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In biological systems, SeO\n                    <jats:sub>3<\/jats:sub>\n                    <jats:sup>2\u2212<\/jats:sup>\n                    undergoes multistep reduction, generating selenium species with distinct oxidation states and redox properties. In this study, we investigated the cardiovascular effects of a glutathione\/selenite mixture (GSH\/SeO\n                    <jats:sub>3<\/jats:sub>\n                    <jats:sup>2\u2212<\/jats:sup>\n                    ) in spontaneously hypertensive rats (SHRs). Arterial pulse waves were recorded using a pressure microcatheter and vascular tension in isolated arteries was assessed by isometric wire myography. Intravenous administration of GSH\/SeO\n                    <jats:sub>3<\/jats:sub>\n                    <jats:sup>2\u2212<\/jats:sup>\n                    induced a pronounced hypotensive response, accompanied by reductions in heart rate and augmentation index. Furthermore, GSH\/SeO\n                    <jats:sub>3<\/jats:sub>\n                    <jats:sup>2\u2212<\/jats:sup>\n                    elicited heterogeneous vasomotor responses across mesenteric, femoral, and aortic vascular beds. Marked vasorelaxation observed in the mesenteric artery, a representative resistance vessel, appeared to be associated with the formation of elemental selenium (Se\n                    <jats:sup>0<\/jats:sup>\n                    ) and was partially endothelium-independent. In contrast, aortic segments exhibited marked vasoconstriction. Notably, co-application of superoxide dismutase and catalase attenuated this response, suggesting that aortic segments are more sensitive to ROS generated during the GSH\/SeO\n                    <jats:sub>3<\/jats:sub>\n                    <jats:sup>2\u2212<\/jats:sup>\n                    interaction. The hypotensive effect of GSH\/SeO\n                    <jats:sub>3<\/jats:sub>\n                    <jats:sup>2\u2212<\/jats:sup>\n                    was preserved in SHRs pretreated with losartan and captopril, indicating additional antihypertensive efficacy beyond the pharmacological inhibition of renin-angiotensin-aldosterone system. Importantly, the hypotensive action of GSH\/SeO\n                    <jats:sub>3<\/jats:sub>\n                    <jats:sup>2\u2212<\/jats:sup>\n                    was dependent on sympathetic nervous system activity.\n                  <\/jats:p>","DOI":"10.1007\/s12011-026-05188-1","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T09:16:26Z","timestamp":1782292586000},"page":"7301-7319","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Glutathione\/Selenite Interaction Products as Potent Vascular Smooth Muscle Tone Modulators with Antihypertensive Effects in Spontaneously Hypertensive Rats"],"prefix":"10.1007","volume":"204","author":[{"given":"Lenka","family":"Tomasova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Balis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian","family":"Grman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Zemancikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sona","family":"Cacanyiova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslav","family":"Chovanec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karol","family":"Ondrias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Misak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"key":"5188_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11020251","author":"G Barchielli","year":"2022","unstructured":"Barchielli G, Capperucci A, Tanini D (2022) The role of selenium in pathologies: an updated review. 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