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This study evaluated the effects of late-gestation and early-lactation dietary chromium propionate in ewes on the expression of genes related to myogenesis and lipid metabolism in the progeny. Sixty-nine Dorper \u00d7 Santa In\u00eas ewes were assigned, in a randomized block design, to receive 0 (CR0), 0.5 (CR0.5), or 1.5\u00a0mg\/day (CR1.5) of chromium propionate per ewe from the last 50 days of gestation through the 80 days of lactation. Lambs received no supplemental Cr. After weaning, 18 single-born male lambs (approximately 80 days of age; 31.64\u2009\u00b1\u20096.07\u00a0kg) were finished in a feedlot for 52 days and slaughtered at 47.39\u2009\u00b1\u20097.15\u00a0kg. Samples of longissimus muscle, liver, and subcutaneous adipose tissue were collected for RT-qPCR analysis of MYOD, FASN, LPL, LIPE, IGF1, and IGFBP2. Maternal Cr supplementation altered (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05) offspring gene expression in a tissue- and dose-dependent manner. The CR1.5 treatment downregulated MYOD, FASN, LIPE, and IGF1 in skeletal muscle and liver, while upregulating LPL in muscle and IGFBP2 in liver (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05). In adipose tissue, LPL was upregulated by CR1.5, and LIPE by CR0.5 (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05). These changes are consistent with enhanced lipolysis in adipose tissue and a redirection of energy toward muscle deposition. In conclusion, chromium propionate administered to ewes during late gestation and lactation promotes fetal programming by modulating the expression of myogenic and lipid-metabolism genes in the liver, skeletal muscle, and adipose tissue of the offspring.\n                  <\/jats:p>","DOI":"10.1007\/s12011-026-05185-4","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T21:21:07Z","timestamp":1781817667000},"page":"7243-7250","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Influence of Chromium Propionate Supplementation in Ewes During the Gestational Phase on the Regulation of Genes Associated with Growth and Metabolism in the Offspring"],"prefix":"10.1007","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8313-0737","authenticated-orcid":false,"given":"Daniela L\u00e1zara","family":"de Almeida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5366-0836","authenticated-orcid":false,"given":"Helena Viel Alves","family":"Bezerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5046-1871","authenticated-orcid":false,"given":"Fl\u00e1via Mallaco","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5210-275X","authenticated-orcid":false,"given":"Paulo Roberto","family":"Leme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1883-4911","authenticated-orcid":false,"given":"Luis Orlindo","family":"Tedeschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3265-5090","authenticated-orcid":false,"given":"Heidge","family":"Fukumasu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7584-4548","authenticated-orcid":false,"given":"Sarita Bonagurio","family":"Gallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"5185_CR1","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/J.RVSC.2022.07.014","volume":"151","author":"ED Sartori","year":"2022","unstructured":"Sartori ED, Pereira GR, Barcellos JOJ (2022) Fetal programming in sheep: Effects on pre- and postnatal organs and glands development in lambs. 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Figures 1 and 2 are updated.","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2026","order":8,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":9,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":10,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s12011-026-05243-x","URL":"https:\/\/doi.org\/10.1007\/s12011-026-05243-x","order":11,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no use of generative AI.","order":1,"name":"Ethics","label":"Declaration of Generative AI Use","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing Interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}