{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T08:34:25Z","timestamp":1793090065658,"version":"4.5.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Centre for Advanced Medical Research and Training, Usmanu Danfodiyo University Sokoto","id":[{"id":"https:\/\/ror.org\/006er0w72","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biol Trace Elem Res"],"DOI":"10.1007\/s12011-026-05259-3","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T04:23:41Z","timestamp":1784867021000},"page":"8313-8327","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Parental Iron Deficiency Programs Oxidative Stress and Epigenetic Demethylase Dysregulation (TET and KDM2) in Drosophila melanogaster Offspring"],"prefix":"10.1007","volume":"204","author":[{"given":"Farida","family":"Bashar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasimu Ghandi","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullahi Yahaya","family":"Abbas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Bashir","family":"Bello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustapha Umar","family":"Imam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliu Abdulhameed","family":"Zubair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"5259_CR1","doi-asserted-by":"publisher","unstructured":"Martelli A, Puccio H (2014) Dysregulation of cellular iron metabolism in Friedreich ataxia: From primary iron-sulfur cluster deficit to mitochondrial iron accumulation. Front Pharmacol Front Res Foundation. https:\/\/doi.org\/10.3389\/fphar.2014.00130","DOI":"10.3389\/fphar.2014.00130"},{"key":"5259_CR2","doi-asserted-by":"publisher","first-page":"134798","DOI":"10.1016\/J.IJBIOMAC.2024.134798","volume":"278","author":"S Yang","year":"2024","unstructured":"Yang S, Xing J, Liu D, Song Y, Yu H, Xu S, Zuo Y (2024) Review and new insights into the catalytic structural domains of the Fe(ll) and 2-Oxoglutarate families. Int J Biol Macromol 278:134798. https:\/\/doi.org\/10.1016\/J.IJBIOMAC.2024.134798","journal-title":"Int J Biol Macromol"},{"key":"5259_CR3","doi-asserted-by":"publisher","unstructured":"Ben Zichri- David S, Shkuri L, Ast T (2025) Pulling back the mitochondria\u2019s iron curtain. In NPJ Metabolic Health and Disease. Springer Nat 3(1). https:\/\/doi.org\/10.1038\/s44324-024-00045-y","DOI":"10.1038\/s44324-024-00045-y"},{"key":"5259_CR4","doi-asserted-by":"publisher","first-page":"102164","DOI":"10.1016\/J.REDOX.2021.102164","volume":"47","author":"AD Read","year":"2021","unstructured":"Read AD, Bentley RE, Archer SL, Dunham-Snary KJ (2021) Mitochondrial iron\u2013sulfur clusters: Structure, function, and an emerging role in vascular biology. Redox Biol 47:102164. https:\/\/doi.org\/10.1016\/J.REDOX.2021.102164","journal-title":"Redox Biol"},{"issue":"49","key":"5259_CR5","doi-asserted-by":"publisher","first-page":"3739","DOI":"10.14260\/jemds\/2020\/821","volume":"9","author":"R Sharma","year":"2020","unstructured":"Sharma R, Nachane H (2020) Oxidative stress in iron deficiency anaemia - a gender-based analysis. Pilot Study 9(49):3739\u20133742. https:\/\/doi.org\/10.14260\/jemds\/2020\/821","journal-title":"Pilot Study"},{"issue":"2","key":"5259_CR6","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1089\/ars.2010.3492","volume":"15","author":"AR Cyr","year":"2011","unstructured":"Cyr AR, Domann FE (2011) The Redox Basis of Epigenetic Modifications: From Mechanisms to Functional Consequences. Antioxid Redox Signal 15(2):551\u2013589. https:\/\/doi.org\/10.1089\/ars.2010.3492","journal-title":"Antioxid Redox Signal"},{"issue":"8","key":"5259_CR7","doi-asserted-by":"publisher","first-page":"3697","DOI":"10.1021\/ac500447w","volume":"86","author":"F Capuano","year":"2014","unstructured":"Capuano F, M\u00fclleder M, Kok R, Blom HJ, Ralser M (2014) Cytosine DNA methylation is found in drosophila melanogaster but absent in saccharomyces cerevisiae, schizosaccharomyces pombe, and other yeast species. Anal Chem 86(8):3697\u20133702. https:\/\/doi.org\/10.1021\/ac500447w","journal-title":"Anal Chem"},{"key":"5259_CR8","doi-asserted-by":"publisher","unstructured":"Deshmukh S, Abhyankar V, Vellarikkal SK, Sivasubbu S, Scaria V, Deobagkar D (2020) Genome-wide comparison of DNA methylation between life cycle stages of Drosophila melanogaster using high-throughput sequencing techniques. BioRxiv 20200106895920. https:\/\/doi.org\/10.1101\/2020.01.06.895920","DOI":"10.1101\/2020.01.06.895920"},{"issue":"21","key":"5259_CR9","doi-asserted-by":"publisher","first-page":"3357","DOI":"10.4161\/cc.26540","volume":"12","author":"TL Dunwell","year":"2013","unstructured":"Dunwell TL, McGuffn LJ, Dunwell JM, Pfeifer GP (2013) The mysterious presence of a 5-methylcytosine oxidase in the Drosophila genome: Possible explanations. Cell Cycle 12(21):3357\u20133365. https:\/\/doi.org\/10.4161\/cc.26540","journal-title":"Cell Cycle"},{"issue":"11","key":"5259_CR10","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1080\/15592294.2020.1767323","volume":"15","author":"JN Ismail","year":"2020","unstructured":"Ismail JN (2020) Ten-eleven translocation proteins and their role beyond DNA demethylation \u2013 what we can learn from the fly. Epigenetics 15(11):1139\u20131150. https:\/\/doi.org\/10.1080\/15592294.2020.1767323","journal-title":"Epigenetics"},{"key":"5259_CR11","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/B978-0-12-387685-0.00003-2","volume":"101","author":"V Krauss","year":"2011","unstructured":"Krauss V, Reuter G (2011) DNA Methylation in drosophila-a critical evaluation. Prog Mol Biol Transl Sci 101:177\u2013191. https:\/\/doi.org\/10.1016\/B978-0-12-387685-0.00003-2","journal-title":"Prog Mol Biol Transl Sci"},{"issue":"3","key":"5259_CR12","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1016\/j.celrep.2018.12.053","volume":"26","author":"G Xiao","year":"2019","unstructured":"Xiao G, Liu ZH, Zhao M, Wang HL, Zhou B (2019) Transferrin 1 Functions in Iron Trafficking and Genetically Interacts with Ferritin in Drosophila melanogaster. Cell Rep 26(3):748\u2013758e5. https:\/\/doi.org\/10.1016\/j.celrep.2018.12.053","journal-title":"Cell Rep"},{"issue":"5","key":"5259_CR13","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/J.CMET.2010.09.014","volume":"12","author":"RT Birse","year":"2010","unstructured":"Birse RT, Choi J, Reardon K, Rodriguez J, Graham S, Diop S, Ocorr K, Bodmer R, Oldham S (2010) High fat diet-induced obesity and heart dysfunction is regulated by the TOR pathway in Drosophila. Cell Metabol 12(5):533. https:\/\/doi.org\/10.1016\/J.CMET.2010.09.014","journal-title":"Cell Metabol"},{"key":"5259_CR14","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1146\/annurev-physiol-022522-102832","volume":"85","author":"AV Harrison","year":"2023","unstructured":"Harrison AV, Lorenzo FR, McClain DA (2023) Iron and the Pathophysiology of Diabetes. Annu Rev Physiol 85:339\u2013362. https:\/\/doi.org\/10.1146\/annurev-physiol-022522-102832","journal-title":"Annu Rev Physiol"},{"issue":"12","key":"5259_CR15","doi-asserted-by":"publisher","first-page":"118535","DOI":"10.1016\/j.bbamcr.2019.118535","volume":"1866","author":"D Galaris","year":"2019","unstructured":"Galaris D, Barbouti A, Pantopoulos K (2019) Iron homeostasis and oxidative stress: An intimate relationship. Biochim et Biophys Acta - Mol Cell Res 1866(12):118535. https:\/\/doi.org\/10.1016\/j.bbamcr.2019.118535","journal-title":"Biochim et Biophys Acta - Mol Cell Res"},{"issue":"7","key":"5259_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/advs.202002715","volume":"8","author":"Y Gong","year":"2021","unstructured":"Gong Y, Xue Y, Li X, Zhang Z, Zhou W, Marcolongo P, Benedetti A, Mao S, Han L, Ding G, Sun Z (2021) Inter- and Transgenerational Effects of Paternal Exposure to Inorganic Arsenic. Adv Sci 8(7):1\u201314. https:\/\/doi.org\/10.1002\/advs.202002715","journal-title":"Adv Sci"},{"issue":"1191","key":"5259_CR17","doi-asserted-by":"publisher","first-page":"2","DOI":"10.3390\/nu11051191","volume":"11","author":"YC Lien","year":"2019","unstructured":"Lien YC, Condon DE, Georgie MK, Simmons RA, Tran PV, Georgieff MK, Simmons RA, Tran PV (2019) Dysregulation of Neuronal Genes by Fetal-Neonatal Iron Deficiency Anemia Is Associated with Altered DNA Methylation in the Rat Hippocampus. Nutrients 11(1191):2\u201316. https:\/\/doi.org\/10.3390\/nu11051191","journal-title":"Nutrients"},{"issue":"1","key":"5259_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12864-016-3216-y","volume":"17","author":"KM Schachtschneider","year":"2016","unstructured":"Schachtschneider KM, Liu Y, Rund LA, Madsen O, Johnson RW, Groenen MAM, Schook LB (2016) Impact of neonatal iron deficiency on hippocampal DNA methylation and gene transcription in a porcine biomedical model of cognitive development. BMC Genomics 17(1):1\u201314. https:\/\/doi.org\/10.1186\/s12864-016-3216-y","journal-title":"BMC Genomics"},{"issue":"6","key":"5259_CR19","doi-asserted-by":"publisher","first-page":"3254","DOI":"10.1096\/FJ.201701080R","volume":"32","author":"AG Woodman","year":"2018","unstructured":"Woodman AG, Mah R, Keddie D, Noble RMN, Panahi S, Gragasin FS, Lemieux H, Bourque SL (2018) Prenatal iron deficiency causes sex-dependent mitochondrial dysfunction and oxidative stress in fetal rat kidneys and liver. FASEB J 32(6):3254\u20133263. https:\/\/doi.org\/10.1096\/FJ.201701080R","journal-title":"FASEB J"},{"issue":"18","key":"5259_CR20","doi-asserted-by":"publisher","first-page":"4715","DOI":"10.1113\/JP278223","volume":"597","author":"AG Woodman","year":"2019","unstructured":"Woodman AG, Noble RMN, Panahi S, Gragasin FS, Bourque SL (2019) Perinatal iron deficiency combined with a high salt diet in adulthood causes sex-dependent vascular dysfunction in rats. J Physiol 597(18):4715\u20134728. https:\/\/doi.org\/10.1113\/JP278223","journal-title":"J Physiol"},{"key":"5259_CR21","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1210\/en.2011-1700","volume":"153","author":"SL Bourque","year":"2012","unstructured":"Bourque SL, Komolova M, McCabe K, Adams MA, Nakatsu K (2012) Perinatal iron deficiency combined with a high-fat diet causes obesity and cardiovascular dysregulation. Endocrinology 153:1174\u20131182","journal-title":"Endocrinology"},{"key":"5259_CR22","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1053\/meta.2001.22516","volume":"50","author":"RM Lewis","year":"2001","unstructured":"Lewis RM, Petry CJ, Ozanne SE, Hales CN (2001) Effects of maternal iron restriction in the rat on blood pressure, glucose tolerance, and serum lipids in the 3-month-old offspring. Metabolism 50:562\u2013567","journal-title":"Metabolism"},{"issue":"5","key":"5259_CR23","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1152\/physiol.00023.2018","volume":"33","author":"CS Rashid","year":"2018","unstructured":"Rashid CS, Bansal A, Simmons RA (2018) Oxidative stress, intrauterine growth restriction, and developmental programming of type 2 diabetes. Physiology 33(5):348\u2013359. https:\/\/doi.org\/10.1152\/physiol.00023.2018","journal-title":"Physiology"},{"issue":"5","key":"5259_CR24","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1093\/humupd\/dmz017","volume":"25","author":"MJ Xavier","year":"2019","unstructured":"Xavier MJ, Roman SD, Aitken RJ, Nixon B (2019) Transgenerational inheritance: How impacts to the epigenetic and genetic information of parents affect offspring health. Hum Reprod Update 25(5):519\u2013541. https:\/\/doi.org\/10.1093\/humupd\/dmz017","journal-title":"Hum Reprod Update"},{"issue":"September","key":"5259_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fnmol.2018.00292","volume":"11","author":"I Lacal","year":"2018","unstructured":"Lacal I, Ventura R (2018) Epigenetic Inheritance: Concepts, Mechanisms and Perspectives. Front Mol Neurosci 11(September):1\u201322. https:\/\/doi.org\/10.3389\/fnmol.2018.00292","journal-title":"Front Mol Neurosci"},{"issue":"11033","key":"5259_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1756-0500-2-217","volume":"2009","author":"HH Kavi","year":"2009","unstructured":"Kavi HH, Birchler JA (2009) Drosophila KDM2 is a H3K4me3 demethylase regulating nucleolar. BMC Res Notes 2009(11033):1\u20137. https:\/\/doi.org\/10.1186\/1756-0500-2-217","journal-title":"BMC Res Notes"},{"issue":"3","key":"5259_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/antiox12030771","volume":"12","author":"K Rubio","year":"2023","unstructured":"Rubio K, Hern\u00e1ndez-Cruz EY, Rogel-Ayala DG, Sarvari P, Isidoro C, Barreto G, Pedraza-Chaverri J (2023) Nutriepigenomics in Environmental-Associated Oxidative Stress. Antioxidants 12(3):1\u201328. https:\/\/doi.org\/10.3390\/antiox12030771","journal-title":"Antioxidants"},{"issue":"2","key":"5259_CR28","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1111\/joim.13049","volume":"288","author":"C Ling","year":"2020","unstructured":"Ling C (2020) Epigenetic regulation of insulin action and secretion \u2013 role in the pathogenesis of type 2 diabetes. J Intern Med 288(2):158\u2013167. https:\/\/doi.org\/10.1111\/joim.13049","journal-title":"J Intern Med"},{"key":"5259_CR29","doi-asserted-by":"publisher","unstructured":"Szab\u00f3 M, M\u00e1t\u00e9 B, Cs\u00e9p K, Benedek T (2018) Epigenetic modifications linked to T2D, the heritability gap, and potential therapeutic targets. Biochem Gen. https:\/\/doi.org\/10.1007\/s10528-018-9863-8","DOI":"10.1007\/s10528-018-9863-8"}],"container-title":["Biological Trace Element Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-026-05259-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12011-026-05259-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12011-026-05259-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T07:40:35Z","timestamp":1793086835000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12011-026-05259-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,24]]},"references-count":29,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2026,11]]}},"alternative-id":["5259"],"URL":"https:\/\/doi.org\/10.1007\/s12011-026-05259-3","relation":{},"ISSN":["1559-0720"],"issn-type":[{"value":"1559-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,24]]},"assertion":[{"value":"10 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Ethical approval was not required for this study because\n                      Drosophila melanogaster\n                      is an invertebrate species and is not subject to institutional animal ethics regulations.","order":1,"name":"Ethics","label":"Ethical Approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}