{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T07:35:07Z","timestamp":1765438507881,"version":"3.37.3"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2018,3,16]],"date-time":"2018-03-16T00:00:00Z","timestamp":1521158400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Toxicol"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1007\/s12012-018-9450-6","type":"journal-article","created":{"date-parts":[[2018,3,16]],"date-time":"2018-03-16T10:11:54Z","timestamp":1521195114000},"page":"400-406","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of the Effectiveness of Sugammadex for Digoxin Intoxication: An Experimental Study"],"prefix":"10.1007","volume":"18","author":[{"given":"Sule","family":"Ozbilgin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derya Aslan","family":"Yurtlu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beyza","family":"K\u00fc\u00e7\u00fckozta\u015f","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gonca","family":"Kamac\u0131","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sezen","family":"Korkut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3020-1586","authenticated-orcid":false,"given":"B\u00fclent Serhan","family":"Yurtlu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ensari G\u00fcneli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volkan","family":"Hanc\u0131","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"G\u00fcnerli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,3,16]]},"reference":[{"key":"9450_CR1","doi-asserted-by":"publisher","first-page":"911","DOI":"10.3109\/15563650.2012.746424","volume":"50","author":"AC Bronste\u0131n","year":"2012","unstructured":"Bronste\u0131n, A. C., Spyker, D. A., Cantilena, L. R., Rumack, B. H., & Dart, R. C. (2012). 2011 Annual report of the american association of poison control centers national poison data system (NPDS): 29th annual report. Clinical Toxicology, 50, 911\u20131164.","journal-title":"Clinical Toxicology"},{"key":"9450_CR2","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1067\/mem.2002.121401","volume":"39","author":"JW Hafner","year":"2002","unstructured":"Hafner, J. W., Belknap, S. M., Squillante, M. D., & Bucheit, Kay A. (2002). Adverse drug events in emergency department patients. Annals of Emergency Medicine, 39, 258\u2013267.","journal-title":"Annals of Emergency Medicine"},{"key":"9450_CR3","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1111\/j.1742-7843.2006.pto_264.x","volume":"98","author":"LJ Patinen","year":"2006","unstructured":"Patinen, L. J., Kuitunen, T., Pere, P., & Neuvonen, Pertti J. (2006). Drug-related visits to a district hospital emergency room. Basic & Clinical Pharmacology & Toxicology, 98, 212\u2013217.","journal-title":"Basic & Clinical Pharmacology & Toxicology"},{"issue":"5","key":"9450_CR4","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.jchf.2016.01.011","volume":"4","author":"PJ Hauptman","year":"2016","unstructured":"Hauptman, P. J., Blume, S. W., Lewis, E. F., & Ward, S. (2016). Digoxin toxicity and use of digoxin immune fab: Insights from a national hospital database. JACC Heart Failure, 4(5), 357\u2013364.","journal-title":"JACC Heart Failure"},{"issue":"1","key":"9450_CR5","first-page":"28","volume":"7","author":"I See","year":"2014","unstructured":"See, I., Shehab, N., Kegler, S. R., Laskar, S. R., & Budnitz, D. S. (2014). Emergency department visits and hospitalizations for digoxin toxicity: United States, 2005 to 2010. Circulation: Heart Failure, 7(1), 28\u201334.","journal-title":"Circulation: Heart Failure"},{"key":"9450_CR6","doi-asserted-by":"publisher","first-page":"391","DOI":"10.4037\/ajcc2009227","volume":"19","author":"F Eyer","year":"2010","unstructured":"Eyer, F., Steimer, W., M\u00fcller, C., & Zilker, T. (2010). Free and total digoxin in serum during treatment of acute digoxin poisoning with fab fragments: Case study. American Journal of Critical Care, 19, 391.","journal-title":"American Journal of Critical Care"},{"issue":"8","key":"9450_CR7","doi-asserted-by":"publisher","first-page":"824","DOI":"10.3109\/15563650.2014.943907","volume":"52","author":"BSH Chan","year":"2014","unstructured":"Chan, B. S. H., & Buckley, N. A. (2014). Digoxin-specific antibody fragments in the treatment of digoxin toxicity. Clinical Toxicology (Philadelphia, PA), 52(8), 824\u2013836.","journal-title":"Clinical Toxicology (Philadelphia, PA)"},{"key":"9450_CR8","first-page":"789","volume-title":"Goodman & Gillman\u2019s the pharmacological basis of therapeutics","author":"BA Maron","year":"2011","unstructured":"Maron, B. A., & Rocco, T. P. (2011). Pharmacotherapy of congestive heart failure. In L. S. Bruton (Ed.), Goodman & Gillman\u2019s the pharmacological basis of therapeutics (12th ed., pp. 789\u2013813). New York, USA: Mc Graw Hill Publication.","edition":"12"},{"key":"9450_CR9","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1007\/s00134-008-1092-x","volume":"34","author":"F Lapostolle","year":"2008","unstructured":"Lapostolle, F., Borron, S. W., Verdier, C., Arnaud, F., Couvreur, J., M\u00e9garbane, B., et al. (2008). Assessment of digoxin antibody use in patients with elevated serum digoxin following chronic or acute exposure. Intensive Care Medicine, 34, 1448\u20131453.","journal-title":"Intensive Care Medicine"},{"key":"9450_CR10","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1056\/NEJM199702203360801","volume":"336","author":"Digitalis Investigation Group","year":"1997","unstructured":"Digitalis Investigation Group. (1997). The effect of digoxin on mortality and morbidity in patients with heart failure: The digitalis investigation group. New England Journal of Medicine, 336, 525\u2013533.","journal-title":"New England Journal of Medicine"},{"key":"9450_CR11","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1007\/BF00878556","volume":"9","author":"J Leor","year":"1995","unstructured":"Leor, J., Goldbourt, U., Rabinowitz, B., Reicher-Reiss, H., Boyko, V., Kaplinsky, E., et al. (1995). Digoxin and increased mortality among patients recovering from acute myocardial infarction: Importance of digoxin dose. The SPRINT study group. Cardiovascular Drugs and Therapy, 9, 723\u2013729.","journal-title":"Cardiovascular Drugs and Therapy"},{"issue":"3","key":"9450_CR12","doi-asserted-by":"publisher","first-page":"237","DOI":"10.3724\/SP.J.1263.2012.01101","volume":"9","author":"B Kirilmaz","year":"2012","unstructured":"Kirilmaz, B., Saygi, S., Gungor, H., Onsel Turk, U., Alio\u011flu, E., et al. (2012). Digoxin intoxication: An old enemy in modern era. Journal of Geriatric Cardiology, 9(3), 237\u2013242.","journal-title":"Journal of Geriatric Cardiology"},{"issue":"1","key":"9450_CR13","doi-asserted-by":"publisher","first-page":"39","DOI":"10.5455\/2319-2003.ijbcp001012","volume":"1","author":"TA Acharya","year":"2012","unstructured":"Acharya, T. A., Mehta, D. S., & Vekariya, R. S. (2012). Digoxin toxicity: Crucial to diagnose. International Journal of Basic & Clinical Pharmacology, 1(1), 39\u201340.","journal-title":"International Journal of Basic & Clinical Pharmacology"},{"key":"9450_CR14","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.amjmed.2011.09.019","volume":"125","author":"EH Yang","year":"2012","unstructured":"Yang, E. H., Shah, S., & Criley, J. M. (2012). Digitalis toxicity: A fading but crucial complication to recognize. American Journal of Medicine, 125, 337\u2013343.","journal-title":"American Journal of Medicine"},{"key":"9450_CR15","doi-asserted-by":"publisher","first-page":"H1781","DOI":"10.1152\/ajpheart.00707.2004","volume":"289","author":"JA Wasserstrom","year":"2005","unstructured":"Wasserstrom, J. A., & Aistrup, G. L. (2005). Digitalis: New actions for an old drug. American Journal of Physiology-Heart and Circulatory Physiology, 289, H1781\u2013H1793.","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"key":"9450_CR16","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.tox.2006.04.035","volume":"224","author":"R Oubaassine","year":"2006","unstructured":"Oubaassine, R., Bilbault, P., Roegel, J. C., Alexandre, E., Sigrist, S., Lavaux, T., et al. (2006). Cardio protective effect of glucose\u2013insulin infusion on acute digoxin toxicity in rat. Toxicology, 224, 238\u2013243.","journal-title":"Toxicology"},{"issue":"9","key":"9450_CR17","doi-asserted-by":"publisher","first-page":"680","DOI":"10.5812\/kowsar.20741804.2238","volume":"13","author":"F Zand","year":"2011","unstructured":"Zand, F., Asadi, S., & Katibeh, P. (2011). Good outcome after digoxin toxicity despite very high serum potassium level. Iranian Red Crescent Medical Journal, 13(9), 680\u2013681.","journal-title":"Iranian Red Crescent Medical Journal"},{"key":"9450_CR18","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1681\/ASN.2009101047","volume":"21","author":"KE Chan","year":"2010","unstructured":"Chan, K. E., Lazarus, J. M., & Hakim, R. M. (2010). Digoxin associates with mortality in ESRD. Journal of the American Society of Nephrology, 21, 1550\u20131559.","journal-title":"Journal of the American Society of Nephrology"},{"key":"9450_CR19","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1358\/dof.2003.028.04.742715","volume":"28","author":"M-Q Zhang","year":"2003","unstructured":"Zhang, M.-Q. (2003). Drug-specific cyclodextrins: The future of rapid neuromuscular block reversal? Drugs Future, 28, 347\u2013354.","journal-title":"Drugs Future"},{"issue":"10","key":"9450_CR20","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1111\/j.1365-2044.2012.07264.x","volume":"67","author":"Y Tomak","year":"2012","unstructured":"Tomak, Y., Y\u0131lmaz, A., Bostan, H., T\u00fcmkaya, L., Altuner, D., Kalkan, Y., et al. (2012). Effects of sugammadex and rocuronium mast cell number and degranulation in rat liver. Anaesthesia, 67(10), 1101\u20131104.","journal-title":"Anaesthesia"},{"key":"9450_CR21","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1213\/01.ane.0000248224.42707.48","volume":"104","author":"O Sacan","year":"2007","unstructured":"Sacan, O., White, P. F., Tufanogullari, B., & Klein, K. (2007). Sugammadex reversal of rocuronium-induced neuromuscular blockade: A comparison with neostigmine-glycopyrrolate and edrophonium-atropine. Anesthesia and Analgesia, 104, 569\u2013574.","journal-title":"Anesthesia and Analgesia"},{"key":"9450_CR22","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/S0034-7094(13)70208-3","volume":"63","author":"V Hanc\u0131","year":"2013","unstructured":"Hanc\u0131, V., Kiraz, H. A., \u00d6m\u00fcr, D., Ekin, S., Uyan, B., & Yurtlu, S. (2013). Precipitation in gallipoli: Sugammadex\/amiodarone & sugammadex\/dobutamine & sugammadex\/protamine. Brazilian Journal of Anesthesiology, 63, 163\u2013164.","journal-title":"Brazilian Journal of Anesthesiology"},{"issue":"1","key":"9450_CR23","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1093\/bja\/aep093","volume":"103","author":"A Srivastava","year":"2009","unstructured":"Srivastava, A., & Hunter, J. M. (2009). Reversal of neuro muscular block. British Journal of Anaesthesia, 103(1), 115\u2013129.","journal-title":"British Journal of Anaesthesia"},{"issue":"4","key":"9450_CR24","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1111\/bcpt.12089","volume":"113","author":"S Ozbilgin","year":"2013","unstructured":"Ozbilgin, S., Ozbilgin, M., Kucukoztas, B., Kamaci, G., Unek, T., Yurtlu, B. S., et al. (2013). Evaluation of the effectiveness of sugammadex for verapamil intoxication. Basic & Clinical Pharmacology & Toxicology, 113(4), 280\u2013285.","journal-title":"Basic & Clinical Pharmacology & Toxicology"},{"key":"9450_CR25","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1208\/pt060243","volume":"6","author":"R Challa","year":"2005","unstructured":"Challa, R., Ahuja, A., Ali, J., & Khar, R. K. (2005). Cyclodextrins in drug delivery: An updated review. AAPS PharmSciTech, 6, 329\u2013357.","journal-title":"AAPS PharmSciTech"},{"key":"9450_CR26","first-page":"191","volume":"9","author":"GK Dresser","year":"2002","unstructured":"Dresser, G. K., & Bailey, D. G. (2002). A basic conceptual and practical overview of interactions with highly prescribed drugs. The Canadian Journal of Clinical Pharmacology, 9, 191\u2013198.","journal-title":"The Canadian Journal of Clinical Pharmacology"},{"key":"9450_CR27","first-page":"493","volume-title":"Cardiac glycosides and drugs for heart failure. Essentials of medical pharmacology","author":"KD Tripathi","year":"2009","unstructured":"Tripathi, K. D. (2009). Cardiac glycosides and drugs for heart failure. Essentials of medical pharmacology (6th ed., pp. 493\u2013507). Jaypee Brothers: New Delhi.","edition":"6"},{"key":"9450_CR28","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1006\/jmbi.2000.3646","volume":"297","author":"S Schlehuber","year":"2000","unstructured":"Schlehuber, S., Beste, G., & Skerra, A. (2000). A novel type of receptor protein, based on the lipocalin scaffold, with specificity for digoxigenin. Journal of Molecular Biology, 297, 1105\u20131120.","journal-title":"Journal of Molecular Biology"},{"key":"9450_CR29","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/S1359-6446(04)03294-5","volume":"10","author":"S Schlehuber","year":"2005","unstructured":"Schlehuber, S., & Skerra, A. (2005). Lipocalins in drug discovery: From natural ligand-binding proteins to \u201canticalins\u201d. Drug Discovery, 10, 23\u201333.","journal-title":"Drug Discovery"},{"key":"9450_CR30","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/S0022-2836(03)00573-4","volume":"330","author":"IP Kornd\u00f6rfer","year":"2003","unstructured":"Kornd\u00f6rfer, I. P., Schlehuber, S., & Skerra, A. (2003). Structural mechanism of specific ligand recognition by a lipocalin tailored for the complexation of digoxigenin. Journal of Molecular Biology, 330, 385\u2013396.","journal-title":"Journal of Molecular Biology"},{"key":"9450_CR31","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1097\/MJT.0b013e3181ea3173","volume":"18","author":"AR Mottram","year":"2011","unstructured":"Mottram, A. R., Bryant, S. M., & Steven, E. (2011). Effect of cyclodextrin infusion in a rat model of verapamil toxicity. American Journal of Therapeutics, 18, 371\u2013374.","journal-title":"American Journal of Therapeutics"},{"key":"9450_CR32","doi-asserted-by":"publisher","first-page":"63","DOI":"10.5811\/westjem.2011.3.6696","volume":"13","author":"AR Mottram","year":"2012","unstructured":"Mottram, A. R., Bryant, S. M., & Steven, E. (2012). Dose-dependent response to cyclodextrin infusion in a rat model of verapamil toxicity. Western Journal of Emergency Medicine, 13, 63\u201367.","journal-title":"Western Journal of Emergency Medicine"},{"key":"9450_CR33","first-page":"27","volume":"165","author":"DN Juurlink","year":"2001","unstructured":"Juurlink, D. N., McGuigan, M. A., Paton, T. W., & Redelmeier, D. A. (2001). Availability of antidotes at acute care hospitals in Ontario. CMAJ, 165, 27\u201330.","journal-title":"CMAJ"},{"issue":"6","key":"9450_CR34","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1016\/j.ajem.2016.03.038","volume":"34","author":"BS Yurtlu","year":"2016","unstructured":"Yurtlu, B. S., \u00d6zbilgin, \u015e., Yurtlu, D. A., Bozta\u015f, N., Kamac\u0131, G., Akaltun, M., et al. (2016). Intravenous lipid emulsion prolongs survival in rats intoxicated with digoxin. American Journal of Emergency Medicine, 34(6), 1112\u20131116.","journal-title":"American Journal of Emergency Medicine"},{"key":"9450_CR35","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-018-9444-4","author":"CA Turan","year":"2018","unstructured":"Turan, C. A., Ozturk, T. C., Akoglu, E. U., Ak, R., Aygun, K., Sahiner, A., et al. (2018). The role of intralipid emulsion in the rat model of digoxin intoxication. Cardiovascular Toxicology. \n                    https:\/\/doi.org\/10.1007\/s12012-018-9444-4\n                    \n                  .","journal-title":"Cardiovascular Toxicology"}],"container-title":["Cardiovascular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12012-018-9450-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-018-9450-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-018-9450-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,15]],"date-time":"2019-03-15T21:32:26Z","timestamp":1552685546000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12012-018-9450-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,16]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["9450"],"URL":"https:\/\/doi.org\/10.1007\/s12012-018-9450-6","relation":{},"ISSN":["1530-7905","1559-0259"],"issn-type":[{"type":"print","value":"1530-7905"},{"type":"electronic","value":"1559-0259"}],"subject":[],"published":{"date-parts":[[2018,3,16]]},"assertion":[{"value":"16 March 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}