{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:30:45Z","timestamp":1789345845936,"version":"build-2803163510"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2014,8,27]],"date-time":"2014-08-27T00:00:00Z","timestamp":1409097600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Toxicol"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1007\/s12012-014-9276-9","type":"journal-article","created":{"date-parts":[[2014,8,26]],"date-time":"2014-08-26T19:17:02Z","timestamp":1409080622000},"page":"140-146","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["The Effects of High Glucose Levels on Reactive Oxygen Species-Induced Apoptosis and Involved Signaling in Human Vascular Endothelial Cells"],"prefix":"10.1007","volume":"15","author":[{"given":"Qian","family":"Hou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minxiang","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,8,27]]},"reference":[{"key":"9276_CR1","first-page":"141","volume":"45","author":"SR Zatalia","year":"2013","unstructured":"Zatalia, S. R., & Sanusi, H. (2013). The role of antioxidants in the pathophysiology, complications, and management of diabetes mellitus. Acta Medica Indonesia, 45, 141\u2013147.","journal-title":"Acta Medica Indonesia"},{"key":"9276_CR2","first-page":"792393","volume":"2010","author":"IA Oever van den","year":"2010","unstructured":"van den Oever, I. A., Raterman, H. G., Nurmohamed, M. T., & Simsek, S. (2010). Endothelial dysfunction, inflammation, and apoptosis in diabetes mellitus. Mediators of Inflammation, 2010, 792393.","journal-title":"Mediators of Inflammation"},{"key":"9276_CR3","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2174\/1573399052952550","volume":"1","author":"H Nakagami","year":"2005","unstructured":"Nakagami, H., Kaneda, Y., Ogihara, T., & Morishita, R. (2005). Endothelial dysfunction in hyperglycemia as a trigger of atherosclerosis. Current Diabetes Review, 1, 59\u201363.","journal-title":"Current Diabetes Review"},{"key":"9276_CR4","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1182\/blood-2013-09-512749","volume":"123","author":"YW Kim","year":"2014","unstructured":"Kim, Y. W., & Byzova, T. V. (2014). Oxidative stress in angiogenesis and vascular disease. Blood, 123, 625\u2013631.","journal-title":"Blood"},{"key":"9276_CR5","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1253\/circj.CJ-13-1187","volume":"78","author":"Y Teshima","year":"2014","unstructured":"Teshima, Y., Takahashi, N., Nishio, S., Saito, S., Kondo, H., Fukui, A., et al. (2014). Production of reactive oxygen species in the diabetic heart. Roles of mitochondria and NADPH oxidase. Circulation Journal, 78, 300\u2013306.","journal-title":"Circulation Journal"},{"key":"9276_CR6","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1161\/01.RES.74.6.1141","volume":"74","author":"KK Griendling","year":"1994","unstructured":"Griendling, K. K., Minieri, C. A., Ollerenshaw, J. D., & Alexander, R. W. (1994). Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circulation Research, 74, 1141\u20131148.","journal-title":"Circulation Research"},{"key":"9276_CR7","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1161\/01.RES.86.5.494","volume":"86","author":"KK Griendling","year":"2000","unstructured":"Griendling, K. K., Sorescu, D., & Ushio-Fukai, M. (2000). NAD(P)H oxidase: Role in cardiovascular biology and disease. Circulation Research, 86, 494\u2013501.","journal-title":"Circulation Research"},{"key":"9276_CR8","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nri1312","volume":"4","author":"JD Lambeth","year":"2004","unstructured":"Lambeth, J. D. (2004). NOX enzymes and the biology of reactive oxygen. Nature Reviews Immunology, 4, 181\u2013189.","journal-title":"Nature Reviews Immunology"},{"key":"9276_CR9","doi-asserted-by":"crossref","first-page":"C597","DOI":"10.1152\/ajpcell.00331.2011","volume":"302","author":"RM Maalouf","year":"2012","unstructured":"Maalouf, R. M., Eid, A. A., Gorin, Y. C., Block, K., Escobar, G. P., Bailey, S., et al. (2012). Nox4-derived reactive oxygen species mediate cardiomyocyte injury in early type 1 diabetes. American Journal of Physiology. Cell Physiology, 302, C597\u2013C604.","journal-title":"American Journal of Physiology. Cell Physiology"},{"key":"9276_CR10","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s11883-012-0237-0","volume":"14","author":"M Hulsmans","year":"2012","unstructured":"Hulsmans, M., Van Dooren, E., & Holvoet, P. (2012). Mitochondrial reactive oxygen species and risk of atherosclerosis. Current Atherosclerosis Reports, 14, 264\u2013276.","journal-title":"Current Atherosclerosis Reports"},{"key":"9276_CR11","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1002\/jcb.23173","volume":"112","author":"J Qian","year":"2011","unstructured":"Qian, J., Keyes, K. T., Long, B., Chen, G., & Ye, Y. (2011). Impact of HMG-CoA reductase inhibition on oxidant-induced injury in human retinal pigment epithelium cells. Journal of Cellular Biochemistry, 112, 2480\u20132489.","journal-title":"Journal of Cellular Biochemistry"},{"key":"9276_CR12","doi-asserted-by":"crossref","first-page":"8139","DOI":"10.1158\/0008-5472.CAN-03-2301","volume":"64","author":"X Zhang","year":"2004","unstructured":"Zhang, X., Kon, T., Wang, H., Li, F., Huang, Q., Rabbani, Z. N., et al. (2004). Enhancement of hypoxia-induced tumor cell death in vitro and radiation therapy in vivo by use of small interfering RNA targeted to hypoxia-inducible factor-1alpha. Cancer Research, 64, 8139\u20138142.","journal-title":"Cancer Research"},{"key":"9276_CR13","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.exphem.2011.10.001","volume":"40","author":"I Kim","year":"2012","unstructured":"Kim, I., Kim, Y. J., M\u00e9tais, J. Y., Dunbar, C. E., & Larochelle, A. (2012). Transient silencing of PTEN in human CD34(+) cells enhances their proliferative potential and ability to engraft immunodeficient mice. Experimental Hematology, 40, 84\u201391.","journal-title":"Experimental Hematology"},{"key":"9276_CR14","first-page":"4431","volume":"33","author":"R Hiraga","year":"2013","unstructured":"Hiraga, R., Kato, M., Miyagawa, S., & Kamata, T. (2013). Nox4-derived ROS signaling contributes to TGF-\u03b2-induced epithelial-mesenchymal transition in pancreatic cancer cells. Anticancer Research, 33, 4431\u20134438.","journal-title":"Anticancer Research"},{"key":"9276_CR15","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1111\/j.1471-4159.2008.05619.x","volume":"107","author":"Q Chen","year":"2008","unstructured":"Chen, Q., Zhu, X., Zhang, Y., Lee, T. H., Liu, Y., Wetsel, W. C., et al. (2008). Neural plasticity and addiction: integrin-linked kinase and cocaine behavioral sensitization. Journal of Neurochemistry, 107, 679\u2013689.","journal-title":"Journal of Neurochemistry"},{"key":"9276_CR16","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1161\/CIRCULATIONAHA.107.716498","volume":"116","author":"P Song","year":"2007","unstructured":"Song, P., Wu, Y., Xu, J., Xie, Z., Dong, Y., et al. (2007). Reactive nitrogen species induced by hyperglycemia suppresses Akt signaling and triggers apoptosis by upregulating phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10) in an LKB1-dependent manner. Circulation, 116, 1585\u20131595.","journal-title":"Circulation"},{"key":"9276_CR17","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1073\/pnas.0438011100","volume":"100","author":"K Lei","year":"2003","unstructured":"Lei, K., & Davis, R. J. (2003). JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis. Proceedings of the National Academy of Sciences, 100, 2432\u20132437.","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"9276_CR18","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1074\/jbc.274.4.2225","volume":"274","author":"DM Finucane","year":"1999","unstructured":"Finucane, D. M., Bossy-Wetzel, E., Waterhouse, N. J., Cotter, T. G., & Green, D. R. (1999). Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-xL. Journal of Biological Chemistry, 274, 2225\u20132233.","journal-title":"Journal of Biological Chemistry"},{"key":"9276_CR19","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/0092-8674(93)90509-O","volume":"74","author":"ZN Oltvai","year":"1993","unstructured":"Oltvai, Z. N., Milliman, C. L., & Korsmeyer, S. J. (1993). Bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates programmed cell death. Cell, 74, 609\u2013615.","journal-title":"Cell"},{"key":"9276_CR20","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S1097-2765(01)00320-3","volume":"8","author":"EH Cheng","year":"2001","unstructured":"Cheng, E. H., Wei, M. C., Weiler, S., Flavell, R. A., Mak, T. W., Lindsten, T., et al. (2001). BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Molecular Cell, 8, 705\u2013711.","journal-title":"Molecular Cell"},{"key":"9276_CR21","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/j.1349-7006.2005.00065.x","volume":"96","author":"E Sasabe","year":"2005","unstructured":"Sasabe, E., Tatemoto, Y., Li, D., Yamamoto, T., & Osaki, T. (2005). Mechanism of HIF-1alpha-dependent suppression of hypoxia-induced apoptosis in squamous cell carcinoma cells. Cancer Science, 96, 394\u2013402.","journal-title":"Cancer Science"},{"key":"9276_CR22","first-page":"50","volume":"51","author":"J Hasnan","year":"2010","unstructured":"Hasnan, J., Yusof, M. I., Damitri, T. D., Faridah, A. R., Adenan, A. S., & Norbaini, T. H. (2010). Relationship between apoptotic markers (Bax and Bcl-2) and biochemical markers in type 2 diabetes mellitus. Singapore Medical Journal, 51, 50\u201355.","journal-title":"Singapore Medical Journal"},{"key":"9276_CR23","doi-asserted-by":"crossref","first-page":"4660","DOI":"10.1210\/en.2004-0282","volume":"145","author":"G Tell","year":"2004","unstructured":"Tell, G., Pines, A., Arturi, F., Cesaratto, L., Adamson, E., Puppin, C., et al. (2004). Control of phosphatase and tensin homolog (PTEN) gene expression in normal and neoplastic thyroid cells. Endocrinology, 145, 4660\u20134666.","journal-title":"Endocrinology"},{"key":"9276_CR24","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.ijrobp.2011.08.005","volume":"83","author":"Y Zhang","year":"2012","unstructured":"Zhang, Y., Zhang, X., Rabbani, Z. N., Jackson, I. L., & Vujaskovic, Z. (2012). Oxidative stress mediates radiation lung injury by inducing apoptosis. International Journal of Radiation Oncology Biology Physics, 83, 740\u2013748.","journal-title":"International Journal of Radiation Oncology Biology Physics"},{"key":"9276_CR25","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1074\/jbc.M009134200","volume":"276","author":"J Torres","year":"2001","unstructured":"Torres, J., & Pulido, R. (2001). The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation. Journal of Biological Chemistry, 276, 993\u2013998.","journal-title":"Journal of Biological Chemistry"},{"key":"9276_CR26","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1111\/j.1755-148X.2009.00585.x","volume":"22","author":"SV Madhunapantula","year":"2009","unstructured":"Madhunapantula, S. V., & Robertson, G. P. (2009). The PTEN-AKT3 signaling cascade as a therapeutic target in melanoma. Pigment Cell & Melanoma Research, 22, 400\u2013419.","journal-title":"Pigment Cell & Melanoma Research"},{"key":"9276_CR27","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1080\/10715760701689550","volume":"41","author":"ZN Rabbani","year":"2007","unstructured":"Rabbani, Z. N., Salahuddin, F. K., Yarmolenko, P., Batinic-Haberle, I., Thrasher, B. A., Gauter-Fleckenstein, B., et al. (2007). Low molecular weight catalytic metalloporphyrin antioxidant AEOL 10150 protects lungs from fractionated radiation. Free Radical Research, 41, 1273\u20131282.","journal-title":"Free Radical Research"},{"key":"9276_CR28","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1093\/carcin\/bgm052","volume":"28","author":"C Blanco-Aparicio","year":"2007","unstructured":"Blanco-Aparicio, C., Renner, O., Leal, J. F., & Carnero, A. (2007). PTEN, more than the AKT pathway. Carcinogenesis, 28, 1379\u20131386.","journal-title":"Carcinogenesis"},{"key":"9276_CR29","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ejphar.2013.10.034","volume":"720","author":"X Zheng","year":"2013","unstructured":"Zheng, X., Zhu, S., Chang, S., Cao, Y., Dong, J., Li, J., et al. (2013). Protective effects of chronic resveratrol treatment on vascular inflammatory injury in steptozotocin-induced type 2 diabetic rats: role of NF-kappa B signaling. European Journal of Pharmacology, 720, 147\u2013157.","journal-title":"European Journal of Pharmacology"}],"container-title":["Cardiovascular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-014-9276-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12012-014-9276-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-014-9276-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T01:40:25Z","timestamp":1559439625000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12012-014-9276-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,27]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["9276"],"URL":"https:\/\/doi.org\/10.1007\/s12012-014-9276-9","relation":{},"ISSN":["1530-7905","1559-0259"],"issn-type":[{"value":"1530-7905","type":"print"},{"value":"1559-0259","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,27]]}}}