{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:24:10Z","timestamp":1791015850461,"version":"4.1.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,6,22]],"date-time":"2019-06-22T00:00:00Z","timestamp":1561161600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,6,22]],"date-time":"2019-06-22T00:00:00Z","timestamp":1561161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Toxicol"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1007\/s12012-019-09535-8","type":"journal-article","created":{"date-parts":[[2019,6,22]],"date-time":"2019-06-22T14:02:32Z","timestamp":1561212152000},"page":"71-81","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Role of ATP-Sensitive Potassium Channel (KATP) and eNOS in Mediating the Protective Effect of Nicorandil in Cyclophosphamide-Induced Cardiotoxicity"],"prefix":"10.1007","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6211-9558","authenticated-orcid":false,"given":"Marwa M. M.","family":"Refaie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayed","family":"Shehata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maram","family":"El-Hussieny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wedad M.","family":"Abdelraheem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa M. A.","family":"Bayoumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,6,22]]},"reference":[{"key":"9535_CR1","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1016\/j.apjtm.2017.08.005","volume":"10","author":"P Mahipal","year":"2017","unstructured":"Mahipal, P., & Pawar, R. S. (2017). Nephroprotective effect of Murraya koenigii on cyclophosphamide induced nephrotoxicity in rats. Asian Pacific Journal of Tropical Medicine,10, 808\u2013812.","journal-title":"Asian Pacific Journal of Tropical Medicine"},{"key":"9535_CR2","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.etap.2016.05.031","volume":"45","author":"AA Fouad","year":"2016","unstructured":"Fouad, A. A., Qutub, H. O., & Al-Melhim, W. N. (2016). Punicalagin alleviates hepatotoxicity in rats challenged with cyclophosphamide. Environmental Toxicology and Pharmacology,45, 158\u2013162.","journal-title":"Environmental Toxicology and Pharmacology"},{"key":"9535_CR3","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.etp.2017.02.002","volume":"69","author":"H Avci","year":"2017","unstructured":"Avci, H., Epikmen, E. T., Ipek, E., Tunca, R., Birincioglu, S. S., Aksit, H., et al. (2017). Protective effects of silymarin and curcumin on cyclophosphamide-induced cardiotoxicity. Experimental and Toxicologic Pathology,69, 317\u2013327.","journal-title":"Experimental and Toxicologic Pathology"},{"key":"9535_CR4","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.etap.2017.12.020","volume":"58","author":"DH El-Kashef","year":"2018","unstructured":"El-Kashef, D. H. (2018). Role of venlafaxine in prevention of cyclophosphamide-induced lung toxicity and airway hyperactivity in rats. Environmental Toxicology and Pharmacology,58, 70\u201376.","journal-title":"Environmental Toxicology and Pharmacology"},{"key":"9535_CR5","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1139\/cjpp-2014-0204","volume":"92","author":"AM Mahmoud","year":"2014","unstructured":"Mahmoud, A. M. (2014). Hesperidin protects against cyclophosphamide-induced hepatotoxicity by upregulation of PPARgamma and abrogation of oxidative stress and inflammation. Canadian Journal of Physiology and Pharmacology,92, 717\u2013724.","journal-title":"Canadian Journal of Physiology and Pharmacology"},{"key":"9535_CR6","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.cbi.2015.02.021","volume":"231","author":"S Nafees","year":"2015","unstructured":"Nafees, S., Rashid, S., Ali, N., Hasan, S. K., & Sultana, S. (2015). Rutin ameliorates cyclophosphamide induced oxidative stress and inflammation in Wistar rats: Role of NFkappaB\/MAPK pathway. Chemico-Biological Interactions,231, 98\u2013107.","journal-title":"Chemico-Biological Interactions"},{"key":"9535_CR7","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.etap.2018.01.011","volume":"58","author":"MMM Refaie","year":"2018","unstructured":"Refaie, M. M. M., El-Hussieny, M., & Zenhom, N. M. (2018). Protective role of nebivolol in cadmium-induced hepatotoxicity via downregulation of oxidative stress, apoptosis and inflammatory pathways. Environmental Toxicology and Pharmacology,58, 212\u2013219.","journal-title":"Environmental Toxicology and Pharmacology"},{"key":"9535_CR8","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.biopha.2018.02.068","volume":"101","author":"AG Potnuri","year":"2018","unstructured":"Potnuri, A. G., Allakonda, L., & Lahkar, M. (2018). Crocin attenuates cyclophosphamide induced testicular toxicity by preserving glutathione redox system. Biomedicine & Pharmacotherapy,101, 174\u2013180.","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"9535_CR9","doi-asserted-by":"publisher","first-page":"215658721875764","DOI":"10.1177\/2156587218757649","volume":"23","author":"JG Omole","year":"2018","unstructured":"Omole, J. G., Ayoka, O. A., Alabi, Q. K., Adefisayo, M. A., Asafa, M. A., Olubunmi, B. O., et al. (2018). Protective effect of kolaviron on cyclophosphamide-induced cardiac toxicity in rats. Journal of Evidence-Based Integrative Medicine,23, 2156587218757649.","journal-title":"Journal of Evidence-Based Integrative Medicine"},{"key":"9535_CR10","doi-asserted-by":"publisher","first-page":"57","DOI":"10.21307\/ane-2017-036","volume":"77","author":"S Ravindran","year":"2017","unstructured":"Ravindran, S., Swaminathan, K., Ramesh, A., & Kurian, G. A. (2017). Nicorandil attenuates neuronal mitochondrial dysfunction and oxidative stress associated with murine model of vascular calcification. Acta Neurobiologiae Experimentalis (Wars),77, 57\u201367.","journal-title":"Acta Neurobiologiae Experimentalis (Wars)"},{"key":"9535_CR11","doi-asserted-by":"publisher","first-page":"2320","DOI":"10.1159\/000374035","volume":"35","author":"H Wu","year":"2015","unstructured":"Wu, H., Ye, M., Yang, J., Ding, J., Yang, J., Dong, W., et al. (2015). Nicorandil protects the heart from ischemia\/reperfusion injury by attenuating endoplasmic reticulum response-induced apoptosis through PI3K\/Akt signaling pathway. Cellular Physiology and Biochemistry,35, 2320\u20132332.","journal-title":"Cellular Physiology and Biochemistry"},{"key":"9535_CR12","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1111\/bcpt.12078","volume":"113","author":"IT Abdel-Raheem","year":"2013","unstructured":"Abdel-Raheem, I. T., Taye, A., & Abouzied, M. M. (2013). Cardioprotective effects of nicorandil, a mitochondrial potassium channel opener against doxorubicin-induced cardiotoxicity in rats. Basic & Clinical Pharmacology & Toxicology,113, 158\u2013166.","journal-title":"Basic & Clinical Pharmacology & Toxicology"},{"key":"9535_CR13","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1111\/1750-3841.14048","volume":"83","author":"X Zhai","year":"2018","unstructured":"Zhai, X., Yang, X., Zou, P., Shao, Y., Yuan, S., Abd El-Aty, A. M., et al. (2018). Protective effect of chitosan oligosaccharides against cyclophosphamide-induced immunosuppression and irradiation injury in mice. Journal of Food Science,83, 535\u2013542.","journal-title":"Journal of Food Science"},{"key":"9535_CR14","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1007\/s12011-017-1231-8","volume":"185","author":"S Gunes","year":"2018","unstructured":"Gunes, S., Sahinturk, V., Uslu, S., Ayhanci, A., Kacar, S., & Uyar, R. (2018). Protective effects of selenium on cyclophosphamide-induced oxidative stress and kidney injury. Biological Trace Element Research,185, 116\u2013123.","journal-title":"Biological Trace Element Research"},{"key":"9535_CR15","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1002\/nau.21213","volume":"31","author":"M Saito","year":"2012","unstructured":"Saito, M., Ohmasa, F., Tsounapi, P., Inoue, S., Dimitriadis, F., Kinoshita, Y., et al. (2012). Nicorandil ameliorates hypertension-related bladder dysfunction in the rat. Neurourology and Urodynamics,31, 695\u2013701.","journal-title":"Neurourology and Urodynamics"},{"key":"9535_CR16","doi-asserted-by":"publisher","first-page":"14043","DOI":"10.1038\/srep14043","volume":"5","author":"LA Ahmed","year":"2015","unstructured":"Ahmed, L. A., El-Maraghy, S. A., & Rizk, S. M. (2015). Role of the KATP channel in the protective effect of nicorandil on cyclophosphamide-induced lung and testicular toxicity in rats. Scientific Reports,5, 14043.","journal-title":"Scientific Reports"},{"key":"9535_CR17","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.ejphar.2018.04.005","volume":"829","author":"MA Ibrahim","year":"2018","unstructured":"Ibrahim, M. A., Geddawy, A., & Abdel-Wahab, S. (2018). Sitagliptin prevents isoproterenol-induced myocardial infarction in rats by modulating nitric oxide synthase enzymes. European Journal of Pharmacology,829, 63\u201369.","journal-title":"European Journal of Pharmacology"},{"key":"9535_CR18","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1248\/cpb.31.605","volume":"31","author":"M Mihara","year":"1983","unstructured":"Mihara, M., & Uchiyama, M. (1983). Properties of thiobarbituric acid-reactive materials obtained from lipid peroxide and tissue homogenate. Chemical and Pharmaceutical Bulletin (Tokyo),31, 605\u2013611.","journal-title":"Chemical and Pharmaceutical Bulletin (Tokyo)"},{"key":"9535_CR19","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/S0006-291X(72)80218-3","volume":"46","author":"M Nishikimi","year":"1972","unstructured":"Nishikimi, M., Appaji, N., & Yagi, K. (1972). The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen. Biochemical and Biophysical Research Communications,46, 849\u2013854.","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"9535_CR20","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1177\/1535370216643418","volume":"241","author":"DS El-Agamy","year":"2016","unstructured":"El-Agamy, D. S., Abo-Haded, H. M., & Elkablawy, M. A. (2016). Cardioprotective effects of sitagliptin against doxorubicin-induced cardiotoxicity in rats. Experimental Biology and Medicine (Maywood),241, 1577\u20131587.","journal-title":"Experimental Biology and Medicine (Maywood)"},{"key":"9535_CR21","doi-asserted-by":"publisher","first-page":"619","DOI":"10.2144\/000112776","volume":"44","author":"HD VanGuilder","year":"2008","unstructured":"VanGuilder, H. D., Vrana, K. E., & Freeman, W. M. (2008). Twenty-five years of quantitative PCR for gene expression analysis. BioTechniques,44, 619\u2013626.","journal-title":"BioTechniques"},{"key":"9535_CR22","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1080\/01480545.2018.1485688","volume":"1","author":"MG Ewees","year":"2018","unstructured":"Ewees, M. G., Messiha, B. A. S., Abdel-Bakky, M. S., Bayoumi, A. M. A., & Abo-Saif, A. A. (2018). Tempol, a superoxide dismutase mimetic agent, reduces cisplatin-induced nephrotoxicity in rats. Drug and Chemical Toxicology,1, 8. \nhttps:\/\/doi.org\/10.1080\/01480545.2018.1485688\n\n.","journal-title":"Drug and Chemical Toxicology"},{"key":"9535_CR23","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1016\/j.archoralbio.2006.06.007","volume":"51","author":"MA Gonzalez-Moles","year":"2006","unstructured":"Gonzalez-Moles, M. A., Bascones-Ilundain, C., Gil Montoya, J. A., Ruiz-Avila, I., Delgado-Rodriguez, M., & Bascones-Martinez, A. (2006). Cell cycle regulating mechanisms in oral lichen planus: Molecular bases in epithelium predisposed to malignant transformation. Archives of Oral Biology,51, 1093\u20131103.","journal-title":"Archives of Oral Biology"},{"key":"9535_CR24","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.intimp.2018.05.007","volume":"61","author":"IO Sherif","year":"2018","unstructured":"Sherif, I. O. (2018). The effect of natural antioxidants in cyclophosphamide-induced hepatotoxicity: Role of Nrf2\/HO-1 pathway. International Immunopharmacology,61, 29\u201336.","journal-title":"International Immunopharmacology"},{"key":"9535_CR25","doi-asserted-by":"publisher","first-page":"836","DOI":"10.3889\/oamjms.2017.093","volume":"5","author":"DF Mansour","year":"2017","unstructured":"Mansour, D. F., Saleh, D. O., & Mostafa, R. E. (2017). Genistein ameliorates cyclophosphamide\u2014induced hepatotoxicity by modulation of oxidative stress and inflammatory mediators. Open Access Macedonian Journal of Medical Sciences,5, 836\u2013843.","journal-title":"Open Access Macedonian Journal of Medical Sciences"},{"key":"9535_CR26","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.biopha.2017.10.134","volume":"97","author":"AA Elshater","year":"2018","unstructured":"Elshater, A. A., Haridy, M. A. M., Salman, M. M. A., Fayyad, A. S., & Hammad, S. (2018). Fullerene C60 nanoparticles ameliorated cyclophosphamide-induced acute hepatotoxicity in rats. Biomedicine & Pharmacotherapy,97, 53\u201359.","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"9535_CR27","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/S0009-8981(03)00013-5","volume":"329","author":"JP Bertinchant","year":"2003","unstructured":"Bertinchant, J. P., Polge, A., Juan, J. M., Oliva-Lauraire, M. C., Giuliani, I., Marty-Double, C., et al. (2003). Evaluation of cardiac troponin I and T levels as markers of myocardial damage in doxorubicin-induced cardiomyopathy rats, and their relationship with echocardiographic and histological findings. Clinica Chimica Acta,329, 39\u201351.","journal-title":"Clinica Chimica Acta"},{"key":"9535_CR28","doi-asserted-by":"publisher","first-page":"308","DOI":"10.4161\/oxim.3.5.13107","volume":"3","author":"YA Asiri","year":"2010","unstructured":"Asiri, Y. A. (2010). Probucol attenuates cyclophosphamide-induced oxidative apoptosis, p53 and Bax signal expression in rat cardiac tissues. Oxidative Medicine and Cellular Longevity,3, 308\u2013316.","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"9535_CR29","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1002\/jbt.20369","volume":"25","author":"MN Nagi","year":"2011","unstructured":"Nagi, M. N., Al-Shabanah, O. A., Hafez, M. M., & Sayed-Ahmed, M. M. (2011). Thymoquinone supplementation attenuates cyclophosphamide-induced cardiotoxicity in rats. Journal of Biochemical and Molecular Toxicology,25, 135\u2013142.","journal-title":"Journal of Biochemical and Molecular Toxicology"},{"issue":"5","key":"9535_CR30","doi-asserted-by":"publisher","first-page":"308","DOI":"10.4161\/oxim.3.5.13107","volume":"3","author":"YA Asiri","year":"2010","unstructured":"Asiri, Y. A. (2010). Probucol attenuates cyclophosphamide-induced oxidative apoptosis, p53 and Bax signal expression in rat cardiac tissues. Oxidative Medicine and Cellular Longevity,3(5), 308\u2013316.","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"9535_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/bs.ircmb.2015.02.002","volume":"317","author":"A Kupsco","year":"2015","unstructured":"Kupsco, A., & Schlenk, D. (2015). Oxidative stress, unfolded protein response, and apoptosis in developmental toxicity. International Review of Cell and Molecular Biology,317, 1\u201366.","journal-title":"International Review of Cell and Molecular Biology"},{"key":"9535_CR32","doi-asserted-by":"publisher","first-page":"e22271","DOI":"10.1002\/jbt.22271","volume":"33","author":"X Lixin","year":"2019","unstructured":"Lixin, X., Lijun, Y., & Songping, H. (2019). Ganoderic acid A against cyclophosphamide-induced hepatic toxicity in mice. Journal of Biochemical and Molecular Toxicology,33, e22271.","journal-title":"Journal of Biochemical and Molecular Toxicology"},{"key":"9535_CR33","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1016\/j.biopha.2018.12.112","volume":"111","author":"AL Has","year":"2019","unstructured":"Has, A. L., Alotaibi, M. F., Bin-Jumah, M., Elgebaly, H., & Mahmoud, A. M. (2019). Olea europaea leaf extract up-regulates Nrf2\/ARE\/HO-1 signaling and attenuates cyclophosphamide-induced oxidative stress, inflammation and apoptosis in rat kidney. Biomedicine & Pharmacotherapy,111, 676\u2013685.","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"9535_CR34","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.carbpol.2018.10.120","volume":"207","author":"J Tang","year":"2019","unstructured":"Tang, J., Zhen, H., Wang, N., Yan, Q., Jing, H., & Jiang, Z. (2019). Curdlan oligosaccharides having higher immunostimulatory activity than curdlan in mice treated with cyclophosphamide. Carbohydrate Polymers,207, 131\u2013142.","journal-title":"Carbohydrate Polymers"},{"issue":"1","key":"9535_CR35","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1590\/S0102-86502010000100011","volume":"25","author":"A Dantas","year":"2010","unstructured":"Dantas, A., Batista-J\u00fanior, F., Macedo, L., Mendes, M., Azevedo, I., & Medeiros, A. (2010). Protective effect of simvastatin in the cyclophosphamide-induced hemohrragic cystitis in rats. Acta Cir\u00fargica Brasileira,25(1), 43\u201346.","journal-title":"Acta Cir\u00fargica Brasileira"},{"key":"9535_CR36","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/BF02867674","volume":"18","author":"N Singh","year":"2003","unstructured":"Singh, N., & Kumar, R. (2003). Effect of nicorandil and amlodipine on bio-chemical parameters during isoproterenol induced myocardial necrosis in rats. Indian Journal of Clinical Biochemistry,18, 99\u2013102.","journal-title":"Indian Journal of Clinical Biochemistry"},{"key":"9535_CR37","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.ejphar.2007.10.074","volume":"579","author":"M Tajima","year":"2008","unstructured":"Tajima, M., Ishizuka, N., Saitoh, K., & Sakagami, H. (2008). Nicorandil enhances the effect of endothelial nitric oxide under hypoxia-reoxygenation: Role of the KATP channel. European Journal of Pharmacology,579, 86\u201392.","journal-title":"European Journal of Pharmacology"},{"key":"9535_CR38","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1097\/00005344-200108000-00005","volume":"38","author":"S Horinaka","year":"2001","unstructured":"Horinaka, S., Kobayashi, N., Higashi, T., Hara, K., Hara, S., & Matsuoka, H. (2001). Nicorandil enhances cardiac endothelial nitric oxide synthase expression via activation of adenosine triphosphate-sensitive K channel in rat. Journal of Cardiovascular Pharmacology,38, 200\u2013210.","journal-title":"Journal of Cardiovascular Pharmacology"},{"key":"9535_CR39","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1111\/jcmm.13648","volume":"22","author":"TM Lee","year":"2018","unstructured":"Lee, T. M., Lin, S. Z., & Chang, N. C. (2018). Nicorandil regulates the macrophage skewing and ameliorates myofibroblasts by inhibition of RhoA\/Rho-kinase signalling in infarcted rats. Journal of Cellular and Molecular Medicine,22, 1056\u20131069.","journal-title":"Journal of Cellular and Molecular Medicine"},{"key":"9535_CR40","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1016\/j.bcp.2013.07.005","volume":"86","author":"LA Ahmed","year":"2013","unstructured":"Ahmed, L. A., & El-Maraghy, S. A. (2013). Nicorandil ameliorates mitochondrial dysfunction in doxorubicin-induced heart failure in rats: possible mechanism of cardioprotection. Biochemical Pharmacology,86, 1301\u20131310.","journal-title":"Biochemical Pharmacology"},{"key":"9535_CR41","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1177\/1074248416636477","volume":"21","author":"MZ Afzal","year":"2016","unstructured":"Afzal, M. Z., Reiter, M., Gastonguay, C., McGivern, J. V., Guan, X., Ge, Z. D., et al. (2016). Nicorandil, a nitric oxide donor and ATP-sensitive potassium channel opener, protects against dystrophin-deficient cardiomyopathy. Journal of Cardiovascular Pharmacology and Therapeutics,21, 549\u2013562.","journal-title":"Journal of Cardiovascular Pharmacology and Therapeutics"}],"container-title":["Cardiovascular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-019-09535-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12012-019-09535-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-019-09535-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,20]],"date-time":"2020-06-20T23:28:37Z","timestamp":1592695717000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12012-019-09535-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,22]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["9535"],"URL":"https:\/\/doi.org\/10.1007\/s12012-019-09535-8","relation":{},"ISSN":["1530-7905","1559-0259"],"issn-type":[{"value":"1530-7905","type":"print"},{"value":"1559-0259","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,22]]},"assertion":[{"value":"22 June 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All applicable international, national, and\/or institutional guidelines for the care and use of animals were followed. All procedures performed in studies involving animals were in accordance with the ethical standards of the institution or practice at which the studies were conducted. This article does not contain any studies with human participants performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}