{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:14:19Z","timestamp":1760217259697},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2009,4,28]],"date-time":"2009-04-28T00:00:00Z","timestamp":1240876800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc Toxicol"],"published-print":{"date-parts":[[2009,6]]},"DOI":"10.1007\/s12012-009-9038-2","type":"journal-article","created":{"date-parts":[[2009,4,27]],"date-time":"2009-04-27T09:07:36Z","timestamp":1240823256000},"page":"95-102","source":"Crossref","is-referenced-by-count":10,"title":["The Cardiac Effects of Prolonged Vitamin B12 and Folate Deficiency in Rats"],"prefix":"10.1007","volume":"9","author":[{"given":"Omid","family":"Taban-Shomal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heiko","family":"Kilter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heike","family":"Schorr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Umanskaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"H\u00fcbner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"B\u00f6hm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Herrmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Herrmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,4,28]]},"reference":[{"key":"9038_CR1","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1053\/euhj.2000.2493","volume":"22","author":"JG Cleland","year":"2001","unstructured":"Cleland, J. G., Khand, A., & Clark, A. (2001). The heart failure epidemic: Exactly how big is it? European Heart Journal, 22, 623\u2013626. doi: 10.1053\/euhj.2000.2493 .","journal-title":"European Heart Journal"},{"key":"9038_CR2","first-page":"e25","volume":"117","author":"W Rosamond","year":"2008","unstructured":"Rosamond, W., Flegal, K., Furie, K., Go, A., Greenlund, K., Haase, N., et al. (2008). Heart disease and stroke statistics\u20132008 update: A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation, 117, e25\u2013e146. doi: 10.1161\/CIRCULATIONAHA.107.187998 .","journal-title":"Circulation"},{"key":"9038_CR3","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1016\/j.ehj.2004.06.038","volume":"25","author":"GS Bleumink","year":"2004","unstructured":"Bleumink, G. S., Knetsch, A. M., Sturkenboom, M. C., Straus, S. M., Hofman, A., Deckers, J. W., et al. (2004). Quantifying the heart failure epidemic: Prevalence, incidence rate, lifetime risk and prognosis of heart failure The Rotterdam Study. European Heart Journal, 25, 1614\u20131619. doi: 10.1016\/j.ehj.2004.06.038 .","journal-title":"European Heart Journal"},{"key":"9038_CR4","doi-asserted-by":"crossref","unstructured":"Dickstein, K. (2009). ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: Application of natriuretic peptides. Reply. European heart journal, 30, 383.","DOI":"10.1093\/eurheartj\/ehn561"},{"key":"9038_CR5","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.mcna.2004.04.016","volume":"88","author":"S Kenchaiah","year":"2004","unstructured":"Kenchaiah, S., Narula, J., & Vasan, R. S. (2004). Risk factors for heart failure. The Medical Clinics of North America, 88, 1145\u20131172. doi: 10.1016\/j.mcna.2004.04.016 .","journal-title":"The Medical Clinics of North America"},{"key":"9038_CR6","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1001\/jama.289.10.1251","volume":"289","author":"RS Vasan","year":"2003","unstructured":"Vasan, R. S., Beiser, A., D\u2019Agostino, R. B., Levy, D., Selhub, J., Jacques, P. F., et al. (2003). Plasma homocysteine and risk for congestive heart failure in adults without prior myocardial infarction. Journal of the American Medical Association, 289, 1251\u20131257. doi: 10.1001\/jama.289.10.1251 .","journal-title":"Journal of the American Medical Association"},{"key":"9038_CR7","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1093\/ajcn\/85.1.117","volume":"85","author":"M Herrmann","year":"2007","unstructured":"Herrmann, M., M\u00fcller, S., Kindermann, I., G\u00fcnther, L., K\u00f6nig, J., B\u00f6hm, M., et al. (2007). Plasma B vitamins and their relation to the severity of chronic heart failure. The American Journal of Clinical Nutrition, 85, 117\u2013123.","journal-title":"The American Journal of Clinical Nutrition"},{"key":"9038_CR8","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1373\/clinchem.2005.049841","volume":"51","author":"M Herrmann","year":"2005","unstructured":"Herrmann, M., Kindermann, I., M\u00fcller, S., Georg, T., Kindermann, M., B\u00f6hm, M., et al. (2005). Relationship of plasma homocysteine with the severity of chronic heart failure. Clinical Chemistry, 51, 1512\u20131515. doi: 10.1373\/clinchem.2005.049841 .","journal-title":"Clinical Chemistry"},{"key":"9038_CR9","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1161\/CIRCULATIONAHA.106.633750","volume":"115","author":"K Nasir","year":"2007","unstructured":"Nasir, K., Tsai, M., Rosen, B. D., Fernandes, V., Bluemke, D. A., Folsom, A. R., et al. (2007). Elevated homocysteine is associated with reduced regional left ventricular function: The Multi-Ethnic Study of Atherosclerosis. Circulation, 115, 180\u2013187. doi: 10.1161\/CIRCULATIONAHA.106.633750 .","journal-title":"Circulation"},{"key":"9038_CR10","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.carpath.2005.11.001","volume":"15","author":"S Devi","year":"2006","unstructured":"Devi, S., Kennedy, R. H., Joseph, L., Shekhawat, N. S., Melchert, R. B., & Joseph, J. (2006). Effect of long-term hyperhomocysteinemia on myocardial structure and function in hypertensive rats. Cardiovascular Pathology, 15, 75\u201382. doi: 10.1016\/j.carpath.2005.11.001 .","journal-title":"Cardiovascular Pathology"},{"key":"9038_CR11","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1440-1681.2004.03998.x","volume":"31","author":"J Joseph","year":"2004","unstructured":"Joseph, J., Washington, A., Joseph, L., & Kennedy, R. H. (2004). Hyperhomocysteinaemia-induced atrial remodelling in hypertensive rats. Clinical and Experimental Pharmacology & Physiology, 31, 331\u2013337. doi: 10.1111\/j.1440-1681.2004.03998.x .","journal-title":"Clinical and Experimental Pharmacology & Physiology"},{"key":"9038_CR12","doi-asserted-by":"crossref","first-page":"H2567","DOI":"10.1152\/ajpheart.00475.2002","volume":"283","author":"J Joseph","year":"2002","unstructured":"Joseph, J., Washington, A., Joseph, L., Koehler, L., Fink, L. M., Hauer-Jensen, M., et al. (2002). Hyperhomocysteinemia leads to adverse cardiac remodeling in hypertensive rats. American Journal of Physiology. Heart and Circulatory Physiology, 283, H2567\u2013H2574.","journal-title":"American Journal of Physiology. Heart and Circulatory Physiology"},{"key":"9038_CR13","doi-asserted-by":"crossref","first-page":"H679","DOI":"10.1152\/ajpheart.00145.2003","volume":"285","author":"J Joseph","year":"2003","unstructured":"Joseph, J., Joseph, L., Shekhawat, N. S., Devi, S., Wang, J., Melchert, R. B., et al. (2003). Hyperhomocysteinemia leads to pathological ventricular hypertrophy in normotensive rats. American Journal of Physiology. Heart and Circulatory Physiology, 285, H679\u2013H686.","journal-title":"American Journal of Physiology. Heart and Circulatory Physiology"},{"key":"9038_CR14","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1373\/clinchem.2006.077859","volume":"53","author":"M Herrmann","year":"2007","unstructured":"Herrmann, M., Taban-Shomal, O., H\u00fcbner, U., Pexa, A., Kilter, H., Umanskaya, N., et al. (2007). Hyperhomocysteinemia and myocardial expression of brain natriuretic peptide in rats. Clinical Chemistry, 53, 773\u2013780. doi: 10.1373\/clinchem.2006.077859 .","journal-title":"Clinical Chemistry"},{"key":"9038_CR15","first-page":"1392","volume":"41","author":"O Stanger","year":"2003","unstructured":"Stanger, O., Herrmann, W., Pietrzik, K., Fowler, B., Geisel, J., Dierkes, J., et al. (2003). DACH-LIGA homocystein (german, austrian and swiss homocysteine society): Consensus paper on the rational clinical use of homocysteine, folic acid and B-vitamins in cardiovascular and thrombotic diseases: Guidelines and recommendations. Clinical Chemistry and Laboratory Medicine, 41, 1392\u20131403. doi: 10.1515\/CCLM.2003.214 .","journal-title":"Clinical Chemistry and Laboratory Medicine"},{"key":"9038_CR16","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1373\/clinchem.2003.021634","volume":"50","author":"H Refsum","year":"2004","unstructured":"Refsum, H., Smith, A. D., Ueland, P. M., Nexo, E., Clarke, R., McPartlin, J., et al. (2004). Facts and recommendations about total homocysteine determinations: An expert opinion. Clinical Chemistry, 50, 3\u201332. doi: 10.1373\/clinchem.2003.021634 .","journal-title":"Clinical Chemistry"},{"key":"9038_CR17","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1024\/0300-9831.77.1.22","volume":"77","author":"M Gonzalez-Gross","year":"2007","unstructured":"Gonzalez-Gross, M., Sola, R., Albers, U., Barrios, L., Alder, M., Castillo, M. J., et al. (2007). B-vitamins and homocysteine in Spanish institutionalized elderly. International Journal for Vitamin and Nutrition Research, 77, 22\u201333. doi: 10.1024\/0300-9831.77.1.22 .","journal-title":"International Journal for Vitamin and Nutrition Research"},{"key":"9038_CR18","first-page":"1633","volume":"45","author":"W Herrmann","year":"2007","unstructured":"Herrmann, W., Herrmann, M., Joseph, J., & Tyagi, S. C. (2007). Homocysteine, brain natriuretic peptide and chronic heart failure: A critical review. Clinical Chemistry and Laboratory Medicine, 45, 1633\u20131644. doi: 10.1515\/CCLM.2007.360 .","journal-title":"Clinical Chemistry and Laboratory Medicine"},{"key":"9038_CR19","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/S0741-5214(98)70069-2","volume":"28","author":"FN Southern","year":"1998","unstructured":"Southern, F. N., Cruz, N., Fink, L. M., Cooney, C. A., Barone, G. W., Eidt, J. F., et al. (1998). Hyperhomocysteinemia increases intimal hyperplasia in a rat carotid endarterectomy model. Journal of Vascular Surgery, 28, 909\u2013918. doi: 10.1016\/S0741-5214(98)70069-2 .","journal-title":"Journal of Vascular Surgery"},{"key":"9038_CR20","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/BF01002772","volume":"11","author":"LC Junqueira","year":"1979","unstructured":"Junqueira, L. C., Bignolas, G., & Brentani, R. R. (1979). Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections. The Histochemical Journal, 11, 447\u2013455. doi: 10.1007\/BF01002772 .","journal-title":"The Histochemical Journal"},{"key":"9038_CR21","doi-asserted-by":"crossref","first-page":"H2541","DOI":"10.1152\/ajpheart.00806.2004","volume":"288","author":"J Joseph","year":"2005","unstructured":"Joseph, J., Kennedy, R. H., Devi, S., Wang, J., Joseph, L., & Hauer-Jensen, M. (2005). Protective role of mast cells in homocysteine-induced cardiac remodeling. American Journal of Physiology. Heart and Circulatory Physiology, 288, H2541\u2013H2545. doi: 10.1152\/ajpheart.00806.2004 .","journal-title":"American Journal of Physiology. Heart and Circulatory Physiology"},{"key":"9038_CR22","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1136\/jcp.53.11.858","volume":"53","author":"IS Roberts","year":"2000","unstructured":"Roberts, I. S., & Brenchley, P. E. (2000). Mast cells: The forgotten cells of renal fibrosis. Journal of Clinical Pathology, 53, 858\u2013862. doi: 10.1136\/jcp.53.11.858 .","journal-title":"Journal of Clinical Pathology"},{"key":"9038_CR23","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1373\/clinchem.2004.046995","volume":"51","author":"H Gellekink","year":"2005","unstructured":"Gellekink, H., van Oppenraaij-Emmerzaal, D., van Rooij, A., Struys, E. A., den Heijer, M., & Blom, H. J. (2005). Stable-isotope dilution liquid chromatography-electrospray injection tandem mass spectrometry method for fast, selective measurement of S-adenosylmethionine and S-adenosylhomocysteine in plasma. Clinical Chemistry, 51, 1487\u20131492. doi: 10.1373\/clinchem.2004.046995 .","journal-title":"Clinical Chemistry"},{"key":"9038_CR24","doi-asserted-by":"crossref","first-page":"357","DOI":"10.3177\/jnsv.54.357","volume":"54","author":"T Fukuwatari","year":"2008","unstructured":"Fukuwatari, T., Wada, H., & Shibata, K. (2008). Age-related alterations of B-group vitamin contents in urine, blood and liver from rats. Journal of Nutritional Science and Vitaminology, 54, 357\u2013362. doi: 10.3177\/jnsv.54.357 .","journal-title":"Journal of Nutritional Science and Vitaminology"},{"key":"9038_CR25","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1093\/jn\/120.12.1633","volume":"120","author":"AJ Clifford","year":"1990","unstructured":"Clifford, A. J., Heid, M. K., Muller, H. G., & Bills, N. D. (1990). Tissue distribution and prediction of total body folate of rats. The Journal of Nutrition, 120, 1633\u20131639.","journal-title":"The Journal of Nutrition"},{"key":"9038_CR26","first-page":"463","volume-title":"Handbook of Vitamins","author":"WS Beck","year":"2001","unstructured":"Beck, W. S. (2001). Cobalamin (Vitamin B12). In R. B. Rucker, J. W. Sutti, D. B. McCormick, & L. J. Machlin (Eds.), Handbook of Vitamins (pp. 463\u2013512). New York: Marcel Dekker."},{"key":"9038_CR27","doi-asserted-by":"crossref","first-page":"15089","DOI":"10.1073\/pnas.2436385100","volume":"100","author":"AM Troen","year":"2003","unstructured":"Troen, A. M., Lutgens, E., Smith, D. E., Rosenberg, I. H., & Selhub, J. (2003). The atherogenic effect of excess methionine intake. Proceedings of the National Academy of Sciences of the United States of America, 100, 15089\u201315094. doi: 10.1073\/pnas.2436385100 .","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"9038_CR28","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1161\/01.CIR.0000129138.08493.4D","volume":"109","author":"AS Vriese De","year":"2004","unstructured":"De Vriese, A. S., Blom, H. J., Heil, S. G., Mortier, S., Kluijtmans, L. A., Van de Voorde, J., et al. (2004). Endothelium-derived hyperpolarizing factor-mediated renal vasodilatory response is impaired during acute and chronic hyperhomocysteinemia. Circulation, 109, 2331\u20132336. doi: 10.1161\/01.CIR.0000129138.08493.4D .","journal-title":"Circulation"},{"key":"9038_CR29","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0021-9150(99)00036-2","volume":"144","author":"W Herrmann","year":"1999","unstructured":"Herrmann, W., Quast, S., Ullrich, M., Schultze, H., Bodis, M., & Geisel, J. (1999). Hyperhomocysteinemia in high-aged subjects: Relation of B-vitamins, folic acid, renal function and the methylenetetrahydrofolate reductase mutation. Atherosclerosis, 144, 91\u2013101. doi: 10.1016\/S0021-9150(99)00036-2 .","journal-title":"Atherosclerosis"},{"key":"9038_CR30","doi-asserted-by":"crossref","unstructured":"Herrmann, M., Tami, A., Wildemann, B., Wolny, M., Wagner, A., Schorr, H., Taban-Shomal, O., Umanskaya, N., Ross, S., Garcia, P., H\u00fcbner, U., & Herrmann, W. (2009). Hyperhomocysteinemia induces a tissue specific accumulation of homocysteine in bone by collagen binding and adversely affects bone. Bone, 44, 467\u2013475.","DOI":"10.1016\/j.bone.2008.10.051"},{"key":"9038_CR31","first-page":"427","volume-title":"Handbook of Vitamins","author":"B Brody Tand Shane","year":"2001","unstructured":"Brody Tand Shane, B. (2001). Folic Acid. In R. B. Rucker, J. W. Sutti, D. B. McCormick, & L. J. Machlin (Eds.), Handbook of Vitamins (pp. 427\u2013462). New York: Marcel Dekker."}],"container-title":["Cardiovascular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-009-9038-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12012-009-9038-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-009-9038-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T21:40:19Z","timestamp":1559425219000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12012-009-9038-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4,28]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["9038"],"URL":"https:\/\/doi.org\/10.1007\/s12012-009-9038-2","relation":{},"ISSN":["1530-7905","1559-0259"],"issn-type":[{"value":"1530-7905","type":"print"},{"value":"1559-0259","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,28]]}}}