{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:16:21Z","timestamp":1762431381747,"version":"3.37.3"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2018,2,3]],"date-time":"2018-02-03T00:00:00Z","timestamp":1517616000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Toxicol"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1007\/s12012-018-9444-4","type":"journal-article","created":{"date-parts":[[2018,2,3]],"date-time":"2018-02-03T08:56:23Z","timestamp":1517648183000},"page":"329-336","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The Role of Intralipid Emulsion in the Rat Model of Digoxin Intoxication"],"prefix":"10.1007","volume":"18","author":[{"given":"Cansu Arslan","family":"Turan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4760-0076","authenticated-orcid":false,"given":"Tuba Cimilli","family":"Ozturk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebru Unal","family":"Akoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohat","family":"Ak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kemal","family":"Aygun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Sahiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Engin","family":"Sumer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adnan","family":"Somay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozge Ecmel","family":"Onur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,2,3]]},"reference":[{"issue":"33","key":"9444_CR1","doi-asserted-by":"publisher","first-page":"e7679","DOI":"10.1097\/MD.0000000000007679","volume":"96","author":"H Wang","year":"2017","unstructured":"Wang, H., Wang, H.-J., Chen, Y.-D., Tao, T., Guo, Y.-T., Zhao, X.-N., et al. (2017). Prognostic factors of clinical endpoints in elderly patients with atrial fibrillation during a 2-year follow-up in China: An observational cohort study. Medicine, 96(33), e7679.","journal-title":"Medicine"},{"issue":"1","key":"9444_CR2","doi-asserted-by":"publisher","first-page":"18","DOI":"10.18773\/austprescr.2016.006","volume":"39","author":"M Pincus","year":"2016","unstructured":"Pincus, M. (2016). Management of digoxin toxicity. Australian Prescriber, 39(1), 18\u201320.","journal-title":"Australian Prescriber"},{"issue":"2","key":"9444_CR3","first-page":"1","volume":"16","author":"W Palatnick","year":"2014","unstructured":"Palatnick, W., & Jelic, T. (2014). Emergency department management of calcium-channel blocker, beta blocker, and digoxin toxicity. Emergency Medicine Practice, 16(2), 1\u201319.","journal-title":"Emergency Medicine Practice"},{"key":"9444_CR4","doi-asserted-by":"crossref","unstructured":"Duan, Q., Xu, Y., Marck, P., Kalisz, J., Morgan, E.E., & Pierre, S.V. (2017). Pre-and post-conditioning by cardiac glycosides in the mouse heart. Journal of Cardiovascular Pharmacology.","DOI":"10.1097\/FJC.0000000000000549"},{"issue":"6","key":"9444_CR5","doi-asserted-by":"publisher","first-page":"540","DOI":"10.3109\/15563650.2015.1045979","volume":"53","author":"C Kang","year":"2015","unstructured":"Kang, C., Kim, D. H., Kim, S. C., Lee, S. H., Jeong, J. H., Kang, T.-S., et al. (2015). The effects of intravenous lipid emulsion on prolongation of survival in a rat model of calcium channel blocker toxicity. Clinical Toxicology, 53(6), 540\u2013544.","journal-title":"Clinical Toxicology"},{"issue":"4","key":"9444_CR6","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.annemergmed.2010.06.001","volume":"56","author":"T Niiya","year":"2010","unstructured":"Niiya, T., Litonius, E., Pet\u00e4j\u00e4, L., Neuvonen, P. J., & Rosenberg, P. H. (2010). Intravenous lipid emulsion sequesters amiodarone in plasma and eliminates its hypotensive action in pigs. Annals of Emergency Medicine, 56(4), 402\u2013408.","journal-title":"Annals of Emergency Medicine"},{"issue":"8","key":"9444_CR7","doi-asserted-by":"publisher","first-page":"e156","DOI":"10.1097\/CCM.0b013e318287f874","volume":"41","author":"MR Fettiplace","year":"2013","unstructured":"Fettiplace, M. R., Ripper, R., Lis, K., Lin, B., Lang, J., Zider, B., et al. (2013). Rapid cardiotonic effects of lipid emulsion infusion. Critical Care Medicine, 41(8), e156\u2013e162.","journal-title":"Critical Care Medicine"},{"issue":"5","key":"9444_CR8","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/j.resuscitation.2009.01.023","volume":"80","author":"AC Young","year":"2009","unstructured":"Young, A. C., Velez, L. I., & Kleinschmidt, K. C. (2009). Intravenous fat emulsion therapy for intentional sustained-release verapamil overdose. Resuscitation, 80(5), 591\u2013593.","journal-title":"Resuscitation"},{"issue":"18 suppl 2","key":"9444_CR9","doi-asserted-by":"publisher","first-page":"S501","DOI":"10.1161\/CIR.0000000000000264","volume":"132","author":"EJ Lavonas","year":"2015","unstructured":"Lavonas, E. J., Drennan, I. R., Gabrielli, A., Heffner, A. C., Hoyte, C. O., Orkin, A. M., et al. (2015). Part 10: Special circumstances of resuscitation. Circulation, 132(18 suppl 2), S501\u2013S518.","journal-title":"Circulation"},{"issue":"2","key":"9444_CR10","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1197\/j.aem.2005.08.016","volume":"13","author":"S Tebbutt","year":"2006","unstructured":"Tebbutt, S., Harvey, M., Nicholson, T., & Cave, G. (2006). Intralipid prolongs survival in a rat model of verapamil toxicity. Academic Emergency Medicine, 13(2), 134\u2013139.","journal-title":"Academic Emergency Medicine"},{"issue":"3","key":"9444_CR11","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.tox.2006.04.035","volume":"224","author":"R Oubaassine","year":"2006","unstructured":"Oubaassine, R., Bilbault, P., Roegel, J., Alexandre, E., Sigrist, S., Lavaux, T., et al. (2006). Cardio protective effect of glucose\u2013insulin infusion on acute digoxin toxicity in rat. Toxicology, 224(3), 238\u2013243.","journal-title":"Toxicology"},{"issue":"1","key":"9444_CR12","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1177\/019262338601400106","volume":"14","author":"LC Racusen","year":"1986","unstructured":"Racusen, L. C., & Solez, K. (1986). Nephrotoxic tubular and interstitial lesions: Morphology and classification. Toxicologic Pathology, 14(1), 45\u201357.","journal-title":"Toxicologic Pathology"},{"issue":"8","key":"9444_CR13","first-page":"08","volume":"8","author":"R Mannan","year":"2014","unstructured":"Mannan, R., Misra, V., Misra, S., Singh, P. A., & Dwivedi, M. (2014). A comparative evaluation of scoring systems for assessing necro-inflammatory activity and fibrosis in liver biopsies of patients with chronic viral hepatitis. Journal of Clinical and Diagnostic Research: JCDR, 8(8), 08.","journal-title":"Journal of Clinical and Diagnostic Research: JCDR"},{"issue":"6","key":"9444_CR14","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1016\/0168-8278(95)80226-6","volume":"22","author":"K Ishak","year":"1995","unstructured":"Ishak, K., Baptista, A., Bianchi, L., Callea, F., De Groote, J., Gudat, F., et al. (1995). Histological grading and staging of chronic hepatitis. Journal of Hepatology, 22(6), 696\u2013699.","journal-title":"Journal of Hepatology"},{"issue":"4","key":"9444_CR15","first-page":"1071","volume":"88","author":"GL Weinberg","year":"1998","unstructured":"Weinberg, G. L., VadeBoncouer, T., Ramaraju, G. A., Garcia-Amaro, M. F., & Cwik, M. J. (1998). Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats. The Journal of the American Society of Anesthesiologists, 88(4), 1071\u20131075.","journal-title":"The Journal of the American Society of Anesthesiologists"},{"issue":"2","key":"9444_CR16","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1097\/AAP.0b013e3181d246c3","volume":"35","author":"GL Weinberg","year":"2010","unstructured":"Weinberg, G. L. (2010). Treatment of local anesthetic systemic toxicity (LAST). Regional Anesthesia and Pain Medicine, 35(2), 188\u2013193.","journal-title":"Regional Anesthesia and Pain Medicine"},{"issue":"1","key":"9444_CR17","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1097\/00000542-200607000-00033","volume":"105","author":"MA Rosenblatt","year":"2006","unstructured":"Rosenblatt, M. A., Abel, M., Fischer, G. W., Itzkovich, C. J., & Eisenkraft, J. B. (2006). Successful use of a 20% lipid emulsion to resuscitate a patient after a presumed bupivacaine-related cardiac arrest. Anesthesiology: The Journal of the American Society of Anesthesiologists, 105(1), 217\u2013218.","journal-title":"Anesthesiology: The Journal of the American Society of Anesthesiologists"},{"issue":"4","key":"9444_CR18","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1097\/CCM.0b013e318208eddf","volume":"39","author":"SK Dix","year":"2011","unstructured":"Dix, S. K., Rosner, G. F., Nayar, M., Harris, J. J., Guglin, M. E., Winterfield, J. R., et al. (2011). Intractable cardiac arrest due to lidocaine toxicity successfully resuscitated with lipid emulsion. Critical Care Medicine, 39(4), 872\u2013874.","journal-title":"Critical Care Medicine"},{"issue":"9","key":"9444_CR19","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1016\/j.ajem.2014.05.019","volume":"32","author":"SE Cevik","year":"2014","unstructured":"Cevik, S. E., Tasyurek, T., & Guneysel, O. (2014). Intralipid emulsion treatment as an antidote in lipophilic drug intoxications. The American Journal of Emergency Medicine, 32(9), 1103\u20131108.","journal-title":"The American Journal of Emergency Medicine"},{"issue":"1","key":"9444_CR20","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1007\/BF03161005","volume":"2","author":"G Cave","year":"2006","unstructured":"Cave, G., Harvey, M. G., & Castle, C. D. (2006). The role of fat emulsion therapy in a rodent model of propranolol toxicity: A preliminary study. Journal of Medical Toxicology, 2(1), 4\u20137.","journal-title":"Journal of Medical Toxicology"},{"key":"9444_CR21","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000002707","author":"S Tsujikawa","year":"2017","unstructured":"Tsujikawa, S., Matsuura, T., Hori, K., Mori, T., Kuno, M., & Nishikawa, K. (2017). Superior efficacy of lipid emulsion infusion over serum alkalinization in reversing amitriptyline-induced cardiotoxicity in Guinea Pig. Anesthesia and Analgesia. \n                    https:\/\/doi.org\/10.1213\/ANE.0000000000002707\n                    \n                  .","journal-title":"Anesthesia and Analgesia"},{"issue":"5","key":"9444_CR22","doi-asserted-by":"publisher","first-page":"426","DOI":"10.3109\/15563650.2011.583251","volume":"49","author":"J Jovic-Stosic","year":"2011","unstructured":"Jovic-Stosic, J., Gligic, B., Putic, V., Brajkovic, G., & Spasic, R. (2011). Severe propranolol and ethanol overdose with wide complex tachycardia treated with intravenous lipid emulsion: A case report. Clinical Toxicology, 49(5), 426\u2013430.","journal-title":"Clinical Toxicology"},{"issue":"8","key":"9444_CR23","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1016\/j.ajem.2016.04.001","volume":"34","author":"T Xanthos","year":"2016","unstructured":"Xanthos, T., Psichalakis, N., Russell, D., Papalois, A., Koutsovasilis, A., Athanasopoulos, D., et al. (2016). Intralipid\u2122 administration attenuates the hypotensive effects of acute intravenous amiodarone overdose in a swine model. The American Journal of Emergency Medicine, 34(8), 1389\u20131393.","journal-title":"The American Journal of Emergency Medicine"},{"issue":"5","key":"9444_CR24","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1097\/ACO.0b013e32832eb93f","volume":"22","author":"U Leskiw","year":"2009","unstructured":"Leskiw, U., & Weinberg, G. L. (2009). Lipid resuscitation for local anesthetic toxicity: Is it really lifesaving? Current Opinion in Anesthesiology, 22(5), 667\u2013671.","journal-title":"Current Opinion in Anesthesiology"},{"issue":"2","key":"9444_CR25","first-page":"380","volume":"110","author":"J-X Mazoit","year":"2009","unstructured":"Mazoit, J.-X., Le Guen, R., Beloeil, H., & Benhamou, D. (2009). Binding of long-lasting local anesthetics to lipid emulsions. The Journal of the American Society of Anesthesiologists, 110(2), 380\u2013386.","journal-title":"The Journal of the American Society of Anesthesiologists"},{"issue":"8","key":"9444_CR26","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1111\/j.1365-2044.2006.04723.x","volume":"61","author":"G Weinberg","year":"2006","unstructured":"Weinberg, G. (2006). In defence of lipid resuscitation. Anaesthesia, 61(8), 807\u2013808.","journal-title":"Anaesthesia"},{"issue":"4","key":"9444_CR27","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1097\/00115550-200607000-00004","volume":"31","author":"GL Weinberg","year":"2006","unstructured":"Weinberg, G. L., Ripper, R., Murphy, P., Edelman, L. B., Hoffman, W., Strichartz, G., et al. (2006). Lipid infusion accelerates removal of bupivacaine and recovery from bupivacaine toxicity in the isolated rat heart. Regional Anesthesia and Pain Medicine, 31(4), 296\u2013303.","journal-title":"Regional Anesthesia and Pain Medicine"},{"issue":"1","key":"9444_CR28","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/S0008-6363(00)00151-6","volume":"48","author":"M Velde Van de","year":"2000","unstructured":"Van de Velde, M., DeWolff, M., Leather, H. A., & Wouters, P. F. (2000). Effects of lipids on the functional and metabolic recovery from global myocardial stunning in isolated rabbit hearts. Cardiovascular Research, 48(1), 129\u2013137.","journal-title":"Cardiovascular Research"},{"issue":"1","key":"9444_CR29","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1213\/01.ane.0000248220.01320.58","volume":"104","author":"SN Stehr","year":"2007","unstructured":"Stehr, S. N., Ziegeler, J. C., Pexa, A., Oertel, R., Deussen, A., Koch, T., et al. (2007). The effects of lipid infusion on myocardial function and bioenergetics in l-bupivacaine toxicity in the isolated rat heart. Anesthesia and Analgesia, 104(1), 186\u2013192.","journal-title":"Anesthesia and Analgesia"},{"issue":"14","key":"9444_CR30","doi-asserted-by":"publisher","first-page":"6452","DOI":"10.1073\/pnas.89.14.6452","volume":"89","author":"J Huang","year":"1992","unstructured":"Huang, J., Xian, H., & Bacaner, M. (1992). Long-chain fatty acids activate calcium channels in ventricular myocytes. Proceedings of the National Academy of Sciences, 89(14), 6452\u20136456.","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"2","key":"9444_CR31","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/BF03160965","volume":"4","author":"DE Turner-Lawrence","year":"2008","unstructured":"Turner-Lawrence, D. E., & Kerns, W. (2008). Intravenous fat emulsion: A potential novel antidote. Journal of Medical Toxicology, 4(2), 109\u2013114.","journal-title":"Journal of Medical Toxicology"},{"issue":"6","key":"9444_CR32","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1016\/j.ajem.2016.03.038","volume":"34","author":"BS Yurtlu","year":"2016","unstructured":"Yurtlu, B. S., \u00d6zbilgin, \u015e., Yurtlu, D. A., Bozta\u015f, N., Kamac\u0131, G., Akaltun, M., et al. (2016). Intravenous lipid emulsion prolongs survival in rats intoxicated with digoxin. The American Journal of Emergency Medicine, 34(6), 1112\u20131116.","journal-title":"The American Journal of Emergency Medicine"}],"container-title":["Cardiovascular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12012-018-9444-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-018-9444-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-018-9444-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,2]],"date-time":"2019-02-02T20:19:09Z","timestamp":1549138749000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12012-018-9444-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,3]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["9444"],"URL":"https:\/\/doi.org\/10.1007\/s12012-018-9444-4","relation":{},"ISSN":["1530-7905","1559-0259"],"issn-type":[{"type":"print","value":"1530-7905"},{"type":"electronic","value":"1559-0259"}],"subject":[],"published":{"date-parts":[[2018,2,3]]},"assertion":[{"value":"3 February 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"Authors declare here that there is not any financial support or relationships that may pose a competing interest and all applicable international, national and\/or institutional guidelines for the care and use of animals were followed. Yeditepe University Medical Faculty Experimental Animals Research Laboratory, Ethics Committee approved the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}