{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:56:16Z","timestamp":1786982176564,"version":"build-2736575974"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T00:00:00Z","timestamp":1391558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc Toxicol"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1007\/s12012-014-9248-0","type":"journal-article","created":{"date-parts":[[2014,2,4]],"date-time":"2014-02-04T10:59:36Z","timestamp":1391511576000},"page":"243-250","source":"Crossref","is-referenced-by-count":12,"title":["Effect of Nigella sativa Supplementation to Exercise Training in a Novel Model of Physiological Cardiac Hypertrophy"],"prefix":"10.1007","volume":"14","author":[{"given":"L. I.","family":"Al-Asoom","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. A.","family":"Al-Shaikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. O.","family":"Bamosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. N.","family":"El-Bahai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,2,5]]},"reference":[{"issue":"24","key":"9248_CR1","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1161\/01.CIR.0000075572.40158.77","volume":"107","author":"PD Thompson","year":"2003","unstructured":"Thompson, P. D., Buchner, D., Pina, I. L., Balady, G. J., Williams, M. A., Marcus, B. H., et al. (2003). Exercise and physical activity in the prevention and treatment of atherosclerotic cardiovascular disease: A statement from the Council on Clinical Cardiology (subcommittee on exercise, rehabilitation, and prevention) and the Council on Nutrition, Physical Activity, and Metabolism (subcommittee on physical activity). Circulation, 107(24), 3109\u20133116.","journal-title":"Circulation"},{"issue":"12","key":"9248_CR2","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1161\/CIRCULATIONAHA.110.939959","volume":"122","author":"S Gielen","year":"2010","unstructured":"Gielen, S., Schuler, G., & Adams, V. (2010). Cardiovascular effects of exercise training: Molecular mechanisms. Circulation, 122(12), 1221\u20131238.","journal-title":"Circulation"},{"issue":"1","key":"9248_CR3","doi-asserted-by":"crossref","first-page":"e004473","DOI":"10.1161\/JAHA.112.004473","volume":"2","author":"VA Cornelissen","year":"2013","unstructured":"Cornelissen, V. A., & Smart, N. A. (2013). Exercise training for blood pressure: A systematic review and meta-analysis. Journal of the American Heart Association, 2(1), e004473.","journal-title":"Journal of the American Heart Association"},{"issue":"Pt 21","key":"9248_CR4","doi-asserted-by":"crossref","first-page":"5011","DOI":"10.1113\/jphysiol.2009.181339","volume":"587","author":"B Benito","year":"2009","unstructured":"Benito, B., & Nattel, S. (2009). Exercise training as a treatment for heart failure: Potential mechanisms and clinical implications. Journal of Physiology, 587(Pt 21), 5011\u20135013.","journal-title":"Journal of Physiology"},{"issue":"4","key":"9248_CR5","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1161\/HYPERTENSIONAHA.108.126805","volume":"53","author":"CD Garciarena","year":"2009","unstructured":"Garciarena, C. D., Pinilla, O. A., Nolly, M. B., Laguens, R. P., Escudero, E. M., Cingolani, H. E., et al. (2009). Endurance training in the spontaneously hypertensive rat: Conversion of pathological into physiological cardiac hypertrophy. Hypertension, 53(4), 708\u2013714.","journal-title":"Hypertension"},{"issue":"3","key":"9248_CR6","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1177\/2040622313480382","volume":"4","author":"C Maeyer De","year":"2013","unstructured":"De Maeyer, C., Beckers, P., Vrints, C. J., & Conraads, V. M. (2013). Exercise training in chronic heart failure. Therapeutic Advances in Chronic Disease, 4(3), 105\u2013117.","journal-title":"Therapeutic Advances in Chronic Disease"},{"issue":"2","key":"9248_CR7","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/jcp.21094","volume":"212","author":"A Clerk","year":"2007","unstructured":"Clerk, A., Cullingford, T. E., Fuller, S. J., Giraldo, A., Markou, T., Pikkarainen, S., et al. (2007). Signaling pathways mediating cardiac myocyte gene expression in physiological and stress responses. Journal of Cellular Physiology, 212(2), 311\u2013322.","journal-title":"Journal of Cellular Physiology"},{"issue":"3","key":"9248_CR8","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1253\/circj.68.247","volume":"68","author":"SK Seimi","year":"2004","unstructured":"Seimi, S. K., Seinosuke, K., Tsuyoshi, S., Tomomi, U., Tetsuaki, H., Miki, K., et al. (2004). Glycogen synthase kinase-3beta is involved in the process of myocardial hypertrophy stimulated by insulin-like growth factor-1. Circulation Journal, 68(3), 247\u2013253.","journal-title":"Circulation Journal"},{"issue":"4","key":"9248_CR9","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1097\/HJH.0b013e3283505101","volume":"30","author":"S Sagara","year":"2012","unstructured":"Sagara, S., Osanai, T., Itoh, T., Izumiyama, K., Shibutani, S., Hanada, K., et al. (2012). Overexpression of coupling factor 6 attenuates exercise-induced physiological cardiac hypertrophy by inhibiting PI3K\/Akt signaling in mice. Journal of Hypertension, 30(4), 778\u2013786.","journal-title":"Journal of Hypertension"},{"issue":"8","key":"9248_CR10","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nrm1983","volume":"7","author":"J Heineke","year":"2006","unstructured":"Heineke, J., & Molkentin, J. D. (2006). Regulation of cardiac hypertrophy by intracellular signalling pathways. Nature Reviews Molecular Cell Biology, 7(8), 589\u2013600.","journal-title":"Nature Reviews Molecular Cell Biology"},{"issue":"12","key":"9248_CR11","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.2165\/00007256-200535120-00004","volume":"35","author":"NB Vollaard","year":"2005","unstructured":"Vollaard, N. B., Shearman, J. P., & Cooper, C. E. (2005). Exercise-induced oxidative stress: Myths, realities and physiological relevance. Sports Medicine, 35(12), 1045\u20131062.","journal-title":"Sports Medicine"},{"issue":"8","key":"9248_CR12","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1136\/hrt.2005.068270","volume":"93","author":"M Seddon","year":"2007","unstructured":"Seddon, M., Looi, Y. H., & Shah, A. M. (2007). Oxidative stress and redox signalling in cardiac hypertrophy and heart failure. Heart, 93(8), 903\u2013907.","journal-title":"Heart"},{"key":"9248_CR13","first-page":"293769","volume":"2011","author":"I Afanas\u2019ev","year":"2011","unstructured":"Afanas\u2019ev, I. (2011). ROS and RNS signaling in heart disorders: Could antioxidant treatment be successful? Oxidative Medicine and Cellular Longevity, 2011, 293769.","journal-title":"Oxidative Medicine and Cellular Longevity"},{"issue":"4","key":"9248_CR14","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/ptr.1309","volume":"17","author":"BH Ali","year":"2003","unstructured":"Ali, B. H., & Blunden, G. (2003). Pharmacological and toxicological properties of Nigella sativa. Phytotherapy Research, 17(4), 299\u2013305.","journal-title":"Phytotherapy Research"},{"issue":"1","key":"9248_CR15","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0378-8741(01)00216-1","volume":"76","author":"MS Al-Ghamdi","year":"2001","unstructured":"Al-Ghamdi, M. S. (2001). The anti-inflammatory, analgesic and antipyretic activity of Nigella sativa. Journal of Ethnopharmacology, 76(1), 45\u201348.","journal-title":"Journal of Ethnopharmacology"},{"issue":"5","key":"9248_CR16","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/1099-1573(200008)14:5<323::AID-PTR621>3.0.CO;2-Q","volume":"14","author":"M Burits","year":"2000","unstructured":"Burits, M., & Bucar, F. (2000). Antioxidant activity of Nigella sativa essential oil. Phytotherapy Research, 14(5), 323\u2013328.","journal-title":"Phytotherapy Research"},{"issue":"13\u201314","key":"9248_CR17","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/j.intimp.2005.06.008","volume":"5","author":"ML Salem","year":"2005","unstructured":"Salem, M. L. (2005). Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. International Immunopharmacology, 5(13\u201314), 1749\u20131770.","journal-title":"International Immunopharmacology"},{"issue":"3\u20134","key":"9248_CR18","doi-asserted-by":"crossref","first-page":"242","DOI":"10.5144\/0256-4947.2001.242","volume":"21","author":"ZA Hawsawi","year":"2001","unstructured":"Hawsawi, Z. A., Ali, B. A., & Bamosa, A. O. (2001). Effect of Nigella sativa (black seed) and thymoquinone on blood glucose in albino rats. Annals of Saudi Medicine, 21(3\u20134), 242\u2013244.","journal-title":"Annals of Saudi Medicine"},{"issue":"2","key":"9248_CR19","first-page":"195","volume":"46","author":"AO Bamosa","year":"2002","unstructured":"Bamosa, A. O., Ali, B. A., & al-Hawsawi, Z. A. (2002). The effect of thymoquinone on blood lipids in rats. Indian Journal of Physiology and Pharmacology, 46(2), 195\u2013201.","journal-title":"Indian Journal of Physiology and Pharmacology"},{"issue":"3","key":"9248_CR20","doi-asserted-by":"crossref","first-page":"e115","DOI":"10.1016\/j.ijcard.2007.07.075","volume":"131","author":"MN El-Bahai","year":"2009","unstructured":"El-Bahai, M. N., Al-Hariri, M. T., Yar, T., & Bamosa, A. O. (2009). Cardiac inotropic and hypertrophic effects of Nigella sativa supplementation in rats. International Journal of Cardiology, 131(3), e115\u2013e117.","journal-title":"International Journal of Cardiology"},{"issue":"2","key":"9248_CR21","first-page":"141","volume":"52","author":"T Yar","year":"2008","unstructured":"Yar, T., El-Hariri, M., El-Bahai, M. N., & Bamosa, A. O. (2008). Effects of Nigella sativa supplementation for one month on cardiac reserve in rats. Indian Journal of Physiology and Pharmacology, 52(2), 141\u2013148.","journal-title":"Indian Journal of Physiology and Pharmacology"},{"key":"9248_CR22","volume-title":"Review of medical physiology","year":"2005","unstructured":"Ganong, W. F. (Ed.). (2005). Review of medical physiology (22nd ed.). New York: McGraw Hill.","edition":"22"},{"issue":"5","key":"9248_CR23","doi-asserted-by":"crossref","first-page":"E929","DOI":"10.1152\/ajpendo.00539.2001","volume":"283","author":"J Manetta","year":"2002","unstructured":"Manetta, J., Brun, J. F., Maimoun, L., Callis, A., Prefaut, C., & Mercier, J. (2002). Effect of training on the GH\/IGF-I axis during exercise in middle-aged men: Relationship to glucose homeostasis. American Journal of Physiology. Endocrinology and Metabolism, 283(5), E929\u2013E936.","journal-title":"American Journal of Physiology. Endocrinology and Metabolism"},{"issue":"5","key":"9248_CR24","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1136\/bjsm.35.5.303","volume":"35","author":"JL Chicharro","year":"2001","unstructured":"Chicharro, J. L., Lopez-Calderon, A., Hoyos, J., Martin-Velasco, A. I., Villa, G., Villanua, M. A., et al. (2001). Effects of an endurance cycling competition on resting serum insulin-like growth factor I (IGF-I) and its binding proteins IGFBP-1 and IGFBP-3. British Journal of Sports Medicine, 35(5), 303\u2013307.","journal-title":"British Journal of Sports Medicine"},{"issue":"4","key":"9248_CR25","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1152\/japplphysiol.00482.2003","volume":"95","author":"K Iwasaki","year":"2003","unstructured":"Iwasaki, K., Zhang, R., Zuckerman, J. H., & Levine, B. D. (2003). Dose\u2013response relationship of the cardiovascular adaptation to endurance training in healthy adults: How much training for what benefit? Journal of Applied Physiology, 95(4), 1575\u20131583.","journal-title":"Journal of Applied Physiology"},{"issue":"8","key":"9248_CR26","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1519\/JSC.0b013e3181dc4571","volume":"25","author":"Y Meckel","year":"2011","unstructured":"Meckel, Y., Nemet, D., Bar-Sela, S., Radom-Aizik, S., Cooper, D. M., Sagiv, M., et al. (2011). Hormonal and inflammatory responses to different types of sprint interval training. Journal of Strength and Conditioning Research, 25(8), 2161\u20132169.","journal-title":"Journal of Strength and Conditioning Research"},{"issue":"1 Pt 2","key":"9248_CR27","first-page":"R308","volume":"275","author":"A Eliakim","year":"1998","unstructured":"Eliakim, A., Brasel, J. A., Mohan, S., Wong, W. L., & Cooper, D. M. (1998). Increased physical activity and the growth hormone-IGF-I axis in adolescent males. American Journal of Physiology, 275(1 Pt 2), R308\u2013R314.","journal-title":"American Journal of Physiology"},{"issue":"1","key":"9248_CR28","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1249\/MSS.0b013e3181b07c4d","volume":"42","author":"BC Nindl","year":"2010","unstructured":"Nindl, B. C., & Pierce, J. R. (2010). Insulin-like growth factor I as a biomarker of health, fitness, and training status. Medicine and Science in Sports and Exercise, 42(1), 39\u201349.","journal-title":"Medicine and Science in Sports and Exercise"},{"issue":"6","key":"9248_CR29","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1080\/02640419308730018","volume":"11","author":"M Alen","year":"1993","unstructured":"Alen, M., Pakarinen, A., & Hakkinen, K. (1993). Effects of prolonged training on serum thyrotropin and thyroid hormones in elite strength athletes. Journal of Sports Sciences, 11(6), 493\u2013497.","journal-title":"Journal of Sports Sciences"},{"issue":"2","key":"9248_CR30","first-page":"142","volume":"31","author":"A Pakarinen","year":"1991","unstructured":"Pakarinen, A., Hakkinen, K., & Alen, M. (1991). Serum thyroid hormones, thyrotropin and thyroxine binding globulin in elite athletes during very intense strength training of one week. Journal of Sports Medicine and Physical Fitness, 31(2), 142\u2013146.","journal-title":"Journal of Sports Medicine and Physical Fitness"},{"issue":"4","key":"9248_CR31","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1007\/BF00417982","volume":"57","author":"A Pakarinen","year":"1988","unstructured":"Pakarinen, A., Alen, M., Hakkinen, K., & Komi, P. (1988). Serum thyroid hormones, thyrotropin and thyroxine binding globulin during prolonged strength training. European Journal of Applied Physiology and Occupational Physiology, 57(4), 394\u2013398.","journal-title":"European Journal of Applied Physiology and Occupational Physiology"},{"issue":"3","key":"9248_CR32","first-page":"457","volume":"49","author":"D Rosolowska-Huszcz","year":"1998","unstructured":"Rosolowska-Huszcz, D. (1998). The effect of exercise training intensity on thyroid activity at rest. Journal of Physiology and Pharmacology, 49(3), 457\u2013466.","journal-title":"Journal of Physiology and Pharmacology"},{"issue":"Suppl 7","key":"9248_CR33","first-page":"89","volume":"59","author":"M Grandys","year":"2008","unstructured":"Grandys, M., Majerczak, J., Duda, K., Zapart-Bukowska, J., Sztefko, K., & Zoladz, J. A. (2008). The effect of endurance training on muscle strength in young, healthy men in relation to hormonal status. Journal of Physiology and Pharmacology, 59(Suppl 7), 89\u2013103.","journal-title":"Journal of Physiology and Pharmacology"},{"issue":"1","key":"9248_CR34","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1530\/acta.0.1140041","volume":"114","author":"H Hohtari","year":"1987","unstructured":"Hohtari, H., Pakarinen, A., & Kauppila, A. (1987). Serum concentrations of thyrotropin, thyroxine, triiodothyronine and thyroxine binding globulin in female endurance runners and joggers. Acta Endocrinologica, 114(1), 41\u201346.","journal-title":"Acta Endocrinologica"},{"issue":"11","key":"9248_CR35","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1161\/hh2301.100982","volume":"89","author":"GG Neri Serneri","year":"2001","unstructured":"Neri Serneri, G. G., Boddi, M., Modesti, P. A., Cecioni, I., Coppo, M., Padeletti, L., et al. (2001). Increased cardiac sympathetic activity and insulin-like growth factor-I formation are associated with physiological hypertrophy in athletes. Circulation Research, 89(11), 977\u2013982.","journal-title":"Circulation Research"},{"issue":"5","key":"9248_CR36","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1161\/01.HYP.18.5.575","volume":"18","author":"IT Meredith","year":"1991","unstructured":"Meredith, I. T., Friberg, P., Jennings, G. L., Dewar, E. M., Fazio, V. A., Lambert, G. W., et al. (1991). Exercise training lowers resting renal but not cardiac sympathetic activity in humans. Hypertension, 18(5), 575\u2013582.","journal-title":"Hypertension"},{"issue":"5","key":"9248_CR37","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.ejvs.2007.12.007","volume":"35","author":"JM Saxton","year":"2008","unstructured":"Saxton, J. M., Zwierska, I., Hopkinson, K., Espigares, E., Choksy, S., Nawaz, S., et al. (2008). Effect of upper- and lower-limb exercise training on circulating soluble adhesion molecules, hs-CRP and stress proteins in patients with intermittent claudication. European Journal of Vascular and Endovascular Surgery, 35(5), 607\u2013613.","journal-title":"European Journal of Vascular and Endovascular Surgery"},{"issue":"1","key":"9248_CR38","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S1734-1140(09)70004-0","volume":"61","author":"C Lawson","year":"2009","unstructured":"Lawson, C., & Wolf, S. (2009). ICAM-1 signaling in endothelial cells. Pharmacological Reports, 61(1), 22\u201332.","journal-title":"Pharmacological Reports"},{"issue":"12","key":"9248_CR39","doi-asserted-by":"crossref","first-page":"4219","DOI":"10.1161\/01.CIR.96.12.4219","volume":"96","author":"SJ Hwang","year":"1997","unstructured":"Hwang, S. J., Ballantyne, C. M., Sharrett, A. R., Smith, L. C., Davis, C. E., Gotto, A. M., Jr, et al. (1997). Circulating adhesion molecules VCAM-1, ICAM-1, and E-selectin in carotid atherosclerosis and incident coronary heart disease cases: The Atherosclerosis Risk In Communities (ARIC) study. Circulation, 96(12), 4219\u20134225.","journal-title":"Circulation"},{"issue":"9","key":"9248_CR40","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1053\/euhj.2000.2285","volume":"22","author":"S Adamopoulos","year":"2001","unstructured":"Adamopoulos, S., Parissis, J., Kroupis, C., Georgiadis, M., Karatzas, D., Karavolias, G., et al. (2001). Physical training reduces peripheral markers of inflammation in patients with chronic heart failure. European Heart Journal, 22(9), 791\u2013797.","journal-title":"European Heart Journal"},{"issue":"8","key":"9248_CR41","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.numecd.2005.09.004","volume":"16","author":"G Zoppini","year":"2006","unstructured":"Zoppini, G., Targher, G., Zamboni, C., Venturi, C., Cacciatori, V., Moghetti, P., et al. (2006). Effects of moderate-intensity exercise training on plasma biomarkers of inflammation and endothelial dysfunction in older patients with type 2 diabetes. Nutrition, Metabolism, and Cardiovascular Diseases, 16(8), 543\u2013549.","journal-title":"Nutrition, Metabolism, and Cardiovascular Diseases"},{"issue":"1","key":"9248_CR42","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0021-9150(03)00013-3","volume":"169","author":"AL Yang","year":"2003","unstructured":"Yang, A. L., & Chen, H. I. (2003). Chronic exercise reduces adhesion molecules\/iNOS expression and partially reverses vascular responsiveness in hypercholesterolemic rabbit aortae. Atherosclerosis, 169(1), 11\u201317.","journal-title":"Atherosclerosis"},{"issue":"11","key":"9248_CR43","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1046\/j.1365-2362.1997.2220763.x","volume":"27","author":"JJ Poveda","year":"1997","unstructured":"Poveda, J. J., Riestra, A., Salas, E., Cagigas, M. L., Lopez-Somoza, C., Amado, J. A., et al. (1997). Contribution of nitric oxide to exercise-induced changes in healthy volunteers: Effects of acute exercise and long-term physical training. European Journal of Clinical Investigation, 27(11), 967\u2013971.","journal-title":"European Journal of Clinical Investigation"},{"key":"9248_CR44","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1472-6793-8-12","volume":"8","author":"C Moraes de","year":"2008","unstructured":"de Moraes, C., Davel, A. P., Rossoni, L. V., Antunes, E., & Zanesco, A. (2008). Exercise training improves relaxation response and SOD-1 expression in aortic and mesenteric rings from high caloric diet-fed rats. BMC Physiology, 8, 12.","journal-title":"BMC Physiology"},{"issue":"2","key":"9248_CR45","doi-asserted-by":"crossref","first-page":"H786","DOI":"10.1152\/ajpheart.00678.2006","volume":"292","author":"T Otsuki","year":"2007","unstructured":"Otsuki, T., Maeda, S., Iemitsu, M., Saito, Y., Tanimura, Y., Ajisaka, R., et al. (2007). Vascular endothelium-derived factors and arterial stiffness in strength- and endurance-trained men. American Journal of Physiology Heart and Circulatory Physiology, 292(2), H786\u2013H791.","journal-title":"American Journal of Physiology Heart and Circulatory Physiology"},{"issue":"6","key":"9248_CR46","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1590\/S0066-782X2008000600010","volume":"90","author":"JA Garcia","year":"2008","unstructured":"Garcia, J. A., & Incerpi, E. K. (2008). Factors and mechanisms involved in left ventricular hypertrophy and the anti-hypertrophic role of nitric oxide. Arquivos Brasileiros de Cardiologia, 90(6), 409\u2013416.","journal-title":"Arquivos Brasileiros de Cardiologia"},{"issue":"1","key":"9248_CR47","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1536\/jhj.43.25","volume":"43","author":"H Kohno","year":"2002","unstructured":"Kohno, H., Furukawa, S., Naito, H., Minamitani, K., Ohmori, D., & Yamakura, F. (2002). Contribution of nitric oxide, angiotensin II and superoxide dismutase to exercise-induced attenuation of blood pressure elevation in spontaneously hypertensive rats. Japanese Heart Journal, 43(1), 25\u201334.","journal-title":"Japanese Heart Journal"},{"issue":"2","key":"9248_CR48","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.freeradbiomed.2007.02.001","volume":"44","author":"MC Gomez-Cabrera","year":"2008","unstructured":"Gomez-Cabrera, M. C., Domenech, E., & Vina, J. (2008). Moderate exercise is an antioxidant: Upregulation of antioxidant genes by training. Free Radical Biology & Medicine, 44(2), 126\u2013131.","journal-title":"Free Radical Biology & Medicine"},{"issue":"2","key":"9248_CR49","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.freeradbiomed.2007.02.006","volume":"44","author":"SK Powers","year":"2008","unstructured":"Powers, S. K., Quindry, J. C., & Kavazis, A. N. (2008). Exercise-induced cardioprotection against myocardial ischemia-reperfusion injury. Free Radical Biology & Medicine, 44(2), 193\u2013201.","journal-title":"Free Radical Biology & Medicine"},{"issue":"3","key":"9248_CR50","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/jlb.65.3.337","volume":"65","author":"T Finkel","year":"1999","unstructured":"Finkel, T. (1999). Signal transduction by reactive oxygen species in non-phagocytic cells. Journal of Leukocyte Biology, 65(3), 337\u2013340.","journal-title":"Journal of Leukocyte Biology"},{"issue":"7","key":"9248_CR51","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S0022-2828(03)00145-7","volume":"35","author":"H Nakagami","year":"2003","unstructured":"Nakagami, H., Takemoto, M., & Liao, J. K. (2003). NADPH oxidase-derived superoxide anion mediates angiotensin II-induced cardiac hypertrophy. Journal of Molecular and Cellular Cardiology, 35(7), 851\u2013859.","journal-title":"Journal of Molecular and Cellular Cardiology"},{"issue":"3","key":"9248_CR52","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1006\/phrs.1999.0585","volume":"41","author":"MN Nagi","year":"2000","unstructured":"Nagi, M. N., & Mansour, M. A. (2000). Protective effect of thymoquinone against doxorubicin-induced cardiotoxicity in rats: A possible mechanism of protection. Pharmacological Research, 41(3), 283\u2013289.","journal-title":"Pharmacological Research"},{"issue":"3","key":"9248_CR53","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/jat.1057","volume":"25","author":"MA Abdel-Wahhab","year":"2005","unstructured":"Abdel-Wahhab, M. A., & Aly, S. E. (2005). Antioxidant property of Nigella sativa (black cumin) and Syzygium aromaticum (clove) in rats during aflatoxicosis. Journal of Applied Toxicology, 25(3), 218\u2013223.","journal-title":"Journal of Applied Toxicology"},{"issue":"1","key":"9248_CR54","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1002\/ar.a.20056","volume":"279","author":"M Kanter","year":"2004","unstructured":"Kanter, M., Coskun, O., Korkmaz, A., & Oter, S. (2004). Effects of Nigella sativa on oxidative stress and beta-cell damage in streptozotocin-induced diabetic rats. The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology, 279(1), 685\u2013691.","journal-title":"The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology"}],"container-title":["Cardiovascular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-014-9248-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12012-014-9248-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-014-9248-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T05:00:41Z","timestamp":1565154041000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12012-014-9248-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,5]]},"references-count":54,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["9248"],"URL":"https:\/\/doi.org\/10.1007\/s12012-014-9248-0","relation":{},"ISSN":["1530-7905","1559-0259"],"issn-type":[{"value":"1530-7905","type":"print"},{"value":"1559-0259","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,5]]}}}