yan X (2023) Co-exposure to arsenic and fluoride to explore the interactive effect on oxidative stress and autophagy in myocardial tissue and cell. Ecotoxicol Environ Saf 253:114647. https:\/\/doi.org\/10.1016\/j.ecoenv.2023.114647","journal-title":"Ecotoxicol Environ Saf"},{"key":"5016_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.144924","volume":"767","author":"X Yan","year":"2021","unstructured":"Yan X, Chen X, Tian X, Qiu Y, Wang J, Yu G, Dong N, Feng J, Xie J, Nalesnik M, Niu R, Xiao B, Song G, Quinones S, Ren X (2021) Co-exposure to inorganic arsenic and fluoride prominently disrupts gut microbiota equilibrium and induces adverse cardiovascular effects in offspring rats. Sci Total Environ 767:144924. https:\/\/doi.org\/10.1016\/j.scitotenv.2020.144924","journal-title":"Sci Total Environ"},{"key":"5016_CR26","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-025-02149-4","volume":"23","author":"R Luo","year":"2025","unstructured":"Luo R, Yao Y, Chen Z, Sun X (2025) An examination of the LPS-TLR4 immune response through the analysis of molecular structures and protein-protein interactions. Cell communication and signaling\u202f: CCS 23:142. https:\/\/doi.org\/10.1186\/s12964-025-02149-4","journal-title":"Cell communication and signaling : CCS"},{"key":"5016_CR27","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.tox.2013.08.009","volume":"312","author":"XS Dong","year":"2013","unstructured":"Dong XS, Xu XY, Sun YQ, Wei L, Jiang ZH, Liu Z (2013) Toll-like receptor 4 is involved in myocardial damage following Paraquat poisoning in mice. Toxicology 312:115\u2013122. https:\/\/doi.org\/10.1016\/j.tox.2013.08.009","journal-title":"Toxicology"},{"key":"5016_CR28","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1093\/cvr\/cvz066","volume":"115","author":"M Fujiwara","year":"2019","unstructured":"Fujiwara M, Matoba T, Koga JI, Okahara A, Funamoto D, Nakano K, Tsutsui H, Egashira K (2019) Nanoparticle incorporating Toll-like receptor 4 inhibitor attenuates myocardial ischaemia-reperfusion injury by inhibiting monocyte-mediated inflammation in mice. Cardiovasc Res 115:1244\u20131255. https:\/\/doi.org\/10.1093\/cvr\/cvz066","journal-title":"Cardiovasc Res"},{"key":"5016_CR29","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-18756-2","volume":"8","author":"X Cui","year":"2018","unstructured":"Cui X, Ye L, Li J, Jin L, Wang W, Li S, Bao M, Wu S, Li L, Geng B, Zhou X, Zhang J, Cai J (2018) Metagenomic and metabolomic analyses unveil dysbiosis of gut microbiota in chronic heart failure patients. Sci Rep 8:635. https:\/\/doi.org\/10.1038\/s41598-017-18756-2","journal-title":"Sci Rep"},{"key":"5016_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2022.134405","volume":"404","author":"YAM Ferreira","year":"2023","unstructured":"Ferreira YAM, Jamar G, Estadella D, Pisani LP (2023) Proanthocyanidins in grape seeds and their role in gut microbiota-white adipose tissue axis. Food Chem 404:134405. https:\/\/doi.org\/10.1016\/j.foodchem.2022.134405","journal-title":"Food Chem"},{"key":"5016_CR31","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1093\/cvr\/cvab030","volume":"118","author":"M Kim","year":"2022","unstructured":"Kim M, Huda MN, Bennett BJ (2022) Sequence meets function-microbiota and cardiovascular disease. Cardiovasc Res 118:399\u2013412. https:\/\/doi.org\/10.1093\/cvr\/cvab030","journal-title":"Cardiovasc Res"},{"key":"5016_CR32","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.plipres.2009.06.002","volume":"49","author":"X Wang","year":"2010","unstructured":"Wang X, Quinn PJ (2010) Lipopolysaccharide: biosynthetic pathway and structure modification. Prog Lipid Res 49:97\u2013107. https:\/\/doi.org\/10.1016\/j.plipres.2009.06.002","journal-title":"Prog Lipid Res"},{"key":"5016_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2023.131816","author":"Q Zhao","year":"2023","unstructured":"Zhao Q, Hao Y, Yang X, Mao J, Tian F, Gao Y, Tian X, Yan X, Qiu Y (2023) Mitigation of maternal fecal microbiota transplantation on neurobehavioral deficits of offspring rats prenatally exposed to arsenic: role of microbiota-gut-brain axis. J Hazard Mater. https:\/\/doi.org\/10.1016\/j.jhazmat.2023.131816","journal-title":"J Hazard Mater"},{"key":"5016_CR34","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1093\/cvr\/cvab114","volume":"118","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Zhang S, Li B, Luo Y, Gong Y, Jin X, Zhang J, Zhou Y, Zhuo X, Wang Z, Zhao X, Han X, Gao Y, Yu H, Liang D, Zhao S, Sun D, Wang D, Xu W, Qu G, Bo W, Li D, Wu Y, Li Y (2022) Gut microbiota dysbiosis promotes age-related atrial fibrillation by lipopolysaccharide and glucose-induced activation of NLRP3-inflammasome. Cardiovasc Res 118:785\u2013797. https:\/\/doi.org\/10.1093\/cvr\/cvab114","journal-title":"Cardiovasc Res"},{"key":"5016_CR35","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.toxlet.2023.03.001","volume":"379","author":"GP Moran","year":"2023","unstructured":"Moran GP, Zgaga L, Daly B, Harding M, Montgomery T (2023) Does fluoride exposure impact on the human microbiome? Toxicol Lett 379:11\u201319. https:\/\/doi.org\/10.1016\/j.toxlet.2023.03.001","journal-title":"Toxicol Lett"},{"key":"5016_CR36","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1021\/acs.chemrestox.2c00410","volume":"36","author":"Y Yang","year":"2023","unstructured":"Yang Y, Chi L, Liu CW, Hsiao YC, Lu K (2023) Chronic arsenic exposure perturbs gut microbiota and bile acid homeostasis in mice. Chem Res Toxicol 36:1037\u20131043. https:\/\/doi.org\/10.1021\/acs.chemrestox.2c00410","journal-title":"Chem Res Toxicol"},{"key":"5016_CR37","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00900-1","volume":"8","author":"Z Jie","year":"2017","unstructured":"Jie Z, Xia H, Zhong SL, Feng Q, Li S, Liang S, Zhong H, Liu Z, Gao Y, Zhao H, Zhang D, Su Z, Fang Z, Lan Z, Li J, Xiao L, Li J, Li R, Li X, Li F, Ren H, Huang Y, Peng Y, Li G, Wen B, Dong B, Chen JY, Geng QS, Zhang ZW, Yang H, Wang J, Wang J, Zhang X, Madsen L, Brix S, Ning G, Xu X, Liu X, Hou Y, Jia H, He K, Kristiansen K (2017) The gut microbiome in atherosclerotic cardiovascular disease. Nat Commun 8:845. https:\/\/doi.org\/10.1038\/s41467-017-00900-1","journal-title":"Nat Commun"},{"key":"5016_CR38","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1161\/hypertensionaha.115.05315","volume":"65","author":"T Yang","year":"2015","unstructured":"Yang T, Santisteban MM, Rodriguez V, Li E, Ahmari N, Carvajal JM, Zadeh M, Gong M, Qi Y, Zubcevic J, Sahay B, Pepine CJ, Raizada MK, Mohamadzadeh M (2015) Gut dysbiosis is linked to hypertension. Hypertens (Dallas Tex : 1979) 65:1331\u20131340. https:\/\/doi.org\/10.1161\/hypertensionaha.115.05315","journal-title":"Hypertens (Dallas Tex : 1979)"},{"key":"5016_CR39","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1111\/1751-7915.13524","volume":"13","author":"H Xu","year":"2020","unstructured":"Xu H, Wang X, Feng W, Liu Q, Zhou S, Liu Q, Cai L (2020) The gut microbiota and its interactions with cardiovascular disease. Microb Biotechnol 13:637\u2013656. https:\/\/doi.org\/10.1111\/1751-7915.13524","journal-title":"Microb Biotechnol"},{"key":"5016_CR40","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1038\/nrgastro.2016.98","volume":"13","author":"A Khoruts","year":"2016","unstructured":"Khoruts A, Sadowsky MJ (2016) Understanding the mechanisms of faecal microbiota transplantation, Nature reviews. Gastroenterol Hepatol 13:508\u2013516. https:\/\/doi.org\/10.1038\/nrgastro.2016.98","journal-title":"Gastroenterol Hepatol"},{"key":"5016_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2024.108805","volume":"190","author":"M Teffera","year":"2024","unstructured":"Teffera M, Veith AC, Ronnekleiv-Kelly S, Bradfield CA, Nikodemova M, Tussing-Humphreys L, Malecki K (2024) Diverse mechanisms by which chemical pollutant exposure alters gut microbiota metabolism and inflammation. Environ Int 190:108805. https:\/\/doi.org\/10.1016\/j.envint.2024.108805","journal-title":"Environ Int"},{"key":"5016_CR42","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.envint.2018.11.049","volume":"123","author":"F Wu","year":"2019","unstructured":"Wu F, Yang L, Islam MT, Jasmine F, Kibriya MG, Nahar J, Barmon B, Parvez F, Sarwar G, Ahmed A, Eunus M, Islam T, Slavkovich V, Hu J, Li H, Graziano JH, Pei Z, Ahsan H, Chen Y (2019) The role of gut microbiome and its interaction with arsenic exposure in carotid intima-media thickness in a Bangladesh population. Environ Int 123:104\u2013113. https:\/\/doi.org\/10.1016\/j.envint.2018.11.049","journal-title":"Environ Int"},{"key":"5016_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2019.104539","volume":"110","author":"I Palma-Lara","year":"2020","unstructured":"Palma-Lara I, Mart\u00ednez-Castillo M, Quintana-P\u00e9rez JC, Arellano-Mendoza MG, Tamay-Cach F, Valenzuela-Lim\u00f3n OL, Garc\u00eda-Montalvo EA, Hern\u00e1ndez-Zavala A (2020) Arsenic exposure: a public health problem leading to several cancers. Regul Toxicol Pharmacol 110:104539. https:\/\/doi.org\/10.1016\/j.yrtph.2019.104539","journal-title":"Regul Toxicol Pharmacol"},{"key":"5016_CR44","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1007\/s40572-020-00270-9","volume":"7","author":"S Srivastava","year":"2020","unstructured":"Srivastava S, Flora SJS (2020) Fluoride in drinking water and skeletal fluorosis: a review of the global impact. Curr Environ Health Rep 7:140\u2013146. https:\/\/doi.org\/10.1007\/s40572-020-00270-9","journal-title":"Curr Environ Health Rep"},{"key":"5016_CR45","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2025.117911","volume":"292","author":"W Wei","year":"2025","unstructured":"Wei W, Pu S, Yan C, Yang H, Chen H (2025) Exploring the mechanisms of lithium neurotoxicity based on network toxicology and molecular docking. Ecotoxicol Environ Saf 292:117911. https:\/\/doi.org\/10.1016\/j.ecoenv.2025.117911","journal-title":"Ecotoxicol Environ Saf"},{"key":"5016_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2020.153322","volume":"79","author":"Z Du","year":"2020","unstructured":"Du Z, Wang J, Lu Y, Ma X, Wen R, Lin J, Zhou C, Song Z, Li J, Tu P, Jiang Y (2020) The cardiac protection of Baoyuan decoction via gut-heart axis metabolic pathway. Phytomedicine 79:153322. https:\/\/doi.org\/10.1016\/j.phymed.2020.153322","journal-title":"Phytomedicine"},{"key":"5016_CR47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jacbts.2024.09.004","volume":"10","author":"FM Herisson","year":"2025","unstructured":"Herisson FM, Cluzel GL, Llopis-Grimalt MA, O\u2019Donovan AN, Koc F, Karnik K, Laurie I, Canene-Adams K, Ross RP, Stanton C, Caplice NM (2025) Targeting the gut-heart axis improves cardiac remodeling in a clinical scale model of cardiometabolic syndrome. JACC. Basic to translational science 10:1\u201315. https:\/\/doi.org\/10.1016\/j.jacbts.2024.09.004","journal-title":"JACC. Basic to translational science"},{"key":"5016_CR48","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.jare.2022.10.010","volume":"50","author":"G Chen","year":"2023","unstructured":"Chen G, Peng Y, Huang Y, Xie M, Dai Z, Cai H, Dong W, Xu W, Xie Z, Chen D, Fan X, Zhou W, Kan X, Yang T, Chen C, Sun Y, Zeng X, Liu Z (2023) Fluoride induced leaky gut and bloom of erysipelatoclostridium ramosum mediate the exacerbation of obesity in high-fat-diet fed mice. J Adv Res 50:35\u201354. https:\/\/doi.org\/10.1016\/j.jare.2022.10.010","journal-title":"J Adv Res"},{"key":"5016_CR49","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.111452","volume":"128","author":"Z Li","year":"2024","unstructured":"Li Z, Zou X, Lu R, Wan X, Sun S, Wang S, Qu Y, Zhang Y, Li Z, Yang L, Fang S (2024) Arsenic trioxide alleviates atherosclerosis by inhibiting CD36-induced endocytosis and TLR4\/NF-\u03baB-induced inflammation in macrophage and ApoE(-\/-) mice. Int Immunopharmacol 128:111452. https:\/\/doi.org\/10.1016\/j.intimp.2023.111452","journal-title":"Int Immunopharmacol"},{"key":"5016_CR50","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2025.154220","volume":"517","author":"Y Xu","year":"2025","unstructured":"Xu Y, Mo Y, Zhou W, Qin M, Li M, Yin G, Yu H, Chen Y, Du H, Jin Y, Huang H, Ma C, Xia J, Li H, Xie Z, Wang P, Hong Y (2025) Sorafenib induces intestinal toxicity by disturbing gut microbiota and activating the LPS\/TLR4\/NF-\u03baB signaling pathway in mice. Toxicology 517:154220. https:\/\/doi.org\/10.1016\/j.tox.2025.154220","journal-title":"Toxicology"},{"key":"5016_CR51","doi-asserted-by":"publisher","first-page":"6397","DOI":"10.1128\/aem.01665-12","volume":"78","author":"M Monachese","year":"2012","unstructured":"Monachese M, Burton JP, Reid G (2012) Bioremediation and tolerance of humans to heavy metals through microbial processes: a potential role for probiotics? Appl Environ Microbiol 78:6397\u20136404. https:\/\/doi.org\/10.1128\/aem.01665-12","journal-title":"Appl Environ Microbiol"},{"key":"5016_CR52","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07803-9","volume":"9","author":"M Coryell","year":"2018","unstructured":"Coryell M, McAlpine M, Pinkham NV, McDermott TR, Walk ST (2018) The gut microbiome is required for full protection against acute arsenic toxicity in mouse models. Nat Commun 9:5424. https:\/\/doi.org\/10.1038\/s41467-018-07803-9","journal-title":"Nat Commun"},{"key":"5016_CR53","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/j.phrs.2018.11.042","volume":"139","author":"XF Hu","year":"2019","unstructured":"Hu XF, Zhang WY, Wen Q, Chen WJ, Wang ZM, Chen J, Zhu F, Liu K, Cheng LX, Yang J, Shu YW (2019) Fecal microbiota transplantation alleviates myocardial damage in myocarditis by restoring the microbiota composition. Pharmacol Res 139:412\u2013421. https:\/\/doi.org\/10.1016\/j.phrs.2018.11.042","journal-title":"Pharmacol Res"},{"key":"5016_CR54","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2024.106598","volume":"199","author":"L Liao","year":"2024","unstructured":"Liao L, Zhang L, Yang C, Wang T, Feng L, Peng C, Long Y, Dai G, Chang L, Wei Y, Fan X (2024) Sotagliflozin attenuates cardiac dysfunction and depression-like behaviors in mice with myocardial infarction through the gut-heart-brain axis. Neurobiol Dis 199:106598. https:\/\/doi.org\/10.1016\/j.nbd.2024.106598","journal-title":"Neurobiol Dis"},{"key":"5016_CR55","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-016-0222-x","volume":"5","author":"J Li","year":"2017","unstructured":"Li J, Zhao F, Wang Y, Chen J, Tao J, Tian G, Wu S, Liu W, Cui Q, Geng B, Zhang W, Weldon R, Auguste K, Yang L, Liu X, Chen L, Yang X, Zhu B, Cai J (2017) Gut microbiota dysbiosis contributes to the development of hypertension. Microbiome 5:14. https:\/\/doi.org\/10.1186\/s40168-016-0222-x","journal-title":"Microbiome"},{"key":"5016_CR56","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1007\/s13238-018-0549-0","volume":"9","author":"Z Wang","year":"2018","unstructured":"Wang Z, Zhao Y (2018) Gut microbiota derived metabolites in cardiovascular health and disease. Protein Cell 9:416\u2013431. https:\/\/doi.org\/10.1007\/s13238-018-0549-0","journal-title":"Protein Cell"},{"key":"5016_CR57","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/s41579-020-0433-9","volume":"19","author":"Y Fan","year":"2021","unstructured":"Fan Y, Pedersen O (2021) Gut microbiota in human metabolic health and disease. Nat Rev Microbiol 19:55\u201371. https:\/\/doi.org\/10.1038\/s41579-020-0433-9","journal-title":"Nat Rev Microbiol"},{"key":"5016_CR58","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1161\/circulationaha.118.036652","volume":"139","author":"H Bartolomaeus","year":"2019","unstructured":"Bartolomaeus H, Balogh A, Yakoub M, Homann S, Mark\u00f3 L, H\u00f6ges S, Tsvetkov D, Krannich A, Wundersitz S, Avery EG, Haase N, Kr\u00e4ker K, Hering L, Maase M, Kusche-Vihrog K, Grandoch M, Fielitz J, Kempa S, Gollasch M, Zhumadilov Z, Kozhakhmetov S, Kushugulova A, Eckardt KU, Dechend R, Rump LC, Forslund SK, M\u00fcller DN, Stegbauer J, Wilck N (2019) Short-chain fatty acid propionate protects from hypertensive cardiovascular damage. Circulation 139:1407\u20131421. https:\/\/doi.org\/10.1161\/circulationaha.118.036652","journal-title":"Circulation"},{"key":"5016_CR59","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1007\/s00018-020-03656-y","volume":"78","author":"A Ciesielska","year":"2021","unstructured":"Ciesielska A, Matyjek M, Kwiatkowska K (2021) TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling. Cell Mol Life Sci 78:1233\u20131261. https:\/\/doi.org\/10.1007\/s00018-020-03656-y","journal-title":"Cell Mol Life Sci"},{"key":"5016_CR60","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1007\/s10571-020-00791-9","volume":"40","author":"M Liu","year":"2020","unstructured":"Liu M, Xie J, Sun Y (2020) TLR4\/MyD88\/NF-\u03baB-mediated inflammation contributes to cardiac dysfunction in rats of PTSD. Cell Mol Neurobiol 40:1029\u20131035. https:\/\/doi.org\/10.1007\/s10571-020-00791-9","journal-title":"Cell Mol Neurobiol"},{"key":"5016_CR61","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.ejmech.2018.05.033","volume":"154","author":"Y Xu","year":"2018","unstructured":"Xu Y, Chen S, Cao Y, Zhou P, Chen Z, Cheng K (2018) Discovery of novel small molecule TLR4 inhibitors as potent anti-inflammatory agents. Eur J Med Chem 154:253\u2013266. https:\/\/doi.org\/10.1016\/j.ejmech.2018.05.033","journal-title":"Eur J Med Chem"},{"key":"5016_CR62","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.140","volume":"7","author":"Y Yang","year":"2016","unstructured":"Yang Y, Lv J, Jiang S, Ma Z, Wang D, Hu W, Deng C, Fan C, Di S, Sun Y, Yi W (2016) The emerging role of Toll-like receptor 4 in myocardial inflammation. Cell Death Dis 7:e2234. https:\/\/doi.org\/10.1038\/cddis.2016.140","journal-title":"Cell Death Dis"},{"key":"5016_CR63","doi-asserted-by":"publisher","first-page":"2859","DOI":"10.1016\/j.apsb.2021.03.020","volume":"11","author":"Z Zhao","year":"2021","unstructured":"Zhao Z, Li F, Ning J, Peng R, Shang J, Liu H, Shang M, Bao XQ, Zhang D (2021) Novel compound FLZ alleviates rotenone-induced PD mouse model by suppressing TLR4\/MyD88\/NF-\u03baB pathway through microbiota-gut-brain axis. Acta Pharm Sin B 11:2859\u20132879. https:\/\/doi.org\/10.1016\/j.apsb.2021.03.020","journal-title":"Acta Pharm Sin B"},{"key":"5016_CR64","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.107272","volume":"91","author":"J Tang","year":"2021","unstructured":"Tang J, Xu L, Zeng Y, Gong F (2021) Effect of gut microbiota on LPS-induced acute lung injury by regulating the TLR4\/NF-kB signaling pathway. Int Immunopharmacol 91:107272. https:\/\/doi.org\/10.1016\/j.intimp.2020.107272","journal-title":"Int Immunopharmacol"},{"key":"5016_CR65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1089\/ars.2023.0355","volume":"41","author":"J Zhou","year":"2024","unstructured":"Zhou J, Hao J, Zhong Z, Yang J, Lv T, Zhao B, Lin H, Chi J, Guo H (2024) Fecal microbiota transplantation in mice exerts a protective effect against doxorubicin-induced cardiac toxicity by regulating Nrf2-mediated cardiac mitochondrial fission and fusion. Antioxid Redox Signal 41:1\u201323. https:\/\/doi.org\/10.1089\/ars.2023.0355","journal-title":"Antioxid Redox Signal"},{"key":"5016_CR66","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04247-8","volume":"21","author":"S Murugesan","year":"2023","unstructured":"Murugesan S, Al Khodor S (2023) Salivary microbiome and hypertension in the Qatari population. J Transl Med 21:454. https:\/\/doi.org\/10.1186\/s12967-023-04247-8","journal-title":"J Transl Med"},{"key":"5016_CR67","doi-asserted-by":"publisher","first-page":"33084","DOI":"10.1021\/acs.jafc.5c08925","volume":"73","author":"J Hou","year":"2025","unstructured":"Hou J, Ren J, Abbas S, Song Y, Huang H, Cao M, Li F, Gu Z, Xin T, Li Z, Feng J, Ma W, Sun X, Zhao H (2025) )Targeting the gut-heart axis: dextran from gut-derived Weissella cibaria alleviates doxorubicin-induced cardiotoxicity by attenuating low-grade endotoxemia. J Agric Food Chem 73:33084\u201333098. https:\/\/doi.org\/10.1021\/acs.jafc.5c08925","journal-title":"J Agric Food Chem"},{"key":"5016_CR68","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2025.1710051","volume":"16","author":"S Guo","year":"2025","unstructured":"Guo S, Zhang W, Cui X, Yin B (2025) The bidirectional regulatory mechanism of gut microbiota metabolites on myocardial injury in heart failure from the perspective of the gut-heart axis: a review. Front Microbiol 16:1710051. https:\/\/doi.org\/10.3389\/fmicb.2025.1710051","journal-title":"Front Microbiol"},{"key":"5016_CR69","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1093\/cvr\/cvad023","volume":"119","author":"J Zhao","year":"2023","unstructured":"Zhao J, Zhang Q, Cheng W, Dai Q, Wei Z, Guo M, Chen F, Qiao S, Hu J, Wang J, Chen H, Bao X, Mu D, Sun X, Xu B, Xie J (2023) Heart-gut microbiota communication determines the severity of cardiac injury after myocardial ischaemia\/reperfusion. Cardiovasc Res 119:1390\u20131402. https:\/\/doi.org\/10.1093\/cvr\/cvad023","journal-title":"Cardiovasc Res"},{"key":"5016_CR70","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.114101","volume":"148","author":"Z Xu","year":"2025","unstructured":"Xu Z, Wang K, Hu H, Hu Y, Huang J, Luo Z (2025) Sinensetin attenuates LPS-induced acute pulmonary inflammation in mice and RAW264.7 cells by modulating NF-\u03baB p65-mediated immune resistance and STAT3-mediated tissue resilience. Int Immunopharmacol 148:114101. https:\/\/doi.org\/10.1016\/j.intimp.2025.114101","journal-title":"Int Immunopharmacol"}],"container-title":["Biological Trace Element Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-026-05016-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12011-026-05016-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-026-05016-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:06:59Z","timestamp":1782850019000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12011-026-05016-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,5]]},"references-count":70,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["5016"],"URL":"https:\/\/doi.org\/10.1007\/s12011-026-05016-6","relation":{},"ISSN":["1559-0720"],"issn-type":[{"value":"1559-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,5]]},"assertion":[{"value":"29 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}