{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T23:18:16Z","timestamp":1786663096517,"version":"build-2736575974"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2013,5,24]],"date-time":"2013-05-24T00:00:00Z","timestamp":1369353600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc Toxicol"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1007\/s12012-013-9216-0","type":"journal-article","created":{"date-parts":[[2013,5,23]],"date-time":"2013-05-23T19:16:24Z","timestamp":1369336584000},"page":"357-363","source":"Crossref","is-referenced-by-count":29,"title":["Apocynin Ameliorates Cadmium-Induced Hypertension Through Elevation of Endothelium Nitric Oxide Synthase"],"prefix":"10.1007","volume":"13","author":[{"given":"Chukwuemeka R.","family":"Nwokocha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abena","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damion","family":"Douglas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garsha","family":"McCalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalene","family":"Nwokocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul D.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,5,24]]},"reference":[{"key":"9216_CR1","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.jep.2011.03.049","volume":"135","author":"CR Nwokocha","year":"2011","unstructured":"Nwokocha, C. R., Owu, D. U., Ufearo, C. S., & Iwuala, M. O. E. (2011). Comparative study on the efficacy of Garcinia kola in reducing some heavy metal accumulation in liver of Wistar rats. Journal of Ethnopharmacology, 135, 488\u2013491.","journal-title":"Journal of Ethnopharmacology"},{"key":"9216_CR2","doi-asserted-by":"crossref","first-page":"214","DOI":"10.4103\/0974-8490.102266","volume":"4","author":"CR Nwokocha","year":"2012","unstructured":"Nwokocha, C. R., Nwokocha, Magdalene I., Daniel, U., Owu, Chioma Ebe, Nwangwu, Ozioma, & Iwuala, Moses O. (2012). Comparative analysis on the effect of palm oil (Elaeis guineensis) in reducing cadmium and lead accumulation in liver of Wistar rats. Pharmacognosy research, 4, 214\u2013218.","journal-title":"Pharmacognosy research"},{"key":"9216_CR3","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/j.biochi.2009.06.014","volume":"91","author":"GF Nordberg","year":"2009","unstructured":"Nordberg, G. F., Jin, T., Wu, X., Lu, J., Chen, L., Lei, L., et al. (2009). Prevalence of kidney dysfunction in humans\u2014relationship to cadmium dose, metallothionein, immunological and metabolic factors. Biochimie, 91, 1282\u20131285.","journal-title":"Biochimie"},{"key":"9216_CR4","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1023\/B:VERC.0000014277.06785.6f","volume":"27","author":"MV Varoni","year":"2003","unstructured":"Varoni, M. V., Palomba, D., Gianorso, S., & Anania, V. (2003). Cadmium as an environmental factor of hypertension in animals: new perspectives on mechanisms. Veterinary Research Communications, 27, 807\u2013810.","journal-title":"Veterinary Research Communications"},{"key":"9216_CR5","doi-asserted-by":"crossref","first-page":"3196","DOI":"10.1161\/01.CIR.0000130848.18636.B2","volume":"109","author":"A Navas-Acien","year":"2004","unstructured":"Navas-Acien, A., Selvin, E., Sharrett, A. R., Calderon-Aranda, E., Silbergeld, E., & Guallar, E. (2004). Lead, cadmium, smoking, and increased risk of peripheral arterial disease. Circulation, 109, 3196\u20133201.","journal-title":"Circulation"},{"key":"9216_CR6","doi-asserted-by":"crossref","first-page":"208","DOI":"10.4103\/0974-8490.102263","volume":"4","author":"CR Nwokocha","year":"2012","unstructured":"Nwokocha, C. R., Owu, D. U., Nwokocha, M. I., Ufearo, C. S., & Iwuala, M. O. E. (2012). Comparative Study on the Hepatoprotection to Heavy Metals of Zingiber Officinale. Pharmacognosy research, 4, 208\u2013213.","journal-title":"Pharmacognosy research"},{"key":"9216_CR7","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1159\/000138541","volume":"38","author":"R Balaraman","year":"1989","unstructured":"Balaraman, R., Gulati, O. D., Bhatt, J. D., Rathod, S. P., & Hemavathi, K. G. (1989). Cadmium-induced hypertension in rats. Pharmacology, 38, 226\u2013234.","journal-title":"Pharmacology"},{"key":"9216_CR8","first-page":"097","volume":"26","author":"CR Nwokocha","year":"2011","unstructured":"Nwokocha, C. R., Owu, D. U., Ufearo, C., Edidjana, E., Nwogbo, N., & Ekpo, U. (2011). Estimation of absorbed cadmium in tissues of male and female Albino rats through different routes of administration. Nigerian journal of physiological, 26, 097\u2013101.","journal-title":"Nigerian journal of physiological"},{"key":"9216_CR9","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s10534-010-9379-0","volume":"24","author":"W Donpunha","year":"2011","unstructured":"Donpunha, W., Kukongviriyapan, U., Sompamit, K., Pakdeechote, P., Kukongviriyapan, V., & Pannangpetch, P. (2011). Protective effect of ascorbic acid on cadmium- induced hypertension and vascular dysfunction in mice. BioMetals, 24, 105\u2013115.","journal-title":"BioMetals"},{"key":"9216_CR10","doi-asserted-by":"crossref","first-page":"98","DOI":"10.5830\/CVJA-2011-059","volume":"23","author":"CR Nwokocha","year":"2012","unstructured":"Nwokocha, C. R., Ajayi, I. O., Owu, D. U., & Ebeigbe, A. B. (2012). Experimental malaria; the in vitro and in vivo blood pressure paradox. Cardiovasc Journal Africa, 23, 98\u2013102.","journal-title":"Cardiovasc Journal Africa"},{"key":"9216_CR11","first-page":"852","volume":"42","author":"S Liu","year":"2007","unstructured":"Liu, S., Ma, X., Gong, M., Shi, L., Lincoln, T., & Wang, S. (2007). Glucose down-regulation of cGMP-dependent protein kinase I expression in vascular smooth muscle cells involves NAD(P)H oxidase-derived reactive oxygen species. Free Radic. Biology and medicine, 42, 852\u2013863.","journal-title":"Biology and medicine"},{"key":"9216_CR12","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1016\/j.fct.2012.03.079","volume":"50","author":"CR Nwokocha","year":"2012","unstructured":"Nwokocha, C. R., Nwokocha, Magdalene I., Aneto, Imaria, Obi, Joshua, Udekweleze, Damian C., Olatunde, Bukola, et al. (2012). Comparative analysis on the hepatoprotective effect of Lycopersicon esculentum (Tomato) on metal accumulation in Wistar rats. Food and Chemical Toxicology, 50, 2070\u20132073.","journal-title":"Food and Chemical Toxicology"},{"key":"9216_CR13","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.fct.2011.11.003","volume":"50","author":"CR Nwokocha","year":"2012","unstructured":"Nwokocha, C. R., Owu, D. U., Ufearo, C. S., & Iwuala, M. O. E. (2012). Comparative study on the efficacy of Allium sativum (garlic) in reducing some heavy metal accumulation in liver of Wistar rats. Food and Chemical Toxicology, 50, 222\u2013226.","journal-title":"Food and Chemical Toxicology"},{"key":"9216_CR14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2008\/106507","volume":"2008","author":"J Stefanska","year":"2008","unstructured":"Stefanska, J., & Pawliczak, R. (2008). Apocynin: Molecular aptitudes. Mediators of Inflammation, 2008, 1\u201310. doi: 10.1155\/2008\/106507 .","journal-title":"Mediators of Inflammation"},{"key":"9216_CR15","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1161\/HYPERTENSIONAHA.107.100214","volume":"51","author":"S Heumuller","year":"2008","unstructured":"Heumuller, S., Wind, S., Barbosa-Sicard, E., Schmidth, H. H. H. W., Busse, R., Schroder, K., et al. (2008). Apocynin is not an inhibitor of vascular NADPH oxidase but an antioxidant. Hypertension, 51, 211\u2013217.","journal-title":"Hypertension"},{"key":"9216_CR16","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1161\/01.HYP.0000057421.28533.37","volume":"41","author":"S Ulker","year":"2003","unstructured":"Ulker, S., Mckeown, P. P., & Bayraktutan, U. (2003). Vitamins reverse endothelial dysfunction through regulation of eNOS and NAD(P)H oxidase activities. Hypertension, 41, 534\u2013539.","journal-title":"Hypertension"},{"key":"9216_CR17","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1161\/01.HYP.0000037063.90643.0B","volume":"40","author":"CA Hamilton","year":"2002","unstructured":"Hamilton, C. A., Brosnan, M. J., Al-Benna, S., Berg, G., & Dominiczak, A. F. (2002). NAD(P)H oxidase inhibition improves endothelial function in rat and human blood vessels. Hypertension, 40, 755\u2013762.","journal-title":"Hypertension"},{"key":"9216_CR18","doi-asserted-by":"crossref","first-page":"R277","DOI":"10.1152\/ajpregu.00758.2002","volume":"285","author":"B Lasse`gue","year":"2003","unstructured":"Lasse`gue, B., & Clempus, R. E. (2003). Vascular NAD(P)H oxidases: specific features, expression, and regulation. American journal of physiology. Regulatory and comparative physiology, 285, R277\u2013R297.","journal-title":"American journal of physiology. Regulatory and comparative physiology"},{"key":"9216_CR19","doi-asserted-by":"crossref","first-page":"E53","DOI":"10.1152\/ajpendo.1980.238.1.E53","volume":"238","author":"DJ Eakin","year":"1980","unstructured":"Eakin, D. J., Schroeder, L. A., Whanger, P. D., & Weswig, P. H. (1980). Cadmium and nickel influence on blood pressure, plasma renin, and tissue mineral concentrations. American Physiological Society\u2014endocrinology and metabolism, 238, E53\u2013E61.","journal-title":"American Physiological Society\u2014endocrinology and metabolism"},{"key":"9216_CR20","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/oxfordjournals.aje.a116079","volume":"134","author":"J Staessen","year":"1991","unstructured":"Staessen, J., Amery, A., Bernard, A., Bruaux, P., Buchet, J. P., Bulpitt, C. J., et al. (1991). Blood pressure, the prevalence of cardiovascular diseases, and exposure to cadmium: A population study. American journal of Epidemiology, 134, 257\u2013267.","journal-title":"American journal of Epidemiology"},{"key":"9216_CR21","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.toxlet.2007.11.002","volume":"176","author":"N Yoopan","year":"2008","unstructured":"Yoopan, N., Watcharasit, P., Wongsawatkul, O., Piyachaturawat, P., & Satayavivad, J. (2008). Attenuation of eNOS expression in cadmium-induced hypertensive rats. Toxicol Letters, 176, 157\u2013161.","journal-title":"Toxicol Letters"},{"key":"9216_CR22","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1161\/01.HYP.0000112304.26158.5c","volume":"43","author":"H Xu","year":"2004","unstructured":"Xu, H., Fink, G. D., & Galligan, J. J. (2004). Tempol lowers blood pressure and sympathetic nerve activity but not vascular O2- in DOCA-salt rats. Hypertension, 43, 329\u2013334.","journal-title":"Hypertension"},{"key":"9216_CR23","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/ki.2008.509","volume":"75","author":"F Liu","year":"2009","unstructured":"Liu, F., Wei, C. C., Wu, S. J., Chenier, I., Zhang, S. L., Filep, J. G., et al. (2009). Apocynin attenuates tubular apoptosis and tubulointerstitial fibrosis in transgenic mice independent of hypertension. Kidney International, 75, 156\u2013166.","journal-title":"Kidney International"},{"key":"9216_CR24","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1161\/01.HYP.0000038339.67450.60","volume":"40","author":"MK Kim","year":"2002","unstructured":"Kim, M. K., Sasaki, S., Sasazuki, S., Okubo, S., Hayashi, M., & Tsugane, S. (2002). Lack of long-term effect of vitamin C supplementation on blood pressure. Hypertension, 40, 797\u2013803.","journal-title":"Hypertension"},{"key":"9216_CR25","doi-asserted-by":"crossref","first-page":"H528","DOI":"10.1152\/ajpheart.2001.280.2.H528","volume":"280","author":"SJ Duffy","year":"2001","unstructured":"Duffy, S. J., Gokce, N., Holbrook, M., Hunter, L. M., Biogelsen, E. S., Huang, A., et al. (2001). Effect of ascorbic acid treatment on conduit vessel endothelia dysfunction in patients with hypertension. American journal of physiology. Heart and circulatory physiology, 280, H528\u2013H534.","journal-title":"American journal of physiology. Heart and circulatory physiology"},{"key":"9216_CR26","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/sj.jhh.1001992","volume":"20","author":"RH Orakzai","year":"2006","unstructured":"Orakzai, R. H., Orakzai, S. H., Nasir, K., Santos, R. D., Rana, J. S., Pimentel, I., et al. (2006). Association of white blood cell count with systolic blood pressure within the normotensive range. Journal of Human Hypertension, 20, 341\u2013347.","journal-title":"Journal of Human Hypertension"},{"key":"9216_CR27","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.envres.2010.09.004","volume":"110","author":"SE Wagner","year":"2010","unstructured":"Wagner, S. E., Burch, J. B., Bottai, M., Pinney, S. M., Puett, R., Porter, D., et al. (2010). Hypertension and hematologic parameters in a community near a uranium processing facility. Environmental Research, 110, 786\u2013797.","journal-title":"Environmental Research"},{"key":"9216_CR28","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s11255-011-9926-9","volume":"44","author":"A Agorasti","year":"2012","unstructured":"Agorasti, A., Mourvati, E., Trivellas, T., Papadopoulos, V., Bazntiara, I., Christoforidou, A., et al. (2012). Changes in haemostatic and platelet activation markers in non-dipper hypertensive patients. International Urology and Nephrology, 44, 523\u2013533.","journal-title":"International Urology and Nephrology"},{"key":"9216_CR29","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/j.fct.2004.05.001","volume":"42","author":"FM El-Demerdash","year":"2004","unstructured":"El-Demerdash, F. M., Yousef, M. I., Kedwany, F. S., & Baghdadi, H. H. (2004). Cadmium-induced changes in lipid peroxidation, blood hematology, biochemical parameters and semen quality of male rats: protective role of vitamin E and beta-carotene. Food and Chemical Toxicology, 42, 1563\u20131571.","journal-title":"Food and Chemical Toxicology"},{"key":"9216_CR30","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1007\/s00244-010-9502-9","volume":"59","author":"SK Sheir","year":"2010","unstructured":"Sheir, S. K., & Handy, R. D. (2010). Tissue injury and cellular immune responses to cadmium chloride exposure in the common mussel Mytilus edulis: modulation by lipopolysaccharide. Archives of Environmental Contamination and Toxicology, 59, 602\u2013613.","journal-title":"Archives of Environmental Contamination and Toxicology"},{"key":"9216_CR31","doi-asserted-by":"crossref","first-page":"3743","DOI":"10.1182\/blood.V96.12.3743","volume":"1","author":"H Horiguchi","year":"2000","unstructured":"Horiguchi, H., Kayama, F., Oguma, E., Willmore, W. G., Hradecky, P., & Bunn, H. F. (2000). Cadmium and platinum suppression of erythropoietin production in cell culture: clinical implications. Blood, 1, 3743\u20133747.","journal-title":"Blood"},{"key":"9216_CR32","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s00204-003-0444-0","volume":"77","author":"N Obara","year":"2003","unstructured":"Obara, N., Imagawa, S., Nakano, Y., Suzuki, N., Yamamoto, M., & Nagasawa, T. (2003). Suppression of erythropoietin gene expression by cadmium depends on inhibition of HIF-1, not stimulation of GATA-2. Archives of Toxicology, 77, 267\u2013273.","journal-title":"Archives of Toxicology"},{"key":"9216_CR33","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1016\/j.freeradbiomed.2010.03.010","volume":"48","author":"LR Castor","year":"2010","unstructured":"Castor, L. R., Locatelli, K. A., & Ximenes, V. F. (2010). Pro-oxidant activity of apocynin radical. Free radical biology and medicine, 48, 1636\u20131643.","journal-title":"Free radical biology and medicine"},{"key":"9216_CR34","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.cellbi.2007.04.009","volume":"31","author":"A Robaszkiewicz","year":"2007","unstructured":"Robaszkiewicz, A., Bartosz, G., & Balcerczy, k A. (2007). Antioxidative and prooxidative effects of quercetin on A549 cells. Cell Biology International, 31, 1245\u20131250.","journal-title":"Cell Biology International"},{"key":"9216_CR35","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.freeradbiomed.2007.05.009","volume":"43","author":"SK Sandur","year":"2007","unstructured":"Sandur, S. K., Ichikawa, H., Pandey, M. K., Kunnumakkara, A. B., Sung, B., Sethi, G., et al. (2007). Role of pro-oxidants and antioxidants in the anti-inflammatory and apoptotic effects of curcumin (diferuloylmethane). Free radical biology and medicine, 43, 568\u2013580.","journal-title":"Free radical biology and medicine"},{"key":"9216_CR36","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1080\/10623320213638","volume":"9","author":"DK Johnson","year":"2002","unstructured":"Johnson, D. K., Schillinger, K. J., Kwait, D. M., Hughes, C. V., McNamara, E. J., Ishmael, F., et al. (2002). Inhibition of NADPH oxidase activation in endothelial cells by ortho-methoxy-substituted catechols. Endothelium, 9, 191\u2013203.","journal-title":"Endothelium"},{"key":"9216_CR37","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1007\/s10534-012-9582-2","volume":"25","author":"JF Gon\u00e7alves","year":"2012","unstructured":"Gon\u00e7alves, J. F., Duarte, M. M., Fiorenza, A. M., Spanevello, R. M., Mazzanti, C. M., Schmatz, R., et al. (2012). Hematological indices and activity of NTPDase and cholinesterase enzymes in rats exposed to cadmium and treated with N-acetylcysteine. BioMetals, 25, 1195\u20131206.","journal-title":"BioMetals"},{"key":"9216_CR38","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s00210-010-0552-3","volume":"382","author":"J Dharmarajah","year":"2010","unstructured":"Dharmarajah, J., Arthur, J. F., Sobey, C. G., & Drummond, G. R. (2010). The anti-platelet effects of apocynin in mice are not mediated by inhibition of NADPH oxidase activity. Naunyn-Schmiedeberg\u2019s archives of pharmacology, 382, 377\u2013384.","journal-title":"Naunyn-Schmiedeberg\u2019s archives of pharmacology"},{"key":"9216_CR39","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1615\/JEnvironPatholToxicolOncol.v20.i1.110","volume":"20","author":"SV Kumar","year":"2001","unstructured":"Kumar, S. V., Bose, R., & Bhattacharya, S. (2001). Low doses of heavy metals disrupt normal structure and function of rat platelets. Journal of Environmental Pathology, Toxicology and Oncology, 20, 65\u201375.","journal-title":"Journal of Environmental Pathology, Toxicology and Oncology"},{"issue":"11","key":"9216_CR40","doi-asserted-by":"crossref","first-page":"e49128","DOI":"10.1371\/journal.pone.0049128","volume":"7","author":"Z Zhang","year":"2012","unstructured":"Zhang, Z., Yang, Z., Zhu, B., Hu, J., Liew, C. W., Zhang, Y., et al. (2012). Increasing glucose 6-phosphate dehydrogenase activity restores redox balance in vascular endothelial cells exposed to high glucose. PLoS ONE, 7(11), e49128.","journal-title":"PLoS ONE"},{"key":"9216_CR41","first-page":"59","volume":"102","author":"C Urso","year":"2011","unstructured":"Urso, C., & Caimi, G. (2011). Oxidative stress and endothelial dysfunction. Minerva Medica, 102, 59\u201377.","journal-title":"Minerva Medica"},{"key":"9216_CR42","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1016\/S0024-3205(03)00508-3","volume":"22","author":"MA Cotter","year":"2003","unstructured":"Cotter, M. A., & Cameron, N. E. (2003). Effect of the NAD(P)H oxidase inhibitor, apocynin, on peripheral nerve perfusion and function in diabetic rats. Life Sciences, 22, 1813\u20131824.","journal-title":"Life Sciences"},{"key":"9216_CR43","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.freeradbiomed.2006.07.012","volume":"15","author":"T Matsumoto","year":"2006","unstructured":"Matsumoto, T., Miyamori, K., Kobayashi, T., & Kamata, K. (2006). Apocynin normalizes hyperreactivity to phenylephrine in mesenteric arteries from cholesterol-fed mice by improving endothelium-derived hyperpolarizing factor response. Free radical biology and medicine, 15, 1289\u20131303.","journal-title":"Free radical biology and medicine"},{"key":"9216_CR44","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/aps.2012.7","volume":"33","author":"J Gao","year":"2012","unstructured":"Gao, J., Tang, Y. Q., Dai, D. Z., Cheng, Y. S., Zhang, G. L., Zhang, C., et al. (2012). Raisanberine protected pulmonary arterial rings and cardiac myocytes of rats against hypoxia injury by suppressing NADPH oxidase and calcium influx. Acta Pharmacologica Sinica, 33, 625\u2013634.","journal-title":"Acta Pharmacologica Sinica"}],"container-title":["Cardiovascular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-013-9216-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12012-013-9216-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-013-9216-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T02:38:59Z","timestamp":1595817539000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12012-013-9216-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,24]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["9216"],"URL":"https:\/\/doi.org\/10.1007\/s12012-013-9216-0","relation":{},"ISSN":["1530-7905","1559-0259"],"issn-type":[{"value":"1530-7905","type":"print"},{"value":"1559-0259","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,24]]}}}