{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T11:53:54Z","timestamp":1793706834175,"version":"4.6.1"},"reference-count":83,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2011,9,22]],"date-time":"2011-09-22T00:00:00Z","timestamp":1316649600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2011,9,22]],"date-time":"2011-09-22T00:00:00Z","timestamp":1316649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Toxicol"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1007\/s12012-011-9145-8","type":"journal-article","created":{"date-parts":[[2011,9,21]],"date-time":"2011-09-21T14:46:05Z","timestamp":1316616365000},"page":"1-9","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":138,"title":["The History and Future of Probenecid"],"prefix":"10.1007","volume":"12","author":[{"given":"Nathan","family":"Robbins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheryl E.","family":"Koch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Tranter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Rubinstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,9,22]]},"reference":[{"key":"9145_CR1","first-page":"4632","volume":"58","author":"A Anjak","year":"2010","unstructured":"Anjak, A., Haar, L., Min, J., Durga, S., Ren, X., Tranter, M., et al. (2010). Transient receptor potential vanilloid 2 (TRPV2) stimulation is cardioprotective. Journal of Investigative Medicine, 58, 4632.","journal-title":"Journal of Investigative Medicine"},{"key":"9145_CR2","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1113\/jphysiol.1968.sp008660","volume":"199","author":"GW Ashcroft","year":"1968","unstructured":"Ashcroft, G. W., Dow, R. C., & Moir, A. T. B. (1968). The active transport of 5-Hydroxyindol-3-ylacetic Acid and 3-Methoxy-4-hydroxyphenyl acetic acid from a recirculatory perfusion system of the cerebral ventricles of the unanaesthesized dog. Journal of Physiology, 199, 397\u2013425.","journal-title":"Journal of Physiology"},{"key":"9145_CR3","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1124\/mol.57.4.760","volume":"57","author":"E Bakos","year":"2000","unstructured":"Bakos, E., Evers, R., Sink\u00f3, E., V\u00e1radi, A., Borst, P., & Sarkadi, B. (2000). Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions. Molecular Pharmacology, 57, 760\u2013768.","journal-title":"Molecular Pharmacology"},{"key":"9145_CR4","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.neulet.2007.08.035","volume":"435","author":"S Bang","year":"2007","unstructured":"Bang, S., Kim, K. Y., Too, S., Lee, S. H., & Hwang, S. W. (2007). Transient receptor potential Ve expressed in sensory neurons is activated by Probenecid. Neuroscience Letters, 435, 120\u2013125.","journal-title":"Neuroscience Letters"},{"issue":"1","key":"9145_CR5","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1093\/infdis\/129.1.73","volume":"129","author":"M Barza","year":"1974","unstructured":"Barza, M., Brusch, J., Bergeron, M. G., & Weinstein, L. (1974). Penetration of antibiotics into fibrin loci in vivo. 3. Intermittent vs. continuous infusion and the effect of probenecid. Journal Infectious Disease, 129(1), 73\u201378.","journal-title":"Journal Infectious Disease"},{"key":"9145_CR6","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1001\/jama.1944.02850510015003","volume":"126","author":"KH Beyer","year":"1944","unstructured":"Beyer, K. H., Flippin, H. F., Verwey, W. F., & Woodward, R. (1944). Effect of para-aminohippuric acid on plasma concentration of penicillin in man. The Journal of American Medical Association, 126, 1007.","journal-title":"The Journal of American Medical Association"},{"key":"9145_CR7","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1152\/ajplegacy.1947.149.2.355","volume":"149","author":"KH Beyer","year":"1947","unstructured":"Beyer, K. H., Miller, K. A., Russo, H. F., Patch, E. A., & Verwey, W. F. (1947). The inhibitory effect of Carinamide on renal elimination of penicillin. American Journal of Physiologic, 149, 355\u2013368.","journal-title":"American Journal of Physiologic"},{"key":"9145_CR8","first-page":"258","volume":"9","author":"RH Beyer","year":"1950","unstructured":"Beyer, R. H., Wiebelhaus, V. D., Russe, H. F., Peck, H. M., & McKinney, S. E. (1950). Benemid: An anticatabolite; its pharmacological properties. Federation Proceedings, 9, 258.","journal-title":"Federation Proceedings"},{"issue":"3","key":"9145_CR9","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1152\/ajplegacy.1951.166.3.625","volume":"166","author":"KH Beyer","year":"1951","unstructured":"Beyer, K. H., Russo, H. F., Tillson, E. K., Miller, A. K., Verwey, W. F., & Gass, S. R. (1951). \u2018Benemid\u2019, p-(di-n-propylsulfamyl)-benzoic acid; its renal affinity and its elimination. American Journal of Physiologic, 166(3), 625\u2013640.","journal-title":"American Journal of Physiologic"},{"issue":"3","key":"9145_CR10","doi-asserted-by":"crossref","first-page":"346","DOI":"10.3181\/00379727-88-21584","volume":"88","author":"C Bishop","year":"1955","unstructured":"Bishop, C., & Pfaff, W. (1955). Immediate uricosuric effect of probenecid in normal humans. Proceedings of the Society for Experimental Biology and Medicine, 88(3), 346\u2013348.","journal-title":"Proceedings of the Society for Experimental Biology and Medicine"},{"issue":"1","key":"9145_CR11","doi-asserted-by":"crossref","first-page":"18","DOI":"10.7326\/0003-4819-33-1-18","volume":"33","author":"WP Boger","year":"1950","unstructured":"Boger, W. P., Beatty, J. O., Pitts, F., & Flippin, H. F. (1950). The influence of a new benzoic acid derivative on the metabolism of para-aminosalicylic acid (PAS) and penicillin. Annals of Internal Medicine, 33(1), 18\u201331.","journal-title":"Annals of Internal Medicine"},{"key":"9145_CR12","first-page":"276","volume":"36","author":"WP Boger","year":"1950","unstructured":"Boger, W. P., Pitts, F. W., & Gallagher, M. E. (1950). Benemid and carinamide: Comparison of effect on Para-amino-salicylic acid (PAS) plasma concentrations. Journal of Laboratory and Clinical Medicine, 36, 276\u2013282.","journal-title":"Journal of Laboratory and Clinical Medicine"},{"issue":"6","key":"9145_CR13","first-page":"862","volume":"61","author":"WP Boger","year":"1950","unstructured":"Boger, W. P., & Pitts, F. W. (1950). Influence of p-(di-n-propylsulfamyl)-benzoic acid, \u201cbenemid\u201d, on para-aminosalicylic acid (PAS) plasma concentrations. American Review of Tuberculosis, 61(6), 862\u2013867.","journal-title":"American Review of Tuberculosis"},{"key":"9145_CR14","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1001\/archinte.1955.00250070099012","volume":"95","author":"WP Boger","year":"1955","unstructured":"Boger, W. P., & Strickland, S. C. (1955). Probenecid (Benemid): Its uses and side effects in 2502 Patients. American Medical Association Archives of Internal Medicine, 95, 83\u201392.","journal-title":"American Medical Association Archives of Internal Medicine"},{"key":"9145_CR15","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1126\/science.101.2635.673","volume":"101","author":"J Bronfenbrenner","year":"1945","unstructured":"Bronfenbrenner, J., & Favour, C. B. (1945). Increasing and prolonging blood penicillin concentrations following intramuscular administration. Science, 101, 673\u2013674.","journal-title":"Science"},{"key":"9145_CR16","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/0002-9343(55)90241-2","volume":"18","author":"D Bronsky","year":"1955","unstructured":"Bronsky, D., Dubin, A., & Kusher, D. S. (1955). Diuretic action of benemid: Its effects upon the urinary excretion of sodium, chloride, potassium, and water in edematous subjects. American Journal of Medicine, 18, 259\u2013266.","journal-title":"American Journal of Medicine"},{"key":"9145_CR17","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1038\/438006a","volume":"438","author":"D Butler","year":"2005","unstructured":"Butler, D. (2005). Wartime tactics doubles power of scarce bird-flu drug. Nature, 438, 6.","journal-title":"Nature"},{"key":"9145_CR18","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1038\/39807","volume":"389","author":"MJ Caterina","year":"1997","unstructured":"Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D., & Julius, D. (1997). The capsaicin receptor: A heat-activated ion channel in the pain pathway. Nature, 389, 816\u2013824.","journal-title":"Nature"},{"key":"9145_CR19","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1038\/18906","volume":"398","author":"MJ Caterina","year":"1999","unstructured":"Caterina, M. J., Rosen, T. A., Tominaga, M., Brake, A. J., & Julius, D. (1999). A capsaicin-receptor homologue with a high threshold for noxious heat. Nature, 398, 436\u2013441.","journal-title":"Nature"},{"issue":"6","key":"9145_CR20","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1111\/j.1445-5994.2008.01641.x","volume":"38","author":"Y Chung","year":"2008","unstructured":"Chung, Y., Lu, C. Y., Graham, G. G., Mant, A., & Day, R. O. (2008). Utilization of allopurinol in the Australian community. Internal Medicine of Journal, 38(6), 388\u2013395.","journal-title":"Internal Medicine of Journal"},{"key":"9145_CR21","doi-asserted-by":"publisher","first-page":"135","DOI":"10.2165\/00003088-198106020-00004","volume":"6","author":"RF Cunningham","year":"1981","unstructured":"Cunningham, R. F., Israili, Z. H., & Dayton, P. G. (1981). Clinical pharmacokinetics of probenecid. Clinical Pharmacokinetics, 6, 135\u2013151.","journal-title":"Clinical Pharmacokinetics"},{"issue":"4","key":"9145_CR22","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/j.1365-2125.1988.tb03401.x","volume":"26","author":"RO Day","year":"1988","unstructured":"Day, R. O., Miners, J. O., Birkett, D. J., Whitehead, A., Naidoo, D., Hayes, J., et al. (1988). Allopurinol dosage selection: Relationships between dose and plasma oxipurinol and urate concentrations and urinary urate excretion. British Journal of Clinical Pharmacology, 26(4), 423\u2013428.","journal-title":"British Journal of Clinical Pharmacology"},{"key":"9145_CR23","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1152\/ajplegacy.1957.189.3.548","volume":"189","author":"A Despopoulos","year":"1957","unstructured":"Despopoulos, A., & Weissbach, H. (1957). Renal metabolism of 5-hydroxyindolacetic acid. American Journal of Physiology, 189, 548\u2013550.","journal-title":"American Journal of Physiology"},{"issue":"3","key":"9145_CR24","doi-asserted-by":"crossref","first-page":"915","DOI":"10.4049\/jimmunol.140.3.915","volume":"140","author":"F Di Virgilio","year":"1988","unstructured":"Di Virgilio, F., Steinberg, T. H., Swanson, J. A., & Silverstein, S. C. (1988). Fura-2 secretion and sequestration in macrophages. A blocker of organic anion transport reveals that these processes occur via a membrane transport system for organic anions. Journal of Immunology, 140(3), 915\u2013920.","journal-title":"Journal of Immunology"},{"issue":"12","key":"9145_CR25","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1007\/BF02034712","volume":"34","author":"RR Erttmann","year":"1978","unstructured":"Erttmann, R. R. (1978). Kinetics and inotropic action of probenecid in guinea-pig heart in vitro. Cellular and Molecular Life Sciences, 34(12), 1620\u20131622.","journal-title":"Cellular and Molecular Life Sciences"},{"key":"9145_CR26","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/0002-9394(60)90339-1","volume":"50","author":"M Forbes","year":"1960","unstructured":"Forbes, M., & Becker, B. (1960). The transport of organic anions by the rabbit eye. II. In vivo transport of iodopyracet (Diodrast). American Journal of Ophthalmology, 50, 867\u2013875.","journal-title":"American Journal of Ophthalmology"},{"key":"9145_CR27","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1016\/0024-3205(76)90206-X","volume":"18","author":"EK Gordon","year":"1976","unstructured":"Gordon, E. K., Markey, S. P., Sherman, R. L., & Kopin, I. J. (1976). Conjugated 3, 4 dihydroxyphenyl acetic acid (DOPAC) in human and monkey cerebrospinal fluid and rat brain and the effects of Probenecid. Life Sciences, 18, 1285\u20131292.","journal-title":"Life Sciences"},{"key":"9145_CR28","doi-asserted-by":"crossref","unstructured":"Greene, T. A., Alarcon, S., Thomas, A., Berdougo, E., Doranz, B. J., Breslin, P. A. S., & Rucker, J. B. (2011) Probenecid inhibits the human bitter taste receptor TAS2R16 and suppresses bitter perception of salicin. PLOS One, 6(5), e20123.","DOI":"10.1371\/journal.pone.0020123"},{"issue":"6","key":"9145_CR29","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1016\/S0021-9258(19)83641-4","volume":"260","author":"G Grynkiewicz","year":"1985","unstructured":"Grynkiewicz, G., Poenie, M., & Tsien, R. Y. (1985). A new generation of Ca2+ indicators with greatly improved fluorescence properties. Journal of Biological Chemistry, 260(6), 3440\u20133450.","journal-title":"Journal of Biological Chemistry"},{"key":"9145_CR30","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1016\/0024-3205(66)91026-5","volume":"5","author":"HC Guldberg","year":"1966","unstructured":"Guldberg, H. C., Ashcroft, G. W., & Crawford, T. B. B. (1966). Concentration of 5-hydroxyindolyacetic acid and homovanillic acid in the cerebrospinal fluid of the dog before and during treatment with Probenecid. Life Sciences, 5, 1571\u20131575.","journal-title":"Life Sciences"},{"issue":"6","key":"9145_CR31","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1016\/0002-9343(50)90293-2","volume":"9","author":"AB Gutman","year":"1950","unstructured":"Gutman, A. B. (1950). Uric acid metabolism in gout. American Journal of Medicine, 9(6), 799\u2013817.","journal-title":"American Journal of Medicine"},{"key":"9145_CR32","first-page":"279","volume":"64","author":"AB Gutman","year":"1951","unstructured":"Gutman, A. B., & Yu, T. F. (1951). Benemid (p-di-n-propylsulfamyl)-benzoic acid) as uricosuric agent in chronic gouty arthritis. Transactions of the Association of American Physicians, 64, 279\u2013288.","journal-title":"Transactions of the Association of American Physicians"},{"key":"9145_CR33","first-page":"57314","volume":"24","author":"L. Haar","year":"2010","unstructured":"Haar, L., Rubinstein, J., & Tranter, M., et al. (2010) Myocardial TRPV activation associated with high fat diet and cardioprotection. FASEB Journal, 24, 57314.","journal-title":"FASEB Journal"},{"key":"9145_CR34","first-page":"84","volume":"45","author":"ML Hilaire","year":"2010","unstructured":"Hilaire, M. L., & Wozniak, J. R. (2010). Gout: Overview and newer therapeutic developments. Formulary, 45, 84\u201390.","journal-title":"Formulary"},{"key":"9145_CR35","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1124\/dmd.30.1.13","volume":"30","author":"G Hill","year":"2002","unstructured":"Hill, G., Cihlar, T., Oo, C., Ho, E. S., Prior, K., Wiltshire, H., et al. (2002). The Anti-influenza drug oseltamivir exhibits low potential to induce pharmacokinetic drug interactins via renal secretion-correlation of in vivo and in vitro studies. Drug Metabolism Disposition, 30, 13\u201319.","journal-title":"Drug Metabolism Disposition"},{"key":"9145_CR36","first-page":"249","volume":"35","author":"AL Hilton","year":"1959","unstructured":"Hilton, A. L. (1959). Treatment of gonorrhoea with P.A.M., & probenecid. The British Journal of Venereal Diseases, 35, 249\u2013251.","journal-title":"The British Journal of Venereal Diseases"},{"issue":"2","key":"9145_CR37","first-page":"107","volume":"47","author":"AL Hilton","year":"1971","unstructured":"Hilton, A. L. (1971). PAM plus probenecid and procaine penicillin plus probenecid in gonorrhoea. The British Journal of Venereal Diseases, 47(2), 107\u2013110.","journal-title":"The British Journal of Venereal Diseases"},{"issue":"34","key":"9145_CR38","doi-asserted-by":"publisher","first-page":"35741","DOI":"10.1074\/jbc.M404164200","volume":"279","author":"HZ Hu","year":"2004","unstructured":"Hu, H. Z., Gu, Q., Wang, C., Colton, C. K., Tang, J., Kinoshita-Kawada, M., et al. (2004). 2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3. Journal of Biological Chemistry, 279(34), 35741\u201335748.","journal-title":"Journal of Biological Chemistry"},{"key":"9145_CR39","first-page":"617","volume-title":"Gilman\u2019s Goodman the pharmacological basis of therapeutics","author":"PA Insel","year":"1996","unstructured":"Insel, P. A. (1996). Analgesic-antipyretic and anti-inflammatory agents and drugs employed in the treatment of gout. In J. G. Hardman, L. E. Limbird, P. B. Molinoff, R. W. Ruddon, & A. Goodman Gilman (Eds.), Gilman\u2019s Goodman the pharmacological basis of therapeutics (9th ed., pp. 617\u2013657). USA: McGraw-Hill.","edition":"9"},{"issue":"7","key":"9145_CR40","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1021\/jm00277a004","volume":"15","author":"ZH Israili","year":"1972","unstructured":"Israili, Z. H., Percel, J. M., Cunningham, R. F., Dayton, P. G., Y\u00fc, T. F., Gutman, A. B., et al. (1972). Metabolites of probenecid. Chemical, physical, and pharmacological studies. Journal of Medicinal Chemistry, 15(7), 709\u2013713.","journal-title":"Journal of Medicinal Chemistry"},{"issue":"5","key":"9145_CR41","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1124\/mol.107.037044","volume":"72","author":"V Juvin","year":"2007","unstructured":"Juvin, V., Penna, A., Chemin, J., Lin, Y. L., & Rassendren, F. A. (2007). Pharmacological characterization and molecular determinants of the activation of transient receptor potential V2 channel orthologs by 2-aminoethoxydiphenyl borate. Molecular Pharmacology, 72(5), 1258\u20131268.","journal-title":"Molecular Pharmacology"},{"key":"9145_CR42","first-page":"F789","volume":"249","author":"AM Kahn","year":"1985","unstructured":"Kahn, A. M., & Weinman, E. J. (1985). Urate transport in the proximal tubule: In vivo and in vesicle studies. American Journal of Physiology, 249, F789\u2013F798.","journal-title":"American Journal of Physiology"},{"issue":"2","key":"9145_CR43","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.amjmed.2010.09.012","volume":"124","author":"R Keenan","year":"2011","unstructured":"Keenan, R., O\u2019brien, W., Lee, K., Crittenden, D., Fisher, M., Goldfarb, D., et al. (2011). Prevalence of contraindications and prescription of pharmacologic therapies for gout. The American Journal of Medicine, 124(2), 155\u2013163.","journal-title":"The American Journal of Medicine"},{"issue":"7843","key":"9145_CR44","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1016\/S0140-6736(73)92799-2","volume":"302","author":"S Kenwright","year":"1973","unstructured":"Kenwright, S., & Levi, A. J. (1973). Impairment of hepatic uptake of rifamycin antibiotics by probenecid, and its therapeutic implications. Lancet, 302(7843), 1401\u20131405.","journal-title":"Lancet"},{"issue":"1","key":"9145_CR45","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/BF00402393","volume":"18","author":"J Korf","year":"1970","unstructured":"Korf, J., & van Praag, H. M. (1970). The intravenous probenecid test: A possible aid in evaluation of the serotonin hypothesis on the pathogenesis of depressions. Psychopharmacologia, 18(1), 129\u2013132.","journal-title":"Psychopharmacologia"},{"key":"9145_CR46","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1186\/1471-2164-7-159","volume":"7","author":"C Kunert-Keil","year":"2006","unstructured":"Kunert-Keil, C., Bisping, F., Kr\u00fcger, J., & Brinkmeier, H. (2006). Tissue-specific expression of TRP channel genes in the mouse and its variation in three different mouse strains. BMC Genomics, 7, 159.","journal-title":"BMC Genomics"},{"key":"9145_CR47","first-page":"435","volume":"13","author":"D Kushner","year":"1954","unstructured":"Kushner, D., Dubin, A., & Bronsky, D. (1954). Effect of Benemid on excretion of water, sodium and chloride in congestive heart failure. Federation Proceedings, 13, 435.","journal-title":"Federation Proceedings"},{"issue":"6","key":"9145_CR48","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/0021-9681(55)90193-4","volume":"2","author":"W Kuzell","year":"1955","unstructured":"Kuzell, W., Schaffarzick, R., Naugler, W., Koets, P., Mankle, E., Brown, B., et al. (1955). Some observations on 520 gouty patients. Journal of Chronic Diseases, 2(6), 645\u2013669.","journal-title":"Journal of Chronic Diseases"},{"key":"9145_CR49","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1001\/archpsyc.1978.01770260115014","volume":"35","author":"CR Lake","year":"1978","unstructured":"Lake, C. R., Wood, J. H., Ziegler, M. G., Ebert, M. H., & Kopin, I. J. (1978). Probenecid-induced norepinephrine elevations in plasma and CSF. Archives of General Psychiatry, 35, 237\u2013240.","journal-title":"Archives of General Psychiatry"},{"key":"9145_CR50","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1111\/j.1365-2125.2009.03564.x","volume":"69","author":"CB Landersdorfer","year":"2010","unstructured":"Landersdorfer, C. B., Kirkpatrick, C. M., Kinzig, M., Bulitta, J. B., Holzgrabe, U., Jaehde, U., et al. (2010). Competitive inhibition of renal tubular secretion of ciprofloxacin and metabolite by Probenecid. British Journal of Clinical Pharmacology, 69, 167\u2013178.","journal-title":"British Journal of Clinical Pharmacology"},{"issue":"5","key":"9145_CR51","doi-asserted-by":"publisher","first-page":"2145","DOI":"10.1083\/jcb.105.5.2145","volume":"105","author":"A Malgaroli","year":"1987","unstructured":"Malgaroli, A., Milani, D., Meldolesi, J., & Pozzan, T. (1987). Fura-2 measurement of cytosolic free Ca2\u00a0+\u00a0in monolayers and suspensions of various types of animal cells. Journal of Cell Biology, 105(5), 2145\u20132155.","journal-title":"Journal of Cell Biology"},{"issue":"3","key":"9145_CR52","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/0143-4160(89)90071-7","volume":"10","author":"PM McDonough","year":"1989","unstructured":"McDonough, P. M., & Button, D. C. (1989). Measurement of cytoplasmic calcium concentration in cell suspensions: Correction for extracellular fura-2 through use of Mn2\u00a0+\u00a0and probenecid. Cell Calcium, 10(3), 171\u2013180.","journal-title":"Cell Calcium"},{"issue":"3","key":"9145_CR53","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0022-3565(25)07713-4","volume":"102","author":"SE McKinney","year":"1951","unstructured":"McKinney, S. E., Peck, H. M., Bochey, J. M., Byham, B. B., Schuchardt, G. S., & Beyer, K. H. (1951). Benemid p-(di-n-sulfyaml)-benzoid acid; toxicologic properties. The Journal of Pharmacology and Experimental Therapeutics, 102(3), 208\u2013214.","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"issue":"4","key":"9145_CR54","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1097\/00007611-195104000-00004","volume":"44","author":"M Meads","year":"1951","unstructured":"Meads, M., Knight, V. H., & Izlar, H. L., Jr. (1951). The enhancement of serum penicillin in man by benemid. Southern Medical Journal, 44(4), 297\u2013302.","journal-title":"Southern Medical Journal"},{"issue":"3","key":"9145_CR55","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1254\/jjp.61.165","volume":"61","author":"M Mitsui","year":"1993","unstructured":"Mitsui, M., Abe, A., Tajimi, M., & Karaki, H. (1993). Leakage of the fluorescent Ca2\u00a0+\u00a0indicator fura-2 in smooth muscle. Japanese Journal of Pharmacology, 61(3), 165\u2013170.","journal-title":"Japanese Journal of Pharmacology"},{"issue":"1","key":"9145_CR56","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1159\/000221788","volume":"20","author":"D M\u00fcnnich","year":"1974","unstructured":"M\u00fcnnich, D., B\u00e9k\u00e9si, S., Lakatos, M., & Bardovics, E. (1974). Treatment of typhoid carriers with amoxycillin and in combination with probenecid. Chemotherapy, 20(1), 29\u201338.","journal-title":"Chemotherapy"},{"key":"9145_CR57","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/S0022-3565(25)27785-0","volume":"158","author":"NH Neff","year":"1967","unstructured":"Neff, N. H., Tozer, T. N., & Brodie, B. B. (1967). Application of steady-state kinetics to studies of the transfer of 5-hydroxyindolacetic acid and from brain to plasma. The Journal of Pharmacology and Experimental Therapeutics, 158, 214\u2013218.","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"issue":"6","key":"9145_CR58","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.ceca.2006.01.009","volume":"39","author":"A Penna","year":"2006","unstructured":"Penna, A., Juvin, V., Chemin, J., Compan, V., Monet, M., & Rassendren, F. A. (2006). PI3-kinase promotes TRPV2 activity independently of channel translocation to the plasma membrane. Cell Calcium, 39(6), 495\u2013507.","journal-title":"Cell Calcium"},{"issue":"23","key":"9145_CR59","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/0024-3205(70)90041-X","volume":"9","author":"JM Perel","year":"1970","unstructured":"Perel, J. M., Cunningham, R. F., Fales, H. M., & Dayton, P. G. (1970). Identification and renal excretion of probenecid metabolites in man. Life Sciences Pt. I: Physiology and Pharmacology, 9(23), 1337\u20131343.","journal-title":"Life Sciences Pt. I: Physiology and Pharmacology"},{"issue":"24","key":"9145_CR60","doi-asserted-by":"publisher","first-page":"6231","DOI":"10.1523\/JNEUROSCI.0504-08.2008","volume":"28","author":"N Qin","year":"2008","unstructured":"Qin, N., Neeper, M. P., Liu, Y., Hutchinson, T. L., Lubin, M. L., & Flores, C. M. (2008). TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons. Journal of Neuroscience, 28(24), 6231\u20136238.","journal-title":"Journal of Neuroscience"},{"key":"9145_CR61","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3181\/00379727-53-14171","volume":"53","author":"CH Rammelkamp","year":"1943","unstructured":"Rammelkamp, C. H., & Bradley, S. E. (1943). Excretion of penicillin in man. Proceedings of Society Experimental Biology and Medicine, 53, 30.","journal-title":"Proceedings of Society Experimental Biology and Medicine"},{"key":"9145_CR62","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1056\/NEJM195703282561304","volume":"256","author":"ES Reynolds","year":"1957","unstructured":"Reynolds, E. S., Schlant, R. C., Gonick, H. C., & Dammin, G. J. (1957). Fatal Massive Necrosis of the liver as a manifestation of hypersensitivity to probenecid. New England Journal of Medicine, 256, 592\u2013596.","journal-title":"New England Journal of Medicine"},{"issue":"1","key":"9145_CR63","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1093\/rheumatology\/kep306","volume":"49","author":"TG Rider","year":"2010","unstructured":"Rider, T. G., & Jordan, K. M. (2010). The modern management of gout. Rheumatology (Oxford), 49(1), 5\u201314.","journal-title":"Rheumatology (Oxford)"},{"key":"9145_CR64","first-page":"80","volume":"14","author":"F Roch-Ramel","year":"1999","unstructured":"Roch-Ramel, F., & Guisan, B. (1999). Renal transport of urate in humans. News Physiol Science, 14, 80\u201384.","journal-title":"News Physiol Science"},{"issue":"1","key":"9145_CR65","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1113\/jphysiol.2006.120832","volume":"580","author":"RA Rose","year":"2007","unstructured":"Rose, R. A., Hatano, N., Ohya, S., Imaizumi, Y., & Giles, W. R. (2007). C-type natriuretic peptide activates a non-selective cation current in acutely isolated rat cardiac fibroblasts via natriuretic peptideC receptor-mediated signaling. Journal of Physiology, 580(1), 255\u2013274.","journal-title":"Journal of Physiology"},{"key":"9145_CR66","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1124\/jpet.110.168765","volume":"334","author":"GW Schnabolk","year":"2010","unstructured":"Schnabolk, G. W., Gupta, B., Mulgaonkar, A., Kulkarni, M., & Sweet, D. H. (2010). Prganic anion transporter 6 (S\/c22a20) specificity and sertoli cell-specific expression provide new insight on potential endogenous roles. Journal of Pharmaceutical Experimental Therapeutic, 334, 927\u2013935.","journal-title":"Journal of Pharmaceutical Experimental Therapeutic"},{"issue":"11","key":"9145_CR67","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1002\/jps.2600711114","volume":"71","author":"A Selen","year":"1982","unstructured":"Selen, A., Amidon, G. L., & Welling, P. G. (1982). Pharmacokinetics of probenecid following oral doses to human volunteers. Journal of Pharmaceutical Science, 71(11), 1238\u20131242.","journal-title":"Journal of Pharmaceutical Science"},{"issue":"2","key":"9145_CR68","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.ntt.2010.10.002","volume":"33","author":"D Silva-Adaya","year":"2011","unstructured":"Silva-Adaya, D., P\u00e9rez-De La Cruz, V., Villeda-Hern\u00e1ndez, J., Carrillo-Mora, P., Gonz\u00e1lez-Herrera, I. G., Garc\u00eda, E., et al. (2011). Protective effect of l-kynurenine and probenecid on 6-hydroxydopamine-induced striatal toxicity in rats: Implications of modulating kynurenate as a protective strategy. Neurotoxicology and Teratology, 33(2), 303\u2013312.","journal-title":"Neurotoxicology and Teratology"},{"issue":"7","key":"9145_CR69","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1172\/JCI102651","volume":"31","author":"JH Sirota","year":"1952","unstructured":"Sirota, J. H., Yu, T. F., & Gutman, A. B. (1952). Effect of benemid (p-[di-n-propylsulfamyl]-benzoic acid) on urate clearance and other discrete renal functions in gouty subjects. Journal of Clinical Investigation, 31(7), 692\u2013701.","journal-title":"Journal of Clinical Investigation"},{"key":"9145_CR70","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1136\/ard.2007.076182","volume":"67","author":"D Solomon","year":"2008","unstructured":"Solomon, D., Avorn, J., Levin, R., & Brookhart, M. (2008). Uric acid lowering therapy: Prescribing patterns in a large cohort of older adults. Annals of Rheumatic Disease, 67, 609\u2013613.","journal-title":"Annals of Rheumatic Disease"},{"issue":"5","key":"9145_CR71","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1002\/jps.2600690526","volume":"69","author":"DE Smith","year":"1980","unstructured":"Smith, D. E., Gee, W. L., Brater, D. C., Lin, E. T., & Benet, L. Z. (1980). Preliminary evaluation of furosemide-probenecid interaction in humans. Journal of Pharmaceutical Science, 69(5), 571\u2013575.","journal-title":"Journal of Pharmaceutical Science"},{"key":"9145_CR72","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3899\/jrheum.101160","volume":"38","author":"SL Stocker","year":"2011","unstructured":"Stocker, S. L., Graham, G. G., McLachlan, A. J., Williams, K. M., & Day, R. O. (2011). Pharmacokinetic and pharmacodynamic interaction between allopurinol and probenecid in patients with gout. The Journal of Rheumatology, 38, 5.","journal-title":"The Journal of Rheumatology"},{"issue":"1","key":"9145_CR73","first-page":"1","volume":"2","author":"JH Talbott","year":"1951","unstructured":"Talbott, J. H. (1951). Clinical and metabolic effects of benemid in gout. Bulletin on the Rheumatic Diseases, 2(1), 1\u20132.","journal-title":"Bulletin on the Rheumatic Diseases"},{"issue":"12","key":"9145_CR74","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.2165\/00003495-200666120-00002","volume":"66","author":"GG Teng","year":"2006","unstructured":"Teng, G. G., Nair, R., & Saag, K. G. (2006). Pathophysiology, clinical presentation and treatment of gout. Drugs, 66(12), 1547\u20131563.","journal-title":"Drugs"},{"issue":"1\u20132","key":"9145_CR75","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/0143-4160(85)90041-7","volume":"6","author":"RY Tsien","year":"1985","unstructured":"Tsien, R. Y., Rink, T. J., & Poenie, M. (1985). Measurement of cytosolic free Ca2+ in individual small cells using fluorescence microscopy with dual excitation wavelengths. Cell Calcium, 6(1\u20132), 145\u2013157.","journal-title":"Cell Calcium"},{"issue":"11","key":"9145_CR76","doi-asserted-by":"crossref","first-page":"751","DOI":"10.5414\/CPP48751","volume":"48","author":"Y Utsynomiya","year":"2010","unstructured":"Utsynomiya, Y., Hara, Y., Ito, H., Okonogi, H., Miyazaki, Y., Hashimoto, Y., et al. (2010). Effects of probenecid on the pharmacokinetics of mizoribine and co-administration of the two drugs in patients with nephrotic syndrome. International Journal of Clinical Pharmacology Therapeutics, 48(11), 751\u2013755.","journal-title":"International Journal of Clinical Pharmacology Therapeutics"},{"issue":"6","key":"9145_CR77","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1001\/archpsyc.1973.01750360053007","volume":"28","author":"H. M. Praag","year":"1973","unstructured":"van Praag, H. M., Korf, J., & Schut, D. (1973) Cerebral monoamines and depression. An investigation with the Probenecid technique. Archives of General Psychiatry, 28(6), 827\u2013831.","journal-title":"Archives of General Psychiatry"},{"key":"9145_CR78","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/BF00429084","volume":"33","author":"H. M. Praag","year":"1973","unstructured":"van Praag, H. M., Flentge, F., Korf, L., Dols, L. C., & Schut, T. (1973). The influence of probenecid on the metabolism of serotonin, dopamine, and their precursors in man. Psychopharmacologia, 33, 141\u2013151.","journal-title":"Psychopharmacologia"},{"key":"9145_CR79","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1124\/mol.109.055624","volume":"75","author":"J Vriens","year":"2009","unstructured":"Vriens, J., Appendino, G., & Nilius, B. (2009). Pharmacology of vanilloid transient receptor potential cation channels. Molecular Pharmacolgy., 75, 1262\u20131279.","journal-title":"Molecular Pharmacolgy."},{"issue":"1","key":"9145_CR80","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1177\/0091270002239705","volume":"43","author":"DL Wolf","year":"2003","unstructured":"Wolf, D. L., Rodr\u00edguez, C. A., Mucci, M., Ingrosso, A., Duncan, B. A., & Nickens, D. J. (2003). Pharmacokinetics and renal effects of cidofovir with a reduced dose of probenecid in HIV-infected patients with cytomegalovirus retinitis. Journal of Clinical Pharmacology, 43(1), 43\u201351.","journal-title":"Journal of Clinical Pharmacology"},{"issue":"5","key":"9145_CR81","first-page":"774","volume":"4","author":"WQ Wolfson","year":"1948","unstructured":"Wolfson, W. Q., Cohn, C., Levine, R., & Huddlestun, B. (1948). Transport and excretion of uric acid in man. III Physiological significance of the uricosuric effect of caronamide. American Federation for Clinical Research, 4(5), 774.","journal-title":"American Federation for Clinical Research"},{"issue":"3","key":"9145_CR82","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/j.clinthera.2010.03.017","volume":"32","author":"H Wu","year":"2010","unstructured":"Wu, H., Liu, M., Wang, S., Feng, W., Yao, W., Zhao, H., et al. (2010). Pharmacokinetic properties and bioequivalence of two compound formulations of 1500\u00a0mg ampicillin (1167\u00a0mg)\/probenecid (333\u00a0mg): a randomized-sequence, single-dose, open-label, two-period crossover study in healthy Chinese male volunteers. Clinical Therapeutics, 32(3), 597\u2013606.","journal-title":"Clinical Therapeutics"},{"issue":"6","key":"9145_CR83","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1016\/0002-9343(51)90028-9","volume":"11","author":"TF Y\u00fc","year":"1951","unstructured":"Y\u00fc, T. F., & Gutman, A. B. (1951). Mobilization of gouty tophi by protracted use of uricosuric agents. American Journal of Medicine, 11(6), 765\u2013769.","journal-title":"American Journal of Medicine"}],"container-title":["Cardiovascular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-011-9145-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12012-011-9145-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-011-9145-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-011-9145-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T19:38:34Z","timestamp":1741721914000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12012-011-9145-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,22]]},"references-count":83,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["9145"],"URL":"https:\/\/doi.org\/10.1007\/s12012-011-9145-8","relation":{},"ISSN":["1530-7905","1559-0259"],"issn-type":[{"value":"1530-7905","type":"print"},{"value":"1559-0259","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,22]]},"assertion":[{"value":"22 September 2011","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}