{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T10:08:35Z","timestamp":1794564515213,"version":"4.9.1"},"reference-count":153,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biol Trace Elem Res"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Selenium is an element that plays a crucial role in the proper functioning of the body. It is a component of selenoproteins, which exhibit strong antioxidant properties. This allows it to neutralize reactive oxygen species and protect cells from oxidative stress. It also plays a crucial role in supporting the proper functioning of the immune system. In this context, particular importance is attributed to its influence on the Th1\/Th2 immune response and the activity of T lymphocytes and NK cells. There is a mutual relationship between selenium and the intestinal microbiota. Microorganisms in the gastrointestinal tract participate in the accumulation, transformation, and differentiation of selenium\u2019s chemical forms. These processes influence selenium\u2019s bioavailability and its activity in the host organism. The development of metagenomic methods has enabled the identification of specific selenium-dependent metabolic pathways within the microbiome. This represents an important research direction in the development of this field of biotechnology. In turn, appropriate selenium levels and selenoprotein activity influence the composition of the intestinal microbiota and the metabolite profile it produces. It is worth emphasizing that in the context of the development of microbiome engineering, there are also emerging concepts of designing probiotics capable of controlled selenium biotransformation. The beneficial properties of selenium for organisms depend on its appropriate chemical form and dose. It is worth noting that selenium deficiency can impair the antioxidant system, leading to a redox imbalance. Such processes can weaken the integrity of the intestinal barrier, leading to the development of various gastrointestinal diseases. Therefore, the interaction with intestinal microflora is such a crucial element of selenium\u2019s action. Microorganisms inhabiting the digestive tract participate in the processes of accumulation and transformation of various chemical forms of this element. These biochemical properties of microorganisms are crucial for the bioavailability of selenium in the human body. Therefore, the appropriate form of selenium is crucial for the proper functioning of the intestinal barrier. This article discusses the importance of selenium in redox processes and in the function of the gut microbiota. It highlights the potential role of this element in the prevention and treatment of gastrointestinal diseases. Future research should focus on further understanding these interactions and developing targeted approaches that utilize selenium-dependent pathways to restore intestinal homeostasis.<\/jats:p>","DOI":"10.1007\/s12011-026-05132-3","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T01:44:16Z","timestamp":1777599856000},"page":"6552-6563","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Selenium: From Redox Signaling to Interactions with the Gut Microbiome"],"prefix":"10.1007","volume":"204","author":[{"given":"Marek","family":"Kieliszek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,1]]},"reference":[{"key":"5132_CR1","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.clnesp.2025.09.031","volume":"70","author":"I Rivas","year":"2025","unstructured":"Rivas I, Miranda M, Herrero-Latorre C et al (2025) Serum reference intervals for essential and toxic trace elements in a healthy population: A basis for nutritional monitoring and clinical intervention. Clin Nutr ESPEN 70:227\u2013239. https:\/\/doi.org\/10.1016\/j.clnesp.2025.09.031","journal-title":"Clin Nutr ESPEN"},{"key":"5132_CR2","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.3390\/antiox14111299","volume":"14","author":"F Gorini","year":"2025","unstructured":"Gorini F, Tonacci A (2025) Selenium: A Key Element in Inflammatory Bowel Disease. Antioxidants 14:1299. https:\/\/doi.org\/10.3390\/antiox14111299","journal-title":"Antioxidants"},{"key":"5132_CR3","doi-asserted-by":"publisher","unstructured":"Szkopek D, Mendel M, Kinsner M et al (2025) Cannabidiol and nano-selenium mediate intestinal barrier function by affecting mucosal microstructures, and gut-associated immunological and oxidative stress response in the gut of chickens infected with C. perfringens. Front Immunol 16:1529449. https:\/\/doi.org\/10.3389\/fimmu.2025.1529449","DOI":"10.3389\/fimmu.2025.1529449"},{"key":"5132_CR4","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1007\/s12035-024-04343-w","volume":"62","author":"AV Skalny","year":"2025","unstructured":"Skalny AV, Aschner M, Santamaria A et al (2025) The Role of Gut Microbiota in the Neuroprotective Effects of Selenium in Alzheimer\u2019s Disease. Mol Neurobiol 62:1675\u20131692. https:\/\/doi.org\/10.1007\/s12035-024-04343-w","journal-title":"Mol Neurobiol"},{"key":"5132_CR5","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1021\/acs.estlett.8b00563","volume":"5","author":"Q Zhai","year":"2018","unstructured":"Zhai Q, Cen S, Li P et al (2018) Effects of Dietary Selenium Supplementation on Intestinal Barrier and Immune Responses Associated with Its Modulation of Gut Microbiota. Environ Sci Technol Lett 5:724\u2013730. https:\/\/doi.org\/10.1021\/acs.estlett.8b00563","journal-title":"Environ Sci Technol Lett"},{"key":"5132_CR6","doi-asserted-by":"publisher","first-page":"7652","DOI":"10.1021\/acs.jafc.1c02622","volume":"69","author":"B Callej\u00f3n-Leblic","year":"2021","unstructured":"Callej\u00f3n-Leblic B, Selma-Royo M, Collado MC et al (2021) Impact of Antibiotic-Induced Depletion of Gut Microbiota and Selenium Supplementation on Plasma Selenoproteome and Metal Homeostasis in a Mice Model. J Agric Food Chem 69:7652\u20137662. https:\/\/doi.org\/10.1021\/acs.jafc.1c02622","journal-title":"J Agric Food Chem"},{"key":"5132_CR7","doi-asserted-by":"publisher","first-page":"109917","DOI":"10.1016\/j.jnutbio.2025.109917","volume":"142","author":"Y Wang","year":"2025","unstructured":"Wang Y, Lin Y, Feng J et al (2025) Correlation of serum trace elements with clinical features and gut microbiota in patients with Crohn\u2019s disease. J Nutr Biochem 142:109917. https:\/\/doi.org\/10.1016\/j.jnutbio.2025.109917","journal-title":"J Nutr Biochem"},{"key":"5132_CR8","doi-asserted-by":"publisher","first-page":"3620","DOI":"10.3390\/nu16213620","volume":"16","author":"JA Sousa","year":"2024","unstructured":"Sousa JA, McKay DM, Raman M (2024) Selenium, Immunity, and Inflammatory Bowel Disease. Nutrients 16:3620. https:\/\/doi.org\/10.3390\/nu16213620","journal-title":"Nutrients"},{"key":"5132_CR9","doi-asserted-by":"publisher","unstructured":"He L, Zhang L, Peng Y, He Z (2025) Selenium in cancer management: exploring the therapeutic potential. Front Oncol 14. https:\/\/doi.org\/10.3389\/fonc.2024.1490740","DOI":"10.3389\/fonc.2024.1490740"},{"key":"5132_CR10","doi-asserted-by":"publisher","first-page":"294","DOI":"10.3390\/antiox14030294","volume":"14","author":"J-G Lee","year":"2025","unstructured":"Lee J-G, Jang J-Y, Baik S-M (2025) Selenium as an Antioxidant: Roles and Clinical Applications in Critically Ill and Trauma Patients: A Narrative Review. Antioxidants 14:294. https:\/\/doi.org\/10.3390\/antiox14030294","journal-title":"Antioxidants"},{"key":"5132_CR11","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1016\/j.mehy.2006.09.058","volume":"68","author":"X Zhou","year":"2007","unstructured":"Zhou X, Ji W-J, Zhu Y et al (2007) Enhancement of endogenous defenses against ROS by supra-nutritional level of selenium is more safe and effective than antioxidant supplementation in reducing hypertensive target organ damage. Med Hypotheses 68:952\u2013956. https:\/\/doi.org\/10.1016\/j.mehy.2006.09.058","journal-title":"Med Hypotheses"},{"key":"5132_CR12","doi-asserted-by":"publisher","first-page":"e07704","DOI":"10.2903\/j.efsa.2023.7704","volume":"21","author":"D Turck","year":"2023","unstructured":"EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, Bohn T et al (2023) Scientific opinion on the tolerable upper intake level for selenium. EFSA J 21:e07704. https:\/\/doi.org\/10.2903\/j.efsa.2023.7704","journal-title":"EFSA J"},{"key":"5132_CR13","doi-asserted-by":"publisher","first-page":"1136458","DOI":"10.3389\/fnut.2023.1136458","volume":"10","author":"Y Sun","year":"2023","unstructured":"Sun Y, Wang Z, Gong P et al (2023) Review on the health-promoting effect of adequate selenium status. Front Nutr 10:1136458. https:\/\/doi.org\/10.3389\/fnut.2023.1136458","journal-title":"Front Nutr"},{"key":"5132_CR14","doi-asserted-by":"publisher","first-page":"2367","DOI":"10.3390\/nu16142367","volume":"16","author":"F Li","year":"2024","unstructured":"Li F, Hong X, Wang H et al (2024) Association of Dietary Selenium Intake with Type 2 Diabetes in Middle-Aged and Older Adults in China. Nutrients 16:2367. https:\/\/doi.org\/10.3390\/nu16142367","journal-title":"Nutrients"},{"key":"5132_CR15","doi-asserted-by":"publisher","first-page":"251","DOI":"10.3390\/antiox11020251","volume":"11","author":"G Barchielli","year":"2022","unstructured":"Barchielli G, Capperucci A, Tanini D (2022) The Role of Selenium in Pathologies: An Updated Review. Antioxidants 11:251. https:\/\/doi.org\/10.3390\/antiox11020251","journal-title":"Antioxidants"},{"key":"5132_CR16","doi-asserted-by":"publisher","unstructured":"Dahlen CR, Reynolds LP, Caton JS (2022) Selenium supplementation and pregnancy outcomes. Front Nutr 9. https:\/\/doi.org\/10.3389\/fnut.2022.1011850","DOI":"10.3389\/fnut.2022.1011850"},{"key":"5132_CR17","doi-asserted-by":"publisher","DOI":"10.26599\/FSHW.2026.9250936","author":"Z-R Du","year":"2026","unstructured":"Du Z-R, Li C, Cai M-Y et al (2026) Selenium nanoparticles functionalized by mushroom polysaccharides potentiated neuroprotection of selenium against Parkinson\u2019s disease with lower toxicity. Food Sci Hum Wellness. https:\/\/doi.org\/10.26599\/FSHW.2026.9250936","journal-title":"Food Sci Hum Wellness"},{"key":"5132_CR18","doi-asserted-by":"publisher","first-page":"4458","DOI":"10.3390\/nu14214458","volume":"14","author":"S Fu","year":"2022","unstructured":"Fu S, Zhang L, Ma F et al (2022) Effects of Selenium on Chronic Kidney Disease: A Mendelian Randomization Study. Nutrients 14:4458. https:\/\/doi.org\/10.3390\/nu14214458","journal-title":"Nutrients"},{"key":"5132_CR19","doi-asserted-by":"publisher","unstructured":"Fan AM, Vinceti M (2015) Selenium and its Compounds. Hamilton & Hardy\u2019s Industrial Toxicology. In: Raymond D. Harbison, Marie M. Bourgeois, Giffe T. Johnson (Book Eds). Wiley, Ltd, pp 205\u2013228. https:\/\/doi.org\/10.1002\/9781118834015.ch30","DOI":"10.1002\/9781118834015.ch30"},{"key":"5132_CR20","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.freeradbiomed.2018.01.028","volume":"127","author":"M Benhar","year":"2018","unstructured":"Benhar M (2018) Roles of mammalian glutathione peroxidase and thioredoxin reductase enzymes in the cellular response to nitrosative stress. Free Radic Biol Med 127:160\u2013164. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2018.01.028","journal-title":"Free Radic Biol Med"},{"key":"5132_CR21","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.5c08885","author":"K Lima Bruno","year":"2026","unstructured":"Lima Bruno K, Salvador Tessaro P, Soares F M, et al (2026) Combining Gold and Selenium as Emerging Bioactive Compounds: From Synthesis to Therapeutic Potential. ACS Omega 11(5):6834\u20136847. https:\/\/doi.org\/10.1021\/acsomega.5c08885","journal-title":"ACS Omega"},{"key":"5132_CR22","doi-asserted-by":"publisher","first-page":"105346","DOI":"10.1016\/j.exphem.2025.105346","volume":"155","author":"Y Aoyama","year":"2025","unstructured":"Aoyama Y, Yamazaki H, Inoue D (2025) Emerging paradigms in redox regulation: the role of selenoproteins in normal and malignant hematopoiesis. Exp Hematol 155:105346. https:\/\/doi.org\/10.1016\/j.exphem.2025.105346","journal-title":"Exp Hematol"},{"key":"5132_CR23","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.3390\/biom15081115","volume":"15","author":"M Pace","year":"2025","unstructured":"Pace M, Giorgi C, Lombardozzi G et al (2025) Exploring the Antioxidant Roles of Cysteine and Selenocysteine in Cellular Aging and Redox Regulation. Biomolecules 15:1115. https:\/\/doi.org\/10.3390\/biom15081115","journal-title":"Biomolecules"},{"key":"5132_CR24","doi-asserted-by":"publisher","first-page":"45104","DOI":"10.1038\/s41598-025-31644-4","volume":"15","author":"T Wang","year":"2025","unstructured":"Wang T, Chen S, Lu S et al (2025) Effects of dietary selenium yeast supplementation on the production performance, egg quality, antioxidant and plasma biochemical parameters of laying hens. Sci Rep 15:45104. https:\/\/doi.org\/10.1038\/s41598-025-31644-4","journal-title":"Sci Rep"},{"key":"5132_CR25","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1093\/jn\/nxac016","volume":"152","author":"K Zhang","year":"2022","unstructured":"Zhang K, Li S, Zhao Q et al (2022) Multi-Omics Profiling Reveals Se Deficiency-Induced Redox Imbalance, Metabolic Reprogramming, and Inflammation in Pig Muscle. J Nutr 152:1207\u20131219. https:\/\/doi.org\/10.1093\/jn\/nxac016","journal-title":"J Nutr"},{"key":"5132_CR26","doi-asserted-by":"publisher","first-page":"101519","DOI":"10.1016\/j.redox.2020.101519","volume":"36","author":"C Tang","year":"2020","unstructured":"Tang C, Li S, Zhang K et al (2020) Selenium deficiency-induced redox imbalance leads to metabolic reprogramming and inflammation in the liver. Redox Biol 36:101519. https:\/\/doi.org\/10.1016\/j.redox.2020.101519","journal-title":"Redox Biol"},{"key":"5132_CR27","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1038\/s41538-025-00589-3","volume":"9","author":"X Wang","year":"2025","unstructured":"Wang X, Zhong Y, Zhu Z et al (2025) Gut microbiota: a new perspective for bioavailability of selenium and human health. Npj Sci Food 9:228. https:\/\/doi.org\/10.1038\/s41538-025-00589-3","journal-title":"Npj Sci Food"},{"key":"5132_CR28","doi-asserted-by":"publisher","first-page":"e70019","DOI":"10.1111\/jwas.70019","volume":"56","author":"E Zahran","year":"2025","unstructured":"Zahran E, Wang B, Amoah K et al (2025) Dietary selenium nanoparticles (SeNPs) mediate intestinal microbiome and microbiota-derived metabolites regulating the growth and immunity of Nile tilapia. J World Aquac Soc 56:e70019. https:\/\/doi.org\/10.1111\/jwas.70019","journal-title":"J World Aquac Soc"},{"key":"5132_CR29","doi-asserted-by":"publisher","first-page":"3309","DOI":"10.3390\/ani15223309","volume":"15","author":"F Meng","year":"2025","unstructured":"Meng F, Zhao Y, Guo Y et al (2025) Rectal Microbiome Reveals the Improved Effect of Dietary Selenium Levels on Lactation Performance and Milk Fatty Acid Profiles in Lactating Donkeys. Animals 15:3309. https:\/\/doi.org\/10.3390\/ani15223309","journal-title":"Animals"},{"key":"5132_CR30","doi-asserted-by":"publisher","first-page":"9391","DOI":"10.48048\/tis.2025.9391","volume":"22","author":"S Likidtaveesin","year":"2025","unstructured":"Likidtaveesin S, Changtong N, Jarussophon N, Chunhachart O (2025) Biosynthesis of Selenium Nanoparticles and Selenium-Enriched g-Polyglutamic Acid (Se-PGA) by Bacillus subtilis. Trends Sci 22:9391\u20139391. https:\/\/doi.org\/10.48048\/tis.2025.9391","journal-title":"Trends Sci"},{"key":"5132_CR31","doi-asserted-by":"publisher","unstructured":"Hu Y, Jin X, Gao F et al (2022) Selenium-enriched Bifidobacterium longum DD98 effectively ameliorates dextran sulfate sodium-induced ulcerative colitis in mice. Front Microbiol 13. https:\/\/doi.org\/10.3389\/fmicb.2022.955112","DOI":"10.3389\/fmicb.2022.955112"},{"key":"5132_CR32","doi-asserted-by":"publisher","unstructured":"Rui W, Sun Y, Li X et al (2025) Selenium-Enriched Akkermansia muciniphila: A Novel Probiotic Bacterium for Se Supplementation. Probiotics Antimicrob Proteins 18:2639\u20132653. https:\/\/doi.org\/10.1007\/s12602-025-10713-0","DOI":"10.1007\/s12602-025-10713-0"},{"key":"5132_CR33","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1023\/a:1009290213301","volume":"11","author":"RJ Turner","year":"1998","unstructured":"Turner RJ, Weiner JH, Taylor DE (1998) Selenium metabolism in Escherichia coli. Biometals Int J Role Met Ions Biol Biochem Med 11:223\u2013227. https:\/\/doi.org\/10.1023\/a:1009290213301","journal-title":"Biometals Int J Role Met Ions Biol Biochem Med"},{"key":"5132_CR34","doi-asserted-by":"publisher","unstructured":"Ferreira RLU, Sena-Evangelista KCM, de Azevedo EP et al (2021) Selenium in Human Health and Gut Microflora: Bioavailability of Selenocompounds and Relationship With Diseases. Front Nutr 8. https:\/\/doi.org\/10.3389\/fnut.2021.685317","DOI":"10.3389\/fnut.2021.685317"},{"key":"5132_CR35","doi-asserted-by":"publisher","first-page":"3133","DOI":"10.3390\/nu14153133","volume":"14","author":"K Zhu","year":"2022","unstructured":"Zhu K, Yang S, Li T et al (2022) Advances in the Study of the Mechanism by Which Selenium and Selenoproteins Boost Immunity to Prevent Food Allergies. Nutrients 14:3133. https:\/\/doi.org\/10.3390\/nu14153133","journal-title":"Nutrients"},{"key":"5132_CR36","doi-asserted-by":"publisher","first-page":"120","DOI":"10.3390\/molecules29010120","volume":"29","author":"LB Maia","year":"2024","unstructured":"Maia LB, Maiti BK, Moura I, Moura JJG (2024) Selenium\u2014More than Just a Fortuitous Sulfur Substitute in Redox Biology. Molecules 29:120. https:\/\/doi.org\/10.3390\/molecules29010120","journal-title":"Molecules"},{"key":"5132_CR37","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s12011-010-8656-7","volume":"134","author":"WC Hawkes","year":"2010","unstructured":"Hawkes WC, Alkan Z (2010) Regulation of redox signaling by selenoproteins. Biol Trace Elem Res 134:235\u2013251. https:\/\/doi.org\/10.1007\/s12011-010-8656-7","journal-title":"Biol Trace Elem Res"},{"key":"5132_CR38","doi-asserted-by":"publisher","first-page":"383","DOI":"10.3390\/antiox9050383","volume":"9","author":"Y Zhang","year":"2020","unstructured":"Zhang Y, Roh YJ, Han S-J et al (2020) Role of Selenoproteins in Redox Regulation of Signaling and the Antioxidant System: A Review. Antioxidants 9:383. https:\/\/doi.org\/10.3390\/antiox9050383","journal-title":"Antioxidants"},{"key":"5132_CR39","doi-asserted-by":"publisher","unstructured":"Jiang Z, Wang Z, Zhao Y, Peng M (2024) Unveiling the vital role of soil microorganisms in selenium cycling: a review. Front Microbiol 15:1448539. https:\/\/doi.org\/10.3389\/fmicb.2024.1448539","DOI":"10.3389\/fmicb.2024.1448539"},{"key":"5132_CR40","doi-asserted-by":"publisher","first-page":"e23195","DOI":"10.1002\/jbt.23195","volume":"36","author":"M Banerjee","year":"2022","unstructured":"Banerjee M, Chakravarty D, Kalwani P, Ballal A (2022) Voyage of selenium from environment to life: Beneficial or toxic? J Biochem Mol Toxicol 36:e23195. https:\/\/doi.org\/10.1002\/jbt.23195","journal-title":"J Biochem Mol Toxicol"},{"key":"5132_CR41","doi-asserted-by":"publisher","first-page":"e00842","DOI":"10.1002\/asia.202500842","volume":"20","author":"J Hu","year":"2025","unstructured":"Hu J, Liang W, Yi L (2025) Strategies for the Development of Donors and Precursors of Hydrogen Selenide (H2Se). Chem \u2013 Asian J 20:e00842. https:\/\/doi.org\/10.1002\/asia.202500842","journal-title":"Chem \u2013 Asian J"},{"key":"5132_CR42","doi-asserted-by":"publisher","first-page":"19315","DOI":"10.1039\/D4SC05788K","volume":"15","author":"UD Sarkar","year":"2024","unstructured":"Sarkar UD, Rana M, Chakrapani H (2024) Phenacylselenoesters allow facile selenium transfer and hydrogen selenide generation. Chem Sci 15:19315\u201319321. https:\/\/doi.org\/10.1039\/D4SC05788K","journal-title":"Chem Sci"},{"key":"5132_CR43","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1016\/j.bbagen.2007.03.007","volume":"1770","author":"KT Suzuki","year":"2007","unstructured":"Suzuki KT, Kurasaki K, Suzuki N (2007) Selenocysteine \u03b2-lyase and methylselenol demethylase in the metabolism of Se-methylated selenocompounds into selenide. Biochim Biophys Acta BBA - Gen Subj 1770:1053\u20131061. https:\/\/doi.org\/10.1016\/j.bbagen.2007.03.007","journal-title":"Biochim Biophys Acta BBA - Gen Subj"},{"key":"5132_CR44","doi-asserted-by":"publisher","first-page":"5373","DOI":"10.1007\/s00253-015-6650-x","volume":"99","author":"M Kieliszek","year":"2015","unstructured":"Kieliszek M, B\u0142a\u017cejak S, Gientka I, Bzducha-Wr\u00f3bel A (2015) Accumulation and metabolism of selenium by yeast cells. Appl Microbiol Biotechnol 99:5373\u20135382. https:\/\/doi.org\/10.1007\/s00253-015-6650-x","journal-title":"Appl Microbiol Biotechnol"},{"key":"5132_CR45","doi-asserted-by":"publisher","first-page":"100563","DOI":"10.1016\/j.xhgg.2026.100563","volume":"7","author":"Z Xia","year":"2026","unstructured":"Xia Z, Liu H, Guo P et al (2026) EEFSEC deficiency underlies a human selenopathy with primary neurodevelopmental origins via midbrain-hindbrain hypoplasia. Hum Genet Genomics Adv 7:100563. https:\/\/doi.org\/10.1016\/j.xhgg.2026.100563","journal-title":"Hum Genet Genomics Adv"},{"key":"5132_CR46","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s10552-025-02123-y","volume":"37","author":"S Bera","year":"2026","unstructured":"Bera S, Liu L, Ma W et al (2026) Contributions of selenoproteins to breast cancer etiology and racial disparity. Cancer Causes Control 37:35. https:\/\/doi.org\/10.1007\/s10552-025-02123-y","journal-title":"Cancer Causes Control"},{"key":"5132_CR47","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1016\/j.yexcr.2010.02.032","volume":"316","author":"ESJ Arn\u00e9r","year":"2010","unstructured":"Arn\u00e9r ESJ (2010) Selenoproteins\u2014What unique properties can arise with selenocysteine in place of cysteine? Exp Cell Res 316:1296\u20131303. https:\/\/doi.org\/10.1016\/j.yexcr.2010.02.032","journal-title":"Exp Cell Res"},{"key":"5132_CR48","doi-asserted-by":"publisher","first-page":"e202404580","DOI":"10.1002\/chem.202404580","volume":"31","author":"A Madabeni","year":"2025","unstructured":"Madabeni A, Zeisel L, Thorn-Seshold O, Orian L (2025) Selenium Nucleophilicity and Electrophilicity in the Intra- and Intermolecular SN2 Reactions of Selenenyl Sulfide Probes. Chem \u2013 Eur J 31:e202404580. https:\/\/doi.org\/10.1002\/chem.202404580","journal-title":"Chem \u2013 Eur J"},{"key":"5132_CR49","doi-asserted-by":"publisher","first-page":"16644","DOI":"10.1039\/D5CP01736J","volume":"27","author":"P Delre","year":"2025","unstructured":"Delre P, Chahine A, Mangiatordi GF et al (2025) Shedding light on the HSAB-guided sulfur\u2013selenium antagonism in mercury coordination and reactivity toward biologically relevant systems: a DFT and MD study. Phys Chem Chem Phys 27:16644\u201316663. https:\/\/doi.org\/10.1039\/D5CP01736J","journal-title":"Phys Chem Chem Phys"},{"key":"5132_CR50","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.freeradbiomed.2018.03.035","volume":"127","author":"MJ Maroney","year":"2018","unstructured":"Maroney MJ, Hondal RJ (2018) Selenium versus sulfur: Reversibility of chemical reactions and resistance to permanent oxidation in proteins and nucleic acids. Free Radic Biol Med 127:228\u2013237. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2018.03.035","journal-title":"Free Radic Biol Med"},{"key":"5132_CR51","doi-asserted-by":"publisher","unstructured":"Jacob C, Giles GI, Giles NM, Sies H Sulfur and Selenium: The Role of Oxidation State in Protein Structure and Function. https:\/\/doi.org\/10.1002\/anie.200300573","DOI":"10.1002\/anie.200300573"},{"key":"5132_CR52","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1021\/acschembio.6b00031","volume":"11","author":"HJ Reich","year":"2016","unstructured":"Reich HJ, Hondal RJ (2016) Why Nature Chose Selenium. ACS Chem Biol 11:821\u2013841. https:\/\/doi.org\/10.1021\/acschembio.6b00031","journal-title":"ACS Chem Biol"},{"key":"5132_CR53","doi-asserted-by":"publisher","first-page":"14724","DOI":"10.1021\/acsami.7b03377","volume":"9","author":"D Song","year":"2017","unstructured":"Song D, Cheng Y, Li X et al (2017) Biogenic Nanoselenium Particles Effectively Attenuate Oxidative Stress-Induced Intestinal Epithelial Barrier Injury by Activating the Nrf2 Antioxidant Pathway. ACS Appl Mater Interfaces 9:14724\u201314740. https:\/\/doi.org\/10.1021\/acsami.7b03377","journal-title":"ACS Appl Mater Interfaces"},{"key":"5132_CR54","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1113\/EP085746","volume":"101","author":"F Liu","year":"2016","unstructured":"Liu F, Cottrell JJ, Furness JB et al (2016) Selenium and vitamin E together improve intestinal epithelial barrier function and alleviate oxidative stress in heat-stressed pigs. Exp Physiol 101:801\u2013810. https:\/\/doi.org\/10.1113\/EP085746","journal-title":"Exp Physiol"},{"key":"5132_CR55","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1089\/ars.2012.5013","volume":"18","author":"RJ Hondal","year":"2013","unstructured":"Hondal RJ, Marino SM, Gladyshev VN (2013) Selenocysteine in Thiol\/Disulfide-Like Exchange Reactions. Antioxid Redox Signal 18:1675\u20131689. https:\/\/doi.org\/10.1089\/ars.2012.5013","journal-title":"Antioxid Redox Signal"},{"key":"5132_CR56","doi-asserted-by":"publisher","first-page":"465","DOI":"10.3390\/antiox9060465","volume":"9","author":"T P\u00e1lla","year":"2020","unstructured":"P\u00e1lla T, Mirzahosseini A, Nosz\u00e1l B (2020) Species-Specific, pH-Independent, Standard Redox Potential of Selenocysteine and Selenocysteamine. Antioxidants 9:465. https:\/\/doi.org\/10.3390\/antiox9060465","journal-title":"Antioxidants"},{"key":"5132_CR57","doi-asserted-by":"publisher","first-page":"11708","DOI":"10.3390\/ijms222111708","volume":"22","author":"R Ye","year":"2021","unstructured":"Ye R, Huang J, Wang Z et al (2021) Trace Element Selenium Effectively Alleviates Intestinal Diseases. Int J Mol Sci 22:11708. https:\/\/doi.org\/10.3390\/ijms222111708","journal-title":"Int J Mol Sci"},{"key":"5132_CR58","doi-asserted-by":"publisher","first-page":"10109","DOI":"10.3390\/ijms241210109","volume":"24","author":"J Chaudi\u00e8re","year":"2023","unstructured":"Chaudi\u00e8re J (2023) Biological and Catalytic Properties of Selenoproteins. Int J Mol Sci 24:10109. https:\/\/doi.org\/10.3390\/ijms241210109","journal-title":"Int J Mol Sci"},{"key":"5132_CR59","doi-asserted-by":"publisher","first-page":"2560","DOI":"10.3390\/cancers14102560","volume":"14","author":"Y Zhao","year":"2022","unstructured":"Zhao Y, Wang H, Zhou J, Shao Q (2022) Glutathione Peroxidase GPX1 and Its Dichotomous Roles in Cancer. Cancers 14:2560. https:\/\/doi.org\/10.3390\/cancers14102560","journal-title":"Cancers"},{"key":"5132_CR60","doi-asserted-by":"publisher","first-page":"799","DOI":"10.3390\/biom13050799","volume":"13","author":"F Zhang","year":"2023","unstructured":"Zhang F, Li X, Wei Y (2023) Selenium and Selenoproteins in Health. Biomolecules 13:799. https:\/\/doi.org\/10.3390\/biom13050799","journal-title":"Biomolecules"},{"key":"5132_CR61","doi-asserted-by":"publisher","first-page":"628","DOI":"10.3390\/nu14030628","volume":"14","author":"C Hogan","year":"2022","unstructured":"Hogan C, Perkins AV (2022) Selenoproteins in the Human Placenta: How Essential Is Selenium to a Healthy Start to Life? Nutrients 14:628. https:\/\/doi.org\/10.3390\/nu14030628","journal-title":"Nutrients"},{"key":"5132_CR62","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.freeradbiomed.2013.11.001","volume":"67","author":"B Speckmann","year":"2014","unstructured":"Speckmann B, Gerloff K, Simms L et al (2014) Selenoprotein S is a marker but not a regulator of endoplasmic reticulum stress in intestinal epithelial cells. Free Radic Biol Med 67:265\u2013277. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2013.11.001","journal-title":"Free Radic Biol Med"},{"key":"5132_CR63","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1111\/all.70095","volume":"81","author":"Y Pat","year":"2026","unstructured":"Pat Y, Yazici D, Zeyneloglu C et al (2026) Cellular Stress, Inflammation and Barrier Damage in Gut Epithelial Cells Caused by Aspartame. Allergy 81:884\u2013901. https:\/\/doi.org\/10.1111\/all.70095","journal-title":"Allergy"},{"key":"5132_CR64","doi-asserted-by":"publisher","first-page":"7806","DOI":"10.1128\/MCB.24.17.7806-7819.2004","volume":"24","author":"S Fujioka","year":"2004","unstructured":"Fujioka S, Niu J, Schmidt C et al (2004) NF-kappaB and AP-1 connection: mechanism of NF-kappaB-dependent regulation of AP-1 activity. Mol Cell Biol 24:7806\u20137819. https:\/\/doi.org\/10.1128\/MCB.24.17.7806-7819.2004","journal-title":"Mol Cell Biol"},{"key":"5132_CR65","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/s10787-024-01635-4","volume":"33","author":"G Kannan","year":"2025","unstructured":"Kannan G, Paul BM, Thangaraj P (2025) Stimulation, regulation, and inflammaging interventions of natural compounds on nuclear factor kappa B (NF-kB) pathway: a comprehensive review. Inflammopharmacology 33:145\u2013162. https:\/\/doi.org\/10.1007\/s10787-024-01635-4","journal-title":"Inflammopharmacology"},{"key":"5132_CR66","doi-asserted-by":"publisher","first-page":"e202402248","DOI":"10.1002\/cbdv.202402248","volume":"22","author":"X Li","year":"2025","unstructured":"Li X, Li S, Li N (2025) Research Progress on Natural Products Alleviating Liver Inflammation and Fibrosis via NF-\u03baB Pathway. Chem Biodivers 22:e202402248. https:\/\/doi.org\/10.1002\/cbdv.202402248","journal-title":"Chem Biodivers"},{"key":"5132_CR67","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1016\/j.freeradbiomed.2011.06.028","volume":"51","author":"JM Heilman","year":"2011","unstructured":"Heilman JM, Burke TJ, McClain CJ, Watson WH (2011) Transactivation of gene expression by NF-\u03baB is dependent on thioredoxin reductase activity. Free Radic Biol Med 51:1533\u20131542. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2011.06.028","journal-title":"Free Radic Biol Med"},{"key":"5132_CR68","doi-asserted-by":"publisher","DOI":"10.20517\/2394-5079.2024.95","author":"F Villarruel-Melquiades","year":"2024","unstructured":"Villarruel-Melquiades F, Aguirre-Maldonado I, Herrera-L\u00f3pez EE et al (2024) Activator protein-1 in liver pathology: from precancerous diseases to hepatocellular carcinoma. Hepatoma Res 10:51. https:\/\/doi.org\/10.20517\/2394-5079.2024.95","journal-title":"Hepatoma Res"},{"key":"5132_CR69","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/S0955-0674(97)80068-3","volume":"9","author":"M Karin","year":"1997","unstructured":"Karin M, Liu Z, Zandi E (1997) AP-1 function and regulation. Curr Opin Cell Biol 9:240\u2013246. https:\/\/doi.org\/10.1016\/S0955-0674(97)80068-3","journal-title":"Curr Opin Cell Biol"},{"key":"5132_CR70","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1002\/biof.5520230304","volume":"23","author":"S Shalini","year":"2005","unstructured":"Shalini S, Bansal M p (2005) Role of selenium in regulation of spermatogenesis: Involvement of activator protein 1. BioFactors 23:151\u2013162. https:\/\/doi.org\/10.1002\/biof.5520230304","journal-title":"BioFactors"},{"key":"5132_CR71","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1142\/S0192415X25500041","volume":"53","author":"Y Li","year":"2025","unstructured":"Li Y, Wang X, Li S et al (2025) Therapeutic Effects of Natural Products in the Treatment of Chronic Diseases: The Role in Regulating KEAP1-NRF2 Pathway. Am J Chin Med 53:67\u201396. https:\/\/doi.org\/10.1142\/S0192415X25500041","journal-title":"Am J Chin Med"},{"key":"5132_CR72","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1038\/s41392-024-02095-6","volume":"10","author":"B Li","year":"2025","unstructured":"Li B, Ming H, Qin S et al (2025) Redox regulation: mechanisms, biology and therapeutic targets in diseases. Signal Transduct Target Ther 10:72. https:\/\/doi.org\/10.1038\/s41392-024-02095-6","journal-title":"Signal Transduct Target Ther"},{"key":"5132_CR73","doi-asserted-by":"publisher","first-page":"2306333","DOI":"10.1002\/advs.202306333","volume":"11","author":"J Huang","year":"2024","unstructured":"Huang J, Xue S, Teixeira AP, Fussenegger M (2024) A Gene-Switch Platform Interfacing with Reactive Oxygen Species Enables Transcription Fine-Tuning by Soluble and Volatile Pharmacologics and Food Additives. Adv Sci 11:2306333. https:\/\/doi.org\/10.1002\/advs.202306333","journal-title":"Adv Sci"},{"key":"5132_CR74","doi-asserted-by":"publisher","first-page":"30165","DOI":"10.1038\/s41598-024-81375-1","volume":"14","author":"Y Wang","year":"2024","unstructured":"Wang Y, Wang S, Ma C et al (2024) Nrf2 depletion enhanced curcumin therapy effect in gastric cancer by inducing the excessive accumulation of ROS. Sci Rep 14:30165. https:\/\/doi.org\/10.1038\/s41598-024-81375-1","journal-title":"Sci Rep"},{"key":"5132_CR75","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.3390\/life13041045","volume":"13","author":"GA Shilovsky","year":"2023","unstructured":"Shilovsky GA, Dibrova DV (2023) Regulation of Cell Proliferation and Nrf2-Mediated Antioxidant Defense: Conservation of Keap1 Cysteines and Nrf2 Binding Site in the Context of the Evolution of KLHL Family. Life 13:1045. https:\/\/doi.org\/10.3390\/life13041045","journal-title":"Life"},{"key":"5132_CR76","doi-asserted-by":"publisher","first-page":"826204","DOI":"10.3389\/fcell.2022.826204","volume":"10","author":"J Zhou","year":"2022","unstructured":"Zhou J, Zheng Q, Chen Z (2022) The Nrf2 Pathway in Liver Diseases. Front Cell Dev Biol 10:826204. https:\/\/doi.org\/10.3389\/fcell.2022.826204","journal-title":"Front Cell Dev Biol"},{"key":"5132_CR77","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/s41573-025-01145-0","volume":"24","author":"DD Zhang","year":"2025","unstructured":"Zhang DD (2025) Thirty years of NRF2: advances and therapeutic challenges. Nat Rev Drug Discov 24:421\u2013444. https:\/\/doi.org\/10.1038\/s41573-025-01145-0","journal-title":"Nat Rev Drug Discov"},{"key":"5132_CR78","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1134\/S1990750819040085","volume":"13","author":"NY Rusetskaya","year":"2019","unstructured":"Rusetskaya NY, Fedotov IV, Koftina VA, Borodulin VB (2019) Selenium Compounds in Redox Regulation of Inflammation and Apoptosis. Biochem Mosc Suppl Ser B Biomed Chem 13:277\u2013292. https:\/\/doi.org\/10.1134\/S1990750819040085","journal-title":"Biochem Mosc Suppl Ser B Biomed Chem"},{"key":"5132_CR79","doi-asserted-by":"publisher","first-page":"S168","DOI":"10.1134\/S0006297922140139","volume":"87","author":"WB Minich","year":"2022","unstructured":"Minich WB (2022) Selenium Metabolism and Biosynthesis of Selenoproteins in the Human Body. Biochem Mosc 87:S168\u2013S177. https:\/\/doi.org\/10.1134\/S0006297922140139","journal-title":"Biochem Mosc"},{"key":"5132_CR80","first-page":"319","volume-title":"Anion Channels and Transporters","author":"ER Geertsma","year":"2024","unstructured":"Geertsma ER, Oliver D (2024) SLC26 Anion Transporters. In: Fahlke C (ed) Anion Channels and Transporters. Springer International Publishing, Cham, pp 319\u2013360"},{"key":"5132_CR81","doi-asserted-by":"publisher","first-page":"e70250","DOI":"10.1111\/1541-4337.70250","volume":"24","author":"H Li","year":"2025","unstructured":"Li H, Liu H, Tang X et al (2025) From Soil to Table: A Comprehensive Review of Selenium-Fortified Foods. Compr Rev Food Sci Food Saf 24:e70250. https:\/\/doi.org\/10.1111\/1541-4337.70250","journal-title":"Compr Rev Food Sci Food Saf"},{"key":"5132_CR82","doi-asserted-by":"publisher","first-page":"2126","DOI":"10.1017\/S0007114512004412","volume":"109","author":"C Thiry","year":"2013","unstructured":"Thiry C, Ruttens A, Pussemier L, Schneider Y-J (2013) An in vitro investigation of species-dependent intestinal transport of selenium and the impact of this process on selenium bioavailability. Br J Nutr 109:2126\u20132134. https:\/\/doi.org\/10.1017\/S0007114512004412","journal-title":"Br J Nutr"},{"key":"5132_CR83","doi-asserted-by":"publisher","first-page":"834","DOI":"10.3390\/antiox12040834","volume":"12","author":"H V\u00e1zquez-Meza","year":"2023","unstructured":"V\u00e1zquez-Meza H, Vilchis-Landeros MM, V\u00e1zquez-Carrada M et al (2023) Cellular Compartmentalization, Glutathione Transport and Its Relevance in Some Pathologies. Antioxidants 12:834. https:\/\/doi.org\/10.3390\/antiox12040834","journal-title":"Antioxidants"},{"key":"5132_CR84","doi-asserted-by":"publisher","first-page":"e70275","DOI":"10.1111\/1751-7915.70275","volume":"18","author":"G Laz\u00faen-L\u00f3pez","year":"2025","unstructured":"Laz\u00faen-L\u00f3pez G, P\u00e9rez-Muelas E, Ruiz-Fresneda MA et al (2025) Subcellular Mechanisms of Se(IV) Reduction in Stenotrophomonas bentonitica: Linking Environmental Detoxification and Antimicrobial Activity of Se Nanostructures Within a Circular Economy Framework. Microb Biotechnol 18:e70275. https:\/\/doi.org\/10.1111\/1751-7915.70275","journal-title":"Microb Biotechnol"},{"key":"5132_CR85","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/s41580-024-00730-2","volume":"25","author":"H Sies","year":"2024","unstructured":"Sies H, Mailloux RJ, Jakob U (2024) Fundamentals of redox regulation in biology. Nat Rev Mol Cell Biol 25:701\u2013719. https:\/\/doi.org\/10.1038\/s41580-024-00730-2","journal-title":"Nat Rev Mol Cell Biol"},{"key":"5132_CR86","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1089\/ars.2010.3275","volume":"14","author":"SJ Fairweather-Tait","year":"2011","unstructured":"Fairweather-Tait SJ, Bao Y, Broadley MR et al (2011) Selenium in Human Health and Disease. Antioxid Redox Signal 14:1337\u20131383. https:\/\/doi.org\/10.1089\/ars.2010.3275","journal-title":"Antioxid Redox Signal"},{"key":"5132_CR87","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3390\/medicina61010003","volume":"61","author":"Z Bir\u0123ele","year":"2025","unstructured":"Bir\u0123ele Z, Vimba PM, \u0160ev\u010denko A et al (2025) The Association of Plasma Selenium and Selenoprotein P Levels with Depression Severity and Anxiety Symptoms Among Medical Students in Latvia. Med (Mex) 61:3. https:\/\/doi.org\/10.3390\/medicina61010003","journal-title":"Med (Mex)"},{"key":"5132_CR88","doi-asserted-by":"publisher","first-page":"2993","DOI":"10.1007\/s12011-023-03900-z","volume":"202","author":"K Pyrzynska","year":"2024","unstructured":"Pyrzynska K, Sentkowska A (2024) Selenium Species in Diabetes Mellitus Type 2. Biol Trace Elem Res 202:2993\u20133004. https:\/\/doi.org\/10.1007\/s12011-023-03900-z","journal-title":"Biol Trace Elem Res"},{"key":"5132_CR89","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.3390\/jcm14041274","volume":"14","author":"G Batyrova","year":"2025","unstructured":"Batyrova G, Taskozhina G, Umarova G et al (2025) Unveiling the Role of Selenium in Child Development: Impacts on Growth, Neurodevelopment and Immunity. J Clin Med 14:1274. https:\/\/doi.org\/10.3390\/jcm14041274","journal-title":"J Clin Med"},{"key":"5132_CR90","doi-asserted-by":"publisher","unstructured":"Saito Y (2022) Essential trace element selenium and redox regulation: its metabolism, physiological function, and related diseases. Redox Exp Med 2022:R149\u2013R158. https:\/\/doi.org\/10.1530\/REM-22-0010","DOI":"10.1530\/REM-22-0010"},{"key":"5132_CR91","doi-asserted-by":"publisher","first-page":"123981","DOI":"10.1016\/j.lfs.2025.123981","volume":"381","author":"A Mohsenzadeh","year":"2025","unstructured":"Mohsenzadeh A, Pourasgar S, Mohammadi A et al (2025) The gut microbiota and cardiovascular disease: Exploring the role of microbial dysbiosis and metabolites in pathogenesis and therapeutics. Life Sci 381:123981. https:\/\/doi.org\/10.1016\/j.lfs.2025.123981","journal-title":"Life Sci"},{"key":"5132_CR92","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1007\/s00018-021-04060-w","volume":"79","author":"A Chakrabarti","year":"2022","unstructured":"Chakrabarti A, Geurts L, Hoyles L et al (2022) The microbiota-gut-brain axis: pathways to better brain health. Perspectives on what we know, what we need to investigate and how to put knowledge into practice. Cell Mol Life Sci CMLS 79:80. https:\/\/doi.org\/10.1007\/s00018-021-04060-w","journal-title":"Cell Mol Life Sci CMLS"},{"key":"5132_CR93","doi-asserted-by":"publisher","unstructured":"Fu Y, Lyu J, Wang S (2023) The role of intestinal microbes on intestinal barrier function and host immunity from a metabolite perspective. Front Immunol 14. https:\/\/doi.org\/10.3389\/fimmu.2023.1277102","DOI":"10.3389\/fimmu.2023.1277102"},{"key":"5132_CR94","doi-asserted-by":"publisher","first-page":"e220111","DOI":"10.1530\/JOE-22-0111","volume":"256","author":"S Fujisaka","year":"2023","unstructured":"Fujisaka S, Watanabe Y, Tobe K (2023) The gut microbiome: a core regulator of metabolism. J Endocrinol 256:e220111. https:\/\/doi.org\/10.1530\/JOE-22-0111","journal-title":"J Endocrinol"},{"key":"5132_CR95","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.tjnut.2023.12.021","volume":"154","author":"Y-Q Yan","year":"2024","unstructured":"Yan Y-Q, Liu M, Xu Z-J et al (2024) Optimum Doses and Forms of Selenium Maintaining Reproductive Health via Regulating Homeostasis of Gut Microbiota and Testicular Redox, Inflammation, Cell Proliferation, and Apoptosis in Roosters. J Nutr 154:369\u2013380. https:\/\/doi.org\/10.1016\/j.tjnut.2023.12.021","journal-title":"J Nutr"},{"key":"5132_CR96","doi-asserted-by":"publisher","first-page":"741294","DOI":"10.1016\/j.aquaculture.2024.741294","volume":"593","author":"X Shang","year":"2024","unstructured":"Shang X, Geng L, Wei H et al (2024) Selenium-enriched Lactobacillus plantarum alleviate of high alkalinity-induced microbiota-gut-blood systems affect by improving the gut microbiota. Aquaculture 593:741294. https:\/\/doi.org\/10.1016\/j.aquaculture.2024.741294","journal-title":"Aquaculture"},{"key":"5132_CR97","doi-asserted-by":"publisher","first-page":"114089","DOI":"10.1016\/j.foodres.2024.114089","volume":"180","author":"S Liang","year":"2024","unstructured":"Liang S, Yu J, Zhao M et al (2024) In vitro digestion and fecal fermentation of selenocompounds: impact on gut microbiota, antioxidant activity, and short-chain fatty acids. Food Res Int 180:114089. https:\/\/doi.org\/10.1016\/j.foodres.2024.114089","journal-title":"Food Res Int"},{"key":"5132_CR98","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1038\/s41419-026-08466-x","volume":"17","author":"C Xia","year":"2026","unstructured":"Xia C, Sun X, Shao J et al (2026) Selenomethionine as a dual-mechanism ferroptosis inhibitor: selenium-supply-driven GPX4 biosynthesis beyond transsulfuration and reductive-capacity-mediated ROS scavenging independent of GPX4 activity. Cell Death Dis 17:224. https:\/\/doi.org\/10.1038\/s41419-026-08466-x","journal-title":"Cell Death Dis"},{"key":"5132_CR99","doi-asserted-by":"publisher","first-page":"e0065923","DOI":"10.1128\/spectrum.00659-23","volume":"11","author":"L Qiao","year":"2023","unstructured":"Qiao L, Dou X, Song X et al (2023) Selenite Bioremediation by Food-Grade Probiotic Lactobacillus casei ATCC 393: Insights from Proteomics Analysis. Microbiol Spectr 11:e0065923. https:\/\/doi.org\/10.1128\/spectrum.00659-23","journal-title":"Microbiol Spectr"},{"key":"5132_CR100","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/15476286.2025.2472448","volume":"22","author":"N Peiter","year":"2025","unstructured":"Peiter N, Einert A, Just P et al (2025) Defining the methanogenic SECIS element in vivo by targeted mutagenesis. RNA Biol 22:1\u201313. https:\/\/doi.org\/10.1080\/15476286.2025.2472448","journal-title":"RNA Biol"},{"key":"5132_CR101","doi-asserted-by":"publisher","unstructured":"Cai J, Su W, Chen X, Zheng H (2022) Advances in the study of selenium and human intestinal bacteria. Front Nutr 9. https:\/\/doi.org\/10.3389\/fnut.2022.1059358","DOI":"10.3389\/fnut.2022.1059358"},{"key":"5132_CR102","doi-asserted-by":"publisher","unstructured":"Luo L, Hou X, Yi D et al (2025) Selenium-Enriched Microorganisms: Metabolism, Production, and Applications. Microorganisms 13. https:\/\/doi.org\/10.3390\/microorganisms13081849","DOI":"10.3390\/microorganisms13081849"},{"key":"5132_CR103","doi-asserted-by":"publisher","unstructured":"Shahidin, Wang Y, Wu Y et al (2025) Selenium and Selenoproteins: Mechanisms, Health Functions, and Emerging Applications. Molecules 30. https:\/\/doi.org\/10.3390\/molecules30030437","DOI":"10.3390\/molecules30030437"},{"key":"5132_CR104","doi-asserted-by":"publisher","first-page":"3239","DOI":"10.1038\/s41598-017-03558-3","volume":"7","author":"D Song","year":"2017","unstructured":"Song D, Li X, Cheng Y et al (2017) Aerobic biogenesis of selenium nanoparticles by Enterobacter cloacae Z0206 as a consequence of fumarate reductase mediated selenite reduction. Sci Rep 7:3239. https:\/\/doi.org\/10.1038\/s41598-017-03558-3","journal-title":"Sci Rep"},{"key":"5132_CR105","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1007\/s00284-009-9358-2","volume":"58","author":"WJ Hunter","year":"2009","unstructured":"Hunter WJ, Manter DK (2009) Reduction of selenite to elemental red selenium by Pseudomonas sp. Strain CA5. Curr Microbiol 58:493\u2013498. https:\/\/doi.org\/10.1007\/s00284-009-9358-2","journal-title":"Curr Microbiol"},{"key":"5132_CR106","doi-asserted-by":"publisher","first-page":"124690","DOI":"10.1016\/j.jhazmat.2020.124690","volume":"406","author":"S Huang","year":"2021","unstructured":"Huang S, Wang Y, Tang C et al (2021) Speeding up selenite bioremediation using the highly selenite-tolerant strain Providencia rettgeri HF16-A novel mechanism of selenite reduction based on proteomic analysis. J Hazard Mater 406:124690. https:\/\/doi.org\/10.1016\/j.jhazmat.2020.124690","journal-title":"J Hazard Mater"},{"key":"5132_CR107","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1042\/BST20120087","volume":"40","author":"CS Butler","year":"2012","unstructured":"Butler CS, Debieux CM, Dridge EJ et al (2012) Biomineralization of selenium by the selenate-respiring bacterium Thauera selenatis. Biochem Soc Trans 40:1239\u20131243. https:\/\/doi.org\/10.1042\/BST20120087","journal-title":"Biochem Soc Trans"},{"key":"5132_CR108","doi-asserted-by":"publisher","first-page":"133850","DOI":"10.1016\/j.jhazmat.2024.133850","volume":"468","author":"B Zhong","year":"2024","unstructured":"Zhong B, Xu W, Gong M et al (2024) Molecular mechanisms of selenite reduction by Lactiplantibacillus plantarum BSe: An integrated genomic and transcriptomic analysis. J Hazard Mater 468:133850. https:\/\/doi.org\/10.1016\/j.jhazmat.2024.133850","journal-title":"J Hazard Mater"},{"key":"5132_CR109","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1002\/biof.5520260305","volume":"26","author":"AM Abdou","year":"2006","unstructured":"Abdou AM, Higashiguchi S, Horie K et al (2006) Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans. BioFactors 26:201\u2013208. https:\/\/doi.org\/10.1002\/biof.5520260305","journal-title":"BioFactors"},{"key":"5132_CR110","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/s41538-022-00145-3","volume":"6","author":"L Qiao","year":"2022","unstructured":"Qiao L, Zhang X, Pi S et al (2022) Dietary supplementation with biogenic selenium nanoparticles alleviate oxidative stress-induced intestinal barrier dysfunction. Npj Sci Food 6:30. https:\/\/doi.org\/10.1038\/s41538-022-00145-3","journal-title":"Npj Sci Food"},{"key":"5132_CR111","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.jff.2016.06.032","volume":"25","author":"J Fern\u00e1ndez","year":"2016","unstructured":"Fern\u00e1ndez J, Redondo-Blanco S, Guti\u00e9rrez-del-R\u00edo I et al (2016) Colon microbiota fermentation of dietary prebiotics towards short-chain fatty acids and their roles as anti-inflammatory and antitumour agents: A review. J Funct Foods 25:511\u2013522. https:\/\/doi.org\/10.1016\/j.jff.2016.06.032","journal-title":"J Funct Foods"},{"key":"5132_CR112","doi-asserted-by":"publisher","first-page":"fuad039","DOI":"10.1093\/femsre\/fuad039","volume":"47","author":"R Mart\u00edn","year":"2023","unstructured":"Mart\u00edn R, Rios-Covian D, Huillet E et al (2023) Faecalibacterium: a bacterial genus with promising human health applications. FEMS Microbiol Rev 47:fuad039. https:\/\/doi.org\/10.1093\/femsre\/fuad039","journal-title":"FEMS Microbiol Rev"},{"key":"5132_CR113","doi-asserted-by":"publisher","first-page":"fiaf054","DOI":"10.1093\/femsec\/fiaf054","volume":"101","author":"JN Z\u00fcnd","year":"2025","unstructured":"Z\u00fcnd JN, Caflisch M, Mujezinovic D et al (2025) Deciphering oxidative stress responses in human gut microbes and fecal microbiota: a cultivation-based approach. FEMS Microbiol Ecol 101:fiaf054. https:\/\/doi.org\/10.1093\/femsec\/fiaf054","journal-title":"FEMS Microbiol Ecol"},{"key":"5132_CR114","doi-asserted-by":"publisher","first-page":"2492","DOI":"10.1096\/fj.11-181990","volume":"25","author":"MV Kasaikina","year":"2011","unstructured":"Kasaikina MV, Kravtsova MA, Lee BC et al (2011) Dietary selenium affects host selenoproteome expression by influencing the gut microbiota. FASEB J 25:2492\u20132499. https:\/\/doi.org\/10.1096\/fj.11-181990","journal-title":"FASEB J"},{"key":"5132_CR115","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1039\/C8MT00142A","volume":"10","author":"J Wang","year":"2018","unstructured":"Wang J, Liu Z, He X et al (2018) Selenium deficiency induces duodenal villi cell apoptosis via an oxidative stress-induced mitochondrial apoptosis pathway and an inflammatory signaling-induced death receptor pathway. Metallomics 10:1390\u20131400. https:\/\/doi.org\/10.1039\/C8MT00142A","journal-title":"Metallomics"},{"key":"5132_CR116","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/978-981-13-8763-0_4","volume-title":"Oxidative Stress in Microbial Diseases","author":"B Dam","year":"2019","unstructured":"Dam B, Misra A, Banerjee S (2019) Role of Gut Microbiota in Combating Oxidative Stress. In: Chakraborti S, Chakraborti T, Chattopadhyay D, Shaha C (eds) Oxidative Stress in Microbial Diseases. Springer, Singapore, pp 43\u201382"},{"key":"5132_CR117","doi-asserted-by":"publisher","first-page":"2323","DOI":"10.4103\/NRR.NRR-D-24-00468","volume":"20","author":"P Chakraborty","year":"2025","unstructured":"Chakraborty P, Laird AS (2025) Understanding activity of butyrate at a cellular level. Neural Regen Res 20:2323\u20132324. https:\/\/doi.org\/10.4103\/NRR.NRR-D-24-00468","journal-title":"Neural Regen Res"},{"key":"5132_CR118","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1111\/febs.17005","volume":"291","author":"SS Pedersen","year":"2024","unstructured":"Pedersen SS, Ingerslev LR, Olsen M et al (2024) Butyrate functions as a histone deacetylase inhibitor to protect pancreatic beta cells from IL-1\u03b2-induced dysfunction. FEBS J 291:566\u2013583. https:\/\/doi.org\/10.1111\/febs.17005","journal-title":"FEBS J"},{"key":"5132_CR119","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1186\/s12887-025-05635-3","volume":"25","author":"Y Zhao","year":"2025","unstructured":"Zhao Y, Xu X, Liu S et al (2025) Butyrate inhibits histone deacetylase 2 expression to alleviate liver fibrosis in biliary atresia. BMC Pediatr 25:286. https:\/\/doi.org\/10.1186\/s12887-025-05635-3","journal-title":"BMC Pediatr"},{"key":"5132_CR120","doi-asserted-by":"publisher","unstructured":"Parada Venegas D, De la Fuente MK, Landskron G et al (2019) Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases. Front Immunol 10. https:\/\/doi.org\/10.3389\/fimmu.2019.00277","DOI":"10.3389\/fimmu.2019.00277"},{"key":"5132_CR121","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.1111\/jgh.15970","volume":"37","author":"K Peng","year":"2022","unstructured":"Peng K, Xia S, Xiao S, Yu Q (2022) Short-chain fatty acids affect the development of inflammatory bowel disease through intestinal barrier, immunology, and microbiota: A promising therapy? J Gastroenterol Hepatol 37:1710\u20131718. https:\/\/doi.org\/10.1111\/jgh.15970","journal-title":"J Gastroenterol Hepatol"},{"key":"5132_CR122","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1038\/nature12721","volume":"504","author":"Y Furusawa","year":"2013","unstructured":"Furusawa Y, Obata Y, Fukuda S et al (2013) Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature 504:446\u2013450. https:\/\/doi.org\/10.1038\/nature12721","journal-title":"Nature"},{"key":"5132_CR123","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s10534-022-00468-4","volume":"36","author":"H Yujiao","year":"2023","unstructured":"Yujiao H, Xinyu T, Xue F et al (2023) Selenium deficiency increased duodenal permeability and decreased expression of antimicrobial peptides by activating ROS\/NF-\u03baB signal pathway in chickens. Biometals Int J Role Met Ions Biol Biochem Med 36:137\u2013152. https:\/\/doi.org\/10.1007\/s10534-022-00468-4","journal-title":"Biometals Int J Role Met Ions Biol Biochem Med"},{"key":"5132_CR124","doi-asserted-by":"publisher","first-page":"mfad028","DOI":"10.1093\/mtomcs\/mfad028","volume":"15","author":"L Lei","year":"2023","unstructured":"Lei L, Jing M, Yingce Z et al (2023) Selenium deficiency causes oxidative stress and activates inflammation, apoptosis, and necroptosis in the intestine of weaned calves. Met Integr Biometal Sci 15:mfad028. https:\/\/doi.org\/10.1093\/mtomcs\/mfad028","journal-title":"Met Integr Biometal Sci"},{"key":"5132_CR125","doi-asserted-by":"publisher","unstructured":"Duncan SH, Conti E, Ricci L, Walker AW (2023) Links between Diet, Intestinal Anaerobes, Microbial Metabolites and Health. Biomedicines 11(5):1338. https:\/\/doi.org\/10.3390\/biomedicines11051338","DOI":"10.3390\/biomedicines11051338"},{"key":"5132_CR126","doi-asserted-by":"publisher","first-page":"1675065","DOI":"10.3389\/fmicb.2025.1675065","volume":"16","author":"L Zeng","year":"2025","unstructured":"Zeng L, Qian Y, Cui X et al (2025) Immunomodulatory role of gut microbial metabolites: mechanistic insights and therapeutic frontiers. Front Microbiol 16:1675065. https:\/\/doi.org\/10.3389\/fmicb.2025.1675065","journal-title":"Front Microbiol"},{"key":"5132_CR127","doi-asserted-by":"publisher","first-page":"2515","DOI":"10.1038\/ismej.2015.64","volume":"9","author":"CCR Smith","year":"2015","unstructured":"Smith CCR, Snowberg LK, Gregory Caporaso J et al (2015) Dietary input of microbes and host genetic variation shape among-population differences in stickleback gut microbiota. ISME J 9:2515\u20132526. https:\/\/doi.org\/10.1038\/ismej.2015.64","journal-title":"ISME J"},{"key":"5132_CR128","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.humic.2018.01.001","volume":"7\u20138","author":"B Senghor","year":"2018","unstructured":"Senghor B, Sokhna C, Ruimy R, Lagier J-C (2018) Gut microbiota diversity according to dietary habits and geographical provenance. Hum Microbiome J 7\u20138:1\u20139. https:\/\/doi.org\/10.1016\/j.humic.2018.01.001","journal-title":"Hum Microbiome J"},{"key":"5132_CR129","doi-asserted-by":"publisher","first-page":"113151","DOI":"10.1016\/j.envres.2022.113151","volume":"212","author":"PJ Ankley","year":"2022","unstructured":"Ankley PJ, Graves SD, Xie Y et al (2022) Effects of in situ experimental selenium exposure on finescale dace (Phoxinus neogaeus) gut microbiome. Environ Res 212:113151. https:\/\/doi.org\/10.1016\/j.envres.2022.113151","journal-title":"Environ Res"},{"key":"5132_CR130","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s41021-021-00220-3","volume":"43","author":"Z-X Zhang","year":"2021","unstructured":"Zhang Z-X, Xiang H, Sun G-G et al (2021) Effect of dietary selenium intake on gut microbiota in older population in Enshi region. Genes Environ Off J Jpn Environ Mutagen Soc 43:56. https:\/\/doi.org\/10.1186\/s41021-021-00220-3","journal-title":"Genes Environ Off J Jpn Environ Mutagen Soc"},{"key":"5132_CR131","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1186\/s12866-025-03909-5","volume":"25","author":"L Su","year":"2025","unstructured":"Su L, Yi H, Xu E et al (2025) Colonic bacterial community responding to selenium-enriched yeast supplementation associated with improved gut mucus function in growing-finishing pigs. BMC Microbiol 25:213. https:\/\/doi.org\/10.1186\/s12866-025-03909-5","journal-title":"BMC Microbiol"},{"key":"5132_CR132","doi-asserted-by":"publisher","first-page":"1291010","DOI":"10.3389\/fmicb.2023.1291010","volume":"14","author":"S Jiang","year":"2023","unstructured":"Jiang S, Zhang B, Fan X et al (2023) Gut microbiome predicts selenium supplementation efficiency across different Chinese adult cohorts using hybrid modeling and feature refining. Front Microbiol 14:1291010. https:\/\/doi.org\/10.3389\/fmicb.2023.1291010","journal-title":"Front Microbiol"},{"key":"5132_CR133","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1079\/PHN2001143","volume":"4","author":"KM Brown","year":"2001","unstructured":"Brown KM, Arthur JR (2001) Selenium, selenoproteins and human health: a review. Public Health Nutr 4:593\u2013599. https:\/\/doi.org\/10.1079\/PHN2001143","journal-title":"Public Health Nutr"},{"key":"5132_CR134","doi-asserted-by":"publisher","unstructured":"Zhang Y, Wang Y, Li B, Selenoprotein H et al Functions as a PPAR\u03b1 Coactivator to Link Selenium Homeostasis to Hepatic Lipid Metabolism and Protect against Steatohepatitis. Adv Sci n\/a e19563. https:\/\/doi.org\/10.1002\/advs.202519563","DOI":"10.1002\/advs.202519563"},{"key":"5132_CR135","doi-asserted-by":"publisher","first-page":"e40139","DOI":"10.1016\/j.heliyon.2024.e40139","volume":"10","author":"S Liu","year":"2024","unstructured":"Liu S, Lin T, Wang W et al (2024) Selenium deficiency in inflammatory bowel disease: A comprehensive meta-analysis. Heliyon 10:e40139. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e40139","journal-title":"Heliyon"},{"key":"5132_CR136","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.3390\/biomedicines12102167","volume":"12","author":"M Chalcarz","year":"2024","unstructured":"Chalcarz M, Grabarek BO, Sirek T et al (2024) Evaluation of Selenium Concentrations in Patients with Crohn\u2019s Disease and Ulcerative Colitis. Biomedicines 12:2167. https:\/\/doi.org\/10.3390\/biomedicines12102167","journal-title":"Biomedicines"},{"key":"5132_CR137","doi-asserted-by":"publisher","first-page":"3461","DOI":"10.1007\/s12011-022-03442-w","volume":"201","author":"Y He","year":"2023","unstructured":"He Y, Peng L, Zhao X et al (2023) Selenium Deficiency Induces Inflammatory Response and Decreased Antimicrobial Peptide Expression in Chicken Jejunum Through Oxidative Stress. Biol Trace Elem Res 201:3461\u20133473. https:\/\/doi.org\/10.1007\/s12011-022-03442-w","journal-title":"Biol Trace Elem Res"},{"key":"5132_CR138","doi-asserted-by":"publisher","first-page":"947655","DOI":"10.3389\/fimmu.2022.947655","volume":"13","author":"F Wang","year":"2022","unstructured":"Wang F, Sun N, Zeng H et al (2022) Selenium Deficiency Leads to Inflammation, Autophagy, Endoplasmic Reticulum Stress, Apoptosis and Contraction Abnormalities via Affecting Intestinal Flora in Intestinal Smooth Muscle of Mice. Front Immunol 13:947655. https:\/\/doi.org\/10.3389\/fimmu.2022.947655","journal-title":"Front Immunol"},{"key":"5132_CR139","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2023.1228283","author":"K Iyer","year":"2023","unstructured":"Iyer K, Erkert L, Becker C (2023) Know your neighbors: microbial recognition at the intestinal barrier and its implications for gut homeostasis and inflammatory bowel disease. Front Cell Dev Biol 11:1228283. https:\/\/doi.org\/10.3389\/fcell.2023.1228283","journal-title":"Front Cell Dev Biol"},{"key":"5132_CR140","doi-asserted-by":"publisher","first-page":"G6","DOI":"10.1152\/ajpgi.00275.2006","volume":"292","author":"IR Sanderson","year":"2007","unstructured":"Sanderson IR, Walker WA (2007) TLRs in the Gut I. The role of TLRs\/Nods in intestinal development and homeostasis. Am J Physiol Gastrointest Liver Physiol 292:G6\u201310. https:\/\/doi.org\/10.1152\/ajpgi.00275.2006","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"5132_CR141","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1007\/s10753-013-9761-5","volume":"37","author":"W Zhang","year":"2014","unstructured":"Zhang W, Zhang R, Wang T et al (2014) Selenium Inhibits LPS-Induced Pro-inflammatory Gene Expression by Modulating MAPK and NF-\u03baB Signaling Pathways in Mouse Mammary Epithelial Cells in Primary Culture. Inflammation 37:478\u2013485. https:\/\/doi.org\/10.1007\/s10753-013-9761-5","journal-title":"Inflammation"},{"key":"5132_CR142","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s12026-025-09650-5","volume":"73","author":"X Xiao","year":"2025","unstructured":"Xiao X, Xiang R, Liu J et al (2025) The mechanism of p38 MAPK, NF-\u03baB, and IL-6 in T-2 toxin and\/or selenium deficiency induced spleen injury. Immunol Res 73:93. https:\/\/doi.org\/10.1007\/s12026-025-09650-5","journal-title":"Immunol Res"},{"key":"5132_CR143","doi-asserted-by":"publisher","first-page":"3850","DOI":"10.3748\/wjg.v23.i21.3850","volume":"23","author":"L-X Sang","year":"2017","unstructured":"Sang L-X, Chang B, Zhu J-F et al (2017) Sodium selenite ameliorates dextran sulfate sodium-induced chronic colitis in mice by decreasing Th1, Th17, and \u03b3\u03b4T and increasing CD4(+)CD25(+) regulatory T-cell responses. World J Gastroenterol 23:3850\u20133863. https:\/\/doi.org\/10.3748\/wjg.v23.i21.3850","journal-title":"World J Gastroenterol"},{"key":"5132_CR144","doi-asserted-by":"publisher","first-page":"4234061","DOI":"10.1155\/2016\/4234061","volume":"2016","author":"S Li","year":"2016","unstructured":"Li S, Hong M, Tan H-Y et al (2016) Insights into the Role and Interdependence of Oxidative Stress and Inflammation in Liver Diseases. Oxid Med Cell Longev 2016:4234061. https:\/\/doi.org\/10.1155\/2016\/4234061","journal-title":"Oxid Med Cell Longev"},{"key":"5132_CR145","doi-asserted-by":"publisher","unstructured":"Allameh A, Niayesh-Mehr R, Aliarab A et al (2023) Oxidative Stress in Liver Pathophysiology and Disease. Antioxidants 12(9):1653. https:\/\/doi.org\/10.3390\/antiox12091653","DOI":"10.3390\/antiox12091653"},{"key":"5132_CR146","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s42000-019-00127-3","volume":"19","author":"SA Polyzos","year":"2020","unstructured":"Polyzos SA, Kountouras J, Goulas A, Duntas L (2020) Selenium and selenoprotein P in nonalcoholic fatty liver disease. Hormones 19:61\u201372. https:\/\/doi.org\/10.1007\/s42000-019-00127-3","journal-title":"Hormones"},{"key":"5132_CR147","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/s41419-022-04716-w","volume":"13","author":"L Qiao","year":"2022","unstructured":"Qiao L, Men L, Yu S et al (2022) Hepatic deficiency of selenoprotein S exacerbates hepatic steatosis and insulin resistance. Cell Death Dis 13:275. https:\/\/doi.org\/10.1038\/s41419-022-04716-w","journal-title":"Cell Death Dis"},{"key":"5132_CR148","doi-asserted-by":"publisher","first-page":"952","DOI":"10.3390\/nu14050952","volume":"14","author":"Y Lin","year":"2022","unstructured":"Lin Y, He F, Lian S et al (2022) Selenium Status in Patients with Chronic Liver Disease: A Systematic Review and Meta-Analysis. Nutrients 14:952. https:\/\/doi.org\/10.3390\/nu14050952","journal-title":"Nutrients"},{"key":"5132_CR149","doi-asserted-by":"publisher","first-page":"619","DOI":"10.3390\/nu13020619","volume":"13","author":"S G\u00fcl-Klein","year":"2021","unstructured":"G\u00fcl-Klein S, Haxhiraj D, Seelig J et al (2021) Serum Selenium Status as a Diagnostic Marker for the Prognosis of Liver Transplantation. Nutrients 13:619. https:\/\/doi.org\/10.3390\/nu13020619","journal-title":"Nutrients"},{"key":"5132_CR150","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.aohep.2020.07.006","volume":"19","author":"M Reja","year":"2020","unstructured":"Reja M, Makar M, Visaria A et al (2020) Increased serum selenium levels are associated with reduced risk of advanced liver fibrosis and all-cause mortality in NAFLD patients: National Health and Nutrition Examination Survey (NHANES) III. Ann Hepatol 19:635\u2013640. https:\/\/doi.org\/10.1016\/j.aohep.2020.07.006","journal-title":"Ann Hepatol"},{"key":"5132_CR151","doi-asserted-by":"publisher","first-page":"146","DOI":"10.15430\/JCP.2019.24.3.146","volume":"24","author":"A Yildiz","year":"2019","unstructured":"Yildiz A, Kaya Y, Tanriverdi O (2019) Effect of the Interaction Between Selenium and Zinc on DNA Repair in Association With Cancer Prevention. J Cancer Prev 24:146\u2013154. https:\/\/doi.org\/10.15430\/JCP.2019.24.3.146","journal-title":"J Cancer Prev"},{"key":"5132_CR152","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.2174\/138955708785740625","volume":"8","author":"C Sanmart\u00edn","year":"2008","unstructured":"Sanmart\u00edn C, Plano D, Palop JA (2008) Selenium compounds and apoptotic modulation: a new perspective in cancer therapy. Mini Rev Med Chem 8:1020\u20131031. https:\/\/doi.org\/10.2174\/138955708785740625","journal-title":"Mini Rev Med Chem"},{"key":"5132_CR153","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1093\/mutage\/ges064","volume":"28","author":"S Bera","year":"2013","unstructured":"Bera S, De Rosa V, Rachidi W, Diamond AM (2013) Does a role for selenium in DNA damage repair explain apparent controversies in its use in chemoprevention? Mutagenesis 28:127\u2013134. https:\/\/doi.org\/10.1093\/mutage\/ges064","journal-title":"Mutagenesis"}],"container-title":["Biological Trace Element Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-026-05132-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12011-026-05132-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-026-05132-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T06:38:07Z","timestamp":1785825487000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12011-026-05132-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,1]]},"references-count":153,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["5132"],"URL":"https:\/\/doi.org\/10.1007\/s12011-026-05132-3","relation":{},"ISSN":["1559-0720"],"issn-type":[{"value":"1559-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,1]]},"assertion":[{"value":"19 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The author declare that the research presented does not involve any animal or human study.","order":1,"name":"Ethics","label":"Ethical statement","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}