{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T20:15:46Z","timestamp":1784060146674,"version":"3.55.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T00:00:00Z","timestamp":1774051200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T00:00:00Z","timestamp":1774051200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biol Trace Elem Res"],"DOI":"10.1007\/s12011-026-05077-7","type":"journal-article","created":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T09:18:53Z","timestamp":1774084733000},"page":"5884-5896","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Paternal Chronic Exposure to Copper Nanoparticles (CuNPs) Impairs Testicular Androgen and Estrogen Signalling in Adult Male Offspring in Mice"],"prefix":"10.1007","volume":"204","author":[{"given":"Vanrohlu","family":"Nicy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guruswami","family":"Gurusubramanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas Kumar","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,21]]},"reference":[{"key":"5077_CR1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01891","volume":"9","author":"I Di Gregorio","year":"2019","unstructured":"Di Gregorio I, Busiello RA, Burgos Aceves MA, Lepretti M, Paolella G, Lionetti L (2019) Environmental pollutants effect on brown adipose tissue. Front Physiol 9:1891. https:\/\/doi.org\/10.3389\/fphys.2018.01891","journal-title":"Front Physiol"},{"issue":"19","key":"5077_CR2","doi-asserted-by":"publisher","first-page":"23375","DOI":"10.1007\/s11356-020-08775-4","volume":"27","author":"A Kallel","year":"2020","unstructured":"Kallel A, Ksibi M, Ben Dhia H, Kh\u00e9lifi N (2020) Pollutant removal and the health effects of environmental pollution. Environ Sci Pollut Res Int 27(19):23375\u201323378. https:\/\/doi.org\/10.1007\/s11356-020-08775-4","journal-title":"Environ Sci Pollut Res Int"},{"issue":"3","key":"5077_CR3","doi-asserted-by":"publisher","DOI":"10.1007\/s42452-020-2279-1","volume":"2","author":"MF Al-Hakkani","year":"2020","unstructured":"Al-Hakkani MF (2020) Biogenic copper nanoparticles and their applications: a review. SN Appl Sci 2(3):505. https:\/\/doi.org\/10.1007\/s42452-020-2279-1","journal-title":"SN Appl Sci"},{"issue":"9","key":"5077_CR4","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/S0753-3322(03)00012-X","volume":"57","author":"H Tapiero","year":"2003","unstructured":"Tapiero H, Townsend D\u00c1, Tew KD (2003) Trace elements in human physiology and pathology. Copper. Biomed Pharmacother 57(9):386\u2013398. https:\/\/doi.org\/10.1016\/S0753-3322(03)00012-X","journal-title":"Biomed Pharmacother"},{"issue":"18","key":"5077_CR5","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28186687","volume":"28","author":"MJ Wo\u017aniak-Budych","year":"2023","unstructured":"Wo\u017aniak-Budych MJ, Staszak K, Staszak M (2023) Copper and copper-based nanoparticles in medicine\u2014perspectives and challenges. Molecules 28(18):6687","journal-title":"Molecules"},{"key":"5077_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2019.103220","volume":"71","author":"T Ameh","year":"2019","unstructured":"Ameh T, Sayes CM (2019) The potential exposure and hazards of copper nanoparticles: a review. Environ Toxicol Pharmacol 71:103220. https:\/\/doi.org\/10.1016\/j.etap.2019.103220","journal-title":"Environ Toxicol Pharmacol"},{"issue":"2","key":"5077_CR7","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.taap.2008.06.026","volume":"232","author":"R Lei","year":"2008","unstructured":"Lei R, Wu C, Yang B, Ma H, Shi C, Wang Q, Liao M (2008) Integrated metabolomic analysis of the nano-sized copper particle-induced hepatotoxicity and nephrotoxicity in rats: a rapid in vivo screening method for nanotoxicity. Toxicol Appl Pharmacol 232(2):292\u2013301. https:\/\/doi.org\/10.1016\/j.taap.2008.06.026","journal-title":"Toxicol Appl Pharmacol"},{"issue":"5","key":"5077_CR8","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1080\/17435390.2022.2133647","volume":"16","author":"V Nicy","year":"2022","unstructured":"Nicy V, Das M, Gurusubramanian G, Mondal P, Roy VK (2022) Treatment of copper nanoparticles (CuNPs) for two spermatogenic cycles impairs testicular activity via down-regulating steroid receptors and inhibition of germ cell proliferation in a mice model. Nanotoxicology 16(5):658\u2013678. https:\/\/doi.org\/10.1080\/17435390.2022.2133647","journal-title":"Nanotoxicology"},{"key":"5077_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2024.108669","volume":"129","author":"V Nicy","year":"2024","unstructured":"Nicy V, Gurusubramanian G, Roy VK (2024) Effects of chronic CuNPs treatment followed by termination for two spermatogenic cycles in the testicular functions of mice. Reprod Toxicol 129:108669. https:\/\/doi.org\/10.1016\/j.reprotox.2024.108669","journal-title":"Reprod Toxicol"},{"issue":"8","key":"5077_CR10","doi-asserted-by":"publisher","first-page":"16732","DOI":"10.3390\/ijms140816732","volume":"14","author":"I Iavicoli","year":"2013","unstructured":"Iavicoli I, Fontana L, Leso V, Bergamaschi A (2013) The effects of nanomaterials as endocrine disruptors. Int J Mol Sci 14(8):16732\u201316801. https:\/\/doi.org\/10.3390\/ijms140816732","journal-title":"Int J Mol Sci"},{"key":"5077_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2024.108689","volume":"187","author":"Y Zhang","year":"2024","unstructured":"Zhang Y, Wang B, Sun W, Wang G, Liu Z, Zhang X, Ding J, Han Y, Zhang H (2024) Paternal exposures to endocrine-disrupting chemicals induce intergenerational epigenetic influences on offspring: a review. Environ Int 187:108689. https:\/\/doi.org\/10.1016\/j.envint.2024.108689","journal-title":"Environ Int"},{"issue":"2","key":"5077_CR12","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.reprotox.2008.07.008","volume":"26","author":"MD Anway","year":"2008","unstructured":"Anway MD, Rekow SS, Skinner MK (2008) Comparative anti-androgenic actions of vinclozolin and flutamide on transgenerational adult onset disease and spermatogenesis. Reprod Toxicol 26(2):100\u2013106. https:\/\/doi.org\/10.1016\/j.reprotox.2008.07.008","journal-title":"Reprod Toxicol"},{"issue":"6","key":"5077_CR13","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23063350","volume":"23","author":"D Montjean","year":"2022","unstructured":"Montjean D, Neyroud AS, Yefimova MG, Benkhalifa M, Cabry R, Ravel C (2022) Impact of endocrine disruptors upon non-genetic inheritance. Int J Mol Sci 23(6):3350","journal-title":"Int J Mol Sci"},{"key":"5077_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2020.111001","volume":"203","author":"CC Wei","year":"2020","unstructured":"Wei CC, Yen PL, Chaikritsadakarn A, Huang CW, Chang CH, Liao VHC (2020) Parental CuO nanoparticles exposure results in transgenerational toxicity in Caenorhabditis elegans associated with possible epigenetic regulation. Ecotoxicol Environ Saf 203:111001. https:\/\/doi.org\/10.1016\/j.ecoenv.2020.111001","journal-title":"Ecotoxicol Environ Saf"},{"key":"5077_CR15","first-page":"56","volume":"21","author":"MM Brouwers","year":"2006","unstructured":"Brouwers MM, Feitz WFJ, Zielhuis GA, Roeleveld N (2006) The effects of parental exposure to environmental endocrine disruptors on reproductive health in male offspring. Eur J Epidemiol 21:56\u201356","journal-title":"Eur J Epidemiol"},{"issue":"15","key":"5077_CR16","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21155408","volume":"21","author":"PC Karmakar","year":"2020","unstructured":"Karmakar PC, Ahn JS, Kim YH, Jung SE, Kim BJ, Lee HS, Kim SU, Rahman MS, Pang MG, Ryu BY (2020) Paternal exposure to bisphenol-A transgenerationally impairs testis morphology, germ cell associations, and stemness properties of mouse spermatogonial stem cells. Int J Mol Sci 21(15):5408. https:\/\/doi.org\/10.3390\/ijms21155408","journal-title":"Int J Mol Sci"},{"issue":"31","key":"5077_CR17","doi-asserted-by":"publisher","first-page":"20541","DOI":"10.1021\/acsnano.4c05660","volume":"18","author":"W Shaoyong","year":"2024","unstructured":"Shaoyong W, Wang W, Pan B, Liu R, Yin L, Wangjie R, Tian H, Wang Y, Jin M (2024) Transgenerational inheritance effects of copper oxide nanoparticles (CuONPs) induced asthenospermia and infertility via gamete H3K9me3 insufficiency pathway in mice. ACS Nano 18(31):20541\u201320555. https:\/\/doi.org\/10.1021\/acsnano.4c05660","journal-title":"ACS Nano"},{"issue":"7","key":"5077_CR18","doi-asserted-by":"publisher","first-page":"12379","DOI":"10.3390\/ijms150712379","volume":"15","author":"LI Privalova","year":"2014","unstructured":"Privalova LI, Katsnelson BA, Loginova NV, Gurvich VB, Shur VY, Valamina IE, Makeyev OH, Sutunkova MP, Minigalieva IA, Kireyeva EP, Rusakov VO (2014) Subchronic toxicity of copper oxide nanoparticles and its attenuation with the help of a combination of bioprotectors. Int J Mol Sci 15(7):12379\u2013406.10.3390\/ijms150712379","journal-title":"Int J Mol Sci"},{"issue":"1","key":"5077_CR19","doi-asserted-by":"publisher","first-page":"771","DOI":"10.3892\/mmr.2019.10302","volume":"20","author":"Y Wang","year":"2019","unstructured":"Wang Y, Tang H, Xu M, Luo J, Zhao L, Shi F, Ye G, Lv C, Li Y (2019) Effect of copper nanoparticles on brain cytochrome P450 enzymes in rats. Mol Med Rep 20(1):771\u2013778. https:\/\/doi.org\/10.3892\/mmr.2019.10302","journal-title":"Mol Med Rep"},{"key":"5077_CR20","unstructured":"World Health Organization (1996) Trace elements in human nutrition and health. WHO Library Cataloguing in Publication Data. 105\u2013122."},{"key":"5077_CR21","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.fct.2016.07.004","volume":"95","author":"JC Hannon","year":"2016","unstructured":"Hannon JC, Kerry JP, Cruz-Romero M, Azlin-Hasim S, Morris M, Cummins E (2016) Human exposure assessment of silver and copper migrating from an antimicrobial nanocoated packaging material into an acidic food simulant. Food Chem Toxicol 95:128\u2013136. https:\/\/doi.org\/10.1016\/j.fct.2016.07.004","journal-title":"Food Chem Toxicol"},{"issue":"7","key":"5077_CR22","volume":"6","author":"Authority EF","year":"2008","unstructured":"Authority EF (2008) Conclusion regarding the peer review of the pesticide risk assessment of the active substance bromuconazole. EFSA J 6(7):136r","journal-title":"EFSA J"},{"issue":"6","key":"5077_CR23","doi-asserted-by":"publisher","first-page":"475","DOI":"10.3109\/13625187.2014.945165","volume":"19","author":"HP Verma","year":"2014","unstructured":"Verma HP, Singh SK (2014) Effect of aqueous leaf extract of Dalbergia sissoo Roxb. on spermatogenesis and fertility in male mice. Eur J Contracept Reprod Health Care 19(6):475\u2013486. https:\/\/doi.org\/10.3109\/13625187.2014.945165","journal-title":"Eur J Contracept Reprod Health Care"},{"key":"5077_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2022.134726","volume":"301","author":"M Lu","year":"2022","unstructured":"Lu M, Mu Y, Liu Y (2022) Triphenyltin disrupts the testicular microenvironment and reduces sperm quality in adult male rats. Chemosphere 301:134726. https:\/\/doi.org\/10.1016\/j.chemosphere.2022.134726","journal-title":"Chemosphere"},{"issue":"1","key":"5077_CR25","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1159\/000178170","volume":"1","author":"SG Johnsen","year":"1970","unstructured":"Johnsen SG (1970) Testicular biopsy score count\u2013a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males. Horm Res Paediatr 1(1):2\u201325. https:\/\/doi.org\/10.1159\/000178170","journal-title":"Horm Res Paediatr"},{"issue":"1\u20132","key":"5077_CR26","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72(1\u20132):248\u2013254. https:\/\/doi.org\/10.1016\/0003-2697(76)90527-3","journal-title":"Anal Biochem"},{"issue":"2","key":"5077_CR27","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","volume":"95","author":"H Ohkawa","year":"1979","unstructured":"Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95(2):351\u2013358. https:\/\/doi.org\/10.1016\/0003-2697(79)90738-3","journal-title":"Anal Biochem"},{"issue":"2","key":"5077_CR28","first-page":"130","volume":"21","author":"P Kakkar","year":"1984","unstructured":"Kakkar P, Das B, Viswanathan PN (1984) A modified spectrophotometric assay of superoxide dismutase. Indian J Biochem Biophys 21(2):130\u20132 (http:\/\/nopr.niscpr.res.in\/handle\/123456789\/19932)","journal-title":"Indian J Biochem Biophys"},{"issue":"1","key":"5077_CR29","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s12858-018-0097-5","volume":"19","author":"MH Hadwan","year":"2018","unstructured":"Hadwan MH (2018) Simple spectrophotometric assay for measuring catalase activity in biological tissues. BMC Biochem 19(1):7. https:\/\/doi.org\/10.1186\/s12858-018-0097-5","journal-title":"BMC Biochem"},{"issue":"1","key":"5077_CR30","first-page":"158","volume":"70","author":"DE Paglia","year":"1967","unstructured":"Paglia DE, Valentine WN (1967) Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 70(1):158\u2013169","journal-title":"J Lab Clin Med"},{"key":"5077_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2021.127600","volume":"424","author":"Z Tai","year":"2022","unstructured":"Tai Z, Guan P, Zhang T, Liu W, Li L, Wu Y, Li G, Liu JX (2022) Effects of parental environmental copper stress on offspring development: DNA methylation modification and responses of differentially methylated region-related genes in transcriptional expression. J Hazard Mater 424:127600. https:\/\/doi.org\/10.1016\/j.jhazmat.2021.127600","journal-title":"J Hazard Mater"},{"issue":"1546","key":"5077_CR32","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1098\/rstb.2009.0124","volume":"365","author":"C Shaha","year":"2010","unstructured":"Shaha C, Tripathi R, Mishra DP (2010) Male germ cell apoptosis: regulation and biology. Philos Trans R Soc Lond B Biol Sci 365(1546):1501\u20131515. https:\/\/doi.org\/10.1098\/rstb.2009.0124","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"5077_CR33","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1093\/humrep\/deae108.254","volume":"39","author":"Y Luo","year":"2024","unstructured":"Luo Y, Zeng X, Dai X, Li J, Huang G (2024) O-215 Copper oxide nanoparticles (CuONPs) impairs mitophagy and promotes DNA methylation to suppress mouse embryonic pluripotency. Human Reprod 39:108\u2013254. https:\/\/doi.org\/10.1093\/humrep\/deae108.254","journal-title":"Human Reprod"},{"issue":"4","key":"5077_CR34","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1016\/j.reprotox.2012.09.005","volume":"34","author":"C Guerrero-Bosagna","year":"2012","unstructured":"Guerrero-Bosagna C, Covert TR, Haque MM, Settles M, Nilsson EE, Anway MD, Skinner MK (2012) Epigenetic transgenerational inheritance of vinclozolin induced mouse adult onset disease and associated sperm epigenome biomarkers. Reprod Toxicol 34(4):694\u2013707. https:\/\/doi.org\/10.1016\/j.reprotox.2012.09.005","journal-title":"Reprod Toxicol"},{"issue":"6","key":"5077_CR35","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.115.134817","volume":"93","author":"EE Nilsson","year":"2015","unstructured":"Nilsson EE, Skinner MK (2015) Environmentally induced epigenetic transgenerational inheritance of reproductive disease. Biol Reprod 93(6):145. https:\/\/doi.org\/10.1095\/biolreprod.115.134817","journal-title":"Biol Reprod"},{"issue":"1","key":"5077_CR36","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1016\/j.sjbs.2020.11.003","volume":"28","author":"MA Al-Griw","year":"2021","unstructured":"Al-Griw MA, Alghazeer RO, Salama NM, Lwaleed BA, Eskandrani AA, Alansari WS, Alnajeebi AM, Babteen NA, Shamlan G, Elnfati AH (2021) Paternal bisphenol A exposure induces testis and sperm pathologies in mice offspring: possibly due to oxidative stress? Saudi J Biol Sci 28(1):948\u2013955. https:\/\/doi.org\/10.1016\/j.sjbs.2020.11.003","journal-title":"Saudi J Biol Sci"},{"key":"5077_CR37","doi-asserted-by":"publisher","unstructured":"Weinbauer GF, Luetjens CM, Simoni M, Nieschlag E (2010) Physiology of testicular function. Andrology: Male reproductive health and dysfunction. Springer Berlin Heidelberg, Berlin, Heidelberg, pp 11\u201359. https:\/\/doi.org\/10.1007\/978-3-540-78355-8_2","DOI":"10.1007\/978-3-540-78355-8_2"},{"key":"5077_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2022.112817","volume":"161","author":"H Zhang","year":"2022","unstructured":"Zhang H, Shan L, Aniagu S, Jiang Y, Chen T (2022) Paternal acrylamide exposure induces transgenerational effects on sperm parameters and learning capability in mice. Food Chem Toxicol 161:112817. https:\/\/doi.org\/10.1016\/j.fct.2022.112817","journal-title":"Food Chem Toxicol"},{"issue":"3","key":"5077_CR39","doi-asserted-by":"publisher","DOI":"10.3390\/ani10030377","volume":"10","author":"Z Shi","year":"2020","unstructured":"Shi Z, Lv Z, Hu C, Zhang Q, Wang Z, Hamdard E, Dai H, Mustafa S, Shi F (2020) Oral exposure to genistein during conception and lactation period affects the testicular development of male offspring mice. Animals 10(3):377. https:\/\/doi.org\/10.3390\/ani10030377","journal-title":"Animals"},{"key":"5077_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2021.155554","volume":"144","author":"M Das","year":"2021","unstructured":"Das M, Annie L, Derkach KV, Shpakov AO, Gurusubramanian G, Roy VK (2021) Expression and localization of apelin and its receptor in the testes of diabetic mice and its possible role in steroidogenesis. Cytokine 144:155554. https:\/\/doi.org\/10.1016\/j.cyto.2021.155554","journal-title":"Cytokine"},{"key":"5077_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2023.102354","volume":"101","author":"M Das","year":"2023","unstructured":"Das M, Gurusubramanian G, Roy VK (2023) Apelin receptor antagonist (ML221) treatment has a stimulatory effect on the testicular proliferation, antioxidants system and steroidogenesis in adult mice. Neuropeptides 101:102354. https:\/\/doi.org\/10.1016\/j.npep.2023.102354","journal-title":"Neuropeptides"},{"key":"5077_CR42","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.neulet.2015.06.059","volume":"602","author":"S Sandal","year":"2015","unstructured":"Sandal S, Tekin S, Seker FB, Beytur A, Vardi N, Colak C, Tapan T, Yildiz S, Yilmaz B (2015) The effects of intracerebroventricular infusion of apelin-13 on reproductive function in male rats. Neurosci Lett 602:133\u2013138. https:\/\/doi.org\/10.1016\/j.neulet.2015.06.059","journal-title":"Neurosci Lett"},{"issue":"1","key":"5077_CR43","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1080\/13813455.2016.1211709","volume":"123","author":"S Tekin","year":"2017","unstructured":"Tekin S, Erden Y, Sandal S, Etem Onalan E, Ozyalin F, Ozen H, Yilmaz B (2017) Effects of apelin on reproductive functions: relationship with feeding behavior and energy metabolism. Arch Physiol Biochem 123(1):9\u201315. https:\/\/doi.org\/10.1080\/13813455.2016.1211709","journal-title":"Arch Physiol Biochem"},{"issue":"1","key":"5077_CR44","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-62584-w","volume":"10","author":"R Barakat","year":"2020","unstructured":"Barakat R, Lin PC, Park CJ, Zeineldin M, Zhou S, Rattan S, Brehm E, Flaws JA, Ko CJ (2020) Germline-dependent transmission of male reproductive traits induced by an endocrine disruptor, di-2-ethylhexyl phthalate, in future generations. Sci Rep 10(1):5705. https:\/\/doi.org\/10.1038\/s41598-020-62584-w","journal-title":"Sci Rep"},{"issue":"4","key":"5077_CR45","doi-asserted-by":"publisher","first-page":"1934","DOI":"10.1016\/j.tice.2019.101318","volume":"203","author":"DH Ahmed","year":"2025","unstructured":"Ahmed DH, El-Beih NM, El-Hussieny EA, El-Sayed WM (2025) Zinc oxide nanoparticles induced testicular toxicity through inflammation and reducing testosterone and cell viability in adult male rats. Biol Trace Elem Res 203(4):1934\u20131948. https:\/\/doi.org\/10.1016\/j.tice.2019.101318","journal-title":"Biol Trace Elem Res"},{"key":"5077_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2022.113210","volume":"231","author":"Z Guo","year":"2022","unstructured":"Guo Z, Wang X, Zhang P, Sun F, Chen Z, Ma W, Meng F, Hao H, Shang X (2022) Silica nanoparticles cause spermatogenesis dysfunction in mice via inducing cell cycle arrest and apoptosis. Ecotoxicol Environ Saf 231:113210. https:\/\/doi.org\/10.1016\/j.ecoenv.2022.113210","journal-title":"Ecotoxicol Environ Saf"},{"issue":"1","key":"5077_CR47","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010576","volume":"24","author":"JP Klein","year":"2022","unstructured":"Klein JP, Mery L, Boudard D, Ravel C, Cottier M, Bitounis D (2022) Impact of nanoparticles on male fertility: what do we really know? A systematic review. Int J Mol Sci 24(1):576. https:\/\/doi.org\/10.3390\/ijms24010576","journal-title":"Int J Mol Sci"},{"issue":"1","key":"5077_CR48","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-29371-x","volume":"15","author":"A Rezazadeh","year":"2025","unstructured":"Rezazadeh A, Najafpour A, Soleimanzadeh A, Amniattalab A (2025) Intratesticular copper oxide nanoparticles induce dose-dependent chemical castration in male mice. Sci Rep 15(1):44927. https:\/\/doi.org\/10.1038\/s41598-025-29371-x","journal-title":"Sci Rep"},{"issue":"654","key":"5077_CR49","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.bbrc.2023.02.067","volume":"30","author":"X Zheng","year":"2023","unstructured":"Zheng X, Chen J, Kang L, Wei Y, Wu Y, Hong Y, Wang X, Li D, Shen L, Long C, Wei G (2023) Prepubertal exposure to copper oxide nanoparticles induces Leydig cell injury with steroidogenesis disorders in mouse testes. Biochem Biophys Res Commun 30(654):62\u201372. https:\/\/doi.org\/10.1016\/j.bbrc.2023.02.067","journal-title":"Biochem Biophys Res Commun"},{"key":"5077_CR50","doi-asserted-by":"publisher","unstructured":"Poma A, Colafarina S, Fontecchio G, Chichiricc\u00f2 G (2014) Transgenerational effects of NMs. Nanomedicine (NBM) 235\u201354. https:\/\/doi.org\/10.1007\/978-94-017-8739-0_12","DOI":"10.1007\/978-94-017-8739-0_12"},{"issue":"1785","key":"5077_CR51","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2014.0311","volume":"281","author":"T Burton","year":"2014","unstructured":"Burton T, Metcalfe NB (2014) Can environmental conditions experienced in early life influence future generations? Proc R Soc Lond B Biol Sci 281(1785):20140311. https:\/\/doi.org\/10.1098\/rspb.2014.0311","journal-title":"Proc R Soc Lond B Biol Sci"}],"container-title":["Biological Trace Element Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-026-05077-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12011-026-05077-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-026-05077-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T20:02:54Z","timestamp":1784059374000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12011-026-05077-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,21]]},"references-count":51,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["5077"],"URL":"https:\/\/doi.org\/10.1007\/s12011-026-05077-7","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-8068308\/v1","asserted-by":"object"}]},"ISSN":["1559-0720"],"issn-type":[{"value":"1559-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,21]]},"assertion":[{"value":"9 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}