{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T20:47:06Z","timestamp":1762980426434,"version":"3.41.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T00:00:00Z","timestamp":1497398400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"JSPS KAKENHI","award":["16K08559"],"award-info":[{"award-number":["16K08559"]}]},{"name":"The Research Promotion Grant from Toho University Graduate School of Medicine","award":["16-02"],"award-info":[{"award-number":["16-02"]}]},{"name":"Toho University Joint Research Fund","award":["16-05"],"award-info":[{"award-number":["16-05"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Toxicol"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1007\/s12012-017-9417-z","type":"journal-article","created":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T12:45:42Z","timestamp":1497444342000},"page":"91-98","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Amitriptyline May Have Possibility to Induce Brugada Syndrome Rather than Long QT Syndrome"],"prefix":"10.1007","volume":"18","author":[{"given":"Nur Jaharat","family":"Lubna","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Wada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koki","family":"Chiba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Izumi-Nakaseko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Ando","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuhiko T.","family":"Naito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshioki","family":"Satoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Sugiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,6,14]]},"reference":[{"key":"9417_CR1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0165-0327(99)00092-0","volume":"58","author":"IM Anderson","year":"2000","unstructured":"Anderson, I. M. (2000). Selective serotonin reuptake inhibitors versus tricyclic antidepressants: A meta-analysis of efficacy and tolerability. Journal of Affective Disorders, 58, 19\u201336.","journal-title":"Journal of Affective Disorders"},{"key":"9417_CR2","first-page":"510","volume-title":"13th Basic & Clinical Pharmacology","author":"C DeBattista","year":"2015","unstructured":"DeBattista, C. (2015). Antidepressive agents. In B. G. Katzung & A. J. Trevor (Eds.), 13th Basic & Clinical Pharmacology (pp. 510\u2013530). New York: McGraw-Hill Medical."},{"key":"9417_CR3","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1111\/head.12987","volume":"56","author":"Strauss L Doyle","year":"2016","unstructured":"Doyle, Strauss L., Weizenbaum, E., Loder, E. W., & Rizzoli, P. B. (2016). Amitriptyline dose and treatment outcomes in specialty headache practice: A retrospective cohort study. Headache, 56, 1626\u20131634.","journal-title":"Headache"},{"key":"9417_CR4","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/j.1464-5491.2007.02093.x","volume":"24","author":"VM Jose","year":"2007","unstructured":"Jose, V. M., Bhansali, A., Hota, D., & Pandhi, P. (2007). Randomized double-blind study comparing the efficacy and safety of lamotrigine and amitriptyline in painful diabetic neuropathy. Diabetic Medicine, 24, 377\u2013383.","journal-title":"Diabetic Medicine"},{"key":"9417_CR5","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1038\/sj.bjp.0703222","volume":"129","author":"SH Jo","year":"2000","unstructured":"Jo, S. H., Youm, J. B., Lee, C. O., Earm, Y. E., & Ho, W. K. (2000). Blockade of the HERG human cardiac K+ channel by the antidepressant drug amitriptyline. British Journal of Pharmacology, 129, 1474\u20131480.","journal-title":"British Journal of Pharmacology"},{"key":"9417_CR6","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/s13104-016-1963-0","volume":"9","author":"DD Abeyaratne","year":"2016","unstructured":"Abeyaratne, D. D., Liyanapathirana, C., Gamage, A., Karunarathne, P., Botheju, M., & Indrakumar, J. (2016). Survival after severe amitriptyline poisoning with prolonged ventricular tachycardia and cardiac arrest. BMC Research Notes, 9, 167.","journal-title":"BMC Research Notes"},{"key":"9417_CR7","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.hrtlng.2005.01.003","volume":"34","author":"A Enslin","year":"2005","unstructured":"Enslin, A., & Nikoli\u0107, G. (2005). Tricyclic alternans. Heart and Lung, 34, 295\u2013297.","journal-title":"Heart and Lung"},{"key":"9417_CR8","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0735-6757(00)90027-5","volume":"18","author":"ST Dorsey","year":"2000","unstructured":"Dorsey, S. T., & Biblo, L. A. (2000). Prolonged QT interval and torsade de pointes caused by the combination of fluconazole and amitriptyline. American Journal of Emergency Medicine, 18, 227\u2013229.","journal-title":"American Journal of Emergency Medicine"},{"key":"9417_CR9","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0735-6757(92)90205-C","volume":"10","author":"P Lheureux","year":"1992","unstructured":"Lheureux, P., Vranckx, M., Leduc, D., & Askenasi, R. (1992). Flumazenil in mixed benzodiazepine\/tricyclic antidepressant overdose: A placebo-controlled study in the dog. American Journal of Emergency Medicine, 10, 184\u2013188.","journal-title":"American Journal of Emergency Medicine"},{"key":"9417_CR10","doi-asserted-by":"crossref","first-page":"396","DOI":"10.3949\/ccjm.82a.13135","volume":"82","author":"F Mbuvah","year":"2015","unstructured":"Mbuvah, F., Petrosyan, F., Thiruchelvam, N., & Kistangari, G. (2015). Electrocardiographic changes in amitriptyline overdose. Cleveland Clinic Journal of Medicine, 82, 396\u2013398.","journal-title":"Cleveland Clinic Journal of Medicine"},{"key":"9417_CR11","first-page":"358","volume":"66","author":"K Mooren","year":"2008","unstructured":"Mooren, K., Voogel, A. J., & Tan, H. L. (2008). Brugada syndrome induced by amitriptyline toxicity. Netherlands Journal of Medicine, 66, 358\u2013359.","journal-title":"Netherlands Journal of Medicine"},{"key":"9417_CR12","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1093\/europace\/eup114","volume":"11","author":"YG Yap","year":"2009","unstructured":"Yap, Y. G., Behr, E. R., & Camm, A. J. (2009). Drug-induced Brugada syndrome. Europace, 11, 989\u2013994.","journal-title":"Europace"},{"key":"9417_CR13","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/j.1540-8167.2011.02196.x","volume":"23","author":"Y Minoura","year":"2012","unstructured":"Minoura, Y., Di Diego, J. M., Barajas-Mart\u00ednez, H., Zygmunt, A. C., Hu, D., Sicouri, S., et al. (2012). Ionic and cellular mechanisms underlying the development of acquired Brugada syndrome in patients treated with antidepressants. Journal of Cardiovascular Electrophysiology, 23, 423\u2013432.","journal-title":"Journal of Cardiovascular Electrophysiology"},{"key":"9417_CR14","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1038\/bjp.2008.240","volume":"154","author":"A Sugiyama","year":"2008","unstructured":"Sugiyama, A. (2008). Sensitive and reliable proarrhythmia in vivo animal models for predicting drug-induced torsades de pointes in patients with remodeled hearts. British Journal of Pharmacology, 154, 1528\u20131537.","journal-title":"British Journal of Pharmacology"},{"key":"9417_CR15","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/clpt.2013.238","volume":"95","author":"L Johannesen","year":"2014","unstructured":"Johannesen, L., Vicente, J., Gray, R. A., Galeotti, L., Loring, Z., Garnett, C. E., et al. (2014). Improving the assessment of heart toxicity for all new drugs through translational regulatory science. Clinical Pharmacology and Therapeutics, 95, 501\u2013508.","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"9417_CR16","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1253\/circj.66.857","volume":"66","author":"H Yoshida","year":"2002","unstructured":"Yoshida, H., Sugiyama, A., Satoh, Y., Ishida, Y., Kugiyama, K., & Hashimoto, K. (2002). Effects of disopyramide and mexiletine on the terminal repolarization process of the in situ heart assessed using the halothane-anesthetized in vivo canine model. Circulation Journal, 66, 857\u2013862.","journal-title":"Circulation Journal"},{"key":"9417_CR17","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1254\/jjp.88.414","volume":"88","author":"A Sugiyama","year":"2002","unstructured":"Sugiyama, A., & Hashimoto, K. (2002). Effects of a typical I Kr channel blocker sematilide on the relationship between ventricular repolarization, refractoriness and onset of torsades de pointes. Japanese Journal of Pharmacology, 88, 414\u2013421.","journal-title":"Japanese Journal of Pharmacology"},{"key":"9417_CR18","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2131\/jts.40.33","volume":"40","author":"Y Yamazaki-Hashimoto","year":"2015","unstructured":"Yamazaki-Hashimoto, Y., Nakamura, Y., Ohara, H., Cao, X., Kitahara, K., Izumi-Nakaseko, H., et al. (2015). Fluvoxamine by itself has potential to directly induce long QT syndrome at supra-therapeutic concentrations. Journal of Toxicological Sciences, 40, 33\u201342.","journal-title":"Journal of Toxicological Sciences"},{"key":"9417_CR19","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0160-5402(89)90015-6","volume":"22","author":"A Water Van de","year":"1989","unstructured":"Van de Water, A., Verheyen, J., Xhonneux, R., & Reneman, R. S. (1989). An improved method to correct the QT interval of the electrocardiogram for changes in heart rate. Journal of Pharmacological Methods, 22, 207\u2013217.","journal-title":"Journal of Pharmacological Methods"},{"key":"9417_CR20","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/clpt.2014.155","volume":"96","author":"L Johannesen","year":"2014","unstructured":"Johannesen, L., Vicente, J., Mason, J. W., Sanabria, C., Waite-Labott, K., Hong, M., et al. (2014). Differentiating drug-induced multichannel block on the electrocardiogram: Randomized study of dofetilide, quinidine, ranolazine, and verapamil. Clinical Pharmacology and Therapeutics, 96, 549\u2013558.","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"9417_CR21","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0008-6363(03)00319-5","volume":"58","author":"P Smetana","year":"2003","unstructured":"Smetana, P., Batchvarov, V., Hnatkova, K., John Camm, A., & Malik, M. (2003). Sex differences in the rate dependence of the T wave descending limb. Cardiovascular Research, 58, 549\u2013554.","journal-title":"Cardiovascular Research"},{"key":"9417_CR22","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1253\/circj.72.1003","volume":"72","author":"T Ishizaka","year":"2008","unstructured":"Ishizaka, T., Takahara, A., Iwasaki, H., Mitsumori, Y., Kise, H., Nakamura, Y., et al. (2008). Comparison of electropharmacological effects of bepridil and sotalol in halothane-anesthetized dogs. Circulation Journal, 72, 1003\u20131011.","journal-title":"Circulation Journal"},{"key":"9417_CR23","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/BF02089958","volume":"14","author":"S Vandel","year":"1978","unstructured":"Vandel, S., Vandel, B., Sandoz, M., Allers, G., Bechtel, P., & Volmat, R. (1978). Clinical response and plasma concentration of amitriptyline and its metabolite nortriptyline. European Journal of Clinical Pharmacology, 14, 185\u2013190.","journal-title":"European Journal of Clinical Pharmacology"},{"key":"9417_CR24","doi-asserted-by":"crossref","first-page":"144","DOI":"10.3349\/ymj.1999.40.2.144","volume":"40","author":"KS Park","year":"1999","unstructured":"Park, K. S., Kong, I. D., Park, K. C., & Lee, J. W. (1999). Fluoxetine inhibits L-type Ca2+ and transient outward K+ currents in rat ventricular myocytes. Yonsei Medical Journal, 40, 144\u2013151.","journal-title":"Yonsei Medical Journal"},{"key":"9417_CR25","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0300-483X(01)00495-4","volume":"169","author":"Y Ma","year":"2001","unstructured":"Ma, Y., & Henry, J. A. (2001). The antidotal effect of \u03b11-acid glycoprotein on amitriptyline toxicity in cardiac myocytes. Toxicology, 169, 133\u2013144.","journal-title":"Toxicology"},{"key":"9417_CR26","first-page":"697","volume":"38","author":"VE Ziegler","year":"1977","unstructured":"Ziegler, V. E., & Biggs, J. T. (1977). Electrocardiographic findings in patients undergoing amitriptyline treatment. Diseases of the Nervous System, 38, 697\u2013699.","journal-title":"Diseases of the Nervous System"},{"key":"9417_CR27","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1136\/pgmj.55.648.704","volume":"55","author":"CD Burgess","year":"1979","unstructured":"Burgess, C. D., Montgomery, S., Wadsworth, J., & Turner, P. (1979). Cardiovascular effects of amitriptyline, mianserin, zimelidine and nomifensine in depressed patients. Postgraduate Medical Journal, 55, 704\u2013708.","journal-title":"Postgraduate Medical Journal"},{"key":"9417_CR28","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1161\/01.CIR.72.4.898","volume":"72","author":"S Nattel","year":"1985","unstructured":"Nattel, S. (1985). Frequency-dependent effects of amitriptyline on ventricular conduction and cardiac rhythm in dogs. Circulation, 72, 898\u2013906.","journal-title":"Circulation"},{"key":"9417_CR29","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/j.1440-1681.1977.tb02679.x","volume":"4","author":"P Dumovic","year":"1977","unstructured":"Dumovic, P., Trethewie, E. R., & Burrows, G. D. (1977). The effect of tricyclic antidepressant drugs on the isolated perfused guinea-pig heart. Clinical and Experimental Pharmacology and Physiology, 4, 421\u2013424.","journal-title":"Clinical and Experimental Pharmacology and Physiology"},{"key":"9417_CR30","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1254\/jjp.66.303","volume":"66","author":"A Sugiyama","year":"1994","unstructured":"Sugiyama, A., Motomura, S., & Hashimoto, K. (1994). Utilization of an isolated, blood-perfused canine papillary muscle preparation as a model to assess efficacy and adversity of class I antiarrhythmic drugs. Japanese Journal of Pharmacology, 66, 303\u2013316.","journal-title":"Japanese Journal of Pharmacology"},{"key":"9417_CR31","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/BF00570267","volume":"35","author":"P Dumovic","year":"1976","unstructured":"Dumovic, P., Burrows, G. D., Vohra, J., Davies, B., & Scoggins, B. A. (1976). The effect of tricyclic antidepressant drugs on the heart. Archives of Toxicology, 35, 255\u2013262.","journal-title":"Archives of Toxicology"},{"key":"9417_CR32","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1097\/00005344-198401000-00013","volume":"6","author":"S Nattel","year":"1984","unstructured":"Nattel, S., Keable, H., & Sasyniuk, B. I. (1984). Experimental amitriptyline intoxication: Electrophysiologic manifestations and management. Journal of Cardiovascular Pharmacology, 6, 83\u201389.","journal-title":"Journal of Cardiovascular Pharmacology"},{"key":"9417_CR33","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/j.1365-2125.1988.tb03397.x","volume":"26","author":"JW Upward","year":"1988","unstructured":"Upward, J. W., Edwards, J. G., Goldie, A., & Waller, D. G. (1988). Comparative effects of fluoxetine and amitriptyline on cardiac function. British Journal of Clinical Pharmacology, 26, 399\u2013402.","journal-title":"British Journal of Clinical Pharmacology"},{"key":"9417_CR34","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1161\/01.RES.69.3.677","volume":"69","author":"MJ Barber","year":"1991","unstructured":"Barber, M. J., Starmer, C. F., & Grant, A. O. (1991). Blockade of cardiac sodium channels by amitriptyline and diphenylhydantoin evidence for two use-dependent binding sites. Circulation Research, 69, 677\u2013696.","journal-title":"Circulation Research"},{"key":"9417_CR35","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/S0022-3565(24)35384-4","volume":"292","author":"C Nau","year":"2000","unstructured":"Nau, C., Seaver, M., Wang, S. Y., & Wang, G. K. (2000). Block of human heart hH1 sodium channels by amitriptyline. Journal of Pharmacology and Experimental Therapeutics, 292, 1015\u20131023.","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"9417_CR36","doi-asserted-by":"crossref","first-page":"317","DOI":"10.33549\/physiolres.930216","volume":"51","author":"J Hamplov\u00e1-Peichlov\u00e1","year":"2002","unstructured":"Hamplov\u00e1-Peichlov\u00e1, J., Kr\u016fsek, J., Paclt, I., Slav\u00edcek, J., Lis\u00e1, V., & Vyskocil, F. (2002). Citalopram inhibits L-type calcium channel current in rat cardiomyocytes in culture. Physiological Research, 51, 317\u2013321.","journal-title":"Physiological Research"},{"key":"9417_CR37","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1161\/CIRCRESAHA.113.302549","volume":"114","author":"MJ Shen","year":"2014","unstructured":"Shen, M. J., & Zipes, D. P. (2014). Role of the autonomic nervous system in modulating cardiac arrhythmias. Circulation Research, 114, 1004\u20131021.","journal-title":"Circulation Research"},{"key":"9417_CR38","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.clpt.2003.09.019","volume":"75","author":"WA Ray","year":"2004","unstructured":"Ray, W. A., Meredith, S., Thapa, P. B., Hall, K., & Murray, K. T. (2004). Cyclic antidepressants and the risk of sudden cardiac death. Clinical Pharmacology and Therapeutics, 75, 234\u2013241.","journal-title":"Clinical Pharmacology and Therapeutics"},{"issue":"Suppl K","key":"9417_CR39","doi-asserted-by":"crossref","first-page":"K70","DOI":"10.1016\/S1520-765X(01)90009-4","volume":"3","author":"B Darpo","year":"2001","unstructured":"Darpo, B. (2001). Spectrum of drugs prolonging QT interval and the incidence of torsade de pointes. European Heart Journal Supplements, 3(Suppl K), K70\u2013K80.","journal-title":"European Heart Journal Supplements"},{"key":"9417_CR40","first-page":"687","volume":"108","author":"K Wenzel-Seifert","year":"2011","unstructured":"Wenzel-Seifert, K., Wittmann, M., & Haen, E. (2011). QTc prolongation by psychotropic drugs and the risk of Torsade de Pointes. Deutsches Aerzteblatt International, 108, 687\u2013693.","journal-title":"Deutsches Aerzteblatt International"}],"container-title":["Cardiovascular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12012-017-9417-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-017-9417-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-017-9417-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T16:09:59Z","timestamp":1750349399000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12012-017-9417-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,14]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["9417"],"URL":"https:\/\/doi.org\/10.1007\/s12012-017-9417-z","relation":{},"ISSN":["1530-7905","1559-0259"],"issn-type":[{"type":"print","value":"1530-7905"},{"type":"electronic","value":"1559-0259"}],"subject":[],"published":{"date-parts":[[2017,6,14]]}}}