{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:04:08Z","timestamp":1790888648914,"version":"4.1.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2015,9,21]],"date-time":"2015-09-21T00:00:00Z","timestamp":1442793600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Toxicol"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1007\/s12012-015-9343-x","type":"journal-article","created":{"date-parts":[[2015,9,21]],"date-time":"2015-09-21T08:54:18Z","timestamp":1442825658000},"page":"336-344","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Anti-inflammatory, Antithrombotic and Cardiac Remodeling Preventive Effects of Eugenol in Isoproterenol-Induced Myocardial Infarction in Wistar Rat"],"prefix":"10.1007","volume":"16","author":[{"given":"Kais","family":"Mnafgui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raouf","family":"Hajji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Derbali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anis","family":"Gammoudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaddour","family":"Khabbabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hedi","family":"Ellefi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noureddine","family":"Allouche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel","family":"Kadri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neji","family":"Gharsallah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,9,21]]},"reference":[{"key":"9343_CR1","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1002\/prca.200780135","volume":"2","author":"MY White","year":"2008","unstructured":"White, M. Y., Edwards, A. G., Cordwell, S. J., & Van Eyk, J. E. (2008). Mitochondria: A mirror into cellular dysfunction in heart disease. Proteomics-Clinical Applications, 2, 845\u2013861.","journal-title":"Proteomics-Clinical Applications"},{"key":"9343_CR2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM199901143400207","volume":"340","author":"R Ross","year":"1999","unstructured":"Ross, R. (1999). Atherosclerosis-an inflammatory disease. New England Journal of Medicine, 340, 115\u2013126.","journal-title":"New England Journal of Medicine"},{"key":"9343_CR3","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1161\/01.CIR.0000139858.69915.2E","volume":"110","author":"MK Hong","year":"2004","unstructured":"Hong, M. K., Mintz, G. S., Lee, C. W., Kim, Y. H., Lee, S. W., Song, J. M., et al. (2004). Comparison of coronary plaque rupture between stable angina and acute myocardial infarction: A three-vessel intravascular ultrasound study in 235 patients. Circulation, 110, 928\u2013933.","journal-title":"Circulation"},{"key":"9343_CR4","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1016\/S0140-6736(06)68770-9","volume":"367","author":"AD Lopez","year":"2006","unstructured":"Lopez, A. D., Mathers, C. D., Ezzati, M., Jamison, D. T., & Murray, C. J. (2006). Global and regional burden of disease and risk factors, 2001: Systematic analysis of population health data. Lancet, 367, 1747\u20131757.","journal-title":"Lancet"},{"key":"9343_CR5","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0735-1097(99)00630-0","volume":"35","author":"JN Cohn","year":"2000","unstructured":"Cohn, J. N., Ferrari, R., & Sharpe, N. (2000). Cardiac remodeling\u2014concepts and clinical implications: A consensus paper from an international forum on cardiac remodeling. Behalf of an International Forum on Cardiac Remodeling. Journal of the American College of Cardiology, 35, 569\u2013582.","journal-title":"Journal of the American College of Cardiology"},{"key":"9343_CR6","first-page":"398","volume":"294","author":"FN Salloum","year":"2008","unstructured":"Salloum, F. N., Abbate, A., Das, A., Houser, J. E., Mudrick, C. A., Qureshi, I. Z., et al. (2008). Sildenafil (Viagra) attenuates ischemic cardiomyopathy and improves left ventricular function in mice. American Journal of Physiology: Heart and Circulation Physiology, 294, 398\u2013406.","journal-title":"American Journal of Physiology: Heart and Circulation Physiology"},{"key":"9343_CR7","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-015-9323-1","author":"K Mnafgui","year":"2015","unstructured":"Mnafgui, K., Hajji, R., Derbali, F., Khlif, I., Kraiem, F., Ellefi, H., et al. (2015). Protective effect of hydroxytyrosol against cardiac remodeling after isoproterenol-induced myocardial infarction in rat. Cardiovascular Toxicology. doi: 10.1007\/s12012-015-9323-1 .","journal-title":"Cardiovascular Toxicology"},{"key":"9343_CR8","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.ahj.2006.02.022","volume":"152","author":"C Borghi","year":"2006","unstructured":"Borghi, C., Bacchelli, S., Esposti, D. D., & Ambrosioni, E. (2006). Effects of early angiotensin-converting enzyme inhibition in patients with non\u2013ST-elevation acute anterior myocardial infarction. American Heart Journal, 152, 470\u2013477.","journal-title":"American Heart Journal"},{"key":"9343_CR9","doi-asserted-by":"publisher","DOI":"10.3109\/15376516.2015.1053648","author":"K Mnafgui","year":"2015","unstructured":"Mnafgui, K., Khlif, I., Hajji, R., Derbali, F., Kraiem, F., Ellefi, H., et al. (2015). Preventive effects of oleuropein against cardiac remodeling after myocardial infarction in Wistar rat through inhibiting angiotensin-converting enzyme activity. Journal of Toxicology Mechanisms and Methods. doi: 10.3109\/15376516.2015.1053648 .","journal-title":"Journal of Toxicology Mechanisms and Methods"},{"key":"9343_CR10","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s11010-013-1824-2","volume":"385","author":"S Srinivasan","year":"2014","unstructured":"Srinivasan, S., Sathish, G., Jayanthi, M., Muthukumaran, J., Muruganathan, U., & Ramachandran, V. (2014). Ameliorating effect of eugenol on hyperglycemia by attenuating the key enzymes of glucose metabolism in streptozotocin induced diabetic rats. Journal of Molecular and Cellular Biochemistry, 385, 159\u2013168.","journal-title":"Journal of Molecular and Cellular Biochemistry"},{"key":"9343_CR11","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3109\/13813455.2013.822521","volume":"119","author":"K Mnafgui","year":"2013","unstructured":"Mnafgui, K., Kaanich, F., Derbali, A., Hamden, K., Derbali, F., Slama, S., et al. (2013). Inhibition of key enzymes related to diabetes and hypertension by eugenol in vitro and in alloxan-induced diabetic rats. Archive of Physiology and Biochemistry, 119, 225\u2013233.","journal-title":"Archive of Physiology and Biochemistry"},{"key":"9343_CR12","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0891-5849(88)90023-8","volume":"4","author":"CG Fraga","year":"1988","unstructured":"Fraga, C. G., Leibovitz, B. E., & Toppel, A. L. (1988). Lipid peroxidation measured as thiobarbituric acid-reactive substances in tissue slices: Characterization and comparison with homogenates and microsomes. Free Radical Biology and Medicine, 4, 155\u2013161.","journal-title":"Free Radical Biology and Medicine"},{"key":"9343_CR13","first-page":"130","volume":"21","author":"P Kakkar","year":"1984","unstructured":"Kakkar, P., Das, B., & Viswanathan, P. N. (1984). A modified spectrophotometric assay of superoxide dismutase. Indian Journal of Biochemistry & Biophysics, 21, 130\u2013132.","journal-title":"Indian Journal of Biochemistry & Biophysics"},{"key":"9343_CR14","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1126\/science.179.4073.588","volume":"179","author":"JT Rotruck","year":"1973","unstructured":"Rotruck, J. T., Pope, A. L., Ganther, H. E., Swanson, A. B., Hafeman, D. G., & Hoekstra, W. G. (1973). Selenium: Biochemical role as a component of glutathione peroxidase. Science, 179, 588\u2013590.","journal-title":"Science"},{"key":"9343_CR15","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ejphar.2011.02.037","volume":"659","author":"MM Kannan","year":"2011","unstructured":"Kannan, M. M., & Quine, S. D. (2011). Ellagic acid ameliorates isoproterenol induced oxidative stress: Evidence from electrocardiological, biochemical and histological study. European Journal of Pharmacology, 659, 45\u201352.","journal-title":"European Journal of Pharmacology"},{"key":"9343_CR16","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0014-2999(99)00631-7","volume":"382","author":"EJ Whalen","year":"1999","unstructured":"Whalen, E. J., & Lewis, S. J. (1999). In vivo evidence that isoproterenol may increase heart rate in the rat by mechanisms in addition to activation of cardiac b1-or b2-adrenoceptors. European Journal of Pharmacology, 382, 207\u2013210.","journal-title":"European Journal of Pharmacology"},{"key":"9343_CR17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3923\/jpt.2011.1.17","volume":"6","author":"A Upaganlawar","year":"2011","unstructured":"Upaganlawar, A., Gandhi, H., & Balaraman, R. (2011). Isoproterenol induced myocardial infarction: Protective role of natural products. Journal of Pharmacology and Toxicology, 6, 1\u201317.","journal-title":"Journal of Pharmacology and Toxicology"},{"key":"9343_CR18","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S1537-1891(02)00311-7","volume":"40","author":"EN Damiania","year":"2003","unstructured":"Damiania, E. N., Rossonia, L. V., & Vassalloa, D. V. (2003). Vasorelaxant effects of eugenol on rat thoracic aorta. Vascular Pharmacology, 40, 59\u201366.","journal-title":"Vascular Pharmacology"},{"key":"9343_CR19","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/BF02912923","volume":"21","author":"R Choudhary","year":"2006","unstructured":"Choudhary, R., Mishra, K. P., & Subramanyam, C. (2006). Prevention of isoproterenol-induced cardiac hypertrophy by eugenol, an antioxidant. Indian Journal of Clinical Biochemistry, 21, 107\u2013113.","journal-title":"Indian Journal of Clinical Biochemistry"},{"key":"9343_CR20","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1097\/00005344-200402000-00013","volume":"43","author":"S Lahlou","year":"2004","unstructured":"Lahlou, S., Interaminense, L. F. L., Magalh\u00e3es, P. J. C., Leal-Cardoso, J. H., & Duarte, G. P. (2004). Cardiovascular effects of eugenol, a phenolic compound present in many plant essential oils, in normotensive rats. Journal of Cardiovascular Pharmacology, 43, 250\u2013257.","journal-title":"Journal of Cardiovascular Pharmacology"},{"key":"9343_CR21","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.2174\/138161212799504777","volume":"18","author":"AY Gasparyan","year":"2012","unstructured":"Gasparyan, A. Y. (2012). Cardiovascular risk and inflammation: Pathophysiological mechanisms, drug design, and targets. Current Pharmaceutical Design, 18, 1447\u20131449.","journal-title":"Current Pharmaceutical Design"},{"key":"9343_CR22","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1056\/NEJM200010193431602","volume":"343","author":"B Lindahl","year":"2000","unstructured":"Lindahl, B., Toss, H., Siegbahn, A., Venge, P., & Wallentin, L. (2000). Markers of myocardial damage and inflammation in relation to long term mortality in unstable coronary artery disease. FRISC Study Group. Fragmin during instability in Coronary Artery Disease. New England Journal of Medicine, 343, 1139\u20131147.","journal-title":"New England Journal of Medicine"},{"key":"9343_CR23","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1161\/01.CIR.99.7.855","volume":"99","author":"LM Biasucci","year":"1999","unstructured":"Biasucci, L. M., Liuzzo, G., Grillo, R. L., Caligiuri, G., Rebuzzi, A. G., Buffon, A., et al. (1999). Elevated levels of C-reactive protein at discharge in patients with unstable angina predict recurrent instability. Circulation, 99, 855\u2013860.","journal-title":"Circulation"},{"key":"9343_CR24","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1161\/01.ATV.19.6.1368","volume":"19","author":"G Maresca","year":"1999","unstructured":"Maresca, G., Di Blasio, A., Marchioli, R., & Di Minno, G. (1999). Measuring plasma fibrinogen to predict stroke and myocardial infarction: An update. Arteriosclerosis, Thrombosis, and Vascular Biology, 19, 1368\u20131377.","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"9343_CR25","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0021-9150(00)00703-6","volume":"157","author":"J Sutter De","year":"2001","unstructured":"De Sutter, J., De Buyzere, M., Gheeraert, P., Van de Wiele, C., Voet, J., De Pauw, M., et al. (2001). Fibrinogen and C-reactive protein on admission as markers of final infarct size after primary angioplasty for acute myocardial infarction. Atherosclerosis, 157, 189\u2013196.","journal-title":"Atherosclerosis"},{"key":"9343_CR26","doi-asserted-by":"crossref","first-page":"21","DOI":"10.5493\/wjem.v5.i1.21","volume":"5","author":"V Lubrano","year":"2015","unstructured":"Lubrano, V., & Balzan, S. (2015). Consolidated and emerging inflammatory markers in coronary artery disease. World Journal of Experimental Medicine, 5, 21\u201332.","journal-title":"World Journal of Experimental Medicine"},{"key":"9343_CR27","first-page":"74","volume":"86","author":"L Badimon","year":"1992","unstructured":"Badimon, L., Chesebro, J. H., & Badimon, J. J. (1992). Thrombus formation on ruptured atherosclerotic plaques and rethrombosis on evolving thrombi. Circulation, 86, 74\u201385.","journal-title":"Circulation"},{"key":"9343_CR28","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1191\/1358863x03vm494ra","volume":"8","author":"WH Reinhart","year":"2003","unstructured":"Reinhart, W. H. (2003). Fibrinogen -marker or mediator of vascular disease? Vascular Medicine, 8, 211\u2013216.","journal-title":"Vascular Medicine"},{"key":"9343_CR29","first-page":"315","volume":"6","author":"G Coppola","year":"2005","unstructured":"Coppola, G., Rizzo, M., Abrignani, M. G., Corrado, E., Di Girolamo, A., Braschi, A., et al. (2005). Fibrinogen as a predictor of mortality after acute myocardial infarction: A forty-two-month follow-up study. Italian Heart Journal, 6, 315\u2013322.","journal-title":"Italian Heart Journal"},{"key":"9343_CR30","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.metabol.2012.06.003","volume":"62","author":"MM Kannan","year":"2013","unstructured":"Kannan, M. M., & Quine, D. S. (2013). Ellagic acid inhibits cardiac arrhythmias, hypertrophy and hyperlipidaemia during myocardial infarction in rats. Metabolism, 62, 52\u201361.","journal-title":"Metabolism"},{"key":"9343_CR31","first-page":"2417","volume":"290","author":"JL Grobe","year":"2006","unstructured":"Grobe, J. L., Mecca, A. P., Mao, H., & Katovich, M. G. (2006). Chronic angiotensin (1\u20137) prevents cardiac fibrosis in DOCA-salt model of hypertension. American Journal of Physiology: Heart and Circulation Physiology, 290, 2417\u20132423.","journal-title":"American Journal of Physiology: Heart and Circulation Physiology"},{"key":"9343_CR32","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1056\/NEJM199411103311907","volume":"331","author":"WA Border","year":"1994","unstructured":"Border, W. A., & Noble, N. A. (1994). Transforming growth factor \u03b2 in tissue fibrosis. New England Journal of Medicine, 331, 1286\u20131292.","journal-title":"New England Journal of Medicine"},{"key":"9343_CR33","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.ejphar.2012.11.012","volume":"699","author":"SG Roy","year":"2013","unstructured":"Roy, S. G., & Prince, S. M. (2013). Protective effects of sinapic acid on cardiac hypertrophy, dyslipidaemia and altered electrocardiogram in isoproterenol-induced myocardial infarcted rats. European Journal of Pharmacology, 699, 213\u2013218.","journal-title":"European Journal of Pharmacology"},{"key":"9343_CR34","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.cardiores.2003.10.025","volume":"61","author":"LB Becker","year":"2004","unstructured":"Becker, L. B. (2004). New concepts in reactive oxygen species and cardiovascular reperfusion physiology. Cardiovascular Research, 61, 461\u2013470.","journal-title":"Cardiovascular Research"},{"key":"9343_CR35","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.fct.2004.11.019","volume":"43","author":"M Ito","year":"2005","unstructured":"Ito, M., Murakami, K., & Yoshino, M. (2005). Antioxidant action of eugenol compounds: Role of metal ion in the inhibition of lipid peroxidation. Food and Chemical Toxicology, 43, 461\u2013466.","journal-title":"Food and Chemical Toxicology"}],"container-title":["Cardiovascular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-015-9343-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12012-015-9343-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-015-9343-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-015-9343-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T22:39:53Z","timestamp":1653172793000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12012-015-9343-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,21]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["9343"],"URL":"https:\/\/doi.org\/10.1007\/s12012-015-9343-x","relation":{},"ISSN":["1530-7905","1559-0259"],"issn-type":[{"value":"1530-7905","type":"print"},{"value":"1559-0259","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,21]]}}}