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This study evaluated the potential effects of newly synthesized boron arginine monoester (BAM) and boron arginine diester (BAD) in B16-F10 melanoma cell line. Following 48\u00a0h of incubation, the IC\u2085\u2080 values of BAM and BAD were 5.97\u00a0mM and 51.9\u00a0\u00b5M, respectively, suggesting relatively low cytotoxic effects under the tested conditions. Both compounds were associated with changes in apoptosis-related markers, such as an increased Bax\/Bcl-2 ratio and upregulation of p53 expression, suggesting a possible involvement of apoptosis-related processes. In addition, they exhibited modulatory effects on cytokine levels, including TNF-\u03b1, IL-6, and IL-10, depending on the treatment conditions. BAM and BAD exhibited antimicrobial activity against both Gram-positive and Gram-negative bacteria (MIC: 3.12\u201312.5\u00a0\u00b5g\/mL; MBC: 12.5\u201350\u00a0\u00b5g\/mL). These findings are presented for completeness, while the primary focus of this study remains on the compounds\u2019 effects on melanoma cells, apoptosis, and cytokine modulation. Overall, these findings indicate that BAM and BAD possess apoptotic, anti-inflammatory, and antimicrobial properties, suggesting their potential as multifunctional agents in melanoma treatment. Further studies are required to elucidate their mechanisms of action in different models and to evaluate their long-term therapeutic efficacy.<\/jats:p>","DOI":"10.1007\/s12011-026-05172-9","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T10:19:15Z","timestamp":1780741155000},"page":"7054-7069","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Novel Boron\u2013Arginine Derivatives Induce Apoptosis and Exhibit Anti-Inflammatory and Antimicrobial Activities in B16-F10 Melanoma Cells"],"prefix":"10.1007","volume":"204","author":[{"given":"Meliha","family":"Koldemir-G\u00fcnd\u00fcz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aynabat","family":"Esenjanaova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif","family":"Ayd\u0131n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcll\u00fc","family":"Kaymak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015fe","family":"Ko\u00e7ak-Sezgin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dursun Ali","family":"K\u00f6se","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,6]]},"reference":[{"issue":"1","key":"5172_CR1","first-page":"5","volume":"65","author":"RL Siegel","year":"2015","unstructured":"Siegel RL et al (2015) Cancer statistics, 2015. 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